Identifiers and Description
Gene Model Identifier
TTHERM_00257230Standard Name
HMGB2 (High MoBility group 2)Aliases
HMG C | LG2 | HMG-C | PreTt25409 | 22.m00354Description
HMGC high mobility group (HMG) box protein; High-Mobility-Group (HMG) protein; may play a role in the bending or looping of DNA; present in both macro- and micronuclei but with elevated expression during both macronuclear S phase and endoreplication of developing new macronucleiGenome Browser (Macronucleus)
Genome Browser (Micronucleus)
External Links
Gene Ontology Annotations
Cellular Component
- macronucleus (TAS) | GO:0031039
- nucleus (IEA) | GO:0005634
Molecular Function
- DNA binding (IEA) | GO:0003677
Biological Process
- conjugation with mutual genetic exchange (IEP) | GO:0000748
Domains
- ( PF00505 ) HMG (high mobility group) box
Gene Expression Profile
Vegetative Cell Cycle (Zhang et al., 2023)
GeneMania
Tetrahymena Stock Center
No Data fetched for Tetrahymena Stock Center
Homologs
Source Identifier Score Tetrahymena borealis EI9_10404.1 8.001824328206442e-49 Description: nonhistone chromosomal protein LG-1 (101 aa) SGD YDL002C 0.00000000009998509410508463 Description: NHP10 Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair DictyBase DDB_G0270260 0.000000030002053728821195 Description: nhp6 on chromosome: 1 position 4527247 to 4527672 Oxytricha Contig4075.0.g7 0.000000030002053728821195 Description: HMG (high mobility group) box WormBase WBGene00001971 0.000005998506718272351 Description: locus:hmg-1.1 status:Confirmed UniProt:G5EFV4 protein_id:CAB54448.2
General Information
No Data fetched for General Information
Associated Literature
- Ref:31932604: Nabeel-Shah S, Ashraf K, Saettone A, Garg J, Derynck J, Lambert JP, Pearlman RE, Fillingham J (2020) Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila. Scientific reports 10(1):168
- Ref:8264578: Wu M, Allis CD, Sweet MT, Cook RG, Thatcher TH, Gorovsky MA (1994) Four distinct and unusual linker proteins in a mitotically dividing nucleus are derived from a 71-kilodalton polyprotein, lack p34cdc2 sites, and contain protein kinase A sites. Molecular and cellular biology 14(1):10-20
- Ref:8417323: Wang T, Allis CD (1993) An abundant high-mobility-group-like protein is targeted to micronuclei in a cell cycle-dependent and developmentally regulated fashion in Tetrahymena thermophila. Molecular and cellular biology 13(1):163-73
- Ref:1589033: Lilley DM (1992) DNA--protein interactions. HMG has DNA wrapped up. Nature 357(6376):282-3
- Ref:1480473: Wang T, Allis CD (1992) Replication-dependent and independent regulation of HMG expression during the cell cycle and conjugation in Tetrahymena. Nucleic acids research 20(24):6525-33
- Ref:1991550: Schulman IG, Wang TT, Stargell LA, Gorovsky MA, Allis CD (1991) Cell-cell interactions trigger the rapid induction of a specific high mobility group-like protein during early stages of conjugation in Tetrahymena. Developmental biology 143(2):248-57
- Ref:1986218: Schulman IG, Wang T, Wu M, Bowen J, Cook RG, Gorovsky MA, Allis CD (1991) Macronuclei and micronuclei in Tetrahymena thermophila contain high-mobility-group-like chromosomal proteins containing a highly conserved eleven-amino-acid putative DNA-binding sequence. Molecular and cellular biology 11(1):166-74
- Ref:2514183: Suda M, Hayashi H (1989) A protein that accumulates during starvation in Tetrahymena nuclei. Journal of biochemistry 106(4):612-5
- Ref:2476991: Hamana K, Kawada K (1989) Release of nucleosomes from nuclei by bleomycin-induced DNA strand scission. Biochemistry international 18(5):971-9
- Ref:2760016: Hayashi T, Hayashi H, Iwai K (1989) Tetrahymena HMG nonhistone chromosomal protein. Isolation and amino acid sequence lacking the N- and C-terminal domains of vertebrate HMG 1. Journal of biochemistry 105(4):577-81
- Ref:3584238: Schulman IG, Cook RG, Richman R, Allis CD (1987) Tetrahymena contain two distinct and unusual high mobility group (HMG)-like proteins. The Journal of cell biology 104(6):1485-94
- Ref:3109974: Prasanna P, Holmlund CE (1987) Identification in Tetrahymena pyriformis of 3-hydroxy-3-methyl glutaryl coenzyme a lyase: its purification and properties. The International journal of biochemistry 19(4):385-9
- Ref:3671074: Roth SY, Schulman IG, Cook RG, Allis CD (1987) The complete amino acid sequence of an HMG-like protein isolated from the macronucleus of Tetrahymena. Nucleic acids research 15(19):8112
- Ref:6849878: Levy-Wilson B, Denker MS, Ito E (1983) Isolation, characterization, and postsynthetic modifications of tetrahymena high mobility group proteins. Biochemistry 22(7):1715-21
- Ref:6258140: Hamana K, Zama M (1980) Selective release of HMG nonhistone proteins during DNase digestion of Tetrahymena chromatin at different stages of the cell cycle. Nucleic acids research 8(22):5275-88
- Ref:117005: Hamana K, Iwai K (1979) High mobility group nonhistone chromosomal proteins also exist in Tetrahymena. Journal of biochemistry 86(3):789-94
Sequences
>TTHERM_00257230(coding)
ATGGTGGGGAAAAAAAAGTAATATTATAAGAAAAAGATAAATGAATTAGAATCATATAGG
GTGATAGATGACTCATTCATTCATTCATTCATTTAAATATAAATAGAGGTTGGGGGGTTT
TAATCATTCATTCATAATGAATGTACTAATGCTTGTTTGATAATTAGTTTGTTTGTTTAT
TTGTATGCTTTTTGTATGTATGTTGGTAGGAAGGTATTTAGGTTGTATTTTTTAATTAAT
AAATTGAATGGAAATATATTTTTTCTATTGGTTAGTAAAAATTCAATTTTACAACGAGAT
TATCCAATCAGAAAGCAGATACAAAAGACAAGGAGATCAATAATTTCATTATAAAAATAA
TGCAAATTGCTTTTGTTTTAATAATATCAAATAATTAAAAAAATACAAAAGAAAAAAATC
AATAAAAAAACACATCAATCTAAAATGGCCAAATCAAAAGACGACAGCAAGCCCGCTCCC
CCCAAGAGACCCTTATCCGCTTTCTTCTTATTCAAGTAACACAACTACGAATAAGTCAAG
AAGGAAAACCCCAATGCCAAGATCACCGAATTGACCTCCATGATCGCTGAAAAGTGGAAA
GCTGTTGGTGAAAAGGAAAAGAAGAAATACGAAACTTTATAATCTGAAGCTAAGGCTAAG
TACGAAAAGGACATGTAAGCCTACGAAAAGAAGTACGGCAAACCCGAAAAGTAAAAGAAG
ATCAAGAAGAACAAAAAGGGATCCAAGTGA>TTHERM_00257230(gene)
ATGGTGGGGAAAAAAAAGTAATATTATAAGAAAAAGATAAATGAATTAGAATCATATAGG
GTGATAGATGACTCATTCATTCATTCATTCATTTAAATATAAATAGAGGTTGGGGGGTTT
TAATCATTCATTCATAATGAATGTACTAATGCTTGTTTGATAATTAGTTTGTTTGTTTAT
TTGTATGCTTTTTGTATGTATGTTGGTAGGAAGGTATTTAGGTTGTATTTTTTAATTAAT
AAATTGAATGGAAATATATTTTTTCTATTGGTTAGTAAAAATTCAATTTTACAACGAGAT
TATCCAATCAGAAAGCAGATACAAAAGACAAGGAGATCAATAATTTCATTATAAAAATAA
TGCAAATTGCTTTTGTTTTAATAATATCAAATAATTAAAAAAATACAAAAGAAAAAAATC
AATAAAAAAACACATCAATCTAAAATGGCCAAATCAAAAGACGACAGCAAGGTAATTCAT
TTATTTTATAAAGCTTTTCTGATTCTACTTTTGGATTTCTGAGAGTTTCCTTCCTAATAG
AGCCCTCAAAAATACTCCAAAAAACCCGCATAATTCAGCTCTATAACTTTTTCTTTTAGT
GAAGGCTCTAAAAATCTATTATTGATGAGGAATTACCCTCATTTTGCAACTCTTTTGCCT
CCATTCTTATAGACAATTGACTTATCTTTCTTTTTTTATTCAAAATAGCCCGCTCCCCCC
AAGAGACCCTTATCCGCTTTCTTCTTATTCAAGTAACACAACTACGAATAAGTCAAGAAG
GAAAACCCCAATGCCAAGATCACCGAATTGACCTCCATGATCGCTGAAAAGTGGAAAGCT
GTTGGTGAAAAGGAAAAGAAGAAATACGAAACTTTATAATCTGAAGCTAAGGCTAAGTAC
GAAAAGGACATGTAAGCCTACGAAAAGAAGTACGGCAAACCCGAAAAGTAAAAGAAGATC
AAGAAGAACAAAAAGGGATCCAAGTGA>TTHERM_00257230(protein)
MVGKKKQYYKKKINELESYRVIDDSFIHSFIQIQIEVGGFQSFIHNECTNACLIISLFVY
LYAFCMYVGRKVFRLYFLINKLNGNIFFLLVSKNSILQRDYPIRKQIQKTRRSIISLQKQ
CKLLLFQQYQIIKKIQKKKINKKTHQSKMAKSKDDSKPAPPKRPLSAFFLFKQHNYEQVK
KENPNAKITELTSMIAEKWKAVGEKEKKKYETLQSEAKAKYEKDMQAYEKKYGKPEKQKK
IKKNKKGSK