Identifiers and Description

Gene Model Identifier

TTHERM_00294760

Standard Name

DNF1  (Drs2 Neo1 Family )

Aliases

PreTt15586 | 27.m00246 | 3692.m00049

Description

phospholipid-translocating P-type ATPase flippase family protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• integral component of membrane (IEA) | GO:0016021
• membrane (IEA) | GO:0016020

Molecular Function

• ATP binding (IEA) | GO:0005524
• ATP hydrolysis activity (IEA) | GO:0016887
• P-type ion transporter activity (IEA) | GO:0015662

Biological Process

• monoatomic cation transport (IEA) | GO:0006812

Domains

• ( PF00122 ) E1-E2 ATPase
• ( PF00702 ) haloacid dehalogenase-like hydrolase
• ( PF08282 ) haloacid dehalogenase-like hydrolase
• ( TIGR00012 ) ribosomal protein L29
• ( TIGR00099 ) Cof-like hydrolase
• ( TIGR01116 ) calcium-translocating P-type ATPase, SERCA-type
• ( TIGR01484 ) HAD-superfamily hydrolase, subfamily IIB
• ( TIGR01494 ) ATPase, P-type (transporting), HAD superfamily,
• ( TIGR01517 ) calcium-translocating P-type ATPase, PMCA-type
• ( TIGR01647 ) plasma-membrane proton-efflux P-type ATPase
• ( TIGR01652 ) phospholipid-translocating P-type ATPase, flippase

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_25323	0
	Description: None
WormBase	WBGene00019166	9.997093137033517e-262
	Description: locus:tat-2 status:Partially_confirmed UniProt:U4PRL1 protein_id:CDH93216.1
Tetrahymena borealis	EI9_08733.1	9.997093137033517e-262
	Description: phospholipid-translocating P-type ATPase, flippase (1229 aa)
DictyBase	DDB_G0269380	9.997093137033517e-262
	Description: DDB_G0269380 on chromosome: 1 position 2645714 to 2650717
Oxytricha	Contig10125.0.g35	9.997093137033517e-262
	Description: haloacid dehalogenase-like hydrolase
SGD	YAL026C	9.997093137033517e-262
	Description: DRS2 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease

General Information

No.	Gene Name(s)	Paragraph Text
19	FLP10, FLP19, FLP18, FLP17, FLP8, FLP16, FLP15, FLP14, FLP6, FLP13, FLP11, FLP2, FLP1, DNF1 , FLP9, FLP12, FLP4, FLP7, FLP5	The phospholipid flippase family of genes in Tetrahymena contains 20 members, FLP1-FLP20. Preliminary studies show that many of these genes are differentially regulated in response to temperature and/or the presence of a polycyclic aromatic hydrocarbon (pyrene).

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00294760(coding)
ATGCCTAGAAAAAGATGGTAAGACATGCCTGATAGGACTATTGTTAGTAATTGTCCTGAG
CATGTTAAATTTTGTAATAATAGTATCTCAACCACAAAGTACACTCTCTTCACTTTTATT
CCCATGAATCTAGTTGAGTAATTTAGTAAGTTAGCAAATGTCTACTTTTTATTTATTGGA
ATGATGCAAATGATAAATGAAATATCTATTTCGAATGGTTAGCCGGTTATATATGTTCCG
CTTTTTGTTGTTTTGATGATATCTGGAATTAAAGATCTATTTGAAGATATGAAAAGGAAC
AAGTCAGATTAAGAAGAGAATCAAAGATTGGTATGGACTTATAGAAATGGCATGTGGATA
AGAGTATATTGGTAGAGTTTATTAGTAGGAGAAATAGTAAAAGTAGAAAAAAACTAACTC
TTTCCTGCAGATATTTTATGTATGTATACAACTGATTCTAAGGGCCTTTGCTATGTAGAA
ACTAAAAACCTAGATGGCGAAACCAATTTGAAGCGCAAAATATCGAATAAATCTTTATAG
CAATTAGGAGAAGCTGCTATTCTACATTAAAAATTTACTTTTAATTGTGAAAAACCAAAC
CCCTACTTATATAAATTTTAAGGAAACATGGAAATAACAGATGGTTACGATTAATAGTAG
AAAATATCCCTAGATTACAACAATTTTATACTTAGAGGATGCTCTCTGAAAAATACAGAC
TATGTAATTGGCTTGGTTTCTTATACTGGAAGAGATTCTAAAATAATGATGAATACAGTA
AACGCAAGATCAAAGAGATCTCATATAGAAAAAAAAATGAATGTTTTTATTAGTTTGGTC
TTCTTGCTTTAAATAGTAGTATGCTTGTCATTTGCATTAGGTGCTGCAATTTGGTTTAAT
TAAAATAAATCAAGCCTCATTTTTATGCTTGGAGTCAGTAGTACAGCAGAAATAGACAAC
AGTTTTGGTTATTTATTAGTTGTGCAGTGGGGTGCTTGGATTCTTATATTTACTAACTTT
GTTCCTATCAGCTTAATTGTAACCTTGGAAATGGTGAAATTTATGTAAGGAATCAGAATT
ACATAAGATCCAAATACATATTCAAAAACTTATGATATTCAGTGCACTGTGTAATGCAGT
GGATTGAATGAAGAATTAGGATAAGTAGAGTATGTTTTTTCTGATAAAACTGGAACATTA
ACAAGCAACACGATGAAATATAAATGCTTAACAGTGAATGGCGTATCTTATGGTGAGTAA
GATAATATGACTGAATAAGAGTTGATAGATAAGCCTAATGTAACAAATGTTAAATTTTTA
GATAAAAAGTTATTTGAAGACATGTAAGGTAAAAAAGCTATGGGTTCAGAATAGCAACAA
CATCTTTTTACAGCTTTAAAAGTACTCTCTGCTTGCCATACTGTGATTACAGAAAAGACA
TCAGAAGGAATAGAATACAATGCTTCCTCACCAGATGAGCTGGCACTTATAAATTTTGCT
AAATTTTGTGGATTCGAGTATCTTGGAATTGACGAAGACAGTGTTATGAGAATTAAGTAA
GAAAATATAATGCACAGATTTAAGGTATTGAATGTATTAGACTTTAATTCAGTAAGAAAG
CGCATGAGTATTATTGTGGAAGATTCTAATGGCAAGATTTTCTTGTTTTGTAAAGGTGCA
GACAGTGTCTTACAAAAGCTACTTGACTAAAAATTAAATGAAGATCATATAATAGAGTAG
ACATGGATTAACTTAGAAAGGTATGCATCTGTTGGTCTCCGTACTCTTGTTTTAGCATAA
AAAGAAATTTAAAAAGATGAGTACCATTTATGGAATGAACAGTACTAAGTAGCATGCTGC
AGCCTTAAAGACAGAGAAGAAGAAATGGAAAGGTTACAAAAAAAGATAGAAAAAAATCTT
ATCTTAGTAGGAGCTACTGCGATAGAAGATTAATTACAAGACGAAGTTTCTTCAACTATC
TAGCTTATGAAGAAAGCTGGAATAAAAGTTTGGGTGCTGACAGGAGATAAAGTTGAAACA
GCAGTTAATATAGGCTACGCTTGCTCACTTTTGAATGATTAGTTAAGGAGAATTCTTGTT
GATGGTTATAGTTTAGAAGAAGTATAAAAATCTTTACAGGCAGCTTACAAGTCTATCCTA
AATGAAGTTGAAAATCATAACTAAACTATCCTTTAAAGCAATAGAAAAAAGTCATAAAAG
AACGAAATGATAAAGAACTTTAGTTTAGATCTCGCTCTAATCCTGACAGGAGATGCTTTG
ATACACTGTACAGAAAATAAAGAGAATAATGAAACTCTAATGAAAATATCAGAACATTGT
AAAGTAGTTCTTGCTTGTAGAGTTTCGCCTAAACAGAAGTAAGAAATTGTGCATTTAGTT
AGAGTTGCTAAACCAGAGTCAACAACTTTAGCAATTGGAGATGGAGCTAATGATGTGAAT
ATGATAAGTGCTGCTCATGTTGGTGTTGGCATTAGAGGAAAAGAAGGATAACAAGCAGCT
AGAGCAAGCGATTTTGCTGTTGGAGAATTTAAAATATTAAAATCCTTACTTTTTAATCAT
GGAAGAGAATCTTATAGAAAAAATTCAACTTTGATATGCTACAATTTTTACAAAAATATG
CTATTAGTCTTACCATAGTGGTGGTATGCCTTCATTAGTGGGTATTCGGGTTCTTCCATG
TATGACCCTTGGATTTATTAACTTTATAATATGTGTTACACTTCTCTTCCAATTGTTGTA
TATGCTATTTTTGACCAAGAGTTTAGTGATGAATATTTGGTTGAAAATCCTGATCTTTAT
GTCCAAGGTATAAAAGGTTTACTTTTTAATCAAAGAGAATACTGGCTTTGGATAATAAAT
GGATCTTGGCATGCTTTCTTAAGTTGTTTCATAAGCTTTGTAGGTTTAGATGGAACATTT
TAGGTTAATGGAAAAGATTTCTTTTTCTAAGCCACAGGAACTGTTACTTTCGGAGCTACT
GTCTTCATTGGAAATTTAAAAGTTTATATTTTCAGCAACACTTACAACCCAGCTTTATTG
ATAAGTGTTTTTGGAAGTATTATCTTCTATATTTCAAATCATGGGCTGGCAAGCTATTTC
TATGTCACATCTGATATATTCAATACTTTTTCAAACACTTATTCAAGCCCTTACTTTTGG
TTTTGTTCAATAATAATTATAGGAATCGCTACTATATTTGATTCTACTGATAGAAGATGG
GAATATTTTAGCTAAGTACTTAAAAGACAAGATGAAAAGAAATTAGCTTTACTTAATGAG
GCTCTAACATATTAATAAAATGAAGGATTAAATCTTGAAGGTTCAAAAAGTAATTCAGCA
GAAAATAAAAATTATTAACAAGAAAACAGAGACGAGATTATAACGTGTGTTGGGATGCTC
AAAAATGGATACTAAACTTAAGAACCAATAAATCTAAAGTAGCACAAGCCTCTATATGGA
GAAGAAGAAAAGGTGCCTTCCAGCGAATCTCTTAGCAATCCTCCTTATCCAAATAAATCC
GCTAAGACTGTATCTAACCATTAAAATTCCCACATGAATTCTAATTATCTTACTAGCACT
AAGCCATACACAGGATATGCTTTTTCTCAAATAGAGCCCATCACAGAAGCTTAATAAAAG
TATACTTACTGA

>TTHERM_00294760(gene)
ATGCCTAGAAAAAGATGGTAAGACATGCCTGATAGGACTATTGTTAGTAATTGTCCTGAG
CATGTTAAATTTTGTAATAATAGTATCTCAACCACAAAGTACACTCTCTTCACTTTTATT
CCCATGAATCTAGTTGAGTAATTTAGTAAGTTAGCAAATGTCTACTTTTTATTTATTGGA
ATGATGCAAATGATAAATGAAATATCTATTTCGAATGGTTAGCCGGTTATATATGTTCCG
CTTTTTGTTGTTTTGATGATATCTGGAATTAAAGATCTATTTGAAGATATGAAAAGGAAC
AAGTCAGATTAAGAAGAGAATCAAAGATTGGTAAATTTTTGTTTCAACTTAAAATCTAAT
TTCCTCCAATTAGCAATTAAGTTTATTTAGATGCATAAGGAGGAATTTATTCATAAATTC
ATTTATTTATATGATATTTCTACGAAAAAATTACTTTTTTAATAATATTTGGCAATTTAT
TAATAGGTATGGACTTATAGAAATGGCATGTGGATAAGAGTATATTGGTAGAGTTTATTA
GTAGGAGAAATAGTAAAAGTAGAAAAAAACTAACTCTTTCCTGCAGATATTTTATGTATG
TATACAACTGATTCTAAGGGCCTTTGCTATGTAGAAACTAAAAACCTAGATGGCGAAACC
AATTTGAAGCGCAAAATATCGAATAAATCTTTATAGCAATTAGGAGAAGCTGCTATTCTA
CATTAAAAATTTACTTTTAATTGTGAAAAACCAAACCCCTACTTATATAAATTTTAAGGA
AACATGGAAATAACAGATGGTTACGATTAATAGTAGAAAATATCCCTAGATTACAACAAT
TTTATACTTAGAGGATGCTCTCTGAAAAATACAGACTATGTAATTGGCTTGGTTTCTTAT
ACTGGAAGAGATTCTAAAATAATGATGAATACAGTAAACGCAAGATCAAAGAGATCTCAT
ATAGAAAAAAAAATGAATGTTTTTATTAGTTTGGTCTTCTTGCTTTAAATAGTAGTATGC
TTGTCATTTGCATTAGGTGCTGCAATTTGGTTTAATTAAAATAAATCAAGCCTCATTTTT
ATGCTTGGAGTCAGTAGTACAGCAGAAATAGACAACAGTTTTGGTTATTTATTAGTTGTG
CAGTGGGGTGCTTGGATTCTTATATTTACTAACTTTGTTCCTATCAGTAACTTACTTTTA
GTTATTAATTTAAATCATTCAAATTTGAATGAATGCTGTGTTACATTATTATTTTATAAT
TAATTAAATTAAAAGAAATCATAAAATTCTTTTTTCTTCAAATTTAATTAAATTCATTTG
CACACATACACTCAAGCAAATAAACAAATATTGGCTATTTTATTAATTCTAATTTTATTC
GTTTCTTGCTGACTCTATTCTTTTCTGGCTTTTTTTTTATTTTTATTAAAAATCAAATTA
ACTTCAATTTTTTTTTTTGAAAAATATTAATAGGCTTAATTGTAACCTTGGAAATGGTGA
AATTTATGTAAGGAATCAGAATTACATAAGATCCAAATACATATTCAAAAACTTATGATA
TTCAGTGCACTGTGTAATGCAGTGGATTGAATGAAGAATTAGGATAAGTAGAGTATGTTT
TTTCTGATAAAACTGGAACATTAACAAGCAACACGATGAAATATAAATGCTTAACAGTGA
ATGGCGTATCTTATGGTGAGTAAGATAATATGACTGAATAAGAGTTGATAGATAAGCCTA
ATGTAACAAATGTTAAATTTTTAGATAAAAAGTTATTTGAAGACATGTAAGGTAAAAAAG
CTATGGGTTCAGAATAGCAACAACATCTTTTTACAGCTTTAAAAGTACTCTCTGCTTGCC
ATACTGTGATTACAGAAAAGACATCAGAAGGAATAGAATACAATGCTTCCTCACCAGATG
AGCTGGCACTTATAAATTTTGCTAAATTTTGTGGATTCGAGTATCTTGGAATTGACGAAG
ACAGTGTTATGAGAATTAAGTAAGAAAATATAATGCACAGATTTAAGGTATTGAATGTAT
TAGACTTTAATTCAGTAAGAAAGCGCATGAGTATTATTGTGGAAGATTCTAATGGCAAGA
TTTTCTTGTTTTGTAAAGGTGCAGACAGTGTCTTACAAAAGCTACTTGACTAAAAATTAA
ATGAAGATCATATAATAGAGTAGACATGGATTAACTTAGAAAGGTATTTATTTATTTATT
TATAATAAATAATTACCAATTTTTTTATTTCTAATTAATTTAAAAATATAATTTTATTAG
GTATGCATCTGTTGGTCTCCGTACTCTTGTTTTAGCATAAAAAGAAATTTAAAAAGATGA
GTACCATTTATGGAATGAACAGTACTAAGTAGCATGCTGCAGCCTTAAAGACAGAGAAGA
AGAAATGGAAAGGTTACAAAAAAAGATAGAAAAAAATCTTATCTTAGTAGGAGCTACTGC
GATAGAAGATTAATTACAAGACGAAGTTTCTTCAACTATCTAGCTTATGAAGAAAGCTGG
AATAAAAGTAAGATAATTATATAAATATAGATTTAGATTAATATTTAATAAATCATAAAA
GGTTTGGGTGCTGACAGGAGATAAAGTTGAAACAGCAGTTAATATAGGCTACGCTTGCTC
ACTTTTGAATGATTAGTTAAGGAGAATTCTTGTTGATGGTTATAGTTTAGAAGAAGTATA
AAAATCTTTACAGGCAGCTTACAAGTCTATCCTAAATGAAGTTGAAAATCATAACTAAAC
TATCCTTTAAAGCAATAGAAAAAAGTCATAAAAGAACGAAATGATAAAGAACTTTAGTTT
AGATCTCGCTCTAATCCTGACAGGAGATGCTTTGATACACTGTACAGAAAATAAAGAGAA
TAATGAAACTCTAATGAAAATATCAGAACATTGTAAAGTAGTTCTTGCTTGTAGAGTTTC
GCCTAAACAGAAGTAAGAAATTGTGCATTTAGTTAGAGTTGCTAAACCAGAGTCAACAAC
TTTAGCAATTGGAGATGGAGCTAATGATGTGAATATGATAAGTGCTGCTCATGTTGGTGT
TGGCATTAGAGGAAAAGAAGGATAACAAGCAGCTAGAGCAAGCGATTTTGCTGTTGGAGA
ATTTAAAATATTAAAATCCTTACTTTTTAATCATGGAAGAGAATCTTATAGAAAAAATTC
AACTTTGATATGCTACAATTTTTACAAAAATATGCTATTAGTCTTACCATAGTGGTGGTA
TGCCTTCATTAGTGGGTATTCGGGTTCTTCCATGTATGACCCTTGGATTTATTAACTTTA
TAATATGTGTTACACTTCTCTTCCAATTGTTGGTAAATAATAAATAAATTAACTTATTAA
TTCCTTTATTATTGAATAAGCTTTTAATAAATCAAAATAGAATTATTATTAATATTCAAT
TTATAAAAAAACAAATTTAATATTATTTATAATAAAGTATATGCTATTTTTGACCAAGAG
TTTAGTGATGAATATTTGGTTGAAAATCCTGATCTTTATGTCCAAGGTATAAAAGGTTTA
CTTTTTAATCAAAGAGAATACTGGCTTTGGATAATAAATGGATCTTGGCATGCTTTCTTA
AGTTGTTTCATAAGCTTTGTAGGTTTAGATGGAACATTTTAGGTTAATGGAAAAGATTTC
TTTTTCTAAGCCACAGGAACTGTTACTTTCGGAGCTACTGTCTTCATTGGAAATTTAAAA
GTTTATATTTTCAGCAACACTTACAACCCAGCTTTATTGATAAGTGTTTTTGGAAGTATT
ATCTTCTATATTTCAAATCATGGGCTGGCAAGCTATTTCTATGTCACATCTGATATATTC
AATACTTTTTCAAACACTTATTCAAGCCCTTACTTTTGGTTTTGTTCAATAATAATTATA
GGAATCGCTACTATATTTGATTCTACTGATAGAAGATGGGAATATTTTAGCTAAGTACTT
AAAAGACAAGATGAAAAGAAATTAGCTTTACTTAATGAGGCTCTAACATATTAATAAAAT
GAAGGATTAAATCTTGAAGGTTCAAAAAGTAATTCAGCAGAAAATAAAAATTATTAACAA
GAAAACAGAGACGAGATTATAACGTGTGTTGGGATGCTCAAAAATGGATACTAAACTTAA
GAACCAATAAATCTAAAGTAGCACAAGCCTCTATATGGAGAAGAAGAAAAGGTGCCTTCC
AGCGAATCTCTTAGCAATCCTCCTTATCCAAATAAATCCGCTAAGACTGTATCTAACCAT
TAAAATTCCCACATGAATTCTAATTATCTTACTAGCACTAAGCCATACACAGGATATGCT
TTTTCTCAAATAGAGCCCATCACAGAAGCTTAATAAAAGTATACTTACTGA

>TTHERM_00294760(protein)
MPRKRWQDMPDRTIVSNCPEHVKFCNNSISTTKYTLFTFIPMNLVEQFSKLANVYFLFIG
MMQMINEISISNGQPVIYVPLFVVLMISGIKDLFEDMKRNKSDQEENQRLVWTYRNGMWI
RVYWQSLLVGEIVKVEKNQLFPADILCMYTTDSKGLCYVETKNLDGETNLKRKISNKSLQ
QLGEAAILHQKFTFNCEKPNPYLYKFQGNMEITDGYDQQQKISLDYNNFILRGCSLKNTD
YVIGLVSYTGRDSKIMMNTVNARSKRSHIEKKMNVFISLVFLLQIVVCLSFALGAAIWFN
QNKSSLIFMLGVSSTAEIDNSFGYLLVVQWGAWILIFTNFVPISLIVTLEMVKFMQGIRI
TQDPNTYSKTYDIQCTVQCSGLNEELGQVEYVFSDKTGTLTSNTMKYKCLTVNGVSYGEQ
DNMTEQELIDKPNVTNVKFLDKKLFEDMQGKKAMGSEQQQHLFTALKVLSACHTVITEKT
SEGIEYNASSPDELALINFAKFCGFEYLGIDEDSVMRIKQENIMHRFKVLNVLDFNSVRK
RMSIIVEDSNGKIFLFCKGADSVLQKLLDQKLNEDHIIEQTWINLERYASVGLRTLVLAQ
KEIQKDEYHLWNEQYQVACCSLKDREEEMERLQKKIEKNLILVGATAIEDQLQDEVSSTI
QLMKKAGIKVWVLTGDKVETAVNIGYACSLLNDQLRRILVDGYSLEEVQKSLQAAYKSIL
NEVENHNQTILQSNRKKSQKNEMIKNFSLDLALILTGDALIHCTENKENNETLMKISEHC
KVVLACRVSPKQKQEIVHLVRVAKPESTTLAIGDGANDVNMISAAHVGVGIRGKEGQQAA
RASDFAVGEFKILKSLLFNHGRESYRKNSTLICYNFYKNMLLVLPQWWYAFISGYSGSSM
YDPWIYQLYNMCYTSLPIVVYAIFDQEFSDEYLVENPDLYVQGIKGLLFNQREYWLWIIN
GSWHAFLSCFISFVGLDGTFQVNGKDFFFQATGTVTFGATVFIGNLKVYIFSNTYNPALL
ISVFGSIIFYISNHGLASYFYVTSDIFNTFSNTYSSPYFWFCSIIIIGIATIFDSTDRRW
EYFSQVLKRQDEKKLALLNEALTYQQNEGLNLEGSKSNSAENKNYQQENRDEIITCVGML
KNGYQTQEPINLKQHKPLYGEEEKVPSSESLSNPPYPNKSAKTVSNHQNSHMNSNYLTST
KPYTGYAFSQIEPITEAQQKYTY