Identifiers and Description

Gene Model Identifier

TTHERM_00294810

Standard Name

SMC3 (Structural Maintenance of Chromosomes 3)

Aliases

PreTt15591 | 27.m00251 | 3692.m00054

Description

SMC3 SMC family carboxy-terminal domain protein; SMC family; C-terminal domain containing protein; cohesin complex member

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• chromosome (IEA) | GO:0005694
• cohesin complex (IDA) | GO:0008278

Molecular Function

• ATP binding (IEA) | GO:0005524

Biological Process

• chromosome segregation (IDA) | GO:0007059

Domains

• ( PF00005 ) ABC transporter, ATP-binding protein
• ( PF00038 ) Intermediate filament protein
• ( PF00515 ) tetratricopeptide repeat
• ( PF01576 ) Myosin tail
• ( PF02370 ) M protein repeat
• ( PF02463 ) RecF/RecN/SMC N terminal domain
• ( PF04702 ) Vicilin N terminal region
• ( PF07197 ) Protein of unknown function (DUF1409)
• ( PF07719 ) tetratricopeptide repeat
• ( PF08791 ) Viral envelope protein
• ( PF08946 ) Osmosensory transporter coiled coil
• ( TIGR00019 ) peptide chain release factor 1
• ( TIGR00253 ) conserved hypothetical protein TIGR00253
• ( TIGR00634 ) DNA repair protein RecN
• ( TIGR00864 ) polycystin cation channel protein
• ( TIGR01612 ) rhoptry protein
• ( TIGR02168 ) chromosome segregation protein SMC
• ( TIGR02169 ) chromosome segregation protein SMC
• ( TIGR03185 ) DNA sulfur modification protein DndD

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_08738.1	9.997093137033517e-262
	Description: SMC family domain-containing protein (1161 aa)
SGD	YJL074C	5.001636743996964e-56
	Description: SMC3 Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
Oxytricha	Contig17078.0.g58	2.000704504372864e-47
	Description: RecF/RecN/SMC N terminal domain
WormBase	WBGene00004873	1.999534248571833e-46
	Description: locus:smc-3 status:Confirmed UniProt:Q9U2C1 protein_id:CAB57898.4
DictyBase	DDB_G0284499	1.9993007828132465e-27
	Description: smc2 on chromosome: 4 position 2051268 to 2054927
Stentor Coeruleus	SteCoe_15774	0.0000000001026187963170189
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:23555314: Howard-Till RA, Lukaszewicz A, Novatchkova M, Loidl J (2013) A single cohesin complex performs mitotic and meiotic functions in the protist tetrahymena. PLoS genetics 9(3):e1003418

Sequences

>TTHERM_00294810(coding)
ATGAGCATTAAATCAATATCTATAGAAAAATTTAAAAGTTACTCTAACTGCAAGATAGAA
GGACTCTCTGACAATATAAATATTCTGTATGGCAAGAATGGTTCTGGAAAATCTAATTTG
TTGGCTGCTTTATCATTTATAAGTTCTGATTAGTACGATAGAGCTGATCGAGCATAATTA
ATGAAAAATTATAAAGAAGGTGATCCTAAGGTCGAAATAGAGTTAGATAATTTAGTTAAA
ATAGATAAAAAAGATATGGAAGATGAGCCAAAAGCACAAAAAGTTATTCCTACCAGCGGT
GATAGTGTTTTATTAAGTAGAACTTTAGAGTAAAGGGAGAATGTTTATAGGGTAGATGAT
AGAGTTGTTAATTTAAATTAGTTTAATAATATTTTTGAGTGCTTTGGTCTTTCAAGAAAG
AATCCTTTTACAATAGTTGCATAAAATAGAATTTAAGAAATATCAAACATGAGTGATTCA
GAAATCTATAAGTTGTTACAGCAAGTAGCTGGAATAGAAGCTTTTATGAATAAATAAGAA
AAAGCAGAAGAGCTTTTCGAAAAAGCTTAGAGAGAAAAGGAAGGCATAGATTAATCCTTA
CAAGAAATAGAAGATAAAATAAGCTAGTTAAGTGGTGAGAAAGAATAGTATGCACAAAAT
TAAGAATAGGAAATTATTATATAAAGCTTGTAATCTATCTATTATGATAAATTGAAAGAA
GAGCTTTAAAAGAAGAAATTAGAATGCAACAAAGAAATCAATAATCAAAAATTGTAAGAA
GAGAAGTAAAAGCTTCAGGATTTATAAAATTAGAAAGAAGCTAAAAATGAAGAACTATTA
AGATTTAAAGAAAAATTGCAAAGATTAACAGTTATAGAAGAGCAAGTAAAATCAGATTAA
ATGAATCTTTAAAACAAAGTCAACAGTCTTGAGTAGAATATCTAAAAATTAAAATCAATA
AAAACTAACAAAGATGAAAAAGAAATTGAAGCAAGATTAAAAGAAGTTAATATTTAATGC
ACTAAATTATAAAAAGATCTTGATGAAGTCATTGATAAAATAACAAATGAAAAAGATGGG
ATTGACACCAAGCAGTAAGAATATGAGCAATTAGTCTTAAGAGAAAAGTTTAAAACTTAG
TAAGAAAAGCAAAGCTATTTTAATCAGAGAATCCAAGACATTAAACAAAGTATTAGTGAA
AAATCATAAACTTAACAGAATCTTAAAGAGAAAGTGAAAAAATCTGAATAAAGACTAAAC
TTAGTTAATTAAGAAATTGAAAAATTGTAAAATCAAATAAATAGTTTTTAAACTGAATCC
AATAAGGCACAAAAAACTATAAATGATAAAAAGAATTAAATCTAAAAATTGAGACAAGAG
TAGCTTGAAAAGAGAAAGACAATTAATGATAAAAAAATAGAGTTGGAAGATTTAAACAAC
TAAATAAAAAAGAGAGTTGATGATATACAAAAGTAGTTGAAATCAGGATTAATCCAAGCA
ATTGAGCAAATCGAGGAATCAATATAAAAAGAAGGTATTTAGGGATATAAAGGACTGCTT
ATAGATCATCTTTAATTTAATTCTGCACTTACTTATGCATATGATATTGCTCAAAAAGGA
AAATTATTTTCTTTGATAGTCGATAATCAAAATACTGCCTCTTTAATAATTGATATTGTT
AAGAAATTGAAGATTAAAACATCAAATTTAAATATTATTCCCCTAGATTGGGTTGAAGAT
GATATTGATGATGAAAAAGAAAACTAAATTGCAGGATTCGGATTTTAAAAGCTATTTGAT
ACTAGGTATGTTAAGGCAAAAGGAGATCATGCAGATGATATAAAAAGGTTAGCTAAGAAT
ATTTTTGAAAAATATGGTGTAATTAAAGAGTATGAACATGCCCTAGAGGTAGCATCTTAA
TTTAAAGTAAACTGCATTACAGAGAAGAGATAAATTGTTTATAGTGGAGGTTTTATTTCT
CATGTTGGTTTTTGTACTGTGGCTAAAGTAGATAAAATAACACTTTACAATGAATACAAA
AGCTTTAAAGCTAAGAAAGATGCTATTGCTAAAGAAATAGAGCAACTAGAGAAGTCTATG
AATGATATTTAATTGTAATAAAATGATATAAATTCAAATGTAAGCAAAGAATAAGCTAGC
TTAGCAAAATAGAGTAACACTATATTTATGAATCGTTAACTAATTAAATCATCTGAAGTA
GAGAAAAAAGTATTGACTGATGAGTTAAACGAAACAAATTAACTCCTATAGTCTTTTTCT
TAATAACTTAAAGATTTAGAATAAGAGAAAATAGGTTTAGAAAATACTAGCAAATCCTCT
AAATTTGAACCCTTGAATTAAGAGGACAAGTAAAAAATGTATAAACTATAAGAAGAAATT
AAGTCTAAAACTACTGTTTTGTAAAAATCTCTGAAAGAAAAGTAAAATGTAGAAAAAGAG
TATAACAAGTATAGAAATGAAGAATAATAGCTAACTAATCATTTATCCCAATTATCAGAA
GGTGGTGGTATGAAAGATGGTGAAGTCTTATTTTAAAGCATTGATCAAAGAATAAGTTCT
TCAGAGTAAGACCTCAAACATCAAGAAAGTATTCTCAAAGCTTAAAAAGCAATTGTGGAA
AAAGCTACACAAAGTAAGAAAACACTCGAAGAATAAATAAAAAAGATTGAGGGAGAAAGC
TAAGATAAGCTGAAAGAGCAAATTCAAAGCTAGTAAGAACTTTGCAATAATTTAGAATAA
TAAATCAGTGCTTTACTTCTCCGTAAACAACAATATATTTCAAAAGAGTACGAAATAGAT
TAAAAAAAGGAATTACTAGTAGTAAGCCCTGATTTTATCCAAAAAAATTCTCATCTTTCT
AAAGATAATTTAAAAGATAAGCTGAATAGAATTACTTAATAAACAACCATTAAGAAATAC
ACAGCAAAAGATAAAATTCTATTTGAAAAATTAAAAGATTTGGACGAGAAATATGAAGAA
TACAAATCCAAATACACTGAATTAACAAAAAATGAAGAATAAGCCAAAAATCTAATTGAT
TAATTTAAATCAAAATGTGAATAAACTATTAAAATGGCATTTTCTAAGTTTGAGCATTAT
ATGAAAAATTATTTCAAATAAATATCTTCTGCAGGTACAATAGACGTTAAACTTATGCAT
AATCATGAAATCAGTATATCAGTTGCTTTTAAATAAACTACAAATGAAACAAAAAAGACA
AATAGAAAAGAGCTAAGTGGAGGAGAAAAGAGTTGTCTTGCTATTCTTATTTTAATGGCT
CTATAGAGATGTGATCCAGCTCCATACTATATATTTGATGAATTTGATGCAGCATTAGAC
GCTGGTTATATTAGACCTATTGCAAAGATGTAAGTTAATTTTTAATTAAGTATTAAATTA
ATAACACATACTTATTTATTTATTTACTATTACGCAAAAGAATATCTGAAAATAGCTAAA
AGTCTTAATTTTTAATTGTTTCACACAAGTTTGAATTTTTATAAGCTTTACAACAAGAAA
ATTGTAAGTGCTTCTAGATATCACTAAAAGACAAAATAAGCGAGATAGAAGAGAAGACTT
TATCAGCTGCAATAAATTTTGTTAAAAATGGTTGAAAATGTGTTAAAAAGATAAATAGTT
TTTCCAAAAATTAGTCTCCATATAATTAATTATAAATTAAAATATTTTTCCATATATTTA
TTAACTGTATGTAATTTTAATCTAAATCATCAAATAGAGCATTCATTTTTTTTTTTAGCT
TACAAAATTTGTGGCTTATAATTCAATCTTATTTATTTAATTAATTTTAATTAAGAAGCT
GCTTAATTTTCTTGTGTTTATTTATGA

>TTHERM_00294810(gene)
ATGAGCATTAAATCAATATCTATAGAAAAATTTAAAAGTTACTCTAACTGCAAGATAGAA
GGACTCTCTGACAATATAAATATTCTGTATGGCAAGAATGGTTCTGGAAAATCTAATTTG
TTGGCTGGTACATAAAAAATATTACTTAGAAATTTAGCTTTTAATATATTTTTTTTGCTA
AAATTAGCTTTATCATTTATAAGTTCTGATTAGTACGATAGAGCTGATCGAGCATAATTA
ATGAAAGTAATATATATTTTCATAAATAAATTCTAAATTAAGAACTAACCTATTTTTATT
TTATATAGAATTATAAAGAAGGTGATCCTAAGGTCGAAATAGAGTTAGATAATTTAGTTA
AAATAGATAAAAAAGATATGGAAGATGAGCCAAAAGCACAAAAAGTTATTCCTGTACTCT
TTTTTATGAGTTTTATTAATTTAATTATTTTGTATTATTGTTCAAATTGATGAAAAATGT
TAATTTTTATTTAATATTCTTATTTAGACCAGCGGTGATAGTGTTTTATTAAGTAGAACT
TTAGAGTAAAGGGAGAATGTTTATAGGGTAGATGATAGAGTTGTTAATTTAAATTAGTTT
AATAATATTTTTGAGTGCTTTGGTCTTTCAAGAAAGAATCCTTTTACAATAGTTGCATAA
AATAGAATTTAAGAAATATCAAACATGAGTGATTCAGAAATCTATAAGTTGTTACAGCAA
GTAGCTGGAATAGAAGCTTTTATGAATAAATAAGAAAAAGCAGAAGAGCTTTTCGAAAAA
GCTTGTAATTTTTTATTTTAATACTAAATAATAATATGAAGGAAATATAATTTTAAAGAG
AGAGAAAAGGAAGGCATAGATTAATCCTTACAAGAAATAGAAGATAAAATAAGCTAGTTA
AGTGGTGAGAAAGAATAGTATGCACAAAATTAAGAATAGGAAATTATTATATAAAGGTAT
AAAAAACATTATTGCCTTTGAAAATATAAATATGTTTTTTTAATATTTTATTAGCTTGTA
ATCTATCTATTATGATAAATTGAAAGAAGAGCTTTAAAAGAAGAAATTAGAATGCAACAA
AGAAATCAATAATCAAAAATTGTAAGAAGAGAAGTAAAAGCTTCAGGATTTATAAAATTA
GAAAGAAGCTAAAAATGAAGAACTATTAAGATTTAAAGAAAAATTGCAAAGATTAACAGT
TATAGAAGAGCAAGTAAAATCAGATTAAATGAATCTTTAAAACAAAGTCAACAGTCTTGA
GTAGAATATCTAAAAATTAAAATCAATAAAAACTAACAAAGATGAAAAAGAAATTGAAGC
AAGATTAAAAGAAGTTAATATTTAATGCACTAAATTATAAAAAGATCTTGATGAAGTCAT
TGATAAAATAACAAATGAAAAAGATGGGTAAATAAATCATTTTAATATGAATAAAAAAAT
TTTTATTGATGTTTAATTTTGATAAAGGATTGACACCAAGCAGTAAGAATATGAGCAATT
AGTCTTAAGAGAAAAGTTTAAAACTTAGTAAGAAAAGCAAAGCTATTTTAATCAGAGAAT
CCAAGACATTAAACAAAGTATTAGTGAAAAATCATAAACTTAACAGAATCTTAAAGAGAA
AGTGAAAAAATCTGAATAAAGACTAAACTTAGTTAATTAAGAAATTGAAAAATTGTAAAA
TCAAATAAATAGTTTTTAAACTGAATCCAATAAGGCACAAAAAACTATAAATGGTAATTA
ATTAATTAAAATATTTAAATTATTTTTATTAACTTAAAATTAGATAAAAAGAATTAAATC
TAAAAATTGAGACAAGAGTAGCTTGAAAAGAGAAAGACAATTAATGATAAAAAAATAGAG
TTGGAAGATTTAAACAACTAAATAAAAAAGAGAGTTGATGATATACAAAAGTAGTTGAAA
TCAGGATTAATCCAAGCAATTGAGCAAATCGAGGAATCAATATAAAAAGAAGGTATTTAG
GGATATAAAGGACTGCTTATAGATCATCTTTAATTTAATTCTGCACTTACTTATGCATAT
GATATTGCTCAAAAAGGTATTTCACATTTTTTATTTTTCTTGCAAATATTTATTTTTTTA
TAAACTTATTGCTAGGAAAATTATTTTCTTTGATAGTCGATAATCAAAATACTGCCTCTT
TAATAATTGATATTGTTAAGAAATTGAAGATTAAAACATCAAATTTAAATATTATTCCCC
TAGATTGGGTTGAAGATGATATTGATGATGAAAAAGAAAACTAAATTGCAGGATTCGGAT
TTTAAAAGCTATTTGATACTAGGTATGTTAAGGCAAAAGGAGATCATGCAGATGATATAA
AAAGGTTAGCTAAGAATATTTTTGAAAAATATGGTGTAATTAAAGAGTATGAACATGCCC
TAGAGGTAGCATCTTAATTTAAAGTAAACTGCATTACAGAGAAGAGATAAATTGTTTATA
GTGGAGGTTTTATTTCTCATGTTGGTTTTTGTACTGTGGCTAAAGTAGATAAAATAACAC
TTTACAATGAATACAAAAGCTTTAAAGCTAAGAAAGATGCTATTGCTAAAGAAATAGAGC
AACTAGAGAAGTCTATGAATGATATTTAATTGTAATAAAATGATATAAATTCAAATGTAA
GCAAAGAATAAGCTAGCTTAGCAAAATAGAGTAACACTATATTTATGAATCGTTAACTAA
TTAAATCATCTGAAGTAGAGAAAAAAGTATTGACTGATGAGTTAAACGAAACAAATTAAC
TCCTATAGTCTTTTTCTTAATAACTTAAAGATTTAGAATAAGAGAAAATAGGTTTAGAAA
ATACTAGCAAATCCTCTAAATTTGAACCCTTGAATTAAGAGGACAAGTAAAAAATGTATA
AACTATAAGAAGAAATTAAGTCTAAAACTACTGTTTTGTAAAAATCTCTGAAAGAAAAGT
AAAATGTAGAAAAAGAGTATAACAAGTATAGAAATGAAGAATAATAGCTAACTAATCATT
TATCCCAATTATCAGAAGGTGGTGGTATGAAAGATGGTGAAGTCTTATTTTAAAGCATTG
ATCAAAGAATAAGTTCTTCAGAGTAAGACCTCAAACATCAAGAAAGTATTCTCAAAGCTT
AAAAAGCAATTGTGGAAAAAGCTACACAAAGTAAGAAAACACTCGAAGAATAAATAAAAA
AGATTGAGGGAGAAAGCTAAGATAAGCTGAAAGAGCAAATTCAAAGCTAGTAAGAACTTT
GCAATAATTTAGAATAATAAATCAGTGCTTTACTTCTCCGTAAACAACAATATATTTCAA
AAGAGTACGAAATAGATTAAAAAAAGGAATTACTAGTAGTAAGCCCTGATTTTATCCAAA
AAAATTCTCATCTTTCTAAAGATAATTTAAAAGATAAGCTGAATAGAATTACTTAATAAA
CAACCATTAAGAAATACACAGCAAAAGATAAAATTCTATTTGAAAAATTAAAAGATTTGG
ACGAGAAATATGAAGAATACAAATCCAAATACACTGAATTAACAAAAAATGAAGAATAAG
CCAAAAATCTAATTGATTAATTTAAATCAAAATGTGAATAAACTATTAAAATGGCATTTT
CTAAGTTTGAGCATTATATGAAAAATTATTTCAAATAAATATCTTCTGCAGGTACAATAG
ACGTTAAACTTATGCATAATCATGAAATCAGTATATCAGTTGCTTTTAAATAAACTACAA
ATGGTATTTTTAAAGCATCAAAAAAAAGTATTTAACAAAATATTTATTATATTAGAAACA
AAAAAGACAAATAGAAAAGAGCTAAGTGGAGGAGAAAAGAGTTGTCTTGCTATTCTTATT
TTAATGGCTCTATAGAGATGTGATCCAGCTCCATACTATATATTTGATGAATTTGATGCA
GCATTAGACGCTGGTTATATTAGACCTATTGCAAAGATGTAAGTTAATTTTTAATTAAGT
ATTAAATTAATAACACATACTTATTTATTTATTTACTATTACGCAAAAGAATATCTGAAA
ATAGCTAAAAGTCTTAATTTTTAATTGTTTCACACAAGTTTGAATTTTTATAAGCTTTAC
AACAAGAAAATTGTAAGTGCTTCTAGGTAAATATTGAATTTCAATTACTCTATTAAAATT
AATTTAAATAATAGATATCACTAAAAGACAAAATAAGCGAGATAGAAGAGAAGACTTTAT
CAGCTGCAATAAATTTTGTTAAAAATGGTTGAAAATGTGTTAAAAAGATAAATAGTTTTT
CCAAAAATTAGTCTCCATATAATTAATTATAAATTAAAATATTTTTCCATATATTTATTA
ACTGTATGTAATTTTAATCTAAATCATCAAATAGAGCATTCATTTTTTTTTTTAGCTTAC
AAAATTTGTGGCTTATAATTCAATCTTATTTATTTAATTAATTTTAATTAAGAAGCTGCT
TAATTTTCTTGTGTTTATTTATGA

>TTHERM_00294810(protein)
MSIKSISIEKFKSYSNCKIEGLSDNINILYGKNGSGKSNLLAALSFISSDQYDRADRAQL
MKNYKEGDPKVEIELDNLVKIDKKDMEDEPKAQKVIPTSGDSVLLSRTLEQRENVYRVDD
RVVNLNQFNNIFECFGLSRKNPFTIVAQNRIQEISNMSDSEIYKLLQQVAGIEAFMNKQE
KAEELFEKAQREKEGIDQSLQEIEDKISQLSGEKEQYAQNQEQEIIIQSLQSIYYDKLKE
ELQKKKLECNKEINNQKLQEEKQKLQDLQNQKEAKNEELLRFKEKLQRLTVIEEQVKSDQ
MNLQNKVNSLEQNIQKLKSIKTNKDEKEIEARLKEVNIQCTKLQKDLDEVIDKITNEKDG
IDTKQQEYEQLVLREKFKTQQEKQSYFNQRIQDIKQSISEKSQTQQNLKEKVKKSEQRLN
LVNQEIEKLQNQINSFQTESNKAQKTINDKKNQIQKLRQEQLEKRKTINDKKIELEDLNN
QIKKRVDDIQKQLKSGLIQAIEQIEESIQKEGIQGYKGLLIDHLQFNSALTYAYDIAQKG
KLFSLIVDNQNTASLIIDIVKKLKIKTSNLNIIPLDWVEDDIDDEKENQIAGFGFQKLFD
TRYVKAKGDHADDIKRLAKNIFEKYGVIKEYEHALEVASQFKVNCITEKRQIVYSGGFIS
HVGFCTVAKVDKITLYNEYKSFKAKKDAIAKEIEQLEKSMNDIQLQQNDINSNVSKEQAS
LAKQSNTIFMNRQLIKSSEVEKKVLTDELNETNQLLQSFSQQLKDLEQEKIGLENTSKSS
KFEPLNQEDKQKMYKLQEEIKSKTTVLQKSLKEKQNVEKEYNKYRNEEQQLTNHLSQLSE
GGGMKDGEVLFQSIDQRISSSEQDLKHQESILKAQKAIVEKATQSKKTLEEQIKKIEGES
QDKLKEQIQSQQELCNNLEQQISALLLRKQQYISKEYEIDQKKELLVVSPDFIQKNSHLS
KDNLKDKLNRITQQTTIKKYTAKDKILFEKLKDLDEKYEEYKSKYTELTKNEEQAKNLID
QFKSKCEQTIKMAFSKFEHYMKNYFKQISSAGTIDVKLMHNHEISISVAFKQTTNETKKT
NRKELSGGEKSCLAILILMALQRCDPAPYYIFDEFDAALDAGYIRPIAKMQVNFQLSIKL
ITHTYLFIYYYAKEYLKIAKSLNFQLFHTSLNFYKLYNKKIVSASRYHQKTKQARQKRRL
YQLQQILLKMVENVLKRQIVFPKISLHIINYKLKYFSIYLLTVCNFNLNHQIEHSFFFLA
YKICGLQFNLIYLINFNQEAAQFSCVYL