Identifiers and Description

Gene Model Identifier

TTHERM_00446570

Standard Name

HAP5 (Heme Activator Protein)

Aliases

PreTt03924 | 51.m00290 | 3704.m00146

Description

histone-like transcription factor and archaeal histone protein.

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• intracellular anatomical structure (IEA) | GO:0005622
• nucleus (IEA) | GO:0005634

Molecular Function

• DNA binding (IEA) | GO:0003677
• sequence-specific DNA binding (IEA) | GO:0043565

Domains

• ( PF00125 ) Core histone H2A/H2B/H3/H4
• ( PF00505 ) HMG (high mobility group) box
• ( PF00808 ) Histone-like transcription factor (CBF/NF-Y) and

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_10792.1	8.995665346759514e-138
	Description: hypothetical protein (322 aa)
DictyBase	DDB_G0272740	0.000000000010004361180063202
	Description: DDB_G0272740 on chromosome: 2 position 2228582 to 2229156
SGD	YOR358W	0.000000000040005666873964816
	Description: HAP5 Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex
Oxytricha	Contig15089.0.g94	0.000000009000371344152433
	Description: Histone-like transcription factor (CBF/NF-Y) and archaeal histone
WormBase	WBGene00017742	0.0000020007268868677913
	Description: locus:nfyc-1 status:Confirmed UniProt:O17072 protein_id:CCD62352.1

General Information

No Data fetched for General Information

Associated Literature

1. Ref:31932604: Nabeel-Shah S, Ashraf K, Saettone A, Garg J, Derynck J, Lambert JP, Pearlman RE, Fillingham J (2020) Nucleus-specific linker histones Hho1 and Mlh1 form distinct protein interactions during growth, starvation and development in Tetrahymena thermophila. Scientific reports 10(1):168

Sequences

>TTHERM_00446570(coding)
ATGGATTAAGAATAGTTGGAATTCGATTATGAAGATGAGTTTCAGGATCTAAACTTAGAG
TAGTAGCTAGCATAGCCTACAAGGTTTTTAAAAAGCTAAAATGGTGAAAAACAATAAATA
TAAACTAATACAGAAATGTAGAATAAAGAAGATATTACTAATTAAAAGAAGCATTTATAA
AAGCCTAAAAAGCCTTTGAGTGCATACTTTTTATTTATTTAAGACTATAAGCAAAAATGT
GGAAGCAAAATAAACTTGAAAGAAATGGGAAATATATGGAATGAAACTTCGTAAGATGAA
AAGCAAATTGAATAGCAAGGTGACGAGGAAAATGAAGAACAATTAGATAATGAATTAGAT
ATTGCTTTTCCTATATCAAGGATTAAAGGTATTCTTAAAGTTGATGAAGACAATAAACTA
TTAAGCAAAGACACACTCCTTTACTTTGAAAAAGCTACAGAATTATTTGGGGGTTATTTA
GCTTAAAAATGTTTTAGAAATATGCAATAAAATCGCAGAAAAAAATTATAAACTGGTGAT
CTATATGAAGTAATTAAAAGGGACATGTACTTGAACTTCTTATAATGTATGGTGCCTTAA
GAAGCAACTGGTGAAGAAGAAAACCAATAAAATGTAATTAGTGGAAGCTAGCAGTCATCA
AAAACAAAATCTCGCAAAAGATTAGTCATTGCTGACGATGAAGATGTAAACTAAGAAGGC
AACATGGAAATAGAAAATAAAGATTTAGAGTAATAGGAGATTCCTGAATCAAGTAATAAA
AAAAATGTTAATACTAAGAGCAATAATAAACCAGGTAAAAAAGAAAAGGTTGTGCTACCT
CCTGCTAATAATAGCAGGATCGACAGCTTTTTTACTAAAAAGTGA

>TTHERM_00446570(gene)
ATGGATTAAGAATAGGTTTGCATAAATTAAATTTATATAAAAAGATTGAGTGATTAAAGA
TTTCCCTTAAATATTAGTTGGAATTCGATTATGAAGATGAGTTTCAGGATCTAAACTTAG
AGTAGTAGCTAGCATAGCCTACAAGGTTTTTAAAAAGCTAAAATGGTGAAAAACAATAAA
TATAAACTAATACAGAAATGTAGAATAAAGAAGATATTACTAATTAAAAGAAGCATTTAT
AAAAGCCTAAAAAGCCTTTGAGTGCATACTTTTTATTTATTTAAGACTATAAGCAAAGTA
ATTGGTAATTTTCTCAAATGTTTCAGTTATTTATGTATGTGCATTATAAAATTAGAATGT
GGAAGCAAAATAAACTTGAAAGAAATGGGAAATATATGGAATGAAACTTCGTAAGATGAA
AAGCAAGTAAGAAAAATAATTTATTAAATTGAATTATGCATATGTAGTGATGAAAATCTT
AAAAATTAGATATACTATAAAAAATAAGAAGAAGAAAAAGCTCGCTTTAAAAAAGAAATG
GACGAATATGTAAAAATTAATAATTAAACTATTTTAATTTTAAATTTAAAATATTTTTAT
AAAAACATAGATTGAATAGCAAGGTGACGAGGAGTAAAAAATATTTTTAATTAAAAATTG
AGTTTAAATTATTATTTTTGTTAGAAATGAAGAACAATTAGATAATGAATTAGATATTGC
TTTTCCTATATCAAGGATTAAAGGTATTCTTAAAGTTGATGAAGACAATAAACTATTAAG
CAAAGACACACTCCTTTACTTTGAAAAAGCTACAGTAAAATTTCAATGGATTTTTTTATA
GTTTTAATTTTTTGGTTAATTTAAAGGAATTATTTGGGGGTTATTTAGCTTAAAAATGTT
TTAGAAATATGCAATAAAATCGCAGAAAAAAATTATAAACTGGTGATCTATGTAAAATAA
AATAATAAAAATATCTAAAAAATTTAATAAGATTTTAAAAAAATAAGATGAAGTAATTAA
AAGGGACATGTACTTGAACTTCTTATAATGTAATTTATTATTTAGTTGAAAATATTAATA
ATACTTCTAAAAAGGTATGGTGCCTTAAGAAGCAACTGGTGAAGAAGAAAACCAATAAAA
TGTAATTAGTGGAAGCTAGCAGTCATCAAAAACAAAATCTCGCAAAAGATTAGTCATTGC
TGACGATGAAGATGTAAACTAAGAAGGCAACATGGAAATAGAAAATAAAGATTTAGAGTA
ATAGGAGATTCCTGAATCAAGTAATAAAAAAAATGTTAATACTAAGAGCAATAATAAACC
AGGTAAAAAAGAAAAGGTTGTGCTACCTCCTGCTAATAATAGCAGGATCGACAGCTTTTT
TACTAAAAAGTGA

>TTHERM_00446570(protein)
MDQEQLEFDYEDEFQDLNLEQQLAQPTRFLKSQNGEKQQIQTNTEMQNKEDITNQKKHLQ
KPKKPLSAYFLFIQDYKQKCGSKINLKEMGNIWNETSQDEKQIEQQGDEENEEQLDNELD
IAFPISRIKGILKVDEDNKLLSKDTLLYFEKATELFGGYLAQKCFRNMQQNRRKKLQTGD
LYEVIKRDMYLNFLQCMVPQEATGEEENQQNVISGSQQSSKTKSRKRLVIADDEDVNQEG
NMEIENKDLEQQEIPESSNKKNVNTKSNNKPGKKEKVVLPPANNSRIDSFFTKK