Identifiers and Description

Gene Model Identifier

TTHERM_00218760

Standard Name

TEB1 (TElomerase DNA Binding subunit 1; also known as Telomerase- (or TERT-) associated protein of 82 kDa )

Aliases

PreTt22303 | 18.m00329 | 3701.m00089

Description

TEB1 telomerase-associated protein; Telomerase holoenzyme subunit p82; essential gene; knockdown induces telomere shortening- a heterotrimer of telomerase

Genome Browser (Macronucleus)

Full Screen View


Genome Browser (Micronucleus)

Full Screen View

External Links

Gene Ontology Annotations

Cellular Component

Biological Process

Domains

  • ( PF01336 ) OB-fold nucleic acid binding domain
  • ( PF08646 ) Replication factor-A C terminal domain
  • ( PF08792 ) A2L zinc ribbon domain
  • ( TIGR00161 ) conserved hypothetical protein TIGR00161
  • ( TIGR00617 ) replication factor-a protein 1 (rpa1)

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
Tetrahymena borealis EI9_06651.1 9.997093137033517e-262
Description: hypothetical protein (690 aa)
Oxytricha Contig13699.0.g10 0.00008003872323201264
Description: Replication factor-A C terminal domain
SGD YAR007C 0.00020003864201578029
Description: RFA1 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:27895115: Upton HE, Chan H, Feigon J, Collins K (2017) Shared Subunits of Tetrahymena Telomerase Holoenzyme and Replication Protein A Have Different Functions in Different Cellular Complexes. The Journal of biological chemistry 292(1):217-228
  2. Ref:25225329: Upton HE, Hong K, Collins K (2014) Direct single-stranded DNA binding by Teb1 mediates the recruitment of Tetrahymena thermophila telomerase to telomeres. Molecular and cellular biology 34(22):4200-12
  3. Ref:23918804: Hong K, Upton H, Miracco EJ, Jiang J, Zhou ZH, Feigon J, Collins K (2013) Tetrahymena telomerase holoenzyme assembly, activation, and inhibition by domains of the p50 central hub. Molecular and cellular biology 33(19):3962-71
  4. Ref:20363756: Min B, Collins K (2010) Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme. The Journal of biological chemistry 285(22):16434-43

Sequences 

>TTHERM_00218760(coding)
ATGAAATTAACTAAAGGTGGGTCGTATATACTTAAAAAAGTGGACAGAAAATAGTTTTAT
TAAGATGAAGAAATAGTCATGTAAATAAAAAAAATACTTGGTTAAAAAACTACAGATTGC
AAACAATACATAAAATGTGAGTGTATAGATGGTTTGGGAGATGAAGCATTGATTTACTTT
GAGATGCTTGCTAATTAAAATCAGCATTTACAAAAAAACGATGTCATAATGATTTAAGAT
TATTTAAATGATAAAACATAAAACGACAAAATAGTTGTTTTAGTTACAAGGTTTTAATTT
TGTAAAGCCAGTCATGTTTAGCCTAAAACCGCCCAAAAAGAATCCATATAACTATTAAAT
ACTGAAAAAACAATAATTTAAAAGAGTAAAATTACTAAAAATCCAGCTGAAGAAGTTTTA
AAATTTATAGAAGTAAACGAAAAAGATAATAGTTCAAACAGTGAAGATATGATAATTGAA
TAGTAGAAATAAGAAATTAAGAATAATTAAAAAGAAAAACAAAGTATAAATGGATTTAAT
TTGGAAGATAGCTATTCAAATATTTCTGATATTACTAATTTTGGAGGGAAATCTAATTTT
AATATTGGATCACTTTCTGATTAACTTAGTAAATAGACACTGCTAATTTCTTAGTTGTAA
GTAGGTAAAAATAGATTTTCTTTTAAGTTCGAAGGAAGAGTTGTATATAAAAGTAGTACA
TTCCAGAATTAGCAAGACTCTAAGTATTTTTTCATCACAGCATAAGACGCTAATAATTAA
GAAATTAATTTGTCTTTTTGGCAAAAAGTTGATTAAAGCTATTAAACTTTGAAAGTAGGA
TAATATTATTACTTTATAGGAGGAGAAGTTAAATAGTTCAAAAATAATCTAGAATTAAAA
TTTAAGTTTGGAGACTACTAAATAATTCCTAAAGAGACTCTTTCTGCGAATTATGTATAA
CCTTTGGCATTACAACCTTCAAAATAATTTGGAAATGACTCAATAGGAGACTCTGATTAT
TCTATTCATAATTTAATTGAAAAGGAGGAAAGCATCGCTTAAAAGGGCTATAATGGATAA
AAGAATAATAAATATAGATAAAATAACAATAATAGCAAGCATACACTCTTAATATCTGAA
GTATTAAAAACTTCTAAATAATATTTATCAGTATTAGCATAAGTTGTTGATATTCAAAGT
TCAGATAAAAATATAAGATTAAAAATATGTGATAATAGCTGTAATTAAGAACTCAAAGTA
GTCATTTTTCCAGATTTATGCTATGAGTGGAGAGATAAATTTAGTATAAATAAATGGTAT
TATTTTAATGAGTTTGTTAGATAAATTTATAATGATGAAGTTTAGTTGAAAAATAACATT
CATTCTTCAATTAAAGAATCTGATGATTAAAGAAAAGTTATTACTTATAATTAAGAATAG
GGTGTTTTTAAAAAATCAATCTCAATTAATAGCAATGATAGTTTTGAAATTAAGCCTAAA
ATTTCATATAAAAACAATTCTAACTAAGAATAAAGGATTTATTCTTCAATTGAAGAAATA
ATCTAATAAGCATAGGCTTCAGAAATAGGTCAAAAAAAAGAATTCTATGTTTATGGAAAC
TTAGTTTCAATATAGATGAAAAATAAGCTTTATTATTATAGGTGTACTTGTTAGGGTAAG
TCAGTCTTAAAATATCACGGAGATTCATTTTTTTGTGAAAGTTGCTAGTAGTTCATAAAT
CCTTAGGTGCATTTGATGCTTAGAGCATTTGTTTAAGATTCTACAGGGACAATTCCTGTT
ATGATTTTCGATCAGCAGTCAAGCCAACTTATCAACTAAATTGATCCATCAATTCATGTC
TAAGAAGCAGGTTAATATGTTAAAAATTGTATTGAAAATGGATAAGAAGAAATTATAAGA
TAGTTATTTAGTAAATTAGACTTTGCTAGATTTATATTTGAAATTTAATTTGAAAATAAA
GAATTTAATAACGAATAAGAGATAGCATACAAAGTATTAAAAATTGAAAAAGAAAATATT
AAAGAAGAATCTAAATATCTACTAAAAAAGTTAGAGCACTTAATAAACAATAATCAAAAT
AACTGA


>TTHERM_00218760(gene)
ATGAAATTAACTAAAGGTGGGTCGTATATACTTAAAAAAGTGGACAGAAAATAGTTTTAT
TAAGATGAAGAAATAGTCATGTAAATAAAAAAAATACTTGGTTAAAAAACTACAGATTGC
AAACAATACATAAAGTAATCAAAATATATAACTTATCTAAAAAGAAAACAAATTGAGAAT
AAAAAAAATACAAATATAGATGTGAGTGTATAGATGGTTTGGGAGATGAAGCATTGATTT
ACTTTGAGATGCTTGCTAATTAAAATCAGCATTTACAAAAAAACGATGTCATAATGATTT
AAGATTATTTAAATGATAAAACATAAAAGTAAACTTTTAATATTAAAATGAGATAACAAA
ATTAATAAATATTTTTAAAAATCAAGCGACAAAATAGTTGTTTTAGTTACAAGGTTTTAA
TTTTGTAAAGCCAGTCATGTTTAGCCTAAAACCGCCCAAAAAGAATCCATATAACTATTA
AATACTGAAAAAACAATAATTTAAAAGAGTAAAATTACTAAAAATCCAGCTGAAGAAGTA
ATTAGTAGCTTATTTGCAAAGCTGAATGAATATATTATTTTTACATTGAATATATTATTT
TTACGAAATATTTTAGGTTTTAAAATTTATAGAAGTAAACGAAAAAGATAATAGTTCAAA
CAGTGAAGATATGATAATTGAATAGTAGAAATAAGAAATTAAGAATAATTAAAAAGAAAA
ACAAAGTATAAATGGTATTATTTATTTATTTATTAATCAATCTATCAATAATTTAATTTG
AAAATTTTGAGTGAAAAATCCTTGATAAATTTTTTGAACCACTTAGAATTTCTTTGAATA
TGATTTTTTTGTTTTTGATTAGGATTTAATTTGGAAGATAGCTATTCAAATATTTCTGAT
ATTACTAATTTTGGAGGGAAATCTAATTTTAATATTGGATCACTTTCTGATTAACTTAGT
AAATAGACACTGCTAATTTCTTAGTTGTAAGTAGGTAAAAATAGATTTTCTTTTAAGTTC
GAAGGAAGAGTTGTATATAAAAGTAGTACATTCCAGAATTAGCAAGACTCTAAGTATTTT
TTCATCACAGCATAAGACGCTAATAATTAAGAAATTAATTTGTCTTTTTGGCAAAAAGTT
GATTAAAGCTATTAAACTTTGAAAGTAGGATAATATTATTACTTTATAGGAGGAGAAGTT
AAATAGTTCAAAAATAAGTTAATTTATTTCTTTTTTTTTTTAATTTAAATAAAATTTTAT
ATTATAAAAATAGTCTAGAATTAAAATTTAAGTTTGGAGACTACTAAATAATTCCTAAAG
AGACTCTTTCTGCGAATTATGTATAACCTTTGGCATTACAACCTTCAAAATAATTTGGAA
ATGACTCAATAGGAGACTCTGATTATTCTATTCATAATTTAATGTAAAAGTATTTATTAA
AATCAATTTGTTTTGATATTTTTATGAACTTTTTTATAGTGAAAAGGAGGAAAGCATCGC
TTAAAAGGGCTATAATGGATAAAAGAATAATAAATATAGATAAAATAACAATAATAGCAA
GCATACACTCTTAATATCTGAAGTATTAAAAACTTCTAAATAATATTTATCAGTATTAGC
ATAAGTTGTTGTAAGATAATTACTAAGAGGTTTATATGTAGGTATTAATATGTATTTTAT
TTTAAATGAATAGGATATTCAAAGTTCAGATAAAAATATAAGATTAAAAATATGTGATAA
TAGCTGTAATTAAGAACTCAAAGTAGTCATTTTTCCAGATTTATGCTATGAGTGGAGAGA
TAAATTTAGTATAAATAAATGGTATTATTTTAATGAGTTTGTTAGATAAATTTATAATGA
TGAAGTTTAGTTGAAAAATAACATTCATTCTTCAATTAAAGAATCTGATGATTAAAGAAA
AGTTATTACTTATAATTAAGAATAGGGTGTTTTTAAAAAATCAATCTCAATTAATAGCAA
TGATAGTTTTGAAATTAAGCCTAAAATTTCATATAAAAACAATTCTAACTAAGAATAAAG
GATTTATTCTTCAATTGAAGAAATAATCTAATAAGCATAGGCTTCAGAAATAGGTCAAAA
AAAAGAATTCTATGTTTATGGAAACTTAGTTTCAATATAGATGAAAAATAAGCTTTATTA
TTATAGGTGTACTTGTTAGGGTAAGTCAGTCTTAAAATATCACGGAGATTCATTTTTTTG
TGAAAGTTGCTAGTAGTTCATAAATCCTTAGGTGCATTTGATGCTTAGAGCATTTGTTTA
AGATTCTACAGGGACAATTCCTGTTATGATTTTCGATCAGCAGTCAAGCCAACTTATCAA
CTGTAAATTTTTTTGGAAAAAATTAAATAAATTCATAAAATATTTGTTAAATAGAAATTG
ATCCATCAATTCATGTCTAAGAAGCAGGTTAATATGTTAAAAATTGTATTGAAAATGGAT
AAGAAGAAATTATAAGATAGTTATTTAGTAAATTAGACTTTGCTAGATTTATATTTGAAA
TTTAATTTGAAAATAAAGAATTTAATAACGAATAAGAGATAGCATACAAAGTATTAAAAA
TTGAAAAAGAAAATATTAAAGAAGAATCTAAATATCTACTAAAAAAGTTAGAGCACTTAA
TAAACAATAATCAAAATAACTGA


>TTHERM_00218760(protein)
MKLTKGGSYILKKVDRKQFYQDEEIVMQIKKILGQKTTDCKQYIKCECIDGLGDEALIYF
EMLANQNQHLQKNDVIMIQDYLNDKTQNDKIVVLVTRFQFCKASHVQPKTAQKESIQLLN
TEKTIIQKSKITKNPAEEVLKFIEVNEKDNSSNSEDMIIEQQKQEIKNNQKEKQSINGFN
LEDSYSNISDITNFGGKSNFNIGSLSDQLSKQTLLISQLQVGKNRFSFKFEGRVVYKSST
FQNQQDSKYFFITAQDANNQEINLSFWQKVDQSYQTLKVGQYYYFIGGEVKQFKNNLELK
FKFGDYQIIPKETLSANYVQPLALQPSKQFGNDSIGDSDYSIHNLIEKEESIAQKGYNGQ
KNNKYRQNNNNSKHTLLISEVLKTSKQYLSVLAQVVDIQSSDKNIRLKICDNSCNQELKV
VIFPDLCYEWRDKFSINKWYYFNEFVRQIYNDEVQLKNNIHSSIKESDDQRKVITYNQEQ
GVFKKSISINSNDSFEIKPKISYKNNSNQEQRIYSSIEEIIQQAQASEIGQKKEFYVYGN
LVSIQMKNKLYYYRCTCQGKSVLKYHGDSFFCESCQQFINPQVHLMLRAFVQDSTGTIPV
MIFDQQSSQLINQIDPSIHVQEAGQYVKNCIENGQEEIIRQLFSKLDFARFIFEIQFENK
EFNNEQEIAYKVLKIEKENIKEESKYLLKKLEHLINNNQNN