Identifiers and Description

Gene Model Identifier

TTHERM_00257190

Standard Name

KOT1 (Fusion of a ser/thr kinase and an O-linked N-acetylglucosamine transferase)

Aliases

PreTt25405 | 22.m00350

Description

KOT1 tetratricopeptide repeat protein; Fusion of a ser/thr kinase and an O-linked N-acetylglucosamine transferase. TPR Domain containing protein. Sequence similarity to a protein kinase family unique to Tetrahymena thermophila (Eisen et al.- 2006).

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• protein kinase activity (IEA) | GO:0004672
• protein tyrosine kinase activity (IEA) | GO:0004713

Biological Process

• protein phosphorylation (IEA) | GO:0006468

Domains

• ( PF00069 ) protein kinase domain
• ( PF00515 ) tetratricopeptide repeat
• ( PF01239 ) Protein prenyltransferase alpha subunit repeat
• ( PF07714 ) protein tyrosine kinase
• ( PF07719 ) tetratricopeptide repeat
• ( PF07720 ) Tetratricopeptide repeat
• ( PF08238 ) Sel1 repeat
• ( TIGR02521 ) type IV pilus biogenesis/stability protein
• ( TIGR02552 ) type III secretion low calcium
• ( TIGR02795 ) tol-pal system protein YbgF
• ( TIGR02917 ) putative PEP-CTERM system TPR-repeat lipoprotein
• ( TIGR03302 ) outer membrane assembly lipoprotein YfiO

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_10200.1	3.000551941601253e-121
	Description: hypothetical protein (546 aa)
SGD	YFR014C	4.0006511639687014e-23
	Description: CMK1 Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II
Oxytricha	Contig16009.0.g32	3.0007793728221555e-22
	Description: Protein kinase domain
DictyBase	DDB_G0275241	1.9991095569230066e-20
	Description: nek3 on chromosome: 2 position 4983790 to 4987279
WormBase	WBGene00000406	2.99851380290819e-19
	Description: locus:cdk-4 status:Confirmed UniProt:G5EFI3 protein_id:CAA90447.1

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16933976: Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA,

Sequences

>TTHERM_00257190(coding)
ATGGAGAATTCTAATGTTTCTAAAAAATTAGAAAGGATCATTCAACTTTTAAAAGACAAA
CAGCATCTAACAGTGGTTAATCCTAATGCTGGCTCAGGAGCATATGGACAGGTTATGACA
GCAAAAGAGGAGAATGGTGAGGAGGTTGCTATAAAGATAGTTTCTGTTTTTGATGAAATT
GACTCCATAGACGAATAAAAGCTTAAGGAAATCAAATCTGAAGCTTAGTTTTTATAGATG
TGTCACCATCCCAACATAGTATCTTATAAAGGGGAATTCCAGCTTGGGAGTTGCTACTTT
ATAAAAATGGAGAAAGGCGAAATGTCTTTGTAAGAATTTGTTGATAAAAAACTCAATTAG
GGAATGTCGGAGAAGCTTTTCGTGAAATTAGCGCTGTAAATGCTTTCTGCAATTTAGTAT
TTACATTCAAAGAATTATGTTCTAAGAGATATATCTTTAAAGAACGTGCTTTTAGACAAG
GATTATAACATTAAGCTTTGTGATTTTGGTTTAGCTAAGGAAATAAATCCTTAGTTGGCA
ACGCAGGCCTTTCTATAATCTCAGGTTAAGGGAGTGCTCTTTTACTTCCCTCCGGAGGTT
TTGGTCATGACTAACTTTAACAGTGAAGAAAAGAAATCGTAAAAAATATACTAAAACTTT
GATGGTGATGTATGGGCGTTTGGAGTATGCATGTATTTGTTAGGAGGAGCTTCATTCCTT
CACGTTTTGTAGCTAACTTAAGGTAAAGAAACTTTTTAGCTCTCTAAGCTGGTGAGCATC
GAAATAAATTAAATACTGCTTAACACGCTTCAGCTAGATCCAAAACTTAGACCATCAATT
GATAAGATAATTTAAGATTTTAAAAATATATAACTCAATTTAGAGAAAGGGAAAGACGAT
GAAATCGGATATTACTTTAATTAGACTGAACTATTTTAGTAGGCTCAAAAGGAAATAGAT
AATCATAAATATTAGGAAGCTTAAGTTACTCTGGAAAGACTTGTAAAGATAAACACACAT
AATGATTAGTACTTAGCATTACTTGGATTAACACACTTGGAACAGTACTAATGTGAAGAG
TCTAGAAGTATAAGCTAGAAATGCTTGTCAATAAACCCAAAAAATGAGATAGCTTTAAGC
TGTATGGGATACTATTATTATGAAAAAAACGATTTAAAGTAAGCGATGTGTTATTTGCAA
AAGTGCTTGAATTTAAACCCAAAAAATTATAGAGCCTTAACTTATAAAGCATTCGTATTA
AGTAATTAATAAAAATTAGATGAAGAGCTATTAACACTTAAAGAAGCAATCAGCTACAAC
CAGAATTATCCTTATTCAATACTGCAAATTGGCAAATGCTATTTCAAGAAAAAAATGTAC
GAAGATGCCATTACCTCTTTTAAGTAAGTAATAAAGTTGCTACCCACAATATTTTCTCCT
TACTATTGTTTAGGAATTATTTATTATGAGAGAAGTGAATTTGATTAGTCTATTTCATAC
TTTAACAAAGCTTTGGAATTGAATTCTTCAAATTAAAATTGCTTGTACAGTTTGGCGAAA
GTCTATTTAGAAACATTCAATTATTCAAACGCAATTGAAATTTTAAATACGTTAGTACGT
CTTTTTCCCAGTAACGATTTGTATTTGGCTACGTTAGCACTAGCTTATTCTGAAATTAAG
GATGAATAGAAAGTGATGGAATTCAGTCAGAAAAGTTTGTAAATAAATCCACAAAATATT
TTAGCTCTTAATTGTTTGGCTTATTACTACTTCTTAAAGTAATAAAATTAATTAGCTATA
TAGTGTTTGCAAAGTTCAATTAAAGTTAACCCTTGCAATTTTAGAGCATACTTCTACTAA
GCATAAATTTTATTGTCCGAAGGCAAACATGAAGATGCTATACTTAGTGCTAAATATTCT
ATGCAACAGAACAGTAAATTCCCTAATGCTTAATTCCTCTTAGGACAAGTGTTTGAGTAA
ATAGGAAAAATGGACAAAGCCATCAAATACTTCCAAGAAGCAATCATGATTTAGGCTAAA
TATGAATTGCCATACATAGATTTATCTTAAATATATCGCAAAAAGGGTTAATACGATGAT
GCCCTTTTCATATGCAAATTAGCTTTACAAAATAATATAAAAAGTGCTAAAATATATAAC
GAGCTAGGAAAAATTTATGAAAAAAAACAATATTTATCTTAAGCAATAAATTATTTCTCA
GAATGTATTTCACTAAAACCTTCTGAACAAATTTATTAAAACAATTTAAAAAACTGTAAA
GAATTATTAAGCAAAAGTAACTCTAAAATAAAAATTTGA

>TTHERM_00257190(gene)
ATGGAGAATTCTAATGTTTCTAAAAAATTAGAAAGGATCATTCAACTTTTAAAAGACAAA
CAGCATCTAACAGTGGTTAATCCTAATGCTGGCTCAGGAGCATATGGACAGGTTATGACA
GCAAAAGAGGAGAATGGTGAGGAGGTTGCTATAAAGATAGTTTCTGTTTTTGATGAAATT
GACTCCATAGACGAATAAAAGCTTAAGGAAATCAAATCTGAAGCTTAGTTTTTATAGATG
TGTCACCATCCCAACATAGTATCTTATAAAGGGGAATTCCAGCTTGGGAGTTGCTACTTT
ATAAAAATGGAGAAAGGCGAAATGTCTTTGTAAGAATTTGTTGATAAAAAACTCAATTAG
GGAATGTCGGAGAAGCTTTTCGTGAAATTAGCGCTGTAAATGCTTTCTGCAATTTAGTAT
TTACATTCAAAGAATTATGTTCTAAGAGATATATCTTTAAAGAACGTGCTTTTAGACAAG
GATTATAACATTAAGCTTTGTGATTTTGGTTTAGCTAAGGAAATAAATCCTTAGTTGGCA
ACGCAGGCCTTTCTATAATCTCAGGTTAAGGGAGTGCTCTTTTACTTCCCTCCGGAGGTT
TTGGTCATGACTAACTTTAACAGTGAAGAAAAGAAATCGTAAAAAATATACTAAAACTTT
GATGGTGATGTATGGGCGTTTGGAGTATGCATGTATTTGTTAGGAGGAGCTTCATTCCTT
CACGTTTTGTAGCTAACTTAAGGTAAAGAAACTTTTTAGCTCTCTAAGCTGGTGAGCATC
GAAATAAATTAAATACTGCTTAACACGCTTCAGCTAGATCCAAAACTTAGACCATCAATT
GATAAGATAATTTAAGATTTTAAAAATATATAACTCAATTTAGAGAAAGGGAAAGACGAT
GAAATCGGATATTACTTTAATTAGACTGAACTATTTTAGTAGGCTCAAAAGGAAATAGAT
AATCATAAATATTAGGAAGCTTAAGTTACTCTGGAAAGACTTGTAAAGATAAACACACAT
AATGATTAGTACTTAGCATTACTTGGATTAACACACTTGGAACAGTACTAATGTGAAGAG
TCTAGAAGTATAAGCTAGAAATGCTTGTCAATAAACCCAAAAAATGAGATAGCTTTAAGC
TGTATGGGATACTATTATTATGAAAAAAACGATTTAAAGTAAGCGATGTGTTATTTGCAA
AAGTGCTTGAATTTAAACCCAAAAAATTATAGAGCCTTAACTTATAAAGCATTCGTATTA
AGTAATTAATAAAAATTAGATGAAGAGCTATTAACACTTAAAGAAGCAATCAGCTACAAC
CAGAATTATCCTTATTCAATACTGCAAATTGGCAAATGCTATTTCAAGAAAAAAATGTAC
GAAGATGCCATTACCTCTTTTAAGTAAGTAATAAAGTTGCTACCCACAATATTTTCTCCT
TACTATTGTTTAGGAATTATTTATTATGAGAGAAGTGAATTTGATTAGTCTATTTCATAC
TTTAACAAAGCTTTGGAATTGAATTCTTCAAATTAAAATTGCTTGTACAGTTTGGCGAAA
GTCTATTTAGAAACATTCAATTATTCAAACGCAATTGAAATTTTAAATACGTTAGTACGT
CTTTTTCCCAGTAACGATTTGTATTTGGCTACGTTAGCACTAGCTTATTCTGAAATTAAG
GATGAATAGAAAGTGATGGAATTCAGTCAGAAAAGTTTGTAAATAAATCCACAAAATATT
TTAGCTCTTAATTGTTTGGCTTATTACTACTTCTTAAAGTAATAAAATTAATTAGCTATA
TAGTGTTTGCAAAGTTCAATTAAAGTTAACCCTTGCAATTTTAGAGCATACTTCTACTAA
GCATAAATTTTATTGTCCGAAGGCAAACATGAAGATGCTATACTTAGTGCTAAATATTCT
ATGCAACAGAACAGTAAATTCCCTAATGCTTAATTCCTCTTAGGACAAGTGTTTGAGTAA
ATAGGAAAAATGGACAAAGCCATCAAATACTTCCAAGAAGCAATCATGATTTAGGCTAAA
TATGAATTGCCATACATAGATTTATCTTAAATATATCGCAAAAAGGGTTAATACGATGAT
GCCCTTTTCATATGCAAATTAGCTTTACAAAATAATATAAAAAGTGCTAAAATATATAAC
GAGCTAGGAAAAATTTATGAAAAAAAACAATATTTATCTTAAGCAATAAATTATTTCTCA
GAATGTATTTCACTAAAACCTTCTGAACAAATTTATTAAAACAATTTAAAAAACTGTAAA
GAATTATTAAGCAAAAGTAACTCTAAAATAAAAATTTGA

>TTHERM_00257190(protein)
MENSNVSKKLERIIQLLKDKQHLTVVNPNAGSGAYGQVMTAKEENGEEVAIKIVSVFDEI
DSIDEQKLKEIKSEAQFLQMCHHPNIVSYKGEFQLGSCYFIKMEKGEMSLQEFVDKKLNQ
GMSEKLFVKLALQMLSAIQYLHSKNYVLRDISLKNVLLDKDYNIKLCDFGLAKEINPQLA
TQAFLQSQVKGVLFYFPPEVLVMTNFNSEEKKSQKIYQNFDGDVWAFGVCMYLLGGASFL
HVLQLTQGKETFQLSKLVSIEINQILLNTLQLDPKLRPSIDKIIQDFKNIQLNLEKGKDD
EIGYYFNQTELFQQAQKEIDNHKYQEAQVTLERLVKINTHNDQYLALLGLTHLEQYQCEE
SRSISQKCLSINPKNEIALSCMGYYYYEKNDLKQAMCYLQKCLNLNPKNYRALTYKAFVL
SNQQKLDEELLTLKEAISYNQNYPYSILQIGKCYFKKKMYEDAITSFKQVIKLLPTIFSP
YYCLGIIYYERSEFDQSISYFNKALELNSSNQNCLYSLAKVYLETFNYSNAIEILNTLVR
LFPSNDLYLATLALAYSEIKDEQKVMEFSQKSLQINPQNILALNCLAYYYFLKQQNQLAI
QCLQSSIKVNPCNFRAYFYQAQILLSEGKHEDAILSAKYSMQQNSKFPNAQFLLGQVFEQ
IGKMDKAIKYFQEAIMIQAKYELPYIDLSQIYRKKGQYDDALFICKLALQNNIKSAKIYN
ELGKIYEKKQYLSQAINYFSECISLKPSEQIYQNNLKNCKELLSKSNSKIKI