Identifiers and Description

Gene Model Identifier

TTHERM_00112480

Standard Name

THD15 (Tetrahymena Histone Deacetylase 15)

Aliases

PreTt27062 | 8.m00322 | 3812.m02359

Description

THD15 SIR2 family transcriptional regulator; Sir2-like histone deacetylase; suppresses DNA transcription by deacetylation of histones

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
• NAD+ binding (IEA) | GO:0070403
• zinc ion binding (IEA) | GO:0008270

Biological Process

• chromatin silencing (IEA) | GO:0006342
• protein deacetylation (IEA) | GO:0006476
• regulation of transcription (IEA) | GO:0045449

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_03967.1	9.99838497179609e-146
	Description: transcriptional regulator, Sir2 family protein (309 aa)
Oxytricha	Contig9367.0.g58	7.998505003885351e-50
	Description: Sir2 family
DictyBase	DDB_G0283917	8.000462645699572e-47
	Description: sir2A on chromosome: 4 position 1272110 to 1273864
WormBase	WBGene00004800	4.000139296874041e-45
	Description: locus:sir-2.1 status:Partially_confirmed UniProt:D3YT50 protein_id:CBK19468.1
SGD	YPL015C	1.999683289470905e-41
	Description: HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
Stentor Coeruleus	SteCoe_18027	7.095474162284704e-23
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82

Sequences

>TTHERM_00112480(coding)
ATGCATTTAAAAACACTCTTCAAATCATTAATTACTCCAAGTAAGTAAATTACTTTGAGA
ATATCTAACGTATAGCCAGTTATCAACAGTATTAAATTCGATTAAACAAATCATAGTATA
CATAACTCAATCTCACATGAAGTATAGGACAGATCTCAAATAATTGAGAATTTTGCTGAG
AAGTTGTTAGCAAAAAAATATAAATAGATAGCTTTCTTGACAGGAGCAGGAATTAGTGTA
AGTGCTGGAATTCCAGATTTTAGATCTCCTGAAACTGGGCTTTACGCCTAAATAAAAAAA
GAATATGACATAAGTGATCCTTAAAAAATATTTTCAATTAGATATTATCAAGATAATCCT
TTGCCTTTTATGCAAGTTATTAGAGATTTCTTTTCAAGAGAATATCACCCAACTTATGCT
CATAAGTTAATCCATTAAATCTACAAAAGAAAACAACTATTAATAAATATAACCTAAAAT
ATTGATGGCTTAGAGTTAAAAACAGGGATTAATCCCTCAAAAGTAGTCTAAGCACATGGA
CATATGAGAAAGGCTCATTGTGTGAATTGCAATCATATTGTCAATATTGAAACTTACTTA
CAAAACTGCAAACAGTTAAAAAAAACCTAATGCCCCATTTGCAATAATTTAGTGAAGCCA
AAAATTGTTTTCTTTGGAGAGTTTCTTCCTAATGAGTTTTATTAGTCTAGAGATATTTTG
CCAAATTCAGATTGTGTGGTTGTTATGGGAACATCTTTAGGTGTCTTTCCATTTGCTAAT
TTAATAAACGAAGTAGGTACTTCTGTTCCAATATATATAATAAACAATAAACTTCCTAAA
AATATAAGTCATCTTAAAAATCAAATTGAATTTATATAAGGAGATATCAATGAAATTTCT
AAATAAATTATTGATTACATAAATTGA

>TTHERM_00112480(gene)
ATGCATTTAAAAACACTCTTCAAATCATTAATTACTCCAAGTAAGTAAATTACTTTGAGA
ATATCTAACGTATAGCCAGTTATCAACAGTATTAAATTCGATTAAACAAATCATAGTATA
CATAACTCAATCTCACATGAAGTATAGGACAGATCTCAAATAATTGAGAATTTTGCTGAG
AAGTTGTTAGCAAAAAAATATAAATAGATAGCTTTCTTGACAGGAGCAGGAATTAGTGTA
AGTGCTGGAATTCCAGATTTTAGATCTCCTGAAACTGGGCTTTACGCCTAAATAAAAAAA
GAATATGACATAAGTGATCCTTAAAAAATATTTTCAATTAGATATTATCAAGATAATCCT
TTGCCTTTTATGCAAGTTATTAGAGATTTCTTTTCAAGAGAATATCACCCAACTTATGCT
CATAAGTTAATCCATTAAATCTACAAAAGAAAACAACTATTAATAAATATAACCTAAAAT
ATTGATGGCTTAGAGTTAAAAACAGGGATTAATCCCTCAAAAGTAGTCTAAGCACATGGA
CATATGAGAAAGGCTCATTGTGTGAATTGCAATCATATTGTCAATATTGAAACTTACTTA
CAAAACTGCAAACAGTTAAAAAAAACCTAATGCCCCATTTGCAATAATTTAGTGAAGCCA
AAAGTAATTTTATTTCTTTGTTTAAATTTTAATTGTAATGCTAGCAAAAATATAGGAAAT
AAAAATTAGAAATTATTGGCACAATTAGTTGAAAAAAATAAATATTTTAAATTTCAATCA
AAAATATTTATTGAGAATCAACTTTATTTATTATTGAAATTTATCAGTTAGTTTCCATAT
CATAAATTTTTTATATTTATAAAAATAAAAGATTGTTTTCTTTGGAGAGTTTCTTCCTAA
TGAGTTTTATTAGTCTAGAGATATTTTGCCAAATTCAGATTGTGTGGTTGTTATGGGAAC
ATCTTTAGGTGTCTTTCCATTTGCTAATTTAATAAACGAAGTAGGTACTTCTGTTCCAAT
ATATATAATAAACAATAAACTTCCTAAAAATATAAGTCATCTTAAAAATCAAATTGAATT
TATATAAGGAGATATCAATGAAATTTCTAAATAAATTATTGATTACATAAATTGA

>TTHERM_00112480(protein)
MHLKTLFKSLITPSKQITLRISNVQPVINSIKFDQTNHSIHNSISHEVQDRSQIIENFAE
KLLAKKYKQIAFLTGAGISVSAGIPDFRSPETGLYAQIKKEYDISDPQKIFSIRYYQDNP
LPFMQVIRDFFSREYHPTYAHKLIHQIYKRKQLLINITQNIDGLELKTGINPSKVVQAHG
HMRKAHCVNCNHIVNIETYLQNCKQLKKTQCPICNNLVKPKIVFFGEFLPNEFYQSRDIL
PNSDCVVVMGTSLGVFPFANLINEVGTSVPIYIINNKLPKNISHLKNQIEFIQGDINEIS
KQIIDYIN