Identifiers and Description

Gene Model Identifier

TTHERM_00985000

Standard Name

TTLL4B (Tubulin Tyrosine Ligase-Like )

Aliases

PreTt23270 | 184.m00045

Description

TTLL4B tubulin tyrosine ligase family protein; Related to tubulin polyglutamylase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• acid-amino acid ligase activity (ISS) | GO:0016881
• tubulin-tyrosine ligase activity (IEA) | GO:0004835

Biological Process

• cellular protein modification process (IEA) | GO:0006464
• protein polyglutamylation (ISS) | GO:0018095

Domains

• ( PF03133 ) Tubulin-tyrosine ligase family
• ( TIGR00590 ) proliferating cell nuclear antigen (pcna)

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_07233.1	9.997093137033517e-262
	Description: tubulin-tyrosine ligase (624 aa)
Oxytricha	Contig1070.1.g45	2.000127961544401e-120
	Description: Tubulin-tyrosine ligase family
WormBase	WBGene00014232	1.9994274381022833e-63
	Description: locus:ttll-4 Tubulin polyglutamylase ttll-4 status:Partially_confirmed UniProt:Q09647 protein_id:CAA87425.3
Stentor Coeruleus	SteCoe_5424	2.3455513385429143e-59
	Description: None
DictyBase	DDB_G0281541	3.9989916100764785e-24
	Description: DDB_G0281541 on chromosome: 3 position 4627625 to 4629265
SGD	YBR094W	0.00020003864201578029
	Description: PBY1 Putative tubulin tyrosine ligase associated with P-bodies

General Information

No Data fetched for General Information

Associated Literature

1. Ref:15890843: Janke C, Rogowski K, Wloga D, Regnard C, Kajava AV, Strub JM, Temurak N, van Dijk J, Boucher D, van Dorsselaer A, Suryavanshi S, Gaertig J, Eddé B (2005) Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Science (New York, N.Y.) 308(5729):1758-62

Sequences

>TTHERM_00985000(coding)
ATGAATAACTCTTCACCTATAAGAGTAAATAGCTACCTCTAAAGTAACAATTAAGCATGG
TAATTAGCTTAATAGATATGCCAATCGGCAACGAAGTCAAATTAATAAAATACAAGTTCA
ATAGAAAGACCACATTCATAAATTTAAGGTTAGGCTTCTTAATAAATATAGTTAAATGGT
TATAATTTTTAAGGCCACACCAGCATTATTTCGAATGGCAACTATTAGCATCAACTGCAT
CATTAAAAAGTAGCAATTAGCGAATCGCCATAAAGACCTTAATAGCAAATAATAAATAAT
CAAATTATAAAATTAGAGGCATTGGGAGTGCAAAAAGATAATCCGAATTAGATATTTTCA
TTTCATCACTAAAATGGATATTTTAAAAAGAAAAACTATTCCGCAGCAGTAAAGAGGAAT
CTTTCTTAGCAAGTATCTTAGCAATTATTTAACTGCGAATTAAAAGGCATCAATCCTTAA
CATAATATTTTCTGTGATCAAAATAAAGGATCACATTTAAGATCCAGCTCCAACCACGTT
AACCCATATATTTAGTAAAAGATAAATGGGTTTTAGTAAAGTGTTTTACAAAATAAAACT
TTGTACTATGGCTCAAATGCAAGCAATTCCCTTTTATCATCATAACCCTAAAAAATAGAT
ATATTCGCTCGTTCAACTTACTACGTTAGACCTTTATAAGAGCTAGTACAGCTCAACTCA
GGGAAAAGAATTTTGGATCCTTAAAGCTATGCAAATGCTGAAAATATAAATTAACTTGAG
TAACCTGAAAAGGCTTTAATTTAAGAAATTGAATGCAACTAGCAAGAAACTAATACAAGT
TTAAATATTGATGATTCAAGTAAACACAATTAGAGAAATCTTAGTATAAATGAAGGGAAA
ATTCAAAAAGAGATTATTGGATTACAAAATTAGTCATTTGGAATACATTGCGATAATCCA
AACAAAAGGTTGTCAGATAGTATTACAATATAAGCTCCTTTCAGTAGTCACAATTATGAT
TTCCAATAAGAGGATTATAAACTATAGAGAGTAACTCTTAACCCAGTATATAAAACAGAA
TAAAATATAGAAAGATTGGAACCTATTGAAAATGGAGATTAGTTCACTCCTTAAAGCAGC
AATTTGGAATAAAAAAAATCAAAAAAAATACAAAACTTTCCTGATTAGATGCAATTTAGT
GAAACCAAAAGGTAAATAAAACAAGCTGAACTATTTAGGATATCTTCGCCACTCAAATAC
ATAAAATCAAATGCATAGTTCAAATTAAGATCAATTTCATAGTAAGATCCAGCTTTAAAA
AATGTATTATAAGTACAGGAAAGCCCTATCAAGCAAATTTATTAAGAAAGAGAAGTTATT
GTAAAATAAAGTATCACAAATACGAATTTTGCCAACAATCCACTTATGGTTACATCTTCT
ATAGAAAAAACAATAGACTTCTAGCCAAATAATAATATTTAAGATGAAAAAGAGAGAATT
ATAAGCAAAAGCTATTCAGCTGTAAAAAAATCTCTAGCAGAGAGGACGTCAAGGTCTTAA
AACCCTCATGAAATTCTTAATCGAACTTAAAATGTGATTTAGATGTATCAAAGTTAAAAT
AGTTACAATAGCAATTACGGGAGCATAAGGAAGAGTAAGAATCATTATTCTTTTACAAAA
AAGCAGAAGGAAGAAAAAATTGAATAAATCATTTTGAAATGCACAGATAAAACATATTTT
GATCCTGCTGGTGATATGAGAAATGAGTTGCAGTAATAACAGCAAAAGGTTAGTACTTTG
AATAAGAATGATTTCAAAGTCGGAATAAACAGCGAAAAAGCTTCTCCAAAATCATAAACA
GTAATATAAAAATATGGTATTAATCAATCAGAGTAAAAGGAAGGTGATCAAGCCAAAAAA
GTGTTTGTGTTTAAAAAAAATATTAATAAAAATGAAGAAGATGACGATGATGAAGAGAAA
AATCAAAACAACAGTGATAGCGATTCATCGAAAGATTTAGATGTCGATAGTGATGAAGAT
GAAGATGAGGATGAGAATGACTTAGAAGATAGCATCGACTAAGCATTGATTAATTCAGCA
TATGAACCATCAACAGAATGCTCTGCTTCATTTTAACCTCCAGTCTTGCAACCAAATAGA
TATAACAAGCTCTTACTATTAAAAAGTGTGTATGAAAACCGTCCTTTGACCGTATTCTTT
CCCTATCCTCCTTAATGTGGAGATATCATCAGAAACTCTTCTAGAACAGTTGTAGCAACC
GATTATGAAGAAAAAAGGTTTGATATGAGGTTTAAGGTGACCACTAATAGCTTAAATAGG
TGTGTTGGACATGCATTTTAGTATGCAGGTATTAGAGAGACTGAAGATAATGACTGGAAT
ATGGTATGGAGCACTGGAAGAGATAATAGAGTAAAAAATATGATTAAATATTAAAAAATT
AACCACTTCCCATAGTATTGGAATATGGGGAGAAAGGACTGCTTGTGGAAAAATTTGTCT
AAAGTTAAAAGAAAATTTCCATAAGAATATGACTTTATTCCAAATACTTATATATTGTAA
CATTAATCAGATTGGGATAGATTTTTGGCAAAAAGAGATGATGCTGAGAAAGGAAAATTG
TGGATTATGAAGCCTAGCAACTAGGCCTAAGGAAAAAATATAAAGATGATATCAAAGAGA
AGCAAAGTATAAAGAAAGCAAGAATACATTATTTGTGAGTATGTAGCAAATCCACATTTG
ATTGATGGATTAAAATATGATCTTCGTATATATGTTTTAGTCACTTCATATGATCCTCTT
AGGATATACATTTTCGATGATGGTTTGACTCGTTTCGCGACTGAAAAATATTCAACTAAT
ACAAAAGAACTCTCAAAAAGATATGTGCATTTGACTAATTACTCACTTAATAAAAATAAT
CCTAACTTCAAGAAAAACAAGGATGCTAATGAAGATAGTGAAGGCTCGAAGTGGTCATTA
AAAGCTCTATTTAGAAAATACACAGAGATGGGAGTTAACACTGCTCAGTTGTGGGACAGA
ATAAAAGATATTGTAATTAAAACTTGTATTGCAACTGAGCCATATATGACAGATTAGTAT
GTAAAATGTGAAAATCATAGAACAAATTGTTTTGAATTGTATGGCTTTGACATATTAATC
GATGATACCCTAAAGCCTTGGTTGCTTGAAGTAAATGTGCGTCCATCTTTAAGCAGTTCT
TCTCCTTTAGACAGAAGAATAAAGCATACTTTAGTATGTGATACATTCAATTTGATAGGA
ATCTAGCCTTATGATAAAAGAAAGTTTGAAGAAGATCAAAGAAAAAAGATTCCAGGAGTA
TCTGATTAAAAAAGAGGATTTTCTAAAAACTTAAAAGATTTATCAGATTTAAATGAATTC
AACTGTTTGCAAAAGCTTTCACCAGAAGATTGGAATATGCTTTTTGAAACAGACGAAGAG
AACTATAGAACAGGACATTTCGAGAGAATTTTTCCTCCTCCTAAAGATAAAATTGATTTT
TACTTGAAGTTTTTTGAATATGAGAGATATAACAACATAATCATTCGCAGTTGGGTCAAG
TCAAGCACCAACTTTTTAGAAAAAATCTTGAAAAAAGTTTATGAATTTAATGTTTGA

>TTHERM_00985000(gene)
ATGAATAACTCTTCACCTATAAGAGTAAATAGCTACCTCTAAAGTAACAATTAAGCATGG
TAATTAGCTTAATAGATATGCCAATCGGCAACGAAGTCAAATTAATAAAATACAAGTTCA
ATAGAAAGACCACATTCATAAATTTAAGGTTAGGCTTCTTAATAAATATAGTTAAATGGT
TATAATTTTTAAGGCCACACCAGCATTATTTCGAATGGCAACTATTAGCATCAACTGCAT
CATTAAAAAGTAGCAATTAGCGAATCGCCATAAAGACCTTAATAGCAAATAATAAATAAT
CAAATTATAAAATTAGAGGCATTGGGAGTGCAAAAAGATAATCCGAATTAGATATTTTCA
TTTCATCACTAAAATGGATATTTTAAAAAGAAAAACTATTCCGCAGCAGTAAAGAGGAAT
CTTTCTTAGCAAGTATCTTAGCAATTATTTAACTGCGAATTAAAAGGCATCAATCCTTAA
CATAATATTTTCTGTGATCAAAATAAAGGATCACATTTAAGATCCAGCTCCAACCACGTT
AACCCATATATTTAGTAAAAGATAAATGGGTTTTAGTAAAGTGTTTTACAAAATAAAACT
TTGTACTATGGCTCAAATGCAAGCAATTCCCTTTTATCATCATAACCCTAAAAAATAGAT
ATATTCGCTCGTTCAACTTACTACGTTAGACCTTTATAAGAGCTAGTACAGCTCAACTCA
GGGAAAAGAATTTTGGATCCTTAAAGCTATGCAAATGCTGAAAATATAAATTAACTTGAG
TAACCTGAAAAGGCTTTAATTTAAGAAATTGAATGCAACTAGCAAGAAACTAATACAAGT
TTAAATATTGATGATTCAAGTAAACACAATTAGAGAAATCTTAGTATAAATGAAGGGAAA
ATTCAAAAAGAGATTATTGGATTACAAAATTAGTCATTTGGAATACATTGCGATAATCCA
AACAAAAGGTTGTCAGATAGTATTACAATATAAGCTCCTTTCAGTAGTCACAATTATGAT
TTCCAATAAGAGGATTATAAACTATAGAGAGTAACTCTTAACCCAGTATATAAAACAGAA
TAAAATATAGAAAGATTGGAACCTATTGAAAATGGAGATTAGTTCACTCCTTAAAGCAGC
AATTTGGAATAAAAAAAATCAAAAAAAATACAAAACTTTCCTGATTAGATGCAATTTAGT
GAAACCAAAAGGTAAATAAAACAAGCTGAACTATTTAGGATATCTTCGCCACTCAAATAC
ATAAAATCAAATGCATAGTTCAAATTAAGATCAATTTCATAGTAAGATCCAGCTTTAAAA
AATGTATTATAAGTACAGGAAAGCCCTATCAAGCAAATTTATTAAGAAAGAGAGTAAAAA
TTATAAATTTTACATTAAAATTTGATTGAAAATAAAATTTTATTTTTAAAATTAAAAAAA
AAATAGAGTTATTGTAAAATAAAGTATCACAAATACGAATTTTGCCAACAATCCACTTAT
GGTTACATCTTCTATAGAAAAAACAATAGACTTCTAGCCAAATAATAATATTTAAGATGA
AAAAGAGAGAATTATAAGCAAAAGCTATTCAGCTGTAAAAAAATCTCTAGCAGAGAGGAC
GTCAAGGTCTTAAAACCCTCATGAAATTCTTAATCGAACTTAAAATGTGATTTAGATGTA
TCAAAGTTAAAATAGTTACAATAGCAATTACGGGAGCATAAGGAAGAGTAAGAATCATTA
TTCTTTTACAAAAAAGCAGAAGGAAGAAAAAATTGAATAAATCATTTTGAAATGCACAGA
TAAAACATATTTTGATCCTGCTGGTGATATGAGAAATGAGTTGCAGTAATAACAGCAAAA
GGTTAGTACTTTGAATAAGAATGATTTCAAAGTCGGAATAAACAGCGAAAAAGCTTCTCC
AAAATCATAAACAGTAATATAAAAATATGGTATTAATCAATCAGAGTAAAAGGAAGGTGA
TCAAGCCAAAAAAGTGTTTGTGTTTAAAAAAAATATTAATAAAAATGAAGAAGATGACGA
TGATGAAGAGAAAAATCAAAACAACAGTGATAGCGATTCATCGAAAGATTTAGATGTCGA
TAGTGATGAAGATGAAGATGAGGATGAGAATGACTTAGAAGATAGCATCGACTAAGCATT
GATTAATTCAGCATATGAACCATCAACAGAATGCTCTGCTTCATTTTAACCTCCAGTCTT
GCAACCAAATAGATATAACAAGCTCTTACTATTAAAAAGTGTGTATGAAAACCGTCCTTT
GACCGTATTCTTTCCCTATCCTCCTTAATGTGGAGATATCATCAGAAACTCTTCTAGAAC
AGTTGTAGCAACCGATTATGAAGAAAAAAGGTTTGATATGAGGTAAATTTTTATTTTTTA
AAGTATTTAAGCTGTAATGAAATCATTTAGTTGTTTTTCATTTTTTTTTGATGTTGTTGT
AAATTTTTGTTATATTTTTGCTATGGAAAATATTGAATAATCAAGAAATTAAAAAAAATT
TTGTTTTTTAAAGGTTTAAGGTGACCACTAATAGCTTAAATAGGTGTGTTGGACATGCAT
TTTAGTATGCAGGTATTAGAGAGACTGAAGATAATGACTGGAATATGGTATGGAGCACTG
GAAGAGATAATAGAGTAAAAAATATGATTAAATATTAAAAAATTAACCACTTCCCATAGT
ATTGGAATATGGGGAGAAAGGACTGCTTGTGGAAAAATTTGTCTAAAGTTAAAAGAAAAT
TTCCATAAGAATATGACTTTATTCCAAATACTTATATATTGTAACATTAATCAGATTGGG
ATAGATTTTTGGCAAAAAGAGATGATGCTGAGAAAGGAAAATTGTGGATTATGAAGCCTA
GCAACTAGGCCTAAGGAAAAAATATAAAGATGATATCAAAGAGAAGCAAAGTATAAAGAA
AGCAAGAATACATTATTTGTGAGTATGTAGCAAATCCACATTTGATTGATGGATTAAAAT
ATGATCTTCGTATATATGTTTTAGTCACTTCATATGATCCTCTTAGGATATACATTTTCG
ATGATGGTTTGACTCGTTTCGCGACTGAAAAATATTCAACTAATACAAAAGAACTCTCAA
AAAGATATGTGCATTTGACTAATTACTCACTTAATAAAAATAATCCTAACTTCAAGAAAA
ACAAGGATGCTAATGAAGATAGTGAAGGCTCGAAGTGGTCATTAAAAGCTCTATTTAGAA
AATACACAGAGATGGGAGTTAACACTGCTCAGTTGTGGGACAGAATAAAAGATATTGTAA
TTAAAACTTGTATTGCAACTGAGCCATATATGACAGATTAGTATGTAAAATGTGAAAATC
ATAGAACAAATTGTTTTGAATTGTATGGCTTTGACATATTAATCGATGATACCCTAAAGC
CTTGGTTGCTTGAAGTAAATGTGCGTCCATCTTTAAGCAGTTCTTCTCCTTTAGACAGAA
GAATAAAGCATACTTTAGTATGTGATACATTCAATTTGATAGGAATCTAGCCTTATGATA
AAAGAAAGTTTGAAGAAGATCAAAGAAAAAAGATTCCAGGAGTATCTGATTAAAAAAGAG
GATTTTCTAAAAACTTAAAAGATTTATCAGATTTAAATGAATTCAACTGTTTGCAAAAGC
TTTCACCAGAAGATTGGAATATGCTTTTTGAAACAGACGAAGAGAACTATAGAACAGGAC
ATTTCGAGAGAATTTTTCCTCCTCCTAAAGATAAAATTGATTTTTACTTGAAGTTTTTTG
AATATGAGAGATATAACAACATAATCATTCGCAGTTGGGTCAAGTCAAGCACCAACTTTT
TAGAAAAAATCTTGAAAAAAGTTTATGAATTTAATGTTTGA

>TTHERM_00985000(protein)
MNNSSPIRVNSYLQSNNQAWQLAQQICQSATKSNQQNTSSIERPHSQIQGQASQQIQLNG
YNFQGHTSIISNGNYQHQLHHQKVAISESPQRPQQQIINNQIIKLEALGVQKDNPNQIFS
FHHQNGYFKKKNYSAAVKRNLSQQVSQQLFNCELKGINPQHNIFCDQNKGSHLRSSSNHV
NPYIQQKINGFQQSVLQNKTLYYGSNASNSLLSSQPQKIDIFARSTYYVRPLQELVQLNS
GKRILDPQSYANAENINQLEQPEKALIQEIECNQQETNTSLNIDDSSKHNQRNLSINEGK
IQKEIIGLQNQSFGIHCDNPNKRLSDSITIQAPFSSHNYDFQQEDYKLQRVTLNPVYKTE
QNIERLEPIENGDQFTPQSSNLEQKKSKKIQNFPDQMQFSETKRQIKQAELFRISSPLKY
IKSNAQFKLRSISQQDPALKNVLQVQESPIKQIYQEREVIVKQSITNTNFANNPLMVTSS
IEKTIDFQPNNNIQDEKERIISKSYSAVKKSLAERTSRSQNPHEILNRTQNVIQMYQSQN
SYNSNYGSIRKSKNHYSFTKKQKEEKIEQIILKCTDKTYFDPAGDMRNELQQQQQKVSTL
NKNDFKVGINSEKASPKSQTVIQKYGINQSEQKEGDQAKKVFVFKKNINKNEEDDDDEEK
NQNNSDSDSSKDLDVDSDEDEDEDENDLEDSIDQALINSAYEPSTECSASFQPPVLQPNR
YNKLLLLKSVYENRPLTVFFPYPPQCGDIIRNSSRTVVATDYEEKRFDMRFKVTTNSLNR
CVGHAFQYAGIRETEDNDWNMVWSTGRDNRVKNMIKYQKINHFPQYWNMGRKDCLWKNLS
KVKRKFPQEYDFIPNTYILQHQSDWDRFLAKRDDAEKGKLWIMKPSNQAQGKNIKMISKR
SKVQRKQEYIICEYVANPHLIDGLKYDLRIYVLVTSYDPLRIYIFDDGLTRFATEKYSTN
TKELSKRYVHLTNYSLNKNNPNFKKNKDANEDSEGSKWSLKALFRKYTEMGVNTAQLWDR
IKDIVIKTCIATEPYMTDQYVKCENHRTNCFELYGFDILIDDTLKPWLLEVNVRPSLSSS
SPLDRRIKHTLVCDTFNLIGIQPYDKRKFEEDQRKKIPGVSDQKRGFSKNLKDLSDLNEF
NCLQKLSPEDWNMLFETDEENYRTGHFERIFPPPKDKIDFYLKFFEYERYNNIIIRSWVK
SSTNFLEKILKKVYEFNV