Identifiers and Description

Gene Model Identifier

TTHERM_00219420

Standard Name

Cac2 (CAF1 subunit Cac2)

Aliases

PreTt22370 | 18.m00396 | 3701.m00155

Description

Chromatin assembly factor 1 subunit Cac2 (FAS2). Homolog of human Chaf1b. Cac2 contains WD40 repeats and a highly conserved Asf1-interacting B-domain-like motif. Localizes predominantly to MIC and also to MAC during vegetative growth, similar to Asf1 localization (Nabeel-Shah et al., 2023).

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

  • ( PF00400 ) WD domain, G-beta repeat

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
Tetrahymena borealis EI9_06719.1 9.997093137033517e-262
Description: hypothetical protein (547 aa)
Oxytricha Contig22253.0.g49 2.0002571866765887e-62
Description: WD domain, G-beta repeat
SGD YML102W 1.999002769139511e-37
Description: CAC2 Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humans
DictyBase DDB_G0269800 1.0002869940498747e-21
Description: DDB_G0269800 on chromosome: 1 position 3628624 to 3631009
WormBase WBGene00019627 7.002638123733849e-21
Description: Protein HIRA homolog status:Partially_confirmed UniProt:Q09589 protein_id:CCD72856.1
Stentor Coeruleus SteCoe_30636 6.305116760146989e-16
Description: None

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:37024975: Nabeel-Shah S, Garg J, Ashraf K, Jeyapala R, Lee H, Petrova A, Burns JD, Pu S, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J (2023) Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation. Epigenetics & chromatin 16:10
  2. Ref:34086947: Nabeel-Shah S, Garg J, Saettone A, Ashraf K, Lee H, Wahab S, Ahmed N, Fine J, Derynck J, Pu S, Ponce M, Marcon E, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J (2021) Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila. Nucleic acids research ( ):

Sequences 

>TTHERM_00219420(coding)
ATGAAGTTAGAAAGACCTTTTATAGTATGGCATGGACAATATCAAAGAATTGTCACCTTA
GATGTTCATCCTTTTATAAATTTATTAGTAACAGGAGGTTCCGATGAAGAAGTTTATGAA
GGAGAAGATTTAGAATTTGAAGAAGAAATAGGTTATATCAAGTTGTGGTAGATTAACGAA
AACTACACACCAGGCTAAGGTGGAGATGCAAAACCAGTAACTTTTATAAGAGCTTTAAAA
AAACATTCAAATCCTGTAAATTGTGTTAGATTTTCACCTAATGGTTAGTATTTGGCATCA
GCTTCAGATGATCATAAAATTGTCATTTGGCATGTTGATAAGGGGTTTTAGAATATAAGC
ACTAATTAGAAAATATTCAATTTAGTTCCTAAAAATATATTAGAAGGACACAATCGCGAA
GTTTGTGATCTTAGATGGTTTAATGATAGTACTCATTTAATTTCAGGTGGAATGGATTAT
AGAGCATATATATGGAATGTTAAAGAAGGCGTGATTAAGCAAACTATAGTTGGAGCACAT
AAAAGTTATGTATAAGGAGTAGCTGTAGACCCAAAAATGAAATTTTGTCTTACTTTGGGT
AATGATAGAACTGTCAAAGTATGGAGAAAGCTAAAAAGCAATAATAAAAAGAAAAATATT
TTTGAATACATTCCATCAAATACAATGAAGAGATTACCTTTTGCAGATGTTAATATTGAA
GAAGAAATGCTTTCTGATGATGAAGATAAATCAAGTATTACAGGAAATTAAATGAATGGA
GCTAATGGAGCTGTTAATTAAGCTATGACTTATGGTATGTTTTTGTCAGAAAGATAACTT
AATACATTTGTAAAAAGACCTGATTGGAGTCCAGACGGTTCCTTCTTCTTACTTCCTGCT
GCTATTTATTAAGAGAAGAGAGACTCGAAAATAGAAATGTGCGTTTATTTATATCGTAGA
AATGTGTTAAATAAGCCATCACTCATAATAAATACAAATAATAAACCTGCTATTTGCACT
AGATTCTGTTAAAAATTATTTAAAAAGAAAGAGGAAAATTAATTTAGTATGGTTGATATA
CCATACGTAATAATTTTTGCTATTAGCACAATTGATAATGTTATGATATATTCCACAGCT
TCTCTTTCTCCTCTTGCTGTTGTAGGAAATATTCACTTTGCTCTTATTAATGATTTAACC
TTCTTCTCTAATTAATCTTTAATTATTTGTTCTTCTGACGGTATGTGCTCTTTTGTATTT
TTTGAAGAAAATGACCTTGGAAAACCATTAAATTCAGAAGAAATTTAAGATGAAGAAATT
AGAAATATTGTAAATGTTGAAAGCTTTTATCCAAATGAGCTTCTCAGAGCATTAGTGTAT
CCCAGTTAAACAAAGCAAATACTAAAAGAATACAATGAAAATATTAAATAATAATAAAAA
TAACAATAGTAAATAACAGATATAAATAGTTAAAAAGAAGAAAAAAATAAAGAATATGTT
GTAGAAAAATTTAATTTTGCTTGCATGGAGGAAGAGGAGTAAATTATTCCAATAAAACCT
CAAGAAATATAGTTTAAAACAACTTCTACAGGAGAGAAGAAAAAAGTAATTATTCCTGCA
GTTATTAAGAAATACTGA


>TTHERM_00219420(gene)
ATGAAGTTAGAAAGACCTTTTATAGTATGGCATGGACAATATCAAAGAATTGTCACCTTA
GATGTTCATCCTTTTATAAATTTATTAGTAACAGGAGGTTCCGATGAAGAAGTTTATGAA
GGAGAAGATTTAGAATTTGAAGAAGAAATAGGTTATATCAAGGTAATAAACTATTAAGAT
TATATTTGAAAATATGTCATTGAATTTATTTATTAAACCATTTTTTGCAAATAATATGCT
AAGCTTTTTATAAGGAGTTTTTAATAGATTAAATTTTATTTTTAAGCAATACTTTCCTTT
TTACTAGGGCAAAAATGATAAATTTTAAAGTGTTGATTAAATTATTTTTATAATATGATA
ACTATAGTTGTGGTAGATTAACGAAAACTACACACCAGGCTAAGGTGGAGATGCAAAACC
AGTAACTTTTATAAGAGCTTTAAAAAAACATTCAAATCCTGTAAATTGTGTTAGATTTTC
ACCTAATGGTTAGTATTTGGCATCAGCTTCAGATGGTAGAATAAATTATTTTAATTATCT
AAATTCTAAAAATATGTATGTCTATCTTTAACTTATTTAATAGATCATAAAATTGTCATT
TGGCATGTTGATAAGGGGTTTTAGAATATAAGCACTAATTAGAAAATATTCAATTTAGTT
CCTAAAAATATATTAGAAGGACACAATCGCGAAGTTTGTGATCTTAGATGGTTTAATGAT
AGTACTCATTTAATTTCAGGTGGAATGGATTATAGAGCATATATATGGAATGTTAAAGAA
GGCGTGATTAAGCAAACTATAGTTGGAGCACATAAAAGTTATGTATAAGGAGTAGCTGTA
GACCCAAAAATGAAATTTTGTCTTACTTTGGGTAATGATAGAACTGTCAAAGTATGGAGA
AAGCTAAAAAGCAATAATAAAAAGAAAAATATTTTTGAATACATTCCATCAAATGTAAAT
TTTTTATGAGAAATTTTTTTATCAGCATAATATTTTTTTTCTTTTAAATAAAGACAATGA
AGAGATTACCTTTTGCAGATGTTAATATTGAAGAAGAAATGCTTTCTGATGATGAAGATA
AATCAAGTATTACAGGAAATTAAATGAATGGAGCTAATGGAGCTGTTAATTAAGCTATGA
CTTATGGTATGTTTTTGTCAGAAAGATAACTTAATACATTTGTAAAAAGACCTGATTGGA
GTCCAGACGGTTCCTTCTTCTTACTTCCTGCTGCTATTTATTAAGAGAAGAGAGACTCGA
AAATAGAAATGTGCGTTTATTTATATCGTAGAAATGTGTTAAATAAGCCATCACTCATAA
TAAATACAAATAATAAACCTGCTATTTGCACTAGATTCTGTTAAAAATTATTTAAAAAGA
AAGAGGAAAATTAATTTAGTATGGTTGATATACCATACGTAATAATTTTTGCTATTAGCA
CAATTGATAATGTTATGATATATTCCACAGCTTCTCTTTCTCCTCTTGCTGTTGTAGGAA
ATATTCACTTTGCTCTTATTAATGATTTAACCTTCTTCTCTAATTAATCTTTAATTATTT
GTTCTTCTGACGGTATGTGCTCTTTTGTATTTTTTGAAGAAAATGACCTTGGAAAACCAT
TAAATTCAGAAGGTATGACATTATATTCATTAATTTTATTTAATTTCCTTTCCAAATTTT
TACAAATATTTAAAAAATTTATACTAGAAATTTAAGATGAAGAAATTAGAAATATTGTAA
ATGTTGAAAGCTTTTATCCAAATGAGCTTCTCAGAGCATTAGTGTATCCCAGTTAAACAA
AGCAAATACTAAAAGAATACAATGAAAATATTAAATAATAATAAAAATAACAATAGTAAA
TAACAGATATAAATAGTTAAAAAGAAGAAAAAAATAAAGAATATGTTGTAGAAAAATTTA
ATTTTGCTTGCATGGAGGAAGAGGAGTAAATTATTCCAATAAAACCTCAAGAAATATAGT
TTAAAACAACTTCTACAGGAGAGAAGAAAAAAGTAATTATTCCTGCAGTTATTAAGAAAT
ACTGA


>TTHERM_00219420(protein)
MKLERPFIVWHGQYQRIVTLDVHPFINLLVTGGSDEEVYEGEDLEFEEEIGYIKLWQINE
NYTPGQGGDAKPVTFIRALKKHSNPVNCVRFSPNGQYLASASDDHKIVIWHVDKGFQNIS
TNQKIFNLVPKNILEGHNREVCDLRWFNDSTHLISGGMDYRAYIWNVKEGVIKQTIVGAH
KSYVQGVAVDPKMKFCLTLGNDRTVKVWRKLKSNNKKKNIFEYIPSNTMKRLPFADVNIE
EEMLSDDEDKSSITGNQMNGANGAVNQAMTYGMFLSERQLNTFVKRPDWSPDGSFFLLPA
AIYQEKRDSKIEMCVYLYRRNVLNKPSLIINTNNKPAICTRFCQKLFKKKEENQFSMVDI
PYVIIFAISTIDNVMIYSTASLSPLAVVGNIHFALINDLTFFSNQSLIICSSDGMCSFVF
FEENDLGKPLNSEEIQDEEIRNIVNVESFYPNELLRALVYPSQTKQILKEYNENIKQQQK
QQQQITDINSQKEEKNKEYVVEKFNFACMEEEEQIIPIKPQEIQFKTTSTGEKKKVIIPA
VIKKY