Identifiers and Description

Gene Model Identifier

TTHERM_00526990

Standard Name

THD14 (Tetrahymena Histone Deacetylase 14)

Aliases

PreTt06437 | 66.m00236 | 3722.m00094 | SHD9 | HST2

Description

THD14 SIR2 family histone deacetylase putative; NAD(+)-dependent protein deacetylase; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

Gene Ontology Annotations

Cellular Component

• acrosomal lumen (IEA) | GO:0043160
• host cell lysosome (IEA) | GO:0044187

Molecular Function

• carnitine O-acyltransferase activity (IEA) | GO:0016406

Biological Process

• dorsal/ventral axis specification (IEA) | GO:0009950
• obsolete DNA strand renaturation (IEA) | GO:0000733
• stilbene metabolic process (IEA) | GO:0009810

Domains

• ( PF01853 ) MOZ/SAS family
• ( PF02146 ) transcriptional regulator, Sir2 family
• ( PF02148 ) Zn-finger in ubiquitin-hydrolases and other

Gene Expression Profile

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_13434.1	9.997093137033517e-262
	Description: hypothetical protein (3586 aa)
Oxytricha	Contig9367.0.g58	1.000296925633081e-74
	Description: Sir2 family
DictyBase	DDB_G0283917	9.996907204735647e-62
	Description: sir2A on chromosome: 4 position 1272110 to 1273864
SGD	YPL015C	3.00017180903994e-49
	Description: HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
WormBase	WBGene00004800	8.003782782428492e-46
	Description: locus:sir-2.1 NAD-dependent protein deacetylase sir-2.1 status:Partially_confirmed UniProt:Q21921 protein_id:CAA94364.1
Stentor Coeruleus	SteCoe_29687	9.602680054508676e-24
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:21933443: Slade KM, Freggiaro S, Cottrell KA, Smith JJ, Wiley EA (2011) Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena. BMC cell biology 12( ):40
2. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82

Sequences

>TTHERM_00526990(coding)
ATGAGTTCTGAAATTAGTAAAACAGATTTAAGCAATTTAGAATCAAATACAGATTCTATG
AGCGAGGCTTAGAAGGAAGCTTAATTAATTGGGTTTGCTGTAGAACCTAAGCTTGACTGC
CCTCATTTTGAATAGCTTAATGTTATCACTTTGACAGAAGTCTTTAATGATATGACATTA
GAAACTTTAAATAAGCCTTGTAAGACTTGTAACCATATTGGAGAAAACTGGATTTGCTTA
CATTGTACTGACATATTTTGCTCTAGATATATAAATAAAGATATGGCTAAACACGTTGAA
AGCAATTAAGAGCACTGTCTAGTATTTTCTTTTTCTGATGGTAGTTTTTGGTGCTACAAA
TGTGATAATTACATTTCAAATAAAACTATTAAGGATCTTTAGAAAACATTTTCAAAGGTT
AAGCATGGAGGATAAGAATCAAATGAAGAAGAAGAAGAAAAAGAAGATGATATTCATGCA
ATAGCTGCTTAACTTCTTTAGATGCATCTAAACAAAAAAGGTTAAGATGGTATTTAAGAA
GAATTTACCTACTAAAATTTAATTGATGGTTTGAGAGATATTTCTCCTGATTAAGAGAAA
AATTAAGATGACAAATACAATAACAGACAGTTCAATCGAATTGTGTTTTTGACTGGAGCA
GGTATTAGTGTGTCTGCTGGTATTCCAGATTTTAGAACTCCTGGATCTGGTTTATACTCC
CAACTCTAGAAATACAAGTTGCCATATCCTGAAGCAATTTTTGAAATAAATTATTTCAAA
CATCATCCATAGCCATTCTATACTCTTTGTAAAGAATTCTCAAGTTGCGGATCTCACTTT
ACTTCTAGTCACTTCTTTATAGCTGAAACTAATAGAAGAAATCGTCTTTTAATTAATTTT
TCTTAAAATATTGACGGATTAGAACTAGAAGCAGGACTTCCTGAATCAAAACTAGTTTAA
GCTCATGGTCATTTTAGAACAGCAAAGTGTGTTAACTGTAAAAAAGTTGCAGATATTGAA
TTATTCAATGAAGCAGTTAAAAATGATAAAATATGTTATTGCAAAGAATGTGAGGAAGGT
ATTGTAAAACCTGATATTGTTTTCTTTGGTGAGAGTCTTCCATAGAGTTTCTTTTAATAA
ATAGACAGCTTAAATAAGGCTGATTTGGTATTCGTCATGGGAACTTCTCTCAAAGTTTTT
CCATTTGCAGCTTTAGTTGATTTATTCAAAGAAGATGTCCCAATAGTATTGATTAATAGA
GAAAACCCTGGAATAAAAAGAAGAAGATTCCTATTTTTAGAAGGTGAAATAGATGACAAT
GTAGAAAAAATTATGAAGGATATTTCTTGGGATTTTCCTGAAATTAAAAGAACATACCCT
GAAGGAACTGTATTAGAGAAGAAATAAAACCTTTGA

>TTHERM_00526990(gene)
ATGAGTTCTGAAATTAGTAAAACAGATTTAAGCAATTTAGAATCAAATACAGATTCTATG
AGCGAGGCTTAGAAGGAAGCTTAATTAATTGGGTTTGCTGTAGAACCTAAGCTTGACTGC
CCTCATTTTGAATAGCTTAATGTTATCACTTTGACAGAAGTCTTTAATGATATGACATTA
GAAACTTTAAATAAGCCTTGTAAGACTTGTAACCATATTGGAGAAAACTGGATTTGCTTA
CATTGTACTGACATATTTTGCTCTAGATATATAAATAAAGATATGGCTAAACACGTTGAA
AGCAATTAAGAGCACTGTCTAGTATTTTCTTTTTCTGATGGTAGTTTTTGGTGCTACAAA
TGTGATAATTACATTTCAAATAAAACTATTAAGGATCTTTAGAAAACATTTTCAAAGGTT
AAGCATGGAGGATAAGAATCAAATGAAGAAGAAGAAGAAAAAGAAGATGATATTCATGCA
ATAGCTGCTTAACTTCTTTAGATGCATCTAAACAAAAAAGGTTAAGATGGTATTTAAGAA
GAATTTACCTACTAAAATTTAATTGATGGTTTGAGAGATATTTCTCCTGATTAAGAGAAA
AATTAAGATGACAAATACAATAACAGACAGTTCAATCGAATTGTGTTTTTGACTGGAGCA
GGTATTAGTGTGTCTGCTGGTATTCCAGATTTTAGAACTCCTGGATCTGGTTTATACTCC
CAACTCTAGAAATACAAGTTGCCATATCCTGAAGCAATTTTTGAAATAAATTATTTCAAA
CATCATCCATAGCCATTCTATACTCTTTGTAAAGAATTCTCAAGTTGCGGATCTCACTTT
ACTTCTAGTCACTTCTTTATAGCTGAAACTAATAGAAGAAATCGTCTTTTAATTAATTTT
TCTTAAAATATTGACGGATTAGAACTAGAAGCAGGACTTCCTGAATCAAAACTAGTTTAA
GCTCATGGTCATTTTAGAACAGCAAAGTGTGTTAACTGTAAAAAAGTTGCAGATATTGAA
TTATTCAATGAAGCAGTTAAAAATGATAAAATATGTTATTGCAAAGAATGTGAGGAAGGT
ATTGTAAAACCTGATATTGTTTTCTTTGGTGAGAGTCTTCCATAGAGTTTCTTTTAATAA
ATAGACAGCTTAAATAAGGCTGATTTGGTATTCGTCATGGGTAATAAATACAATATTTTT
TTTTAAAGTTATAAATCTTTTAAAATTTAATATAAATAGGAACTTCTCTCAAAGTTTTTC
CATTTGCAGCTTTAGTTGATTTATTCAAAGAAGATGTCCCAATAGTATTGATTAATAGAG
AAAACCCTGGAATAAAAAGAAGAAGATTCCTATTTTTAGAAGGTGAAATAGATGACAATG
TAGAAAAAATTATGAAGGATATTTCTTGGGATTTTCCTGAAATTAAAAGAACATACCCTG
AAGGAACTGTATTAGAGAAGAAATAAAACCTTTGA

>TTHERM_00526990(protein)
MSSEISKTDLSNLESNTDSMSEAQKEAQLIGFAVEPKLDCPHFEQLNVITLTEVFNDMTL
ETLNKPCKTCNHIGENWICLHCTDIFCSRYINKDMAKHVESNQEHCLVFSFSDGSFWCYK
CDNYISNKTIKDLQKTFSKVKHGGQESNEEEEEKEDDIHAIAAQLLQMHLNKKGQDGIQE
EFTYQNLIDGLRDISPDQEKNQDDKYNNRQFNRIVFLTGAGISVSAGIPDFRTPGSGLYS
QLQKYKLPYPEAIFEINYFKHHPQPFYTLCKEFSSCGSHFTSSHFFIAETNRRNRLLINF
SQNIDGLELEAGLPESKLVQAHGHFRTAKCVNCKKVADIELFNEAVKNDKICYCKECEEG
IVKPDIVFFGESLPQSFFQQIDSLNKADLVFVMGTSLKVFPFAALVDLFKEDVPIVLINR
ENPGIKRRRFLFLEGEIDDNVEKIMKDISWDFPEIKRTYPEGTVLEKKQNL