Identifiers and Description

Gene Model Identifier

TTHERM_00401980

Standard Name

HRS1 (histidyl-tRNA synthetase 1)

Aliases

PreTt12743 | 43.m00261 | 3713.m00087

Description

HRS1 histidine-tRNA ligase; histidyl-tRNA synthetase family protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• cytoplasm (IEA) | GO:0005737

Molecular Function

• aminoacyl-tRNA ligase activity (IEA) | GO:0004812
• ATP binding (IEA) | GO:0005524
• nucleotide binding (IEA) | GO:0000166

Biological Process

• translation (IEA) | GO:0006412
• tRNA aminoacylation for protein translation (IEA) | GO:0006418

Domains

• ( PF00587 ) tRNA synthetase class II core
• ( TIGR00442 ) histidyl-tRNA synthetase
• ( TIGR00443 ) ATP phosphoribosyltransferase, regulatory subunit

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_13986.1	9.997093137033517e-262
	Description: histidyl-tRNA synthetase (464 aa)
DictyBase	DDB_G0269822	3.0008725323024365e-87
	Description: mhisS on chromosome: 1 position 3669575 to 3671080
Stentor Coeruleus	SteCoe_24979	7.984904245686979e-30
	Description: None
Oxytricha	Contig9747.0.g58	7.996806159126539e-24
	Description: Histidyl-tRNA synthetase
SGD	YPR033C	3.998609120989657e-17
	Description: HTS1 Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
WormBase	WBGene00002001	0.000000000000004001928599951003
	Description: locus:hars-1 Histidine--tRNA ligase status:Confirmed UniProt:P34183 protein_id:CAD89746.1

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00401980(coding)
ATGTAGAGATTTAGCTCTTTGCAATCTGTTAAGGGAATGAAGGATTTAGTTGGAAATTAG
CTTTTGAAGCATCGATTTATATTTGATTGCGGTGCTAAGGTAATGGAAAAGCATGGGTAC
TAGATGATTGTTTAAAATATTTTAGAGCATAAATAAGTTTTCTCGAGAACTTTAGGAGAT
ACATCTGAAATTATTAATAAAGAAATGTATGGATTTACTGATTAGTCAGGTAAAGAACTT
GTACTTAGACCAGAAGGTACTGCAAGTGTTGTACGTCATATTTTAGAAAATTCAAAGCAC
TTCGAATAGTAGCAGAAATATTATTATTACGGTCCTATGTATAGATATGAGCGCCCTCAA
CTAGGAAGGCAAAGATAATTTTACTAGCTAGGATGTGAATTTTTACATAAAGAGAATCCT
AAAAATAGCTACTTAATAGATGCTGAGATCATTATAGTAGCTCATAAGTTTTTACAAAGG
GTATTGGGCAAACATTCCGAATTTTAAATGGAGATCAATACAATAGGAGATGTTGAAGAC
AGAGTAAAATACAATTCAATTTTAAAAGAATACTATGAAAAAAATATACACAAACTTTCT
GAATTAAGTAAAATGCGCTTAGAAAGAAATAATCCTTTAAGAATATTTGATTCTAAGGAG
GCATAAGATTAAGATTTAATAGCTAATGCTCCTTAATTTTCAGAAAGTATGAAATAAGAA
AGCAAAGAATACTTTAGAAATCTTTTAGAAGTACTAGATTCTCTTAATATTTCTTACAAG
ATAAATCCTTTACTAGTAAGAGGATTAGATTATTACTCACACACTTGCTTTGAAATCAAA
AATGTTGCTCAATAGGGTAAATCTTAAGACACAATCCTGGCAGGTGGCAGATACGATCAT
CTAGCATCAGTTCTTAACTCAAAAGCTACCAACTTAAACGGAGTAGGCTTTGCATGTGGT
ATCGAAAGAATTGGCTTGCTCTTGCAAGACGATGATCCCAAGTTAAAAGAGTTTGAGAAG
AAAAAGATTAAAATAGGAATTGTTCCTGTCCTAGGAAAATAAAATTTAAGTGATGAATTT
GAAAGAAATCTCAAGCTATATTGCGTCAATTTAATGAATTCAATCTCTGATGATTAAATT
GAAGTCTAACTTGTCCTTCATACATCTAAAATGGATAAGTAAATGGAATATTTATTGAAG
AATGAATTCAAATGGGGTATTTTCATTGGCGAAAATGAGGTGAAAGAAAAAAAAGTGAGC
ATAAAAAATTTATTAGATCGCGAAAGTTTTACTATTGAACGTGAGTAGATAAATAATTAC
CAATTTTGA

>TTHERM_00401980(gene)
ATGTAGAGATTTAGCTCTTTGCAATCTGTTAAGGGAATGAAGGATTTAGTTGGAAAGTAA
TAAATATTTATTACTTTTTCCATTTAAAAATTAAACTATTATAAAACTATAAAGTTAGCT
TTTGAAGCATCGATTTATATTTGATTGCGGTGCTAAGGTAATGGAAAAGCATGGGTACTA
GATGATTGTTTAAAATATTTTAGAGCATAAATAAGTTTTCTCGAGAACTTTAGGAGATAC
ATCTGAAATTATTAATAAAGTAAAAAAAACTTATGCTCTCTTATTTTAATTTAGTCAACT
TTAAATATTCATTTTAAGATTTTTATGAGTATTTTCCTTTTTTTTATATTGTTTCTTAAA
GTTGATAAATTTTGGTTGATTTAATAGATAATTCTAGTTAATTTTTTTGAAATCCATTAA
GATTTTATGTTTTTTTATCTAACCAATTTATGATTCATTTTATAAAAGGAAATGTATGGA
TTTACTGATTAGTCAGGTAAAGAACTTGTACTTAGACCAGAAGGTACTGCAAGTGTTGTA
CGTCATATTTTAGAAAATTCAAAGCACTTCGAATAGTAGCAGAAATATTATTATTACGGT
CCTATGTATAGATATGAGCGCCCTCAACTAGGAAGGCAAAGATAATTTTACTAGCTAGGA
TGTGAATTTTTACATAAAGAGAATCCTAAAAATAGCTACTTAATAGATGCTGAGATCATT
ATAGTAGCTCATAAGTTTTTACAAAGGGTATTGGGCAAACATTCCGAATTTTAAATGGAG
ATCAATACAATAGGAGATGTTGAAGACAGAGTAAAATACAATTCAATTTTAAAAGAATAC
TATGAAAAAAATATACACAAACTTTCTGAATTAAGTAAAATGCGCTTAGAAAGAAATAAT
CCTTTAAGAATATTTGATTCTAAGGAGGCATAAGATTAAGATTTAATAGCTAATGCTCCT
TAATTTTCAGAAAGTATGAAATAAGAAAGCAAAGAATACTTTAGAAATCTTTTAGAAGTA
CTAGATTCTCTTAATATTTCTTACAAGATAAATCCTTTACTAGTAAGAGGATTAGATTAT
TACTCACACACTTGCTTTGAAATCAAAAATGTTGCTCAATAGGGTAAATCTTAAGACACA
ATCCTGGCAGGTGGCAGATACGATCATCTAGCATCAGTTCTTAACTCAAAGTATAATTAA
ATAAAATATTTTTAAATTTTAAATACATTTAATAAAAACCCAAATAAAATCATAGTAGAA
AAAAAATTTAATTTGAAACAATTTAAGTAAATTTGTAAAAAATAATTAGAATTTATGATC
AAAGTTATAAATAACATAAGATTTATTTTTTTAATATTTGCTACAAATACATAATAAATA
AATGGTTGAAATAGCATTTCATTTATATATCAAATTTTTTAAAAATACAAACAGTTATTT
TATTTACTATTAAATAAAATTTTATAAATTAGAAACATTAAATAATATTTCAAATAATTT
TAAATGATTTAATCTAATTTAAATATTCATATTTTATTGTTAATGATTTTGGCTTTTATA
TGGTTTAAGATAAAAAAGATATGAAGATTTTATTTATCTATCTACATTAATTTTATTTAG
GATGTTTTTTATTCTTCTACTAGCACTTTTTTTAGCTATAAGTTGAAATTATATAGAATT
TATTTGGATTAACTATATATTCATTTTCTCCATCATTGCATATGTTGGATTCACCAACAC
TAGAGTATTTTTCCATCTATAGCATTATTTCGGTTTGCTATTAGATTTCTATTTATTACG
ACTATTTTAATACAAGATAGAGGAAAAATAGAACAAGTAGCAAATTCTCCTTCTTTATAT
AAGATATTTTGTTCAATATATAATTGTTTTATGTTCACTTTGTTAAACCACATTTATACA
TTTTAAATTTTATTTTAAATTATAGAGCTACCAACTTAAACGGAGTAGGCTTTGCATGTG
GTATCGAAAGAATTGGCTTGCTCTTGCAAGACGATGATCCCAAGTTAAAAGAGTTTGAGA
AGAAAAAGATTAAAATAGGAATTGTTCCTGTCCTAGGAAAATAAAATTTAAGTGATGAAT
TTGAAAGAAATCTCAAGCTATATTGCGTCAATTTAATGAATTCAATCTCTGATGATTAAA
TTGAAGTCTAACTTGTCCTTCATACATCTAAAATGGATAAGTAAATGGAATATTTATTGA
AGGTAATTACTATTGATATATTATTGAAACTAATTATTGAAAGCAAAAATAGGTTTTAGT
TTTTAAGATGAAGCTTATTTGAAATAGAATGATTTTAAATTTAACATTTTTTGTTTAAAA
TAGAATGAATTCAAATGGGGTATTTTCATTGGCGAAAATGAGGTGAAAGAAAAAAAAGTG
AGCATAAAAAATTTATTAGATCGCGAAAGTTTTACTATTGAACGTGAGTAGATAAATAAT
TACCAATTTTGA

>TTHERM_00401980(protein)
MQRFSSLQSVKGMKDLVGNQLLKHRFIFDCGAKVMEKHGYQMIVQNILEHKQVFSRTLGD
TSEIINKEMYGFTDQSGKELVLRPEGTASVVRHILENSKHFEQQQKYYYYGPMYRYERPQ
LGRQRQFYQLGCEFLHKENPKNSYLIDAEIIIVAHKFLQRVLGKHSEFQMEINTIGDVED
RVKYNSILKEYYEKNIHKLSELSKMRLERNNPLRIFDSKEAQDQDLIANAPQFSESMKQE
SKEYFRNLLEVLDSLNISYKINPLLVRGLDYYSHTCFEIKNVAQQGKSQDTILAGGRYDH
LASVLNSKATNLNGVGFACGIERIGLLLQDDDPKLKEFEKKKIKIGIVPVLGKQNLSDEF
ERNLKLYCVNLMNSISDDQIEVQLVLHTSKMDKQMEYLLKNEFKWGIFIGENEVKEKKVS
IKNLLDRESFTIEREQINNYQF