Identifiers and Description

Gene Model Identifier

TTHERM_00257230

Standard Name

HMB2 (High MoBility group 2)

Aliases

HMG C | LG2 | HMG-C | PreTt25409 | 22.m00354

Description

HMGC high mobility group (HMG) box protein; High-Mobility-Group (HMG) protein; may play a role in the bending or looping of DNA; present in both macro- and micronuclei but with elevated expression during both macronuclear S phase and endoreplication of developing new macronuclei

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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Gene Ontology Annotations

Molecular Function

Biological Process

Domains

  • ( PF00505 ) HMG (high mobility group) box

Gene Expression Profile

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
Tetrahymena borealis EI9_10404.1 8.001824328206442e-49
Description: nonhistone chromosomal protein LG-1 (101 aa)
SGD YDL002C 0.00000000009998509410508463
Description: NHP10 Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair
DictyBase DDB_G0270260 0.000000030002053728821195
Description: nhp6 on chromosome: 1 position 4527247 to 4527672
Oxytricha Contig4075.0.g7 0.000000030002053728821195
Description: HMG (high mobility group) box
WormBase WBGene00001971 0.000005998506718272351
Description: locus:hmg-1.1 status:Confirmed UniProt:G5EFV4 protein_id:CAB54448.2

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:8264578: Wu M, Allis CD, Sweet MT, Cook RG, Thatcher TH, Gorovsky MA (1994) Four distinct and unusual linker proteins in a mitotically dividing nucleus are derived from a 71-kilodalton polyprotein, lack p34cdc2 sites, and contain protein kinase A sites. Molecular and cellular biology 14(1):10-20
  2. Ref:8417323: Wang T, Allis CD (1993) An abundant high-mobility-group-like protein is targeted to micronuclei in a cell cycle-dependent and developmentally regulated fashion in Tetrahymena thermophila. Molecular and cellular biology 13(1):163-73
  3. Ref:1589033: Lilley DM (1992) DNA--protein interactions. HMG has DNA wrapped up. Nature 357(6376):282-3
  4. Ref:1480473: Wang T, Allis CD (1992) Replication-dependent and independent regulation of HMG expression during the cell cycle and conjugation in Tetrahymena. Nucleic acids research 20(24):6525-33
  5. Ref:1991550: Schulman IG, Wang TT, Stargell LA, Gorovsky MA, Allis CD (1991) Cell-cell interactions trigger the rapid induction of a specific high mobility group-like protein during early stages of conjugation in Tetrahymena. Developmental biology 143(2):248-57
  6. Ref:1986218: Schulman IG, Wang T, Wu M, Bowen J, Cook RG, Gorovsky MA, Allis CD (1991) Macronuclei and micronuclei in Tetrahymena thermophila contain high-mobility-group-like chromosomal proteins containing a highly conserved eleven-amino-acid putative DNA-binding sequence. Molecular and cellular biology 11(1):166-74
  7. Ref:2514183: Suda M, Hayashi H (1989) A protein that accumulates during starvation in Tetrahymena nuclei. Journal of biochemistry 106(4):612-5
  8. Ref:2476991: Hamana K, Kawada K (1989) Release of nucleosomes from nuclei by bleomycin-induced DNA strand scission. Biochemistry international 18(5):971-9
  9. Ref:2760016: Hayashi T, Hayashi H, Iwai K (1989) Tetrahymena HMG nonhistone chromosomal protein. Isolation and amino acid sequence lacking the N- and C-terminal domains of vertebrate HMG 1. Journal of biochemistry 105(4):577-81
  10. Ref:3584238: Schulman IG, Cook RG, Richman R, Allis CD (1987) Tetrahymena contain two distinct and unusual high mobility group (HMG)-like proteins. The Journal of cell biology 104(6):1485-94
  11. Ref:3109974: Prasanna P, Holmlund CE (1987) Identification in Tetrahymena pyriformis of 3-hydroxy-3-methyl glutaryl coenzyme a lyase: its purification and properties. The International journal of biochemistry 19(4):385-9
  12. Ref:3671074: Roth SY, Schulman IG, Cook RG, Allis CD (1987) The complete amino acid sequence of an HMG-like protein isolated from the macronucleus of Tetrahymena. Nucleic acids research 15(19):8112
  13. Ref:6849878: Levy-Wilson B, Denker MS, Ito E (1983) Isolation, characterization, and postsynthetic modifications of tetrahymena high mobility group proteins. Biochemistry 22(7):1715-21
  14. Ref:6258140: Hamana K, Zama M (1980) Selective release of HMG nonhistone proteins during DNase digestion of Tetrahymena chromatin at different stages of the cell cycle. Nucleic acids research 8(22):5275-88
  15. Ref:117005: Hamana K, Iwai K (1979) High mobility group nonhistone chromosomal proteins also exist in Tetrahymena. Journal of biochemistry 86(3):789-94

Sequences 

>TTHERM_00257230(coding)
ATGGTGGGGAAAAAAAAGTAATATTATAAGAAAAAGATAAATGAATTAGAATCATATAGG
GTGATAGATGACTCATTCATTCATTCATTCATTTAAATATAAATAGAGGTTGGGGGGTTT
TAATCATTCATTCATAATGAATGTACTAATGCTTGTTTGATAATTAGTTTGTTTGTTTAT
TTGTATGCTTTTTGTATGTATGTTGGTAGGAAGGTATTTAGGTTGTATTTTTTAATTAAT
AAATTGAATGGAAATATATTTTTTCTATTGGTTAGTAAAAATTCAATTTTACAACGAGAT
TATCCAATCAGAAAGCAGATACAAAAGACAAGGAGATCAATAATTTCATTATAAAAATAA
TGCAAATTGCTTTTGTTTTAATAATATCAAATAATTAAAAAAATACAAAAGAAAAAAATC
AATAAAAAAACACATCAATCTAAAATGGCCAAATCAAAAGACGACAGCAAGCCCGCTCCC
CCCAAGAGACCCTTATCCGCTTTCTTCTTATTCAAGTAACACAACTACGAATAAGTCAAG
AAGGAAAACCCCAATGCCAAGATCACCGAATTGACCTCCATGATCGCTGAAAAGTGGAAA
GCTGTTGGTGAAAAGGAAAAGAAGAAATACGAAACTTTATAATCTGAAGCTAAGGCTAAG
TACGAAAAGGACATGTAAGCCTACGAAAAGAAGTACGGCAAACCCGAAAAGTAAAAGAAG
ATCAAGAAGAACAAAAAGGGATCCAAGTGA


>TTHERM_00257230(gene)
ATGGTGGGGAAAAAAAAGTAATATTATAAGAAAAAGATAAATGAATTAGAATCATATAGG
GTGATAGATGACTCATTCATTCATTCATTCATTTAAATATAAATAGAGGTTGGGGGGTTT
TAATCATTCATTCATAATGAATGTACTAATGCTTGTTTGATAATTAGTTTGTTTGTTTAT
TTGTATGCTTTTTGTATGTATGTTGGTAGGAAGGTATTTAGGTTGTATTTTTTAATTAAT
AAATTGAATGGAAATATATTTTTTCTATTGGTTAGTAAAAATTCAATTTTACAACGAGAT
TATCCAATCAGAAAGCAGATACAAAAGACAAGGAGATCAATAATTTCATTATAAAAATAA
TGCAAATTGCTTTTGTTTTAATAATATCAAATAATTAAAAAAATACAAAAGAAAAAAATC
AATAAAAAAACACATCAATCTAAAATGGCCAAATCAAAAGACGACAGCAAGGTAATTCAT
TTATTTTATAAAGCTTTTCTGATTCTACTTTTGGATTTCTGAGAGTTTCCTTCCTAATAG
AGCCCTCAAAAATACTCCAAAAAACCCGCATAATTCAGCTCTATAACTTTTTCTTTTAGT
GAAGGCTCTAAAAATCTATTATTGATGAGGAATTACCCTCATTTTGCAACTCTTTTGCCT
CCATTCTTATAGACAATTGACTTATCTTTCTTTTTTTATTCAAAATAGCCCGCTCCCCCC
AAGAGACCCTTATCCGCTTTCTTCTTATTCAAGTAACACAACTACGAATAAGTCAAGAAG
GAAAACCCCAATGCCAAGATCACCGAATTGACCTCCATGATCGCTGAAAAGTGGAAAGCT
GTTGGTGAAAAGGAAAAGAAGAAATACGAAACTTTATAATCTGAAGCTAAGGCTAAGTAC
GAAAAGGACATGTAAGCCTACGAAAAGAAGTACGGCAAACCCGAAAAGTAAAAGAAGATC
AAGAAGAACAAAAAGGGATCCAAGTGA


>TTHERM_00257230(protein)
MVGKKKQYYKKKINELESYRVIDDSFIHSFIQIQIEVGGFQSFIHNECTNACLIISLFVY
LYAFCMYVGRKVFRLYFLINKLNGNIFFLLVSKNSILQRDYPIRKQIQKTRRSIISLQKQ
CKLLLFQQYQIIKKIQKKKINKKTHQSKMAKSKDDSKPAPPKRPLSAFFLFKQHNYEQVK
KENPNAKITELTSMIAEKWKAVGEKEKKKYETLQSEAKAKYEKDMQAYEKKYGKPEKQKK
IKKNKKGSK