Identifiers and Description

Gene Model Identifier

TTHERM_00825440

Standard Name

TOP2 (TOPoisomerase II)

Aliases

PreTt04008 | 142.m00105 | 3683.m00038

Description

TOP2 DNA topoisomerase IV; DNA gyrase/topoisomerase IV- A subunit family protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

Gene Ontology Annotations

Molecular Function

• glutathionylspermidine synthase activity (IEA) | GO:0008885

Biological Process

• amino acid catabolic process (IEA) | GO:0009063
• cholesterol biosynthetic process (IEA) | GO:0006695
• cytokinin-activated signaling pathway (IEA) | GO:0009736
• negative regulation of protein kinase activity (IEA) | GO:0006469

Domains

• ( PF00204 ) DNA topoisomerase II (N-terminal region)
• ( PF00521 ) DNA gyrase/topoisomerase IV, A subunit
• ( PF02518 ) ATPase, histidine kinase-, DNA gyrase
• ( TIGR01055 ) DNA topoisomerase IV, B subunit
• ( TIGR01058 ) DNA topoisomerase IV, B subunit
• ( TIGR01059 ) DNA gyrase, B subunit
• ( TIGR01062 ) DNA topoisomerase IV, A subunit
• ( TIGR01063 ) DNA gyrase, A subunit

Gene Expression Profile

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_19754	0
	Description: None
WormBase	WBGene00010785	9.997093137033517e-262
	Description: locus:top-2 Probable DNA topoisomerase 2 status:Partially_confirmed UniProt:Q23670 protein_id:CAA88867.1
Tetrahymena borealis	EI9_18275.1	9.997093137033517e-262
	Description: DNA gyrase/topoisomerase IV, A subunit protein (1796 aa)
DictyBase	DDB_G0270418	9.997093137033517e-262
	Description: top2 on chromosome: 1 position 4831688 to 4836353
Oxytricha	Contig14442.0.g108	9.997093137033517e-262
	Description: DNA gyrase/topoisomerase IV, subunit A
SGD	YNL088W	9.997093137033517e-262
	Description: TOP2 Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis

General Information

No Data fetched for General Information

Associated Literature

1. Ref:28621664: Akematsu T, Fukuda Y, Garg J, Fillingham JS, Pearlman RE, Loidl J (2017) Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11. eLife 6( ):

Sequences

>TTHERM_00825440(coding)
ATGAGCAAGCAGGAAAAATCAGTAGAAGAAAGATATTAAAAAAAATCCCAAATTGAGCAT
ATTCTTCTTCGTCCTGACTCTTATGTTGGGTCTATAGAAAATGAATAAAAGTCATTATGG
ATTCTAAACAAGGAGGGAACAGCATTAGAAGAAAAAGAAATAGATTTCGTTCCAGCATTT
TATAAAATATTTGATGAAATTATAGTCAATGCTGCAGATAACTTTTAAAGAAATTAAGAT
GGAGCTCCTATGGATACAATAAAAGTTATGATTGATCAATAAAATCAAATGATCTCAGTT
TGGAATAATGGACAAGGAATCCCTATATAAATTCATAAAGAGCATAATATTTATATTCCA
GAAATGATTTTTGGTCATCTATTAACAAGCTCTAATTACGATGATAAAGAAGAGAAAGTA
GTAGGCGGTCGTAATGGATTTGGTGCTAAATTAACAAATATTTTTTCTAAAAAATTCATT
GTTGAATGCAATGATGACAAGCGTAAAAAATATTACAAGTAAGAATGGCGTAAAAATATG
TCTGAAAGAACAGAGCCTTTGATTACAGAAAATAAAAAAGGTGGTAATTTCACATGTGTA
ACATTCTATCCTGACCTTTCTAAATTCAAGATGCAAAATATTTCTGATGATATGGCAAAT
TTACTAAGAAAAAGAGTTTATGATATGGCTGGTATTTTTAACAATAAGGTCAAAGTTTAT
TTGAATAATGAACAAATAAAAATAAAATCCTTTAGTTAATATGTTAACTTGTTTATACCT
GACATTGAAGAACAATACAAATGCTATGATCCAACTATGACTTCTGACAGATGGGAGATT
TTAGTTACTTTTTCAGATGGTTAATTTAAGTAAGTATCGTTTGTAAATGGTATTTGCACA
TCTAGAGGTGGTAAGCATGTAGATTTTGTCATTGATAAAATTGTTGAGAGAATGCAAGAA
TAAATCTTGAAAAAGAATAAAGATCTTGATATCAAGCCTCATTAAATCAAACAAAATTTA
TTCATATTTATGAATTGCCTTATTGTTAACCCTTCGTTTGATTCTCAAACCAAAGACACT
CTTACAACAAAAGCCTCAGCTTTTGGATCAAAACCTGAATTATCAGAAAAATTTATCAAA
AAAATATTGGGTACTGGTATCATTGAGTAAATTGTTTCCTAAGCTAAAGCTCGTCAGAAT
GCTAAATTAGCAAAAACTTTAAAGGGTGGGAAAAAAGGAAGAATTACAGGTATCCCAAAA
CTTGATGATGCTAATGATGCAGGAACAGCAAGAAGTGAAAACTGTACATTAATCTTAACC
GAAGGAGATTCAGCTAAAGCATTAGCAATGGCTGGTATAGAAGTTGTAGGTAGGGATAAT
TATGGTGTATTCCCATTAAAGGGTAAGCTACTTAATGTTAGAGAAGCAAATAAGAAATAG
ATCATCGAAAACCAAGAAATATAAAATATATGCAAAATCATAGGGCTAGATCCTGCTGTT
TAAAACTATGAAAATACAAAGCAATTAAGGTACGGATCTTTAATGATCATGGCTGATTAG
GATAGTGATGGTTCCCATATTAAAGGTTTGGTCATAAACTTTATTCATCACTTCTGGCCT
TCTCTGTTTAAAATGAAAGGGTTTTTAAAAGAATTTATTACTCCCATCCTTAAAGTTACA
AAAGGAGATGAAGTTCATTCATTCTTTACAATATAAGATTTCAAAAATTTTGCTGCTTAA
AAAGGAGACCGCCTTAAGTAATACAAAGTTAAGTACTACAAAGGTCTTGGTACTTCGACT
GACAAAGAAGCTAAAGAATATTTCTCCAATTTCTATAAGCATCAAATTAATTTTTAATAT
TTAGATGAAAACGATATGGAAGCTATTGAATTAGGTTTTTCAGGTAAAAAAATAAAAGAA
CGTAAGGACTGGCTAGCTAATTATGATCCTAATTCATTTGTTGATTATAATATAAAATAA
TTAAGATACAAGGATTTTATTGATAGAGAGCTTATTCACTTCTCAAATGCTGATAATTTA
AGATCTATCCCATCGTTATGTGATGGCCTAAAGCCTGGTCAAAGAAAAATTCTATTTTCT
TGTTTTAAAAGAAATTTAAAATCAGAAATCAAAGTAGCTTAATTAATTGGTTATGTTGCT
GAGCACTCTGCATATCACCACGGTGAATAATCACTCGCTTCAACTATCATCGGAATGGCA
TAAAATTTTGTAGGTTCTAATAATATAAATCTTATGATGCCTATTGGTTAGTTTGGTACA
CGTAATCAAGGTGGAAAAGAGCATGCCTCTGCAAGATACATTTTTACAAGTCTGAGCAAA
ATTACTAGAATACTTTTTCCAGAGCATGATGATCATGTACTGAAGTATTTAGAAGACGAT
AATCAAGTAGTAGAACCAGAATGGTACATGCCAATTATTCCTATGTGTTTAGTAAATGGT
AGTAGTGGTATTGGTACTGGTTGGTCAACTGATATTCCTAACTATAATCACAAGGAAATT
GTTGAATAAATTAGAGGGAAGCTGGAAGGAAAGCCATTTACTGAATTACATCCTTGGTAC
AAAGGATTTTAAGGTTAAATAGAAATTAATCCTAAAGGTGGGTATATAGTCAAAGGGTAA
TACGAAATCGATGAAGTTGAAGAAACAATAAAAATTACTGAATTACCTGTTGGTAAATGG
ACAAGAGACTATAAGAATTATTTAGAAGAGCTACTATCACCACCAAAAGGAGAACCTGAA
ATTGAAGACATTCGTGAATATCATACAAATAATAGAGTTCATTTTGAAGTACAAGCAATA
CCAGGGAGAATATAATAATGGGGTGACATTGAGAAAAAGCTTAAATTAAGCACAACAATG
CAAACAACTAATATAGTTATGTTTAATGATAAATATAAATTAAAAAGATATCAAAGTACT
GTAGAAATAATGGAAGAATTTTATGCTTTACGTCTCAAATGCTACTAAAAAAGAAAAGAT
TATTTAGTCAGCAAAATTCAAAGAGATGTTGATATTTTATAAAATAAGATGAAATTTATT
ACATTAGTTGTCAATGGTACTTTGGAAATTAGAAATGCCAGAAAGAAAGGAGTTCTGAAT
AAACTTAAGGAGTTAGGTCTGACTCCAATGTCAAAAATAACCAGAATCAATTCGACAAAA
ATCTAGGCATTTGAAGAAAAAAAGAAAGAAAGTTAAGCTGAAAAAAATGAAGATAATGAA
GATGAAGAAGTTTAATAAGACGAAGAGGAAGAAGAAGAATAAGTTTAAGAAGGAGAAATT
CCTTTATCTGAATACAACTACCTTCTCTCTATGCCTATCTTTTCTTTGACAGAAGAAAAG
GTATTATAACTCAAAAAATAAGTAGAAGAAAAGGAAAGTGAACTTTTGATCTTATAAAAG
AAAGAAATAAAAGATATGTGGACAGAAGATTTAGATAAATTCATAGAAGTTATTGAATAA
GTAGAAGAAAAAGAAGAAAAAGAGAGACTTACAGGTAAAGGGTTTACATAGAATGGCAAA
GCCCGTGCTAAAAAGAAAAATAACAATAAAGAAAAAGAATAAAAAAAATAATAAAATAAC
TCTTCAGATGACGAAAGCGAAAAGAAAACTGTTGTAAAAAATAAAAATCCATAAAAATCT
GATAATGAAAAATAAAAGCCAAAAGAAAATAATGATAAATAAAAGAAAATAGATGAAAGT
TTTCTTGTGAAGAAAAAAATGGATGCAGAACAATAAAAAACAGAAGAAAAGGTATAAAAG
AAAGAATAGAAGAAAGAGCCAATGAAGTAGCTCTCACTGATTGAAAGAATATCTTAAAAA
TATAGTAATCAGGCGGAATAATAAGTAACGGCAGATATACTTGACACAAATAAACGTAAA
AAAGATCCATCTTCAACTTCTACCTCTGTTTATTCAATGGATATGCCATAATAAAACCTA
AAGCGAAAGAAAAATAATAAATTGAAAGAAGATGATGATGATTTTGACCTTGATTTAGAT
TTCTTAGAACCTAGTTAGATAATTATGAATCCTAGCTAAGATCCTAATAAAAGAACCTTA
AGGTCAAATGGGAAGAAGCCAAGAACGATTTATAAACTAGATTCGGATTCTGATAATGAT
GAATTCAATCAGTAAAATGATGAATCTGATGAAGAAGAGGAAGAGGAATTTGTTATGATG
CCTTCTAAGAGCAATAAGAAAAAATTATTTGATGAGGATGAGGATGATTGA

>TTHERM_00825440(gene)
ATGAGCAAGCAGGAAAAATCAGTAGAAGAAAGATATTAAAAAAAATCCCAAATTGAGCAT
ATTCTTCTTCGTCCTGACTCTTATGTTGGGTCTATAGAAAATGAATAAAAGGTAAACTAT
AATTTGTTTATTTATTGAATACAACTTAGATAGCTTATATTAAATTTAATATAAAATAGT
CATTATGGATTCTAAACAAGGAGGGAACAGCATTAGAAGAAAAAGAAATAGATTTCGTTC
CAGCATTTTATAAAATATTTGATGAAATTATAGTCAATGCTGCAGATAACTTTTAAAGAA
ATTAAGATGGAGCTCCTATGGATACAATAAAAGTTATGATTGATCAATAAAATCAAATGA
TCTCAGTTTGGAATAATGGACAAGGAATCCCTATATAAATTCATAAAGAGCATAATATTT
ATATTCCAGAAATGATTTTTGGTCATCTATTAACAAGCTCTAATTACGATGATAAAGAAG
AGAAAGTAGTAGGCGGTCGTAATGGATTTGGTGCTAAATTAACAAATATTTTTTCTAAAA
AATTCATTGTTGAATGCAATGATGACAAGCGTAAAAAGTAAAATTTAACTAAAATCTATA
ATTTCTTATCCATTTAAATTTAACTTTAGATATTACAAGTAAGAATGGCGTAAAAATATG
TCTGAAAGAACAGAGCCTTTGATTACAGAAAATAAAAAAGGTGGTAATTTCACATGTGTA
ACATTCTATCCTGACCTTTCTAAATTCAAGATGCAAAATATTTCTGATGATATGGCAAAT
TTACTAAGAAAAAGAGTTTATGATATGGCTGGTATTTTTAACAATAAGGTCAAAGTTTAT
TTGAATAATGAACAAATAAAAATAAAATCCTTTAGTTAATATGTTAACTTGTTTATACCT
GACATTGAAGGTAGCTATTTCTTTTTTATTTAAGAAAATGAATTTGCAATGATGATAAAA
TCTAAATGACAGAAAAATACATACTTATAATGGTAATATATGGTAAAACCATATATTGCT
AGTATGTACTTTCATTGTATGATGGCTTACACTTGATTTTGAGCAAATTCATTTTTTTAA
AATTATTTTTAATTAATTAAATTACTTTTTAAATCAAGAAAATTAAAAATTATTTTTTTA
GAACAATACAAATGCTATGATCCAACTATGACTTCTGACAGATGGGAGATTTTAGTTACT
TTTTCAGATGGTTAATTTAAGTAAGTATCGTTTGTAAATGGTATTTGCACATCTAGAGGT
GGTAAGCATGTAGATTTTGTCATTGATAAAATTGTTGAGAGAATGCAAGAATAAATCTTG
AAAAAGAATAAAGATCTTGATATCAAGCCTCATTAAATCAAACAAAATTTATTCATATTT
ATGAATTGCCTTATTGTTAACCCTTCGTTTGATTCTCAAACCAAAGACACTCTTACAACA
AAAGCCTCAGCTTTTGGATCAAAACCTGAATTATCAGAAAAATTTATCAAAAAAATATTG
GGTACTGGTATCATTGAGTAAATTGTTTCCTAAGCTAAAGCTCGTCAGAATGCTAAATTA
GCAAAAACTTTAAAGGGTGGGAAAAAAGGAAGAATTACAGGTATCCCAAAACTTGATGAT
GCTAATGATGCAGGTATTATTTTATAATTTATGAATAATATCATAAAAATACTGATTTAA
AATATAGGAACAGCAAGAAGTGAAAACTGTACATTAATCTTAACCGAAGGAGATTCAGCT
AAAGCATTAGCAATGGCTGGTATAGAAGTTGTAGGTAGGGATAATTATGGTGTATTCCCA
TTAAAGGGTAAGCTACTTAATGTTAGAGAAGCAAATAAGAAATAGATCATCGAAAACCAA
GAAATATAAAATATATGCAAAATCATAGGGCTAGATCCTGCTGTTTAAAACTATGAAAAT
GTATTTATTTTTTATTATTAAATATTATGCATTTAACTTAACATATATTTTAACAGACAA
AGCAATTAAGGTACGGATCTTTAATGATCATGGCTGATTAGGATAGTGATGGTTCCCATA
TTAAAGGTTTGGTCATAAACTTTATTCATCACTTCTGGCCTTCTCTGTTTAAAATGAAAG
GGTTTTTAAAAGAATTTATTACTCCCATCCTTAAAGTTACAAAAGGAGATGAAGTTCATT
CATTCTTTACAATATAAGATTTCAAAAATTTTGCTGCTTAAAAAGGAGACCGCCTTAAGT
AATACAAAGTTAAGTACTACAAAGGTCTTGGTACTTCGACTGACAAAGAAGCTAAAGAAT
ATTTCTCCAATTTCTATAAGCATCAAATTAATTTTTAATATTTAGATGAAAACGATATGG
AAGCTATTGAATTAGGTTTTTCAGGTAAAAAAATAAAAGAACGTAAGGACTGGCTAGCTA
ATTATGATCCTAATTCATTTGTTGATTATAATATAAAATAATTAAGATACAAGGATTTTA
TTGATAGAGAGCTTATTCACTTCTCAAATGCTGATAATTTAAGATCTATCCCATCGTTAT
GTGATGGCCTAAAGCCTGGTCAAAGAAAAATTCTATTTTCTTGTTTTAAAAGAAATTTAA
AATCAGAAATCAAAGTAACCAGAATAAAAAAATAAATTACTTATTAATTTTTCACTTTAA
TTAAAAAGGTAGCTTAATTAATTGGTTATGTTGCTGAGCACTCTGCATATCACCACGGTG
AATAATCACTCGCTTCAACTATCATCGGAATGGCATAAAATTTTGTAGGTTCTAATAATA
TAAATCTTATGATGCCTATTGGTTAGTTTGGTACACGTAATCAAGGTGGAAAAGAGCATG
CCTCTGCAAGATACATTTTTACAAGTCTGAGCAAAATTACTAGAATACTTTTTCCAGAGC
ATGATGATCATGTACTGAAGTATTTAGAAGACGATAATCAAGTAGTAGAACCAGAATGGT
ATTCATTGAATTTTAACTAACTTTAGAATTAATTTATTTTTAAAAATATAAAGGTACATG
CCAATTATTCCTATGTGTTTAGTAAATGGTAGTAGTGGTATTGGTACTGGTTGGTCAACT
GATATTCCTAACTATAATCACAAGGAAATTGTTGAATAAATTAGAGGGAAGCTGGAAGGA
AAGCCATTTACTGAATTACATCCTTGGTACAAAGGATTTTAAGGTTAAATAGAAATTAAT
CCTAAAGGTGGGTATATAGTCAAAGGGTAATACGAAATCGATGAAGTTGAAGAAACAATA
AAAATTACTGAATTACCTGTTGGTAAATGGACAAGAGACTATAAGGTAGTTTTAATTTGT
TAATTTATTAATGGAGTAAATATAATTAAATTTTTATAAAAGAATTATTTAGAAGAGCTA
CTATCACCACCAAAAGGAGAACCTGAAATTGAAGACATTCGTGAATATCATACAAATAAT
AGAGTTCATTTTGAAGTACAAGCAATACCAGGGAGAATATAATAATGGGGTGACATTGAG
AAAAAGCTTAAATTAAGCACAACAATGCAAACAACTAATATAGTTATGTTTAATGATAAA
TATAAATTAAAAAGATATCAAAGTACTGTAGAAATAATGGAAGAATTTTATGCTTTACGT
CTCAAATGCTACTAAAAAAGAAAAGATTATTTAGTCAGCAAAATTCAAAGAGATGTTGAT
ATTTTATAAAATAAGATGAAATTTATTACATTAGTTGTCAATGGTACTTTGGAAATTAGA
AATGCCAGAAAGAAAGGAGTTCTGAATAAACTTAAGGAGTTAGGTCTGACTCCAATGTCA
AAAATAACCAGAATCAATTCGACAAAAATCTAGGTAAATAAAATTTAAATTTGAAAAAAT
ATTAAAATAAATTTTACAAAAAAACAAAGGCATTTGAAGAAAAAAAGAAAGAAAGTTAAG
CTGAAAAAAATGAAGATAATGAAGATGAAGAAGTTTAATAAGACGAAGAGGAAGAAGAAG
AATAAGTTTAAGAAGGAGAAATTCCTTTATCTGAATACAACTACCTTCTCTCTATGCCTA
TCTTTTCTTTGACAGAAGAAAAGGTAATATTCTTTTTTATTAAATTAAAAAAATCAAGTT
AAAAATTAATATAGGTATTATAACTCAAAAAATAAGTAGAAGAAAAGGAAAGTGAACTTT
TGATCTTATAAAAGAAAGAAATAAAAGATATGTGGACAGAAGATTTAGATAAATTCATAG
AAGTAATACAATTTTAGAATTAATTTTAGATAAAGATTTTTAATAAATAATTTATAGGTT
ATTGAATAAGTAGAAGAAAAAGAAGAAAAAGAGAGACTTACAGGTAAAGGGTTTACATAG
AATGGCAAAGCCCGTGCTAAAAAGAAAAATAACAATAAAGAAAAAGAATAAAAAAAATAA
TAAAATAACTCTTCAGATGACGAAAGCGAAAAGAAAACTGTTGTAAAAAATAAAAATCCA
TAAAAATCTGATAATGAAAAATAAAAGCCAAAAGAAAATAATGATAAATAAAAGAAAATA
GATGAAAGTTTTCTTGTGAAGAAAAAAATGGATGCAGAACAATAAAAAACAGAAGAAAAG
GTATAAAAGAAAGAATAGAAGAAAGAGCCAATGAAGTAGCTCTCACTGATTGAAAGAATA
TCTTAAAAATATAGTAATCAGGCGGAATAATAAGTAACGGCAGATATACTTGACACAAAT
AAACGTAAAAAAGATCCATCTTCAACTTCTACCTCTGTTTATTCAATGGATATGCCATAA
TAAAACCTAAAGGTAATTTAATTTAAATTTTTTATTTTTTTTGACATATTTCTTTTTTCT
AGCGAAAGAAAAATAATAAATTGAAAGAAGATGATGATGATTTTGACCTTGATTTAGATT
TCTTAGAACCTAGTTAGATAATTATGAATCCTAGCTAAGATCCTAATAAAAGAACCTTAA
GGTCAAATGGGAAGAAGCCAAGAACGATTTATAAACTAGATTCGGATTCTGATAATGATG
AATTCAATCAGTAAAATGATGAATCTGATGAAGAAGAGGAAGAGGAATTTGTTATGATGC
CTTCTAAGAGCAATAAGAAAAAATTATTTGATGAGGATGAGGATGATTGA

>TTHERM_00825440(protein)
MSKQEKSVEERYQKKSQIEHILLRPDSYVGSIENEQKSLWILNKEGTALEEKEIDFVPAF
YKIFDEIIVNAADNFQRNQDGAPMDTIKVMIDQQNQMISVWNNGQGIPIQIHKEHNIYIP
EMIFGHLLTSSNYDDKEEKVVGGRNGFGAKLTNIFSKKFIVECNDDKRKKYYKQEWRKNM
SERTEPLITENKKGGNFTCVTFYPDLSKFKMQNISDDMANLLRKRVYDMAGIFNNKVKVY
LNNEQIKIKSFSQYVNLFIPDIEEQYKCYDPTMTSDRWEILVTFSDGQFKQVSFVNGICT
SRGGKHVDFVIDKIVERMQEQILKKNKDLDIKPHQIKQNLFIFMNCLIVNPSFDSQTKDT
LTTKASAFGSKPELSEKFIKKILGTGIIEQIVSQAKARQNAKLAKTLKGGKKGRITGIPK
LDDANDAGTARSENCTLILTEGDSAKALAMAGIEVVGRDNYGVFPLKGKLLNVREANKKQ
IIENQEIQNICKIIGLDPAVQNYENTKQLRYGSLMIMADQDSDGSHIKGLVINFIHHFWP
SLFKMKGFLKEFITPILKVTKGDEVHSFFTIQDFKNFAAQKGDRLKQYKVKYYKGLGTST
DKEAKEYFSNFYKHQINFQYLDENDMEAIELGFSGKKIKERKDWLANYDPNSFVDYNIKQ
LRYKDFIDRELIHFSNADNLRSIPSLCDGLKPGQRKILFSCFKRNLKSEIKVAQLIGYVA
EHSAYHHGEQSLASTIIGMAQNFVGSNNINLMMPIGQFGTRNQGGKEHASARYIFTSLSK
ITRILFPEHDDHVLKYLEDDNQVVEPEWYMPIIPMCLVNGSSGIGTGWSTDIPNYNHKEI
VEQIRGKLEGKPFTELHPWYKGFQGQIEINPKGGYIVKGQYEIDEVEETIKITELPVGKW
TRDYKNYLEELLSPPKGEPEIEDIREYHTNNRVHFEVQAIPGRIQQWGDIEKKLKLSTTM
QTTNIVMFNDKYKLKRYQSTVEIMEEFYALRLKCYQKRKDYLVSKIQRDVDILQNKMKFI
TLVVNGTLEIRNARKKGVLNKLKELGLTPMSKITRINSTKIQAFEEKKKESQAEKNEDNE
DEEVQQDEEEEEEQVQEGEIPLSEYNYLLSMPIFSLTEEKVLQLKKQVEEKESELLILQK
KEIKDMWTEDLDKFIEVIEQVEEKEEKERLTGKGFTQNGKARAKKKNNNKEKEQKKQQNN
SSDDESEKKTVVKNKNPQKSDNEKQKPKENNDKQKKIDESFLVKKKMDAEQQKTEEKVQK
KEQKKEPMKQLSLIERISQKYSNQAEQQVTADILDTNKRKKDPSSTSTSVYSMDMPQQNL
KRKKNNKLKEDDDDFDLDLDFLEPSQIIMNPSQDPNKRTLRSNGKKPRTIYKLDSDSDND
EFNQQNDESDEEEEEEFVMMPSKSNKKKLFDEDEDD