Identifiers and Description

Gene Model Identifier

TTHERM_00058820

Standard Name

AXE1 (Ankyrin/histone H3 methyl transferase and EXosome 3-5 exoribonuclease 1)

Aliases

PreTt13067 | 4.m00466 | 3707.m00111

Description

AXE1 3-prime-5-prime exonuclease; Fusion of ankyrin/histone H3 methyl transferase and exosome 3-5 exoribonuclease; 3'-5' exonuclease family protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• intracellular anatomical structure (IEA) | GO:0005622

Molecular Function

• 3'-5' exonuclease activity (IEA) | GO:0008408
• nucleic acid binding (IEA) | GO:0003676

Biological Process

• nucleobase-containing compound metabolic process (IEA) | GO:0006139

Domains

• ( PF00023 ) Ankyrin repeat
• ( PF01612 ) 3'-5' exonuclease
• ( PF07620 ) SLEI
• ( PF08128 ) Double glycine cleavage site bacteriolysin
• ( TIGR00255 ) conserved hypothetical protein TIGR00255

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_01987.1	9.997093137033517e-262
	Description: 3-5 exonuclease (1059 aa)
Oxytricha	Contig6366.0.g39	8.001824328206442e-49
	Description: Ankyrin repeats (3 copies)
DictyBase	DDB_G0271572	7.999528511121947e-28
	Description: exosc10 on chromosome: 2 position 601251 to 605014
WormBase	WBGene00000796	4.0013320766793207e-25
	Description: locus:crn-3 status:Confirmed UniProt:G5EBX6 protein_id:CAA90108.1
SGD	YOR001W	4.0006511639687014e-23
	Description: RRP6 Nuclear exosome exonuclease component; has 3-5 exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay
Stentor Coeruleus	SteCoe_12809	2.8625185805493937e-20
	Description: None

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00058820(coding)
ATGTATAAAACAGAAGTTAATTTGCTTAATAAAATATGCAAAACAGATTATTTTAGTAAA
TTAAATACTAAACTTGACAATCTGGTTGATTATAATATCATTTTTAATGAATACTGCGAT
TTTTTAATGATTGAGAAATACTCCCTACTTTTAAATGAGCCTAGAATAAATTAATTTAAA
TATAATCAATTTTATTATGATGAAGTGAATCTCAGACAGCAGCTATTTTCCTAATTTTAA
CTAAGTCGAATTAACCAAACAATAAAGATTTCTAATATACTTGTTCAACCATATAGTAAC
AAGGGAACTTATCAATTAGTAAAAGACTTAGACTCTGAATTAGAAGCATAGGCTTATTTT
TTAGATAATACAGAATATTCTTTTTTAGATGTGATAGTCTTTTCTTCTTTACAAAAATGT
AGAATATGGCCAAAGCTCTACAAAGATGGGAAGAAGTCAAAAAAGGAATTACCTTAGCTT
ATTGATTGGTATAAAGTATTTATGAATACATACAAACATGAAATTGAATACTAATTTGAT
CCCAATATTGTGACAAGTAAATACTAAAAAAGACTAGAAATATAAAAGAAAGAAAAAAGA
TTAGATAAAAAATTAATTGAAGCTGTTTAAAGTAAATAATATGATTTAATCCGGAGTCTC
ATAGAAGAAGGCTCAGATATAGAAAGCATAGAGTAGTAGATGTACAAAAAACCAGCTCAT
ATAGCATGTGAACTAGGAGATATAGAGCTTTGTAGGTTTATAGACTAGTTTGGGTGTGAT
TGGGAATCATTAGATAATGAAGAATAGACTCCTATATTCTATGCAGTTACGAGTGGAAAT
TTAGAAGTTGTAAAATTTCTCATTGAAGAAAAAAATGTCAATCATTAACATAAAGAATTT
TAAGATAGGACTCCATTTTATTTGGCTTGTTTCTTAGGAAATATGCCTATTATTGAATAT
TTATATGAAAAAGGTGTGAATATTAATGAGCCATCAAAGCTCAAGCGCTGTGCACTAAGC
AAGGCTTGCTATTTAGGGCATGTAGAAGTAGTAAAATTCCTCGTATCGAAGCCTGAAACT
GATATTACTATGTAAGATTCTAAAGGTAGAACGGGGATGCATAATGCAGCATGGGGAATT
GAAGGTGGGAAAGAAGGAAAGAGGAGGGGAACTTTGAAACTCCCAGACTCTCCTTAATCT
ATAGAAATACTTCATGATTATGGTCATCCTATTGATTTTTAAGATTTTGAAGGAAACACT
CCTTTACTTAGTGCAGCATCCAGCGATGCAAGGGAATCCTTAAGAGTACTAATAAATAGA
GGCGCAAATAGAAATATTAGGAATTTTTATGGAGAAACTCCAGTCTTTTTAGCAGCTAAA
TATGGTCATACTGAGATCTTAAAAACCTTAATTAATGAATATAAATGTGATTGGGAAATG
AGAGATATTAGAAACACTACTCCTTGCGAAATAGCTGCTATAAACTAGAAATATGAATGT
TTTGATATACTTTTAAATTTAGAAATTCAAAACAATACAGTTAATGTTGAGAGTTTCATA
AAAAAAATCAATGATGACTACATCACTCATGAAGAATAACTTAAAATATTTGAATTGTAC
AATAGTAAAGTAGATATTAAGAATCGTATTTAAGATATAGAAAGTGTAATCTCTTTTTTG
ACTAATTGTACTAATCCATAATTAATGCTTAGAATTTAAGAAATAATATTAGATAGATTA
AATCCTTCTCACATTAAACAATTTTTCATTAACTTAGCTGATAATGGCAAGTATGATACA
GCATTTTAAATCTTAGAGACATTTGAATTAAAATATAAAGCTTCAGATAATCAAATTTAG
GGAATTCTGTTTGATCCATAAGAAATTTATAATTTTATTATTAAGGGAGTTAGTGCCACT
GATGAAACAATAAGTAAACTTCTATTTAAGGTTAATAGTGATTGGATCAATTACACAGAT
GATTCAACTAAAAATAACTTTTTACATATATTATGTGAATAGAGGAGAATGAAAATAATA
GTAGATTTAATTACCATAATCAAAGAAAAGAGCATTAATCCTGCTTACTCTTTTACATCT
AACATATATTTGCTAAATAATAATTAGTTTTACACATAGGATTTTGTTAGAAAATACTTA
AATGCAGTCAACTCTTAAAACTTAAATTCGTTAGATATATGTTTACTTTCAAAAGCAAAC
GACATTCATTTGATCATAGATAATTTTATTAGGAGCTTTCTTCATGAAGAACCTTCTTAT
CATTATGTTATACCAAGTTATGACTTTGAAATGATTTCCCAAAGAGACACAGATGTAAAA
TAAATTATTACACTTGAAGCCAATATATTTTTGTCTCAAACAATTCACTTATTTATATTT
TATTTTAAAATAAATTAGCATGCTTTAATCGGTGAATTAGAAGAAGAAGCGAAAAAGCTC
TAAGAACAAATCAAATAAAAAAGTGGAGATCTTTAGCATTTGAATTGTTATTCTTTCTTA
GACGACTTAAGTGTAATTGATTAGTAAAAAGTGACAGTTGAGGACAATTCAGAATAAAAC
CAGAACATTGAAAAATTATATCCAAATAGAAAGTTGTATTTTATAAATTAGATTGATTCA
GATGAATCAAGAATTCTTAAGGAAGAAATCGAAAAAAACAGTATTTTTGGTATTGACCTT
GAGTATTACTCTGAAAATAAAGATAAAAATCTAGGATTTGTATGTACTATTCAGATATCT
ACAGTTAATATGGATTTTATGATAGATGCTATGGCATTAAGAAATTAGATAAATTAATTA
CTAAATAAATCTCTCTTTTTAAATAAAACAAAAATTAAAATTTTGCATGGCTGCGAAAAC
GATATCAAGTGGCTTAAAAACGACTTCGATATTGATATAGTTAATCTATTTGATACAATG
TTTGCAGAAATGATTATTAAAAACAAGCAGCAATCTTACTCTCTCAAAAATTTATCTTAA
GACTATCTAGGTGTAGAACTAGATAAATCATATTAAATTTCAGATTGGAGAATTAGACCT
CTTCCAACTCCAATGATGAATTATGCAAGAGTCGATTCTTTTATTCTGTTGAGACTATTC
CCCATCATGAAATAAATGCTAACATCCAAAAATTTGTTAAATCAAATGTTCCTAAAGTGC
CTTCTTTTCATAATTCGTTAAAGCAATTCCAAAAAAACACAACAATTATAATAATGCTAG
TAAAATAATAATAAGTGA

>TTHERM_00058820(gene)
ATGTATAAAACAGAAGTTAATTTGCTTAATAAAATATGCAAAACAGATTATTTTAGTAAA
TTAAATACTAAACTTGACAATCTGGTTGATTATAATATCATTTTTAATGAATACTGCGAT
TTTTTAATGATTGAGAAATACTCCCTACTTTTAAATGAGCCTAGAATAAATTAATTTAAA
TATAATCAATTTTATTATGATGAAGTGAATCTCAGACAGCAGCTATTTTCCTAATTTTAA
CTAAGTCGAATTAACCAAACAATAAAGATTTCTAATATACTTGTTCAACCATATAGTAAC
AAGGGAACTTATCAATTAGTAAAAGACTTAGACTCTGAATTAGAAGCATAGGCTTATTTT
TTAGATAATACAGAATATTCTTTTTTAGATGTGATAGTCTTTTCTTCTTTACAAAAATGT
AGAATATGGTACAATTTATTGATTTAAATGAATTAAATTTAGCAATCCTTTTTACCATAC
AATAAATAACTTTATTATCAAAACAAAATCAGGCCAAAGCTCTACAAAGATGGGAAGAAG
TCAAAAAAGGAATTACCTTAGCTTATTGATTGGTATAAAGTATTTATGAATACATACAAA
CATGAAATTGAATACTAATTTGATCCCAATATTGTGACAAGTAAATACTAAAAAAGACTA
GAAATATAAAAGAAAGAAAAAAGATTAGATAAAAAATTAATTGAAGCTGTTTAAAGTAAA
TAATATGATTTAATCCGGAGTCTCATAGAAGAAGGCTCAGATATAGAAAGCATAGAGTAG
TAGATGTACAAAAAACCAGCTCATATAGCATGTGAACTAGGAGATATAGAGCTTTGTAGG
TTTATAGACTAGTTTGGGTGTGATTGGGAATCATTAGATAATGAAGAATAGACTCCTATA
TTCTATGCAGTTACGAGTGGAAATTTAGAAGTTGTAAAATTTCTCATTGAAGAAAAAAAT
GTCAATCATTAACATAAAGAATTTTAAGATAGGACTCCATTTTATTTGGCTTGTTTCTTA
GGAAATATGCCTATTATTGAATATTTATATGAAAAAGGTGTGAATATTAATGAGCCATCA
AAGCTCAAGCGCTGTGCACTAAGCAAGGCTTGCTATTTAGGGCATGTAGAAGTAGTAAAA
TTCCTCGTATCGAAGCCTGAAACTGATATTACTATGTAAGATTCTAAAGGTAGAACGGGG
ATGCATAATGCAGCATGGGGAATTGAAGGTGGGAAAGAAGGAAAGAGGAGGGGAACTTTG
AAACTCCCAGACTCTCCTTAATCTATAGAAATACTTCATGATTATGGTAAACTTATGGTA
TTATGTAAGACTTTTTAAAAAAAAAGAATTATTTTTATTAAAAAAAGGTCATCCTATTGA
TTTTTAAGATTTTGAAGGAAACACTCCTTTACTTAGTGCAGCATCCAGCGATGCAAGGGA
ATCCTTAAGAGTACTAATAAATAGAGGCGCAAATAGAAATATTAGGAATTTTTATGGAGA
AACTCCAGTCTTTTTAGCAGCTAAATATGGTCATACTGAGATCTTAAAAACCTTAATTAA
TGAATATAAATGTGATTGGGAAATGAGAGATATTAGAAACACTACTCCTTGCGAAATAGC
TGCTATAAACTAGAAATATGAATGTTTTGATATACTTTTAAATTTAGAAATTCAAAACAA
TACAGTTAATGTTGAGAGTTTCATAAAAAAAATCAATGATGACTACATCACTCATGAAGA
ATAACTTAAAATATTTGAATTGTACAATAGTAAAGTAGATATTAAGAATCGTATTTAAGA
TATAGAAAGTGTAATCTCTTTTTTGACTAATTGTACTAATCCATAATTAATGCTTAGAAT
TTAAGAAATAATATTAGATAGATTAAATCCTTCTCACATTAAACAATTTTTCATTAACTT
AGCTGATAATGGCAAGTATGATACAGCATTTTAAATCTTAGAGACATTTGAATTAAAATA
TAAAGCTTCAGATAATCAAATTTAGGGAATTCTGTTTGATCCATAAGAAATTTATAATTT
TATTATTAAGGGAGTTAGTGCCACTGATGAAACAATAAGTAAACTTCTATTTAAGGTTAA
TAGTGATTGGATCAATTACACAGATGATTCAACTAAAAATAACTTTTTACATATATTATG
TGAATAGAGGAGAATGAAAATAATAGTAGATTTAATTACCATAATCAAAGAAAAGAGCAT
TAATCCTGCTTACTCTTTTACATCTAACATATATTTGCTAAATAATAATTAGTTTTACAC
ATAGGATTTTGTTAGAAAATACTTAAATGCAGTCAACTCTTAAAACTTAAATTCGTTAGA
TATATGTTTACTTTCAAAAGCAAACGACATTCATTTGATCATAGATAATTTTATTAGGAG
CTTTCTTCATGAAGAACCTTCTTATCATTATGTTATACCAAGTTATGACTTTGAAATGAT
TTCCCAAAGAGACACAGATGTAAAATAAATTATTACACTTGAAGCCAATATATTTTTGTC
TCAAACAATTCACTTATTTATATTTTATTTTAAAATAAATTAGCATGCTTTAATCGGTGA
ATTAGAAGAAGAAGCGAAAAAGCTCTAAGAACAAATCAAATAAAAAAGTGGAGATCTTTA
GCATTTGAATTGTTATTCTTTCTTAGACGACTTAAGTGTAATTGATTAGTAAAAAGTGAC
AGTTGAGGACAATTCAGAATAAAACCAGAACATTGAAAAATTATATCCAAATAGAAAGTT
GTATTTTATAAATTAGATTGATTCAGATGAATCAAGAATTCTTAAGGAAGAAATCGAAAA
AAACAGTATTTTTGGTATTGACCTTGAGTATTACTCTGAAAATAAAGATAAAAATCTAGG
ATTTGTATGTACTATTCAGATATCTACAGTTAATATGGATTTTATGATAGATGCTATGGC
ATTAAGAAATTAGATAAATTAATTACTAAATAAATCTCTCTTTTTAAATAAAACAAAAAT
TAAAATTTTGCATGGCTGCGAAAACGATATCAAGTGGCTTAAAAACGACTTCGATATTGA
TATAGTTAATCTATTTGATACAATGTTTGCAGAAATGATTATTAAAAACAAGCAGCAATC
TTACTCTCTCAAAAATTTATCTTAAGACTATCTAGGTGTAGAACTAGATAAATCATATTA
AATTTCAGATTGGAGAATTAGACCTCTTCCAACTCCAATGATGAATTATGCAAGAGTCGA
TTCTTTTATTCTGTTGAGACTATTCCCCATCATGAAATAAATGCTAACATCCAAAAATTT
GTTAAATCAAATGTTCCTAAAGTGCCTTCTTTTCATAATTCGTTAAAGCAATTCCAAAAA
AACACAACAATTATAATAATGCTAGTAAAATAATAATAAGTGA

>TTHERM_00058820(protein)
MYKTEVNLLNKICKTDYFSKLNTKLDNLVDYNIIFNEYCDFLMIEKYSLLLNEPRINQFK
YNQFYYDEVNLRQQLFSQFQLSRINQTIKISNILVQPYSNKGTYQLVKDLDSELEAQAYF
LDNTEYSFLDVIVFSSLQKCRIWPKLYKDGKKSKKELPQLIDWYKVFMNTYKHEIEYQFD
PNIVTSKYQKRLEIQKKEKRLDKKLIEAVQSKQYDLIRSLIEEGSDIESIEQQMYKKPAH
IACELGDIELCRFIDQFGCDWESLDNEEQTPIFYAVTSGNLEVVKFLIEEKNVNHQHKEF
QDRTPFYLACFLGNMPIIEYLYEKGVNINEPSKLKRCALSKACYLGHVEVVKFLVSKPET
DITMQDSKGRTGMHNAAWGIEGGKEGKRRGTLKLPDSPQSIEILHDYGHPIDFQDFEGNT
PLLSAASSDARESLRVLINRGANRNIRNFYGETPVFLAAKYGHTEILKTLINEYKCDWEM
RDIRNTTPCEIAAINQKYECFDILLNLEIQNNTVNVESFIKKINDDYITHEEQLKIFELY
NSKVDIKNRIQDIESVISFLTNCTNPQLMLRIQEIILDRLNPSHIKQFFINLADNGKYDT
AFQILETFELKYKASDNQIQGILFDPQEIYNFIIKGVSATDETISKLLFKVNSDWINYTD
DSTKNNFLHILCEQRRMKIIVDLITIIKEKSINPAYSFTSNIYLLNNNQFYTQDFVRKYL
NAVNSQNLNSLDICLLSKANDIHLIIDNFIRSFLHEEPSYHYVIPSYDFEMISQRDTDVK
QIITLEANIFLSQTIHLFIFYFKINQHALIGELEEEAKKLQEQIKQKSGDLQHLNCYSFL
DDLSVIDQQKVTVEDNSEQNQNIEKLYPNRKLYFINQIDSDESRILKEEIEKNSIFGIDL
EYYSENKDKNLGFVCTIQISTVNMDFMIDAMALRNQINQLLNKSLFLNKTKIKILHGCEN
DIKWLKNDFDIDIVNLFDTMFAEMIIKNKQQSYSLKNLSQDYLGVELDKSYQISDWRIRP
LPTPMMNYARVDSFILLRLFPIMKQMLTSKNLLNQMFLKCLLFIIRQSNSKKTQQLQQCQ
QNNNK