Identifiers and Description

Gene Model Identifier

TTHERM_00191790

Standard Name

CDC5  (Cell Division Cycle  )

Aliases

PreTt08829 | 15.m00540 | 3697.m00251

Description

Serine/Threonine kinase; Polo-like kinase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• protein kinase activity (IEA) | GO:0004672
• protein serine/threonine kinase activity (IEA) | GO:0004674
• protein tyrosine kinase activity (IEA) | GO:0004713

Biological Process

• cell cycle (IEA) | GO:0007049
• protein phosphorylation (IEA) | GO:0006468

Domains

• ( PF00069 ) protein kinase domain
• ( PF00659 ) POLO box duplicated region
• ( PF07714 ) protein tyrosine kinase

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_36445	0
	Description: None
Tetrahymena borealis	EI9_06146.1	9.997093137033517e-262
	Description: protein kinase domain-containing protein (675 aa)
Oxytricha	Contig8263.0.g23	9.997093137033517e-262
	Description: Protein kinase domain
SGD	YMR001C	3.998986577109865e-118
	Description: CDC5 Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate
WormBase	WBGene00004042	9.00055006962023e-115
	Description: locus:plk-1 Serine/threonine-protein kinase plk-1 status:Confirmed UniProt:P34331 protein_id:CCD64438.1
DictyBase	DDB_G0274503	4.001242549923285e-107
	Description: plk on chromosome: 2 position 4379150 to 4382891

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16933976: Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA,

Sequences

>TTHERM_00191790(coding)
ATGGATAAGGCAAACGAAGGTAAAGATTAATTAATCATCATTGAAGAAAAAATTTCAAAA
GTAAATGGTGAGATGGCTGTCAAGAAGTATTTACGAGGCAAGCTATTAGGTAAAGGTGGC
TTTGCTAAGTGCTACGAAGTAACAAATTTAGAAACTAAGAAAATTATTGCAGCAAAAATA
ATTCCAAAACAGACCTTAACAAAAAATAGAGCTCGTCAAAAACTCATTTCAGAAATTAAA
ATTCATAAAAGTTTAAATCATTAGCATGTTGTAGCATTTGAACATGTCTTTGAAGATCAT
GAGAACGTATACATTTTACTAGAGCTCTGCACTAACCATACCCTAAACGAATTAATTAAA
AGACGTAAGAGATTGACTGAACTCGAAGTTTAGTGTTATGTTGTTTAAATAGTTAATGCA
CTTAAATATTTACACAGTCATAAAGTAATCCACAGAGATTTAAAACTAGGTAATCTTTTC
CTAAATGAGAAGATGGAAATTAAGCTAGGTGACTTCGGTCTTGCTACAAAGCTAGAATTT
GACGGAGAAAAAAAGCATACAATTTGTGGTACACCTAACTACATTGCTCCAGAAATTTTA
GATGGAAAAACTGGTCATTCTTATTAGGTTGACATTTGGTCATTGGGAGTTATCATTTAT
ACACTCCTAATAGGAAAGCCACCATTTGAAACTCCTGATGTCAAGACCACATACAAAAAA
ATTAGAAATATCTCTTATGGATTCCCTGAAAACGTTCCTATTTCTGATTAGGCAAGAGGC
TTGATTACTAGAATTTTGAATATAGATCCACAAAGAAGACCGACGTTAGATGAAATTATG
AGCTCATCCTTTTTAAATACTGGTGGTACTATTCCTAAAGTACTACCTTTGGCTACTTTG
GCTTGCCCTCCCTCAGCTTCATACACAAAGTAATTCCTTCCATAAGGAAATGCTCTCAAG
CTTAATCAAGCTCCAATGAGACTAACCGATTCAGCATCTTAGTCAACTACAAACATTAAA
GGTAAAAATGCAAGCACTTCTAATCTTTACTCTAAATAAACAACCACAGGTGCAGTCCCA
GATGCCAGTCGCCCACTTGGAGGAACCACTTCAAATTGGAATTAAGTGTCTAGCTAAAAA
GATTAACGTCCACAAACTCAATAATTCTAAAAATCTGACTTTAAGACATCAATGTCAACT
AAAAATATGGGCTCTGGTTCTTAAAACCCTCTTTTCAACCAGACTAATGCCCCTGGATTA
GCAACAGCATAAAGTCTTAATACATTCACCAAAACAAAAAATAACTTTAATAGCACACAA
AAAGGTTTTATGCAAACTGGTACATAAAATTTTGGTAAACCTGTACAACCTGTTTGGGTT
ACTCAATGGGTAGATTACTCAGCTAAATATGGTTTAGGGTATCTTCTTTCTAACGGATGC
AGTGGTGTCTTCTTTAATGACTCAACAAAAGTGATATTAGACCCTACAACCAATAACATA
GAATACATCGAAAGACTTGGAAACGAAAGATAAGACTTCGTTTAGCAATTCACCTTGAAG
GATTATCCTCCTGAGATGAAAAAGAAGGTTACACTCCTATCTCATTTTAAGAGTTACTTG
GAAGAATAAATGCAAAAATAAAACATTCAAATAGAAGTTCCATAATTCTAAGGAGACTTG
CAACCCTATGTTTATGTAAAGAAGTGGATGAAAACTAAACATGCCATTATGTTCCGTCTT
TCAAACAAAATCGTACAAGTAAGCTTCCAAGATAAGACAGAGATTTTGCTTTCTTCAGAA
AATAAAATGGTTACATACGTAGATCGTAAAGGCACTCGTACTGACTATCCATTATCTACA
GCACTAGAAAGCTCTAATACAGAAATGTCAAAACGTCTTAAATATACTAAAGATATACTG
ACTCACATGTTAAATAATAATACCACAAATAACAACAATGGTAGAGGATCAATGACTAAC
GTAAATCCTACCTAGAATGGTACAGAAAAGGAAAATTATAACTGA

>TTHERM_00191790(gene)
ATGGATAAGGCAAACGAAGGTAAAGATTAATTAATCATCATTGAAGAAAAAATTTCAAAA
GTAAATGGTGAGATGGCTGTCAAGAAGTATTTACGAGGCAAGCTATTAGGTAAAGGTGGC
TTTGCTAAGTGCTACGAAGTAACAAATTTAGAAACTAAGAAAATTATTGCAGCAAAAATA
ATTCCAAAACAGACCTTAACAAAAAATAGAGCTCGTCAAAAACTCATTTCAGAAATTAAA
ATTCATAAAAGTTTAAATCATTAGCATGTTGTAGCATTTGAACATGTCTTTGAAGATCAT
GAGAACGTATACATTTTACTAGAGCTCTGCACTAACCATACCCTAAACGAATTAATTAAA
AGACGTAAGAGATTGACTGAACTCGAAGTTTAGTGTTATGTTGTTTAAATAGTTAATGCA
CTTAAATATTTACACAGTCATAAAGTAATCCACAGAGATTTAAAACTAGGTAATCTTTTC
CTAAATGAGAAGATGGAAATTAAGCTAGGTGACTTCGGTCTTGCTACAAAGCTAGAATTT
GACGGAGAAAAAAAGCATACAATTTGTGGTACACCTAACTACATTGCTCCAGAAATTTTA
GATGGAAAAACTGGTCATTCTTATTAGGTTGACATTTGGTCATTGGGAGTTATCATTTAT
ACACTCCTAATAGGAAAGGTAATCATCATAAAAATTTACAAATTAATCCAAAAACAGCTA
TTTGCATGAGAAAAAGCCCTATCCCAAACTAGAGTTATAATTGGAGTAATACACAAAGAT
AATAAGCAAGTATTACATTAATTTTGAAAGCAAATAGTTGAAGAAAATAAGAAATTAAAT
TCTATTTACTAACTGAATAAATTGATATCTATATAGCTATATATAAAATAAGAAAGAAAC
AAAGAAAAAATATTTATTTATTTCACAGCTTATTTGCAAAATGATAATCAAATATATTTT
TCACATACTTTCTTTTCAAAAAAATAAATAATCAATCAATCAATCAAACAAACAAACAAA
TATTTATTTTTTGAAAGTAGAAGGGAGCGAGCAATTCAACTAAACACTCTATTTATAAAT
TAGCATGATACAATAAAAAGAGCTAATATTTATATAGAAAAAAAAAATTATCAAAAATAG
ACTGAATCAGAATTATTTGAGATAAGCATACAAATTATTTATTTTTAAATTTTAGAAATT
AAATTAATTTAAGCTAATATTGAGCTAAGTTTTTAAATCACTTCTTTAAATTGAAATTCT
TTTGATGGGCTTATTTTTTATACTTAATCGAAAACTTAGCGAGTATTCATTTCAATAGCA
AATAACATTTTTTAATGCAGACAAATAAATTATCTTCGCTTTTAAAATATTTTTCTTTTA
CAAAAAACTGCTTAACTACAAAATAGAGCTTCAATAAGATTTAATTTTTTTAGCAAATCT
TTTCAAATCAAGTATTTTTTTTTTAAAGGCTAATAAATATTCAATAACTACTTAATTTTA
AAATAGCTATGATTAAGGGATGTAAAATTTTTAAAGCGATTTTAAGCAGTCAAAATAAAT
CCTATAAAAATAAATTAAACATAATTGTATATAATAGCCACCATTTGAAACTCCTGATGT
CAAGACCACATACAAAAAAATTAGAAATATCTCTTATGGATTCCCTGAAAACGTTCCTAT
TTCTGATTAGGCAAGAGGCTTGATTACTAGAATTTTGAATATAGATCCACAAAGAAGACC
GACGTTAGATGAAATTATGAGCTCATCCTTTTTAAATACTGGTGGTACTATTCCTAAAGT
ACTACCTTTGGCTACTTTGGCTTGCCCTCCCTCAGCTTCATACACAAAGTAATTCCTTCC
ATAAGGAAATGCTCTCAAGCTTAATCAAGCTCCAATGAGACTAACCGATTCAGCATCTTA
GTCAACTACAAACATTAAAGGTAAAAATGCAAGCACTTCTAATCTTTACTCTAAATAAAC
AACCACAGGTGCAGTCCCAGATGCCAGTCGCCCACTTGGAGGAACCACTTCAAATTGGAA
TTAAGTGTCTAGCTAAAAAGATTAACGTCCACAAACTCAATAATTCTAAAAATCTGACTT
TAAGACATCAATGTCAACTAAAAATATGGGCTCTGGTTCTTAAAACCCTCTTTTCAACCA
GACTAATGCCCCTGGATTAGCAACAGCATAAAGTCTTAATACATTCACCAAAACAAAAAA
TAACTTTAATAGCACACAAAAAGGTTTTATGCAAACTGGTACATAAAATTTTGGTAAACC
TGTACAACCTGTTTGGGTTACTCAATGGGTAGATTACTCAGCTAAATATGGTTTAGGGTA
TCTTCTTTCTAACGGATGCAGTGGTGTCTTCTTTAATGACTCAACAAAAGTGATATTAGA
CCCTACAACCAATAACATAGAATACATCGAAAGACTTGGAAACGAAAGATAAGACTTCGT
TTAGCAATTCACCTTGAAGGATTATCCTCCTGAGATGAAAAAGAAGGTTACACTCCTATC
TCATTTTAAGAGTTACTTGGAAGAATAAATGCAAAAATAAAACATTCAAATAGAAGTTCC
ATAATTCTAAGGAGACTTGCAACCCTATGTTTATGTAAAGAAGTGGATGAAAACTAAACA
TGCCATTATGTTCCGTCTTTCAAACAAAATCGTACAAGTAAGCTTCCAAGATAAGACAGA
GATTTTGCTTTCTTCAGAAAATAAAATGGTTACATACGTAGATCGTAAAGGCACTCGTAC
TGACTATCCATTATCTACAGCACTAGAAAGCTCTAATACAGAAATGTCAAAACGTCTTAA
ATATACTAAAGATATACTGACTCACATGTTAAATAATAATACCACAAATAACAACAATGG
TAGAGGATCAATGACTAACGTAAATCCTACCTAGAATGGTACAGAAAAGGAAAATTATAA
CTGA

>TTHERM_00191790(protein)
MDKANEGKDQLIIIEEKISKVNGEMAVKKYLRGKLLGKGGFAKCYEVTNLETKKIIAAKI
IPKQTLTKNRARQKLISEIKIHKSLNHQHVVAFEHVFEDHENVYILLELCTNHTLNELIK
RRKRLTELEVQCYVVQIVNALKYLHSHKVIHRDLKLGNLFLNEKMEIKLGDFGLATKLEF
DGEKKHTICGTPNYIAPEILDGKTGHSYQVDIWSLGVIIYTLLIGKPPFETPDVKTTYKK
IRNISYGFPENVPISDQARGLITRILNIDPQRRPTLDEIMSSSFLNTGGTIPKVLPLATL
ACPPSASYTKQFLPQGNALKLNQAPMRLTDSASQSTTNIKGKNASTSNLYSKQTTTGAVP
DASRPLGGTTSNWNQVSSQKDQRPQTQQFQKSDFKTSMSTKNMGSGSQNPLFNQTNAPGL
ATAQSLNTFTKTKNNFNSTQKGFMQTGTQNFGKPVQPVWVTQWVDYSAKYGLGYLLSNGC
SGVFFNDSTKVILDPTTNNIEYIERLGNERQDFVQQFTLKDYPPEMKKKVTLLSHFKSYL
EEQMQKQNIQIEVPQFQGDLQPYVYVKKWMKTKHAIMFRLSNKIVQVSFQDKTEILLSSE
NKMVTYVDRKGTRTDYPLSTALESSNTEMSKRLKYTKDILTHMLNNNTTNNNNGRGSMTN
VNPTQNGTEKENYN