Identifiers and Description

Gene Model Identifier

TTHERM_00449170

Standard Name

NRK21 (NIMA-Related Kinase)

Aliases

PreTt15435 | 52.m00213 | 3811.m00970

Description

NRK21 Serine/Threonine kinase domain protein; NIMA-Related Kinase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• protein kinase activity (IEA) | GO:0004672
• protein tyrosine kinase activity (IEA) | GO:0004713

Biological Process

• protein phosphorylation (IEA) | GO:0006468

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_14993.1	9.997093137033517e-262
	Description: hypothetical protein (2244 aa)
Oxytricha	Contig1219.1.g101	1.0000620911535021e-130
	Description: Protein kinase domain
DictyBase	DDB_G0275241	4.000989088096131e-71
	Description: nek3 on chromosome: 2 position 4983790 to 4987279
Stentor Coeruleus	SteCoe_32875	1.733141042341547e-58
	Description: None
WormBase	WBGene00022631	6.001055639413166e-58
	Description: locus:nekl-2 status:Confirmed UniProt:O01775 protein_id:CCD64899.1
SGD	YMR001C	4.999456391042964e-45
	Description: CDC5 Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16611747: Wloga D, Camba A, Rogowski K, Manning G, Jerka-Dziadosz M, Gaertig J (2006) Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms. Molecular biology of the cell 17(6):2799-810

Sequences

>TTHERM_00449170(coding)
ATGAGACCAACTTAGGCACCATCAGCAAATCAATAGTAAGCTGCTGAATATGAACTTTAC
AAGAGAATTAAATTGCTAGGTGAAGGAGCCTTTGGTAAGGCTTATTTAGTAGAAGATTTG
CGTACACATGAATTACTGGTTTAGAAGTAGATGGACATGAAGGCAATGTCTACAGAAGAA
AAACGTGAAACATAAAAAGAGGCAAGAATTTTATAGCAATTAAATCACCCTAACATAGTT
AAATTTAAGGACGTTTATACCACCAAGAAGGGAAAGTTATGTATTATTATGGAATATGCA
GATGGTGGTGATTTGGCAAAGGTAGTTAAGGATGCTAGAGGAAAATATCTTTAGGAAAAA
TAAATTTTAGATTGGTTTACTTAAATTTGTTTGGCTATGAAGCACGTTCATGATAGAAAA
ATTATTCATCGTGACTTGAAAGGACAGAATATTTTTTTGACAAGGAACCATATTGTAAAG
CTAGGTGATTTTGGAATAGCAAGAGTTTTGAGTAAGACAGTAGAAAAGGCAAAAACAATG
GTAGGAACGCCCTATTATTTATCGCCTGAAATTATTGAAAGCAAACCATATTCATTCAAG
ACTGATATTTGGTCTTTGGGAGTCATTTTATATGAGCTTTGTGCATTAAAGCCACCTTTT
AATGCTGATTCTTTGCACTTTTTAGCTTTGAAAATTGTTAAAGGTTAATATTCGCCAATT
CCAACTCATTTCTCAAAAGAAATGAAAAACTTAGTATCAAACCTTCTATAAGTTGATGCT
ATTAGAAGACCTTCTATTAATGATATTATGAAAATGCCTATTATTTAAGAGAGAGTTAAA
AATTTCCTTTCTGAAACAATAAGACAAGTTGAATTCTCACACACCATTCTTCATAATAAA
ATAATTGATGCAAAAGTTAATTTGGCTGACATTAAAATGGTAAACTAAGAATAACCTTGT
CCACCTCATTTAATTTAGCAATACATGAATAAAGATTAAAAAGATCAAAATTAATAATAG
AAGCCTTAAAATCCACCTCCTTAGTAGCCACCTCAATAGTAGTAATAAGCTCCTCAGCCT
TAAAAGGGAGCTAATTTCCACTATAAACCATAATAGAACCCTGTATAAAATTATGCAAAT
AATTACAGACCATAGTCTGCAAGAAATGACTAGGTTCAAAATAATAATATTCAATAGCAA
GTTGCTTAAGATTTAGAAAGAAAAAAAGAAATGGAACGTCTGAAATTAGAGAGAGACAGA
TTGGAGTTAGAAAAGAAGAAAGAATAAGAACGCATAAGATAAGAAAAGGAGAAACTAGCA
TATCAAAAGCTAGAATAAGAAAAGGAAGCCCGATATAAGAGATAGAAGGAATAAGAACTT
AAAGAAAAACAAAGAGAAGAGAGAGAAAGAGAACTGCAAAAAATAGCATTTGAAAATAAA
TAGAGACAACTATAGCTAAATCAAATTAATTAAAAACGTGAAGAAGTTTAAGCAGGAGGT
ATGGCTGTTTTTGCAAATCCTAATTTCAAGCCAAATAAGCAGCCAGTAGTGCCTGTAAAA
AATATTTAACTTCCTGCAAGTAAACCATCTTACAATCCCCCAAAAAGTGGTGGAGAGAAA
AGAAATAATAGTAAACCAGCAGTAGCTAGGTCAGGATCTAGCCATAATTAGCAAAATGTT
TCTGATAAAAAAGTAATTCAGCAAAAGAAAGATGAAGAAGCTAAATAGAAAATTATGGAG
CAGAGAATACAAAGATAAAAGTCAGAGAAAGAAAAGAAAGATTATGAAATGAAACTATAA
AAAGAAAAGGAAGAAGAGCTTCTCAAGAAAAAGGAGGATAAACAAAAAAAGATTGATGAA
CAAAGAGAATAAATGATAAAAGACAGAAGAAAATGGTAAAAAGGAGGAGAGAAATAAATC
GAGTTTGTAGAAAATAAAATAGGTGGAAGCACTCCTAGTAGCAATAACTAATTAGAAAAG
GAATCAGATTAGGATAATACTTCAAATGAATAGCTCGAAAAGAAACAAAAAGTACCTGTC
AAAAAGTGGAGCGTGCCTTAAAAGGTAAATAATAAAAAGGACGATTGGGACATTCAAATA
TTTGAATCAAAGAAAAAACCTACTTAAGCAAAATAAAAAAGTGAAGATAAGCTAGATGAA
TACAATAGTGATGAAGAAAATAAATAAGATAAAAAATTATAGAAAAAATAATCAAAAACA
GAAAAAGATTTAGACGAATATAACTCAGATAGCGATGATTTAAATAATAGAAAGGCTGAT
ATTACAGCTCAGGAAATACCAGAAGACATAGAAGAGAACGTTAGCAAACTTCCAGAAATT
GTCAGAGAAGAAACTTACTTATAAAATGAAGATAATACAGAGTTTAATATTGTCAGCGAA
GCTGATCCCAAGTAGTGCTTGGAATTAATGTAATAATTATAAGAAATAGTTGAAAATGCT
GATAAACTTTAAATAGATGAAAAATTTGCAAGAAATGATTTCTTCGATTTCACAAAGACT
TAAAAAACTAAGAAGTTCAATTAACCAAATAAGTCTAAGGAAAGCTTAACGACATAGGAA
GAAGAAGATGAATAAGAAGTCATCAGAGATGATGACTCTGATGAACCTGAACGTCTCTAA
AACACAGGTAAGTTTTTGGATGATTTCCCTGAGCCTCCAAAATTACAGCCTAAATAAATT
GCCCAGGACGAGCAAGAATCAATAAATATAATTGGCAATGGCCACGAAAAGCTAGAACAT
CTTTATATTGAATTAGAGGAAAAATTGTCTGATAATTTTACTAAAGCATACAAAATTATG
AGTGAAGAACTAAAAAAATTAGATTATAATCTAGATCTCTTAGAAAAGAAGTATGGTGAT
AACAGGTACAGCCAGTTGTTAGATTTCCTATCAAAAGATCAAATTGATAAATATTTAAGG
ATCATCATAACTTTAGTTTGTTTAGAATAATAACTTTATAACTCTAATTGA

>TTHERM_00449170(gene)
ATGAGACCAACTTAGGCACCATCAGCAAATCAATAGTAAGCTGCTGAATATGAACTTTAC
AAGAGAATTAAATTGCTAGGTGAAGGAGCCTTTGGTAAGGCTTATTTAGTAGAAGATTTG
CGTACACATGAATTACTGGTTTAGAAGTAGATGGACATGAAGGCAATGTCTACAGAAGAA
AAACGTGAAACATAAAAAGAGGCAAGAATTTTATAGCAATTAAATCACCCTAACATAGTT
AAATTTAAGGACGTTTATACCACCAAGAAGGGAAAGTTATGTATTATTATGGAATATGCA
GATGGTAATTTATTTTCTATTTAGTAATATATCAAACAAAATATTAAGCATTTATTTACT
GATAAGAAAGCAAAGTTTGTTTCTAAAATGAGCAATTTTTAAAATATTTTATAGGTGGTG
ATTTGGCAAAGGTAGTTAAGGATGCTAGAGGAAAATATCTTTAGGAAAAATAAATTTTAG
ATTGGTTTACTTAAATTTGTTTGGCTATGAAGCACGTTCATGATAGGTATTTATTTACTT
ATTTTGCATTTCAGGATAACAAAAATAAAATTAAGTTTAAAGAAAGATTATATTTGAACA
GGAATGAATTAATCTTTTAAAAATAGAAAAATTATTCATCGTGACTTGAAAGGACAGAAT
ATTTTTTTGACAAGGAACCATATTGTAAAGCTAGGTGATTTTGGAATAGCAAGAGTTTTG
AGTAAGACAGTAGAAAAGGCAAAAACAATGGTAGGAACGCCCTATTATTTATCGCCTGAA
ATTATTGAAAGCAAACCATATTCATTCAAGACTGATATTTGGTCTTTGGGAGTCATTTTA
TATGAGCTTTGTGCATTAAAGCCACCTTTTAATGCTGATTCTTTGCACTTTTTAGCTTTG
AAAATTGTTAAAGGTTAATATTCGCCAATTCCAACTCATTTCTCAAAAGAAATGAAAAAC
TTAGTATCAAACCTTCTATAAGTTGATGCTATTAGAAGACCTTCTATTAATGATATTATG
AAAATGCCTATTATTTAAGAGAGAGTTAAAAATTTCCTTTCTGAAACAATAAGACAAGTT
GAATTCTCACACACCATTCTTCATAATAAAGTAAATTTAAAATTATAGACGTTTGTTTAA
ATTTTTAACTAGTAAGTAAATGATATTTTGTTAAATTTAAACAGCAATTATGTGTTTGTT
TGCTTATTTTAAATTGAGTATTTAAAATTTTTTCACTTTTCTGATATATTAGAATAAGTA
AATATTTATTTTTATTAAATTTAATTTAGATAATTGATGCAAAAGTTAATTTGGCTGACA
TTAAAATGGTAAACTAAGAATAACCTTGTCCACCTCATTTAATTTAGCAATACATGAATA
AAGATTAAAAAGATCAAAATTAATAATAGAAGCCTTAAAATCCACCTCCTTAGTAGCCAC
CTCAATAGTAGTAATAAGCTCCTCAGCCTTAAAAGGGAGCTAATTTCCACTATAAACCAT
AATAGAACCCTGTATAAAATTATGCAAATAATTACAGACCATAGTCTGCAAGAAATGACT
AGGTTCAAAATAATAATATTCAATAGCAAGTTGCTTAAGATTTAGAAAGAAAAAAAGAAA
TGGAACGTCTGAAATTAGAGAGAGACAGATTGGAGTTAGAAAAGAAGAAAGAATAAGAAC
GCATAAGATAAGAAAAGGAGAAACTAGCATATCAAAAGCTAGAATAAGAAAAGGAAGCCC
GATATAAGAGATAGAAGGAATAAGAACTTAAAGAAAAACAAAGAGAAGAGAGAGAAAGAG
AACTGCAAAAAATAGCATTTGAAAATAAATAGAGACAACTATAGCTAAATCAAATTAATT
AAAAACGTGAAGAAGTTTAAGCAGGAGGTATGGCTGTTTTTGCAAATCCTAATTTCAAGC
CAAATAAGCAGCCAGTAGTGCCTGTAAAAAATATTTAACTTCCTGCAAGTAAACCATCTT
ACAATCCCCCAAAAAGTGGTGGAGAGAAAAGAAATAATAGTAAACCAGCAGTAGCTAGGT
CAGGATCTAGCCATAATTAGCAAAATGTTTCTGATAAAAAAGTAATTCAGCAAAAGAAAG
ATGAAGAAGCTAAATAGAAAATTATGGAGCAGAGAATACAAAGATAAAAGTCAGAGAAAG
AAAAGAAAGATTATGAAATGAAACTATAAAAAGAAAAGGAAGAAGAGCTTCTCAAGAAAA
AGGAGGATAAACAAAAAAAGATTGATGAACAAAGAGAATAAATGATAAAAGACAGAAGAG
TAAATAAATATTAATATTAATTATATTAGTTAAATCATATAAAAAAATAAAGAAATGGTA
AAAAGGAGGAGAGAAATAAATCGAGTTTGTAGAAAATAAAATAGGTGGAAGCACTCCTAG
TAGCAATAACTAATTAGAAAAGGAATCAGATTAGGATAATACTTCAAATGAATAGCTCGA
AAAGAAACAAAAAGTACCTGTCAAAAAGTGGAGCGTGCCTTAAAAGGTAAATAATAAAAA
GGACGATTGGGACATTCAAATATTTGAATCAAAGAAAAAACCTACTTAAGCAAAATAAAA
AAGTGAAGATAAGCTAGATGAATACAATAGTGATGAAGAAAATAAATAAGATAAAAAATT
ATAGAAAAAATAATCAAAAACAGAAAAAGATTTAGACGAATATAACTCAGATAGCGATGA
TTTAAATAATAGAAAGGCTGATATTACAGCTCAGGAAATACCAGAAGACATAGAAGAGAA
CGTTAGCAAACTTCCAGAAATTGTCAGAGAAGAAACTTACTTATAAAATGAAGATAATAC
AGAGTTTAATATTGTCAGCGAAGCTGATCCCAAGTAGTGCTTGGAATTAATGTAATAATT
ATAAGAAATAGTTGAAAATGCTGATAAACTTTAAATAGATGAAAAATTTGCAAGAAATGA
TTTCTTCGATTTCACAAAGACTTAAAAAACTAAGAAGTTCAATTAACCAAATAAGTCTAA
GGAAAGCTTAACGACATAGGAAGAAGAAGATGAATAAGAAGTCATCAGAGATGATGACTC
TGATGAACCTGAACGTCTCTAAAACACAGGTAAGTTTTTGGATGATTTCCCTGAGCCTCC
AAAATTACAGCCTAAATAAATTGCCCAGGACGAGCAAGAATCAATAAATATAATTGGCAA
TGGCCACGAAAAGCTAGAACATCTTTATATTGAATTAGAGGAAAAATTGTCTGATAATTT
TACTAAAGCATACAAAATTATGAGTGAAGAAGTAAGATTTTTTAAACTAGGCAAACAAGT
TACTAAATTTATTTTTTATTCAAGCTAAAAAAATTAGATTATAATCTAGATCTCTTAGAA
AAGAAGTATGGTGATAACAGGTACAGCCAGTTGTTAGATTTCCTATCAAAAGATCAAATT
GATAAATATTTAAGGATCATCATAACTTTAGTTTGTTTAGAATAATAACTTTATAACTCT
AATTGA

>TTHERM_00449170(protein)
MRPTQAPSANQQQAAEYELYKRIKLLGEGAFGKAYLVEDLRTHELLVQKQMDMKAMSTEE
KRETQKEARILQQLNHPNIVKFKDVYTTKKGKLCIIMEYADGGDLAKVVKDARGKYLQEK
QILDWFTQICLAMKHVHDRKIIHRDLKGQNIFLTRNHIVKLGDFGIARVLSKTVEKAKTM
VGTPYYLSPEIIESKPYSFKTDIWSLGVILYELCALKPPFNADSLHFLALKIVKGQYSPI
PTHFSKEMKNLVSNLLQVDAIRRPSINDIMKMPIIQERVKNFLSETIRQVEFSHTILHNK
IIDAKVNLADIKMVNQEQPCPPHLIQQYMNKDQKDQNQQQKPQNPPPQQPPQQQQQAPQP
QKGANFHYKPQQNPVQNYANNYRPQSARNDQVQNNNIQQQVAQDLERKKEMERLKLERDR
LELEKKKEQERIRQEKEKLAYQKLEQEKEARYKRQKEQELKEKQREERERELQKIAFENK
QRQLQLNQINQKREEVQAGGMAVFANPNFKPNKQPVVPVKNIQLPASKPSYNPPKSGGEK
RNNSKPAVARSGSSHNQQNVSDKKVIQQKKDEEAKQKIMEQRIQRQKSEKEKKDYEMKLQ
KEKEEELLKKKEDKQKKIDEQREQMIKDRRKWQKGGEKQIEFVENKIGGSTPSSNNQLEK
ESDQDNTSNEQLEKKQKVPVKKWSVPQKVNNKKDDWDIQIFESKKKPTQAKQKSEDKLDE
YNSDEENKQDKKLQKKQSKTEKDLDEYNSDSDDLNNRKADITAQEIPEDIEENVSKLPEI
VREETYLQNEDNTEFNIVSEADPKQCLELMQQLQEIVENADKLQIDEKFARNDFFDFTKT
QKTKKFNQPNKSKESLTTQEEEDEQEVIRDDDSDEPERLQNTGKFLDDFPEPPKLQPKQI
AQDEQESINIIGNGHEKLEHLYIELEEKLSDNFTKAYKIMSEELKKLDYNLDLLEKKYGD
NRYSQLLDFLSKDQIDKYLRIIITLVCLEQQLYNSN