Identifiers and Description

Gene Model Identifier

TTHERM_00245100

Standard Name

TPA1 (Tetrahymena P-type ATPase )

Aliases

PreTt02406 | 21.m00237

Description

TPA1 Na-H/K antiporter P-type ATPase alpha subunit family protein; P-type ATPase; putative Na(+)/K(+) or H(+)/K(+) ATPase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

Gene Ontology Annotations

Molecular Function

• glutathionylspermidine synthase activity (IEA) | GO:0008885
• inorganic anion transmembrane transporter activity (IEA) | GO:0015103
• polyketide synthase activity (IEA) | GO:0016218

Biological Process

• cocaine biosynthetic process (IDA) | GO:0050799 | Ref:9124316
• creatine biosynthetic process (IEA) | GO:0006601
• heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process (IEA) | GO:0015014
• miRNA loading onto RISC (ISS) | GO:0035280 | Ref:9124316
• miRNA loading onto RISC (IEA) | GO:0035280
• peptide catabolic process (IEA) | GO:0043171
• vitamin D metabolic process (IEA) | GO:0042359

Domains

• ( PF00122 ) E1-E2 ATPase
• ( PF00689 ) Cation transporting ATPase, C-terminus
• ( PF00690 ) Cation transporter/ATPase, N-terminus
• ( PF00702 ) haloacid dehalogenase-like hydrolase
• ( PF03720 ) UDP-glucose/GDP-mannose dehydrogenase family, UDP binding
• ( PF07670 ) transporter gate domain protein
• ( PF08282 ) haloacid dehalogenase-like hydrolase
• ( TIGR00338 ) phosphoserine phosphatase SerB
• ( TIGR01106 ) Na,H/K antiporter P-type ATPase, alpha
• ( TIGR01116 ) calcium-translocating P-type ATPase, SERCA-type
• ( TIGR01487 ) SPP-like hydrolase, Archaeal
• ( TIGR01494 ) ATPase, P-type (transporting), HAD superfamily,
• ( TIGR01497 ) K+-transporting ATPase, B subunit
• ( TIGR01511 ) copper-translocating P-type ATPase
• ( TIGR01512 ) cadmium-translocating P-type ATPase
• ( TIGR01517 ) calcium-translocating P-type ATPase, PMCA-type
• ( TIGR01522 ) calcium-transporting P-type ATPase, PMR1-type
• ( TIGR01523 ) potassium/sodium efflux P-type ATPase, fungal-type
• ( TIGR01524 ) magnesium-translocating P-type ATPase
• ( TIGR01525 ) heavy metal translocating P-type ATPase
• ( TIGR01647 ) plasma-membrane proton-efflux P-type ATPase
• ( TIGR01652 ) phospholipid-translocating P-type ATPase, flippase
• ( TIGR01657 ) P-type ATPase of unknown pump

Gene Expression Profile

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_24478	0
	Description: None
WormBase	WBGene00001137	9.997093137033517e-262
	Description: locus:eat-6 status:Confirmed UniProt:P90735 protein_id:CAB02694.1
Tetrahymena borealis	EI9_01247.1	9.997093137033517e-262
	Description: Na,H/K antiporter P-type ATPase, alpha subunit protein (1197 aa)
DictyBase	DDB_G0267924	9.997093137033517e-262
	Description: DDB_G0267924 on chromosome: 1 position 1128799 to 1132710
Oxytricha	Contig21999.0.g128	9.997093137033517e-262
	Description: E1-E2 ATPase
SGD	YGL167C	1.0002857351297358e-115
	Description: PMR1 High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease

General Information

No Data fetched for General Information

Associated Literature

1. Ref:11952090: Linder JU, Schultz JE (2002) Guanylyl cyclases in unicellular organisms. Molecular and cellular biochemistry 230(1-2):149-58
2. Ref:10428960: Linder JU, Engel P, Reimer A, Krüger T, Plattner H, Schultz A, Schultz JE (1999) Guanylyl cyclases with the topology of mammalian adenylyl cyclases and an N-terminal P-type ATPase-like domain in Paramecium, Tetrahymena and Plasmodium. The EMBO journal 18(15):4222-32
3. Ref:9405804: Wang S, Gao D, Penny J, Krishna S, Takeyasu K (1997) P-type ATPases in Tetrahymena. Annals of the New York Academy of Sciences 834( ):158-60
4. Ref:9124316: Wang S, Takeyasu K (1997) Primary structure and evolution of the ATP-binding domains of the P-type ATPases in Tetrahymena thermophila. The American journal of physiology 272(2 Pt 1):C715-28

Sequences

>TTHERM_00245100(coding)
ATGAGTTAGACTAATATTCGTTAGTCAATGAATGGTGTTCGATAGTCAACGTCGAATATA
GCAAGAAAATTTGAAGAAATGAGACAGTCTATATAGCTTAAGAACTCCCAATAAGAAGTT
AGATAGAGCTAGTAAATGCGTAGATATGAAGGTGATTAAGATGATGGAAACAAAGTGGCA
CATTACAATCGCGAGTTAATGGAAGACCATCAACCTATACATACTGAAACAATTATGCTT
TAAGGTACTTCTTCTTAACATGATACTCACTAAAAACCATCAGCTCCAGCAGATAAAAAG
GAGGTTTCTAAAGAAGATTAATCAAAGCAAGCTCTTGTAGAAAAAGTTGATCACAAAATT
TCGTTAGAAGAGCTTAAGGAGAAGTATCAGACAGATTATTAAAAAGGTTTAACTGATTAG
TAAGCTGAACATTTACTTAGAGTCAATGGAGAAAACAAACTTTCAGCTAAAGCAGGTGTC
CCTTTATGGTTAAAGCTTTTGAGAGAAATGACCAATGGATTTTCTATTATGCTTTGGGTA
AGTGCAGGTCTTTGCTTTCTTGCTGAAGGTTTACAGCCTAATCCTTCAAATATCTATTTA
GCTGTTGTGTTAATTATTGTCATTCTAATTACTACAGCAATTACATTTTAATAGAATGCT
AAAAGTGAGGCTTTGATGAACTCCTTCAAGAATTTTATTCCTGCAAAAACTGTAGTTATT
AGAGGGGGCGATACTAAATCAATTGATGCAGCTCATCTTGTTGTTGGTGATATAGTCGTA
ATAAGACTGGGTGAAAAAATTCCTGCTGATATTCGTATTCTTGAATCTAACGAAATGAAA
GTTGACAATTCTCCCTTGACAGGTGAAAGTGAACCCTTACTACGTACGATTGAATGCTCT
CACCCTGAGAGTTATCTTGAAACCTCAAATATAGCCTTCTTCGGAACTCTGTGCAAAGAA
GGTACTGGAAAAGGTATTGTAATTGCCACTGGTGATCGTACTATGCTTGGACAAATTGCT
GATTTATCTTCTGGCGAAAAGAAAACTAAAACTCCTCTTCGTGTTGAACTCGATCGTTTT
GTTATTTTGATTACAGTAATTGCAATCTTCCTTGGTGTCCTCTTTTTCTTACTCGCTTTA
TTGTATATGAAGTATAAATTTAATGATTGCTTAGTCTTCGGTATAGGTATCCTTGTTGCG
AATGTACCTGAAGGTTTGCTAGGTTGCATTACTATCTCTCTCGCTATCACAGCAAAGAAC
CTATCTGCTAAAAGTGTCTTAGTTAAAAACTTAGAAGCCGTTGAAACTCTAGGTTCTACT
TCCTGTATTTGCTCTGACAAAACAGGTACTCTCACATAAAATGTTATGTCAGTCAAAAAC
TTGTGGTACAAAGATAGAATTTACCTATCTAAGAATAAAGTCTAACTTAAGTAAGGAGAA
TTACCTGAATATGACACTGAAGATGTTGATTTTAAAATTCTTTAAAAGGCAGCTATGCTC
AGCAGTGAGGCTCGTTTCGATACCTCTACTGTTAAGGACTAATAAAATATTGACTATTTG
ACCTGTCCTGTATTAGGTGATGCGACTGAAACAGGTATTATTAGATTCTATTAGTATATT
GAAGATGTTAACACCTTCCGTAATAGATATTAAATTGCTAAAAATCCAGATGGTACATTT
GGTAAAATGCCTTTCAATTCTTAGGTTAAGTTTGCTTTAACAATTATTGAAGAACAAACA
TAGGACAGCTTTTATACAGTTTACATAAAAGGTGCTCCAGAAAAAATTTGGACTTACTGC
TCATCAGTTATTGTTAATGGAAGGCCATAGAATTTAGATCAAACTTGGTAGAAAAAATTC
AAAGCTGTTAATCTTACTTTTGGTAAAGGAGGAGAAAGAGTGCTTGGTTTTGCTAAATTA
CATTTACCAGCTACTAAATATCCTCATGGATTTACATTCAATGTATCATCATTACAAAAA
TTCCCTTTTAAACTCGCTGACTTTTAATTTTGCGGTTTAGTCTCCTTGATGGATCCTCCT
AAGACAAGAGTTCCTTATGCTATCTTAGAATGTAGATCTGCTGGTGTGAAAGTTGTCATG
GTAACTGGTGATTAACCTCCTACAGCCGCTGCAATTGCCAAAGAAGTCAATATTATTCCT
AGGGACATTTTAACTAACGAAGATCTTATGGAAAGAGACCCTACCCTTAGCTGGTGGGAT
GCAAGCAAACAGTGTGAAGCTATTATTGTTCACGGCGATAGAATTACAGAATCCTATGAA
AAATCTTTAGGAGAATAAAAGGAAGAACAATTTTATTTAAGAAGCTGGGTTGTAAAGCCT
TATTGTGTTTTTGCAAGAACTACTCCTGCTTAAAAACTATAAATTGTTGATGCCTGTTAA
AAAGAAGGATTTATTGTTGCTGCTACTGGTGATGGTGTTAACGACTCCCCTGCAATCAAG
AAAGCAGATATTGGTATTTCTATGAATCTGTCTGGATCTGATGTAACCAAAGATGCTGCA
GACATGGTTTTAATTGATGACGATTTTGCTTCAATTGTTAACGGTGTTGAAGAAGGAAGA
AAAATTTTTGATAACCTGAAAAAAACTGTAGTTTATCTTCTTACTTCTAATATGACTGAA
ATCGTTCCTTTCTTGGCCTTCATTATTCTTTAAATTCCTTTACCTCTCTCAAGTATTTAT
ATGCTCGTCATTTGTGTTGGTACTGATGTTTGGCCAGCTATCTCTCTCGCTTACGAAGAA
GCTGAGCTCGATGTAATGACTAGAAGACCTCGTACTAAGTAGGAGCATTTAGTTTCTAAC
AAATTAATTACTATAGCTTATCTTTAAACAGGTCAAATAGCTAGTGGTGCTGGATTTTTA
GGTTATTACATAGCATTTAACTATTTTGGATTCCCAGTACTTTCTTTGTTCGGTCTAGCT
TCTGCTACTGGTTATAGACCAAGTAAAAATGATTTTGGTACCTATTATAACCCTTTACTT
TAAAGAGACGACCCTTACTATAACTCCAGGTTATATAATATTACATAATTCAAAAATTGT
AAGGATATTGATGTAGAAAGCATCTCGTATACCATAGATTGGTTTACACTAGATGAAGGT
AATTATGATATGAGAAAATCTTTGGTTAAATGTGATCCTGTAACTGGAGCTTTTATTCCT
TGGATTCATTGGAGTGATTGTGATATAAATAAATAATAAAACTGGTCAAAACTAACATCC
TAAACAGCTTGCTACTCGGTAGAAGCTATTAACTATGCTCAGAGTGTTTATTTCTTAACC
GTAGTTTTACTTTAATGGACTAACGTCTTTGCATGTAAAAGTAGATCTACAAGCTTTACA
ACAACAGCATTTAATCCGATTATGATTCACGGTATTATTTTTGAAACATTACTTACCATT
TTCTTATAATATTGTCCGGGAGTTTAAGATGTGTTTGGTGGTAGGCCTATGTTCTTCTGG
TTATGGACAAGTTGCTTAGCATATACTATATTGTTACTTGTCTATGATGAACTAAGAAAG
TTTATGTGTAGAAGATTTAAATGGTATTATAAGTATTGTTATTGGTGA

>TTHERM_00245100(gene)
ATGAGTTAGACTAATATTCGTTAGTCAATGAATGGTGTTCGATAGTCAACGTCGAATATA
GCAAGAAAATTTGAAGAAATGAGACAGTCTATATAGCTTAAGAACTCCCAATAAGAAGTT
AGATAGAGCTAGTAAATGCGTAGATATGAAGGTGATTAAGATGATGGAAACAAAGTGGCA
CATTACAATCGCGAGTTAATGGAAGACCATCAACCTATACATACTGAAACAATTATGCTT
TAAGGTACTTCTTCTTAACATGATACTCACTAAAAACCATCAGCTCCAGCAGATAAAAAG
GAGGTTTCTAAAGAAGATTAATCAAAGCAAGCTCTTGTAGAAAAAGTTGATCACAAAATT
TCGTTAGAAGAGCTTAAGGAGAAGTATCAGACAGATTATTAAAAAGGTTTAACTGATTAG
TAAGCTGAACATTTACTTAGAGTCAATGGAGAAAACAAACTTTCAGCTAAAGCAGGTGTC
CCTTTATGGTTAAAGCTTTTGAGAGAAATGACCAATGGATTTTCTATTATGCTTTGGGTA
AGTGCAGGTCTTTGCTTTCTTGCTGAAGGTTTACAGCCTAATCCTTCAAATATCTATTTA
GCTGTTGTGTTAATTATTGTCATTCTAATTACTACAGCAATTACATTTTAATAGAATGCT
AAAAGTGAGGCTTTGATGAACTCCTTCAAGAATTTTATTCCTGCAAAAACTGTAGTTATT
AGAGGGGGCGATACTAAATCAATTGATGCAGCTCATCTTGTTGTTGGTGATATAGTCGTA
ATAAGACTGGGTGAAAAAATTCCTGCTGATATTCGTATTCTTGAATCTAACGAAATGAAA
GTTGACAATTCTCCCTTGACAGGTGAAAGTGAACCCTTACTACGTACGATTGAATGCTCT
CACCCTGAGAGTTATCTTGAAACCTCAAATATAGCCTTCTTCGGAACTCTGTGCAAAGAA
GGTACTGGAAAAGGTATTGTAATTGCCACTGGTGATCGTACTATGCTTGGACAAATTGCT
GATTTATCTTCTGGCGAAAAGAAAACTAAAACTCCTCTTCGTGTTGAACTCGATCGTTTT
GTTATTTTGATTACAGTAATTGCAATCTTCCTTGGTGTCCTCTTTTTCTTACTCGCTTTA
TTGTATATGAAGTATAAATTTAATGATTGCTTAGTCTTCGGTATAGGTATCCTTGTTGCG
AATGTACCTGAAGGTTTGCTAGGTTGCATTACTATCTCTCTCGCTATCACAGCAAAGAAC
CTATCTGCTAAAAGTGTCTTAGTTAAAAACTTAGAAGCCGTTGAAACTCTAGGTTCTACT
TCCTGTATTTGCTCTGACAAAACAGGTACTCTCACATAAAATGTTATGTCAGTCAAAAAC
TTGTGGTACAAAGATAGAATTTACCTATCTAAGAATAAAGTCTAACTTAAGTAAGGAGAA
TTACCTGAATATGACACTGAAGATGTTGATTTTAAAATTCTTTAAAAGGCAGCTATGCTC
AGCAGTGAGGCTCGTTTCGATACCTCTACTGTTAAGGACTAATAAAATATTGACTATTTG
ACCTGTCCTGTATTAGGTGATGCGACTGAAACAGGTATTATTAGATTCTATTAGTATATT
GAAGATGTTAACACCTTCCGTAATAGATATTAAATTGCTAAAAATCCAGATGGTACATTT
GGTAAAATGCCTTTCAATTCTTAGGTTAAGTTTGCTTTAACAATTATTGAAGAACAAACA
TAGGACAGCTTTTATACAGTTTACATAAAAGGTGCTCCAGAAAAAATTTGGACTTACTGC
TCATCAGTTATTGTTAATGGAAGGCCATAGAATTTAGATCAAACTTGGTAGAAAAAATTC
AAAGCTGTTAATCTTACTTTTGGTAAAGGAGGAGAAAGAGTGCTTGGTTTTGCTAAATTA
CATTTACCAGCTACTAAATATCCTCATGGATTTACATTCAATGTATCATCATTACAAAAA
TTCCCTTTTAAACTCGCTGACTTTTAATTTTGCGGTTTAGTCTCCTTGATGGATCCTCCT
AAGACAAGAGTTCCTTATGCTATCTTAGAATGTAGATCTGCTGGTGTGAAAGTTGTCATG
GTAACTGGTGATTAACCTCCTACAGCCGCTGCAATTGCCAAAGAAGTCAATATTATTCCT
AGGGACATTTTAACTAACGAAGATCTTATGGAAAGAGACCCTACCCTTAGCTGGTGGGAT
GCAAGCAAACAGTGTGAAGCTATTATTGTTCACGGCGATAGAATTACAGAATCCTATGAA
AAATCTTTAGGAGAATAAAAGGAAGAACAATTTTATTTAAGAAGCTGGGTTGTAAAGCCT
TATTGTGTTTTTGCAAGAACTACTCCTGCTTAAAAACTATAAATTGTTGATGCCTGTTAA
AAAGAAGGATTTATTGTTGCTGCTACTGGTGATGGTGTTAACGACTCCCCTGCAATCAAG
AAAGCAGATATTGGTATTTCTATGAATCTGTCTGGATCTGATGTAACCAAAGATGCTGCA
GACATGGTTTTAATTGATGACGATTTTGCTTCAATTGTTAACGGTGTTGAAGAAGGAAGA
AAAATTTTTGATAACCTGAAAAAAACTGTAGTTTATCTTCTTACTTCTAATATGACTGAA
ATCGTTCCTTTCTTGGCCTTCATTATTCTTTAAATTCCTTTACCTCTCTCAAGTATTTAT
ATGCTCGTCATTTGTGTTGGTACTGATGTTTGGCCAGCTATCTCTCTCGCTTACGAAGAA
GCTGAGCTCGATGTAATGACTAGAAGACCTCGTACTAAGTAGGAGCATTTAGTTTCTAAC
AAATTAATTACTATAGCTTATCTTTAAACAGGTCAAATAGCTAGTGGTGCTGGATTTTTA
GGTTATTACATAGCATTTAACTATTTTGGATTCCCAGTACTTTCTTTGTTCGGTCTAGCT
TCTGCTACTGGTTATAGACCAAGTAAAAATGATTTTGGTACCTATTATAACCCTTTACTT
TAAAGAGACGACCCTTACTATAACTCCAGGTTATATAATATTACATAATTCAAAAATTGT
AAGGATATTGATGTAGAAAGCATCTCGTATACCATAGATTGGTTTACACTAGATGAAGGT
AATTATGATATGAGAAAATCTTTGGTTAAATGTGATCCTGTAACTGGAGCTTTTATTCCT
TGGATTCATTGGAGTGATTGTGATATAAATAAATAATAAAACTGGTCAAAACTAACATCC
TAAACAGCTTGCTACTCGGTAGAAGCTATTAACTATGCTCAGAGTGTTTATTTCTTAACC
GTAGTTTTACTTTAATGGACTAACGTCTTTGCATGTAAAAGTAGATCTACAAGCTTTACA
ACAACAGCATTTAATCCGATTATGATTCACGGTATTATTTTTGAAACATTACTTACCATT
TTCTTATAATATTGTCCGGGAGTTTAAGATGTGTTTGGTGGTAGGCCTATGTTCTTCTGG
TTATGGACAAGTTGCTTAGCATATACTATATTGTTACTTGTCTATGATGAACTAAGAAAG
TTTATGTGTAGAAGATTTAAATGGTATTATAAGTATTGTTATTGGTGA

>TTHERM_00245100(protein)
MSQTNIRQSMNGVRQSTSNIARKFEEMRQSIQLKNSQQEVRQSQQMRRYEGDQDDGNKVA
HYNRELMEDHQPIHTETIMLQGTSSQHDTHQKPSAPADKKEVSKEDQSKQALVEKVDHKI
SLEELKEKYQTDYQKGLTDQQAEHLLRVNGENKLSAKAGVPLWLKLLREMTNGFSIMLWV
SAGLCFLAEGLQPNPSNIYLAVVLIIVILITTAITFQQNAKSEALMNSFKNFIPAKTVVI
RGGDTKSIDAAHLVVGDIVVIRLGEKIPADIRILESNEMKVDNSPLTGESEPLLRTIECS
HPESYLETSNIAFFGTLCKEGTGKGIVIATGDRTMLGQIADLSSGEKKTKTPLRVELDRF
VILITVIAIFLGVLFFLLALLYMKYKFNDCLVFGIGILVANVPEGLLGCITISLAITAKN
LSAKSVLVKNLEAVETLGSTSCICSDKTGTLTQNVMSVKNLWYKDRIYLSKNKVQLKQGE
LPEYDTEDVDFKILQKAAMLSSEARFDTSTVKDQQNIDYLTCPVLGDATETGIIRFYQYI
EDVNTFRNRYQIAKNPDGTFGKMPFNSQVKFALTIIEEQTQDSFYTVYIKGAPEKIWTYC
SSVIVNGRPQNLDQTWQKKFKAVNLTFGKGGERVLGFAKLHLPATKYPHGFTFNVSSLQK
FPFKLADFQFCGLVSLMDPPKTRVPYAILECRSAGVKVVMVTGDQPPTAAAIAKEVNIIP
RDILTNEDLMERDPTLSWWDASKQCEAIIVHGDRITESYEKSLGEQKEEQFYLRSWVVKP
YCVFARTTPAQKLQIVDACQKEGFIVAATGDGVNDSPAIKKADIGISMNLSGSDVTKDAA
DMVLIDDDFASIVNGVEEGRKIFDNLKKTVVYLLTSNMTEIVPFLAFIILQIPLPLSSIY
MLVICVGTDVWPAISLAYEEAELDVMTRRPRTKQEHLVSNKLITIAYLQTGQIASGAGFL
GYYIAFNYFGFPVLSLFGLASATGYRPSKNDFGTYYNPLLQRDDPYYNSRLYNITQFKNC
KDIDVESISYTIDWFTLDEGNYDMRKSLVKCDPVTGAFIPWIHWSDCDINKQQNWSKLTS
QTACYSVEAINYAQSVYFLTVVLLQWTNVFACKSRSTSFTTTAFNPIMIHGIIFETLLTI
FLQYCPGVQDVFGGRPMFFWLWTSCLAYTILLLVYDELRKFMCRRFKWYYKYCYW