Identifiers and Description

Gene Model Identifier

TTHERM_00263330

Standard Name

KIN2 (KINesin)

Aliases

PreTt29398 | 23.m00294

Description

KIN2 kinesin motor catalytic domain protein; Kinesin-II heavy chain homolog; implicated in intraciliary transport; shares essential functions with KIN1 in ciliary assembly and maintenance- rotokinesis and phagocytosis

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• kinesin II complex (ISS) | GO:0016939

Molecular Function

• ATP binding (IEA) | GO:0005524
• microtubule motor activity (IEA) | GO:0003777

Biological Process

• cilium assembly (IGI) | GO:0042384
• microtubule-based movement (IEA) | GO:0007018
• obsolete movement of cell or subcellular component (IGI) | GO:0006928
• phagocytosis (IGI) | GO:0006909
• septum digestion after cytokinesis (IGI) | GO:0000920

Domains

• ( PF00225 ) Kinesin motor domain
• ( PF03789 ) ELK domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_29748	0
	Description: None
Tetrahymena borealis	EI9_14207.1	9.997093137033517e-262
	Description: kinesin motor domain-containing protein (734 aa)
Oxytricha	Contig740.0.g101	3.000294738490095e-167
	Description: Kinesin motor domain
WormBase	WBGene00002222	9.995938456217754e-149
	Description: locus:klp-11 status:Partially_confirmed UniProt:Q19633 protein_id:CAA92295.2
DictyBase	DDB_G0280967	9.996584278131743e-91
	Description: kif3 on chromosome: 3 position 4109358 to 4113107
SGD	YBL063W	6.997420649987812e-71
	Description: KIP1 Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions

General Information

No Data fetched for General Information

Associated Literature

1. Ref:14983519: Awan A, Bernstein M, Hamasaki T, Satir P (2004) Cloning and characterization of Kin5, a novel Tetrahymena ciliary kinesin II. Cell motility and the cytoskeleton 58(1):1-9
2. Ref:12925756: Brown JM, Fine NA, Pandiyan G, Thazhath R, Gaertig J (2003) Hypoxia regulates assembly of cilia in suppressors of Tetrahymena lacking an intraflagellar transport subunit gene. Molecular biology of the cell 14(8):3192-207
3. Ref:10512852: Brown JM, Marsala C, Kosoy R, Gaertig J (1999) Kinesin-II is preferentially targeted to assembling cilia and is required for ciliogenesis and normal cytokinesis in Tetrahymena. Molecular biology of the cell 10(10):3081-96
4. Ref:11212349: Cole DG (1999) Kinesin-II, the heteromeric kinesin. Cell Mol Life Sci 56(3-4):217-26
5. Ref:10772758: Brown JM, Hardin C, Gaertig J (1999) Rotokinesis, a novel phenomenon of cell locomotion-assisted cytokinesis in the ciliate Tetrahymena thermophila. Cell biology international 23(12):841-8

Sequences

>TTHERM_00263330(coding)
ATGACTACAAGTAAAAACAACAGCGAATGCTTTAAGGTAGCTGTAAGATGCAGACCCCTA
AATAATGATGAAATATAAAATGAAAGAAGTTCAGTTGTTTCTGTAAACCCTCAAAGAGGA
GAAATATAAATCAAACAAAAGCATGATTAAGCTGAACAACATAGGATTTTTGCATTTGAC
TAAGTTTTCGAACCTGATATTTAATAAGAGGTTGTGTATAAATGTATTGCCTACCCTATT
GTTGAGAGCGTTTTAGAAGGCTACAATGGAACAATTTTCGCTTATGGCTAAACTGGTACT
GGAAAAACGCATACTATTTAAGGGAGAAATGAGCCAATTAATGAAAGAGGTATCATTCCT
AGGGCTTTTGAACATATTTTCCACTCTATTAAAGGCTCGCCAAACACTTAATTTTTAGTA
CATGTTAGTTTTCTTGAATTATATAATGAAGAGATTTAAGACTTGCTTTCCACCAAGAAT
AAAAAATTAGAATTAAGAGAAAAAGCAGAGACTGGCGTCTTTGTGAAAGATTTAACTAGT
TTTTTAGTTTAAAATGAATAGGAATTAAATGATAAATTTTAGCAAGGTATTTTGAATCGT
AAAGTTGGTTAAACTAAAATGAGTTCATGTTCATCTCGTTCTCACTCTATCCTTTCTGTA
ACTATTGAGAGGTGCGATGTTGTGAATGGGGAAAACCATATTAAAGTAGGTAAGTTAAAT
TTAGTTGACCTCGCTGGATCTGAACGTTAAAGTAAAACTCAAGCAACAGGCTCTCGTTTT
AAAGAAGGAGTATATATTAACTTAAGTTTAACTACTTTAGGTAATGTTATTTCCTCTCTC
ATCGATCCTAAAGCTTCTCATATTCCATATAGAGATTCTAAATTGACTAGAATTCTTTAA
GACTCTCTAGGTGGCAACACCAAAACTGTGATGATCGCTAATATTGGTCCTGCTGATTAT
AACTAAGATGAAACAATATCTACTTTAAGATATGCTCACAGAGCGAAATCAATATAAAAT
CATGCTTAAATTAACGAGGATCCCAAATAAGCAATGATAAGAAAATTTTAAGAGGAAATA
TCTAGCTTAAAATAGTAGTTATCAGGTTTACTTGAAACTGGAGGAGATTTTAATATGAAT
GCTGAAGTTAAAAAGATAGAAAAAATTGTTTTTAAATATGATGACGAAGAAATTATAAAA
TTGAAACAAAAACTTGAATAACAAAAATCTGATATTGAAAATAACTATGAAAATGAAGTA
AAGAAAATAGAAGAAGATAAGTAGTTACAGGAAAAAGAAAAGTAGCAGCTTATTTATTAG
CTTCAGGAAAAAGAACAAAAGTAGCAATAATAAAAATAGCAATAATAAAAACTACTTGGT
AAACTTTAGAAAATGTAACATAAAGTAATACAAGGAGAAGAAACTATGTAGAGAGTTCTT
GAAAACGAAAGATAACTGAATAAAGAATTGCAATAAGCAAATGAAAGAGATCGCTAAGCA
GCTTTACAAATCTAATAAAATGAAGATTTTATATTAGAGATAAACATGAAATTTAAGAAC
CAAGTTGAAGAAAAATAAGAAAAATAGAAAAGAATAAATCTTTTATTTGATAGATTGTGC
TAAATTTAATAATAAAATAAAGATATTGATGAATTTTATGTTTCTGAAATAGACTAGCTA
TAAGAAAGTTACAGAGACTTACAGAAAGAATTAAAATTAAAAAGATTTATCTTAGATTAT
TTCATTCCTTAAAAAGAATTAAAAAGATTATCAGAGAAAGCTATGTATAGTGAAGAATAA
CAAAATTGGGTATATCCTATTCAAAATTTGACTGGTAAATATATGAGAAGATCTGATGAA
AGTTAAGTTTCCCTTAAAGAAATTTAATCTGAAGATCTAGAACAAGATTCAAAAGTTTAT
TTTGTATACACAGAGCAAGGACCTATTAGAGAATAGTTTTTTTACACAACTGAAATAAAA
AAGCAAGAATATGCTTAACGAAAAAATGATCCTCTTAAACAAAATTTTGAATAATCAAAT
ACTTAATTTGTAAAAACTAAAAAGAGATCTAAAAGTTAAATAAATTAAATCTGA

>TTHERM_00263330(gene)
ATGACTACAAGTAAAAACAACAGCGAATGCTTTAAGGTAGCTGTAAGATGCAGACCCCTA
AATAATGATGAAATATAAAATGAAAGAAGTTCAGTTGTTTCTGTAAACCCTCAAAGAGGA
GAAATATAAATCAAACAAAAGCATGATTAAGCTGAACAACATAGGATTTTTGCATTTGAC
TAAGTTTTCGAACCTGATATTTAATAAGAGGTTGTGTATAAATGTATTGCCTACCCTATT
GTTGAGAGCGTTTTAGAAGGCTACAATGGAACAATTTTCGCTTATGGCTAAACTGGTACT
GGAAAAACGCATACTATTTAAGGGAGAAATGAGCCAATTAATGAAAGAGGTATCATTCCT
AGGGCTTTTGAACATATTTTCCACTCTATTAAAGGCTCGCCAAACACTTAATTTTTAGTA
CATGTTAGTTTTCTTGAATTATATAATGAAGAGATTTAAGACTTGCTTTCCACCAAGAAT
AAAAAATTAGAATTAAGAGAAAAAGCAGAGACTGGCGTCTTTGTGAAAGATTTAACTAGT
TTTTTAGTTTAAAATGAATAGGAATTAAATGATAAATTTTAGCAAGGTATTTTGAATCGT
AAAGTTGGTTAAACTAAAATGAGTTCATGTTCATCTCGTTCTCACTCTATCCTTTCTGTA
ACTATTGAGAGGTGCGATGTTGTGAATGGGGAAAACCATATTAAAGTAGGTAAGTTAAAT
TTAGTTGACCTCGCTGGATCTGAACGTTAAAGTAAAACTCAAGCAACAGGCTCTCGTTTT
AAAGAAGGAGTATATATTAACTTAAGTTTAACTACTTTAGGTAATGTTATTTCCTCTCTC
ATCGATCCTAAAGCTTCTCATATTCCATATAGAGATTCTAAATTGACTAGAATTCTTTAA
GACTCTCTAGGTGGCAACACCAAAACTGTGATGATCGCTAATATTGGTAACAAGCGATTT
AAAATAAAACATAACAAATTAAAATTTATTATTAAAATTCTTAATATAATCTTTAATTTT
ACAAAAATAATTTCTTTCTGAAATAGCGAAAGTTTAATCAAACCATTTATTTTATAAATT
TTCCTTTAAAAGAATTTTTATTAACTTTTTAATATTTTTTATAAATTGTGTGTACTTTTT
TTTTTAACAGGTCCTGCTGATTATAACTAAGATGAAACAATATCTACTTTAAGATATGCT
CACAGAGCGAAATCAATATAAAATCATGCTTAAATTAACGAGGATCCCAAATAAGCAATG
ATAAGAAAATTTTAAGAGGAAATATCTAGCTTAAAATAGTAGTTATCAGGTTTACTTGAA
ACTGGAGGAGATTTTAATATGAATGCTGAAGTTAAAAAGGTAATTCAGATATTTTTTTAT
TAAAAAGAAAATAGTTTTAAGATTTAATAAACTTAATATTTATTAGATAGAAAAAATTGT
TTTTAAATATGATGACGAAGAAATTATAAAATTGAAACAAAAACTTGAATAACAAAAATC
TGATATTGAAAATAACTATGAAAATGAAGTAAAGAAAATAGAAGAAGATAAGTAGTTACA
GGAAAAAGAAAAGTAGCAGCTTATTTATTAGCTTCAGGAAAAAGAACAAAAGTAGCAATA
ATAAAAATAGCAATAATAAAAACTACTTGGTAAACTTTAGAAAATGTAACATAAAGTAAT
ACAAGGAGAAGAAACTATGTAGAGAGTTCTTGAAAACGAAAGATAACTGAATAAAGAATT
GCAATAAGCAAATGAAAGAGATCGCTAAGCAGCTTTACAAATCTAATAAAATGAAGATTT
TATATTAGAGATAAACATGAAATTTAAGAACCAAGTTGAAGAAAAATAAGAAAAATAGAA
AAGAATAAATCTTTTATTTGATAGATTGTGCTAAATTTAATAATAAAATAAAGATATTGA
TGAATTTTATGTTTCTGAAATAGACTAGCTATAAGAAAGTTACAGAGACTTACAGAAAGA
ATTAAAATTAAAAAGATTTATCTTAGATTATTTCATTCCTTAAAAAGAATTAAAAAGATT
ATCAGTAAATATTTTTTTTTAATATTAGTCTTATTTTCATCATTAAATAAAATTAGGAGA
AAGCTATGTATAGTGAAGAATAACAAAATTGGGTATATCCTATTCAAAATTTGACTGGTA
AATATATGAGAAGATCTGATGAAAGTTAAGTTTCCCTTAAAGAAATTTAATCTGAAGATC
TAGAACAAGATTCAAAAGTTTATTTTGTATACACAGAGCAAGGACCTATTAGAGAATAGT
TTTTTTACACAACTGAAATAAAAAAGCAAGAATATGCTTAACGAAAAAATGATCCTCTTA
AACAAAATTTTGAATAATCAAATACTTAATTTGTAAAAACTAAAAAGAGATCTAAAAGTT
AAATAAATTAAATCTGA

>TTHERM_00263330(protein)
MTTSKNNSECFKVAVRCRPLNNDEIQNERSSVVSVNPQRGEIQIKQKHDQAEQHRIFAFD
QVFEPDIQQEVVYKCIAYPIVESVLEGYNGTIFAYGQTGTGKTHTIQGRNEPINERGIIP
RAFEHIFHSIKGSPNTQFLVHVSFLELYNEEIQDLLSTKNKKLELREKAETGVFVKDLTS
FLVQNEQELNDKFQQGILNRKVGQTKMSSCSSRSHSILSVTIERCDVVNGENHIKVGKLN
LVDLAGSERQSKTQATGSRFKEGVYINLSLTTLGNVISSLIDPKASHIPYRDSKLTRILQ
DSLGGNTKTVMIANIGPADYNQDETISTLRYAHRAKSIQNHAQINEDPKQAMIRKFQEEI
SSLKQQLSGLLETGGDFNMNAEVKKIEKIVFKYDDEEIIKLKQKLEQQKSDIENNYENEV
KKIEEDKQLQEKEKQQLIYQLQEKEQKQQQQKQQQQKLLGKLQKMQHKVIQGEETMQRVL
ENERQLNKELQQANERDRQAALQIQQNEDFILEINMKFKNQVEEKQEKQKRINLLFDRLC
QIQQQNKDIDEFYVSEIDQLQESYRDLQKELKLKRFILDYFIPQKELKRLSEKAMYSEEQ
QNWVYPIQNLTGKYMRRSDESQVSLKEIQSEDLEQDSKVYFVYTEQGPIREQFFYTTEIK
KQEYAQRKNDPLKQNFEQSNTQFVKTKKRSKSQINQI