Identifiers and Description

Gene Model Identifier

TTHERM_00506900

Standard Name

TWI2 (Tetrahymena piWI 2 )

Aliases

PreTt10673 | 64.m00153 | 3723.m00018

Description

TWI2 piwi-like Twi9p protein; PAZ and Piwi Domain (PPD) protein; similar to the Piwi/Argonaute proteins

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

Gene Ontology Annotations

Molecular Function

• sequence-specific DNA binding (IDA) | GO:0043565 | Ref:19656801

Biological Process

• lipoate metabolic process (IDA) | GO:0009106 | Ref:19656801
• negative regulation of low-density lipoprotein particle receptor catabolic process (IDA) | GO:0032804 | Ref:19656801

Domains

• ( PF02170 ) PAZ domain
• ( PF02171 ) Piwi domain

Gene Expression Profile

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_14909.1	9.997093137033517e-262
	Description: piwi domain-containing protein (808 aa)
Oxytricha	Contig16116.0.g20	1.999022616705709e-90
	Description: Piwi domain
DictyBase	DDB_G0276299	4.997593565024277e-70
	Description: agnA on chromosome: 2 position 6579134 to 6582276
WormBase	WBGene00004178	1.9997677415930956e-65
	Description: locus:prg-1 status:Confirmed UniProt:P90786 protein_id:CAA98113.1
Stentor Coeruleus	SteCoe_1413	1.5007857627073948e-41
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:19656801: Couvillion MT, Lee SR, Hogstad B, Malone CD, Tonkin LA, Sachidanandam R, Hannon GJ, Collins K (2009) Sequence, biogenesis, and function of diverse small RNA classes bound to the Piwi family proteins of Tetrahymena thermophila. Genes & development 23(17):2016-32
2. Ref:12297043: Mochizuki K, Fine NA, Fujisawa T, Gorovsky MA (2002) Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena. Cell 110(6):689-99

Sequences

>TTHERM_00506900(coding)
ATGCTTTAATAGTTGCCTAAAAGACCTCCTAAATCTTCAGCTTAAGATATCAGCAAAATA
TGCAAAAATATTAAGCTGCTCACTAACATGTTTACAATGTAAGTAGAAGCCCCCTAGTCT
TCTGATTCTGATGAACCTCAAGGATTTGTGAACAAAGTTCTTTGCCATTAGTATGATGTT
GAATTCTCTCCTAGTATTGCTGAGGACAACAGAAATCTAAGATACAAAATCTTTAAAGAA
GCACGCAGGAACATTGAATAAATCATTGGAAAATTCTCCTTTTCAGGAAAGTCTCTATTC
TCAATGAGAAATCTTAGCAAAGAAAAGATTAATAAAATCAAGAATATTGATGCAATCAAT
GTTGATGGACAAAAATTCTCTATCCTATTGAGGTTCACTAAAACTTTTGAAGTGAATGAT
GAATCTGCTTAAAATTTAGACAAGACCTCTCCAAACTTCAAAAAAGGTAATCAAGTCACT
TAGTTGCTCAATATCATCTTAAAGTCTATCATGCGTGATGAGAAGTTTTAGGAAATTGGA
AAGAATTCTAAGTTCTATAATGTTAACTCTAGGAATGAAATCGTAATCAAAGGCAGAGAC
GGAAATACTAGTGCCCTCGAAGCATATAAGGGATTCACTTTCAATGTCACTCCAACCTAA
GACAAACTTTACTTAATGGTTGACTACTGCAGCAGAATTATCAGAAAAGAAACTGCTTTA
GAATACTTAAAGAATAACAACAATTAATTGTCTGGTCTTTCAGTAATTACCAAATACAAT
AATTACCAAACTTACTTAATCGACAGAGTAGATGGCCAAAAAACACCTAGTTCTACTTTC
CTTAACTCCAAAACTAACACCTAAATTAGCTTCGCATAATACTATAAGGAGCGTTATAAT
ATTTAAATCAGAGACATGAGATAGCCCTTACTTGTTCACAAAAGAAAATATAGAGAGGCT
AATACTAACATCTAAAAGGTTGAGGAAGTTTATTTAATTCCTGAAATATGCAATATGACA
GGAATGACAGACGAATAACGTGAGAATTTCCAAGCAATGAAGGAAGTTGCTACTCACACC
AAGTTAACTCCTTAAGAAAGATATCAAAATTCTGTTAACAATTGCAGATTTTTAAGCAGC
AAAACAAGCTCCAGTGGAATTAGAATTGATGAAAGAAGCAATTTAATTGACGCTGTTTAA
TTAAGAGCTCCTAAAGTCACTCTAGGAGGTAATAAGACTGCTAATACTGATAGAGGTAAT
TTTGACATGAGAGCTCCTACCTTAGATAAAATCGAGTTTAAGGATTGGACTCTTATTTAT
AACCAAAAAGATGAGAGATCTGTGGATGGTTTCATAGACACTCTTAAGAAGGCTTCCTAG
ACATATGGAATTACTGTCAACGACCCTTTCTTTTTCGCCTAAAGAGATTGGAATGCTAAT
AGTTGGATTAAATCTCTAGATGAGGACTTTTCTAAGAATGACTTACCTTAATTTGTTTTG
AGTTTTGGTCAAGCTTAAAGCGGTTTATATTCTGGTCTGAAGAAATTTTTAACTTCAGAA
GCAGGAATTGAATCCTAGCATGTTAATCCAAGATCCCTCCAAAAGAACGGAATGAGTGTT
GCTTCAAAAATTGCTCTGCAAATTGCCTCTAAACTTGGTAGAAGAATCTGGTAAGTTGAA
ACCCCAACTGGAATTGATAAAAATACCATGATTATAGGTATTGAGACCAGCATGAAAAAG
ATTAAATAGTAGTAGGTTGTAGGTGTTGTTGCTTCCATCGACAAAGACTTTACCAAATAC
TTTTCTGATGTTGAAATTAGGAAAGACAATGATACTACTCTCCCTACTCTCTCTAAGATT
GTTACCAAAGCCATATAAGCTTATGTTAAAAATACCAAAAGTGTTCCTGCTGAAGTGATT
GTTTACAGATAAGGACTTGGTGAAGGTTAAATTCAATAGAGTTGTAACCTTGAAATTAAG
GCCATTTAGAATGGTTTTAGTAACTTCAAGAGCGATTTCAATCCACGTTTAGCCTTTTTC
TAGGTTAATAGAAAAATTGGACAAAAGTTCTATTAATCACCTTAAGGTGACAAAGGTGAA
GTCTCAAATCCTGCTTCAGGTACTATTGTAGCCTCTTAAGTTGTTTAGAACAACTTCGAA
TTCTTCATGGCTGCATAAAACTGCAATTCTGGTGTTTGTACACCCACTAAATACACCTGT
TTGTACAATAACACTAACTTAAAAGAAGATTAAATCTGGTAATTAACTTACTATCAAACT
TTCAATTACTATAACTGGCAAGGACCTGTAAGAGTACCTGCCGCTATGAAGTACGCAGAA
AAACTTGCTAAATTCGTAAGTGACACTATCTAAGAAGCTGCCAACGAAAACTTGACTAAC
AGTCTTTTCTACTTGTGA

>TTHERM_00506900(gene)
ATGCTTTAATAGTTGCCTAAAAGACCTCCTAAATCTTCAGCTTAAGATATCAGCAAAATA
TGCAAAAATATTAAGCTGCTCACTAACATGTTTACAATGTAAGTAGAAGCCCCCTAGTCT
TCTGATTCTGATGAACCTCAAGGATTTGTGAACAAAGTTCTTTGCCATTAGTATGATGTT
GAATTCTCTCCTAGTATTGCTGAGGACAACAGAAATCTAAGATACAAAATCTTTAAAGAA
GCACGCAGGAACATTGAATAAATCATTGGAAAATTCTCCTTTTCAGGAAAGTCTCTATTC
TCAATGAGAAATCTTAGCAAAGAAAAGATTAATAAAATCAAGAATATTGATGCAATCAAT
GTTGATGGACAAAAATTCTCTATCCTATTGAGGTTCACTAAAACTTTTGAAGTGAATGAT
GAATCTGCTTAAAATTTAGACAAGACCTCTCCAAACTTCAAAAAAGGTAATCAAGTCACT
TAGTTGCTCAATATCATCTTAAAGTCTATCATGCGTGATGAGAAGTTTTAGGAAATTGGA
AAGAATTCTAAGTTCTATAATGTTAACTCTAGGAATGAAATCGTAATCAAAGGCAGAGAC
GGAAATACTAGTGCCCTCGAAGCATATAAGGGATTCACTTTCAATGTCACTCCAACCTAA
GACAAACTTTACTTAATGGTTGACTACTGCAGCAGAATTATCAGAAAAGAAACTGCTTTA
GAATACTTAAAGAATAACAACAATTAATTGTCTGGTCTTTCAGTAATTACCAAATACAAT
AATTACCAAACTTACTTAATCGACAGAGTAGATGGCCAAAAAACACCTAGTTCTACTTTC
CTTAACTCCAAAACTAACACCTAAATTAGCTTCGCATAATACTATAAGGAGCGTTATAAT
ATTTAAATCAGAGACATGAGATAGCCCTTACTTGTTCACAAAAGAAAATATAGAGAGGCT
AATACTAACATCTAAAAGGTTGAGGAAGTTTATTTAATTCCTGAAATATGCAATATGACA
GGAATGACAGACGAATAACGTGAGAATTTCCAAGCAATGAAGGAAGTTGCTACTCACACC
AAGTTAACTCCTTAAGAAAGATATCAAAATTCTGTTAACAATTGCAGATTTTTAAGCAGC
AAAACAAGCTCCAGTGGAATTAGAATTGATGAAAGAAGCAATTTAATTGACGCTGTTTAA
TTAAGAGCTCCTAAAGTCACTCTAGGAGGTAATAAGACTGCTAATACTGATAGAGGTAAT
TTTGACATGAGAGCTCCTACCTTAGATAAAATCGAGTTTAAGGATTGGACTCTTATTTAT
AACCAAAAAGATGAGAGATCTGTGGATGGTTTCATAGACACTCTTAAGAAGGCTTCCTAG
ACATATGGAATTACTGTCAACGACCCTTTCTTTTTCGCCTAAAGAGATTGGAATGCTAAT
AGTTGGATTAAATCTCTAGATGAGGACTTTTCTAAGAATGACTTACCTTAATTTGTTTTG
AGTTTTGGTCAAGCTTAAAGCGGTTTATATTCTGGTCTGAAGAAATTTTTAACTTCAGAA
GCAGGAATTGAATCCTAGCATGTTAATCCAAGATCCCTCCAAAAGAACGGAATGAGTGTT
GCTTCAAAAATTGCTCTGCAAATTGCCTCTAAACTTGGTAGAAGAATCTGGTAAGTTGAA
ACCCCAACTGGAATTGATAAAAATACCATGATTATAGGTATTGAGACCAGCATGAAAAAG
ATTAAATAGTAGTAGGTTGTAGGTGTTGTTGCTTCCATCGACAAAGACTTTACCAAATAC
TTTTCTGATGTTGAAATTAGGAAAGACAATGATACTACTCTCCCTACTCTCTCTAAGATT
GTTACCAAAGCCATATAAGCTTATGTTAAAAATACCAAAAGTGTTCCTGCTGAAGTGATT
GTTTACAGATAAGGACTTGGTGAAGGTTAAATTCAATAGAGTTGTAACCTTGAAATTAAG
GCCATTTAGAATGGTTTTAGTAACTTCAAGAGCGATTTCAATCCACGTTTAGCCTTTTTC
TAGGTTAATAGAAAAATTGGACAAAAGTTCTATTAATCACCTTAAGGTGACAAAGGTGAA
GTCTCAAATCCTGCTTCAGGTACTATTGTAGCCTCTTAAGTTGTTTAGAACAACTTCGAA
TTCTTCATGGCTGCATAAAACTGCAATTCTGGTGTTTGTACACCCACTAAATACACCTGT
TTGTACAATAACACTAACTTAAAAGAAGATTAAATCTGGTAATTAACTTACTATCAAACT
TTCAATTACTATAACTGGCAAGGACCTGTAAGAGTACCTGCCGCTATGAAGTACGCAGAA
AAACTTGCTAAATTCGTAAGTGACACTATCTAAGAAGCTGCCAACGAAAACTTGACTAAC
AGTCTTTTCTACTTGTGA

>TTHERM_00506900(protein)
MLQQLPKRPPKSSAQDISKICKNIKLLTNMFTMQVEAPQSSDSDEPQGFVNKVLCHQYDV
EFSPSIAEDNRNLRYKIFKEARRNIEQIIGKFSFSGKSLFSMRNLSKEKINKIKNIDAIN
VDGQKFSILLRFTKTFEVNDESAQNLDKTSPNFKKGNQVTQLLNIILKSIMRDEKFQEIG
KNSKFYNVNSRNEIVIKGRDGNTSALEAYKGFTFNVTPTQDKLYLMVDYCSRIIRKETAL
EYLKNNNNQLSGLSVITKYNNYQTYLIDRVDGQKTPSSTFLNSKTNTQISFAQYYKERYN
IQIRDMRQPLLVHKRKYREANTNIQKVEEVYLIPEICNMTGMTDEQRENFQAMKEVATHT
KLTPQERYQNSVNNCRFLSSKTSSSGIRIDERSNLIDAVQLRAPKVTLGGNKTANTDRGN
FDMRAPTLDKIEFKDWTLIYNQKDERSVDGFIDTLKKASQTYGITVNDPFFFAQRDWNAN
SWIKSLDEDFSKNDLPQFVLSFGQAQSGLYSGLKKFLTSEAGIESQHVNPRSLQKNGMSV
ASKIALQIASKLGRRIWQVETPTGIDKNTMIIGIETSMKKIKQQQVVGVVASIDKDFTKY
FSDVEIRKDNDTTLPTLSKIVTKAIQAYVKNTKSVPAEVIVYRQGLGEGQIQQSCNLEIK
AIQNGFSNFKSDFNPRLAFFQVNRKIGQKFYQSPQGDKGEVSNPASGTIVASQVVQNNFE
FFMAAQNCNSGVCTPTKYTCLYNNTNLKEDQIWQLTYYQTFNYYNWQGPVRVPAAMKYAE
KLAKFVSDTIQEAANENLTNSLFYL