Identifiers and Description

Gene Model Identifier

TTHERM_00467910

Standard Name

NaKa1

Aliases

PreTt18692 | 55.m00247 | 3710.m00096

Description

Orthologue of S. cerevisiae Rrb1 (Ribosome assembly protein). Rrb1 ortholog in humans is known as GRWD1. NaKa-1 contains WD-40 repeats with domain architecture similar to RebL1 and Wdc1 in Tetrahymena (Nabeel-Shah et al. 2021).

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

• ( PF00400 ) WD domain, G-beta repeat

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_15704.1	9.997093137033517e-262
	Description: hypothetical protein (586 aa)
Oxytricha	Contig21203.0.g38	3.999284652801983e-113
	Description: WD domain, G-beta repeat
DictyBase	DDB_G0291566	9.001701800865775e-93
	Description: grwd1 on chromosome: 6 position 556339 to 557876
SGD	YMR131C	2.0009381340492598e-66
	Description: RRB1 Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p
WormBase	WBGene00021899	1.9997677415930956e-65
	Description: status:Confirmed UniProt:Q9N393 protein_id:CCD69848.1
Stentor Coeruleus	SteCoe_7644	8.194012623990515e-40
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:34086947: Nabeel-Shah S, Garg J, Saettone A, Ashraf K, Lee H, Wahab S, Ahmed N, Fine J, Derynck J, Pu S, Ponce M, Marcon E, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J (2021) Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila. Nucleic acids research ( ):

Sequences

>TTHERM_00467910(coding)
ATGAGTGACAATAAAAAGATAAGTTAAAAGAGAAAGCTTGAAACTGCTGAAGATGTTTCA
CTTAATATTAAAGAACAAAACTAGAAAAAAAATCCTAATAAGAAGAAAGGGGATTAAGCA
GTAGTTGACGAATTCGAAAAAAATGAAAATTTTGAAGAGGAAGAAGGATCTGAATTAGAA
TTTGAAGATTGTGAAGATGATATAGATGATGAATATGTTGATGAAAAGACATACAAAAAG
ATTATGTAAGGAAATTTCTAAGAAGATGAAGAGGAATGGGAAGACGATGGAGATGATGAC
GATGATGAAAATGAAGAAATTGGTAATGAAGAAGAAAAATAAGACATAAATGCAAAGAAG
AGAAATAAAAAAAATAAAAACTAAAAAGTTGAATTTATTGATGTTTAATAAAAGCCTTTC
ATGGGTACTGAAAAGAATTTAGAAGAAGATGAAATTCTAGATTTCGATAATAAGGCATAC
GAAATGCTTCATAGAGCTAACACTGAATGGCCTTGCTTGTCATGTGATTTTGTAACTGGA
GAACCTCATAATATTAATAACCCTGGCTTCTAAGAAATGAAAAAGTATCCTTATGATGTT
TATGTAGTAGCAGGTACCTAAAGCAAGTAATAAAATTTCATATACTTAATGAGATGGTCC
AAATTACATAAGACAAAATATGACGATGATTCTGATTACTAAGATGATGATGAAGATGAT
ATCAATAACGACGATGAACCTGAGCTTGCTTTACAAAGTATTTAAATTAAAGACCCTGTT
AATCGTATTAGAGCTATGTAAAACTCACCACTTGTTGCATATTGGACTGAAAATGGAGAT
GTCACTATTGCTGATTTGTCATCTCGTTATGATATACTTAACTAATGGGATCCAAAAATT
TTAGCTTCAAAACCCAAAAACAATCCTAAAGACAAAGTTTTTACCAAAACTTTCCATAAT
TAAGTTGAAGGTTTTGCTCTTGATTGGAGTCCTATTAAGCCTGGCAGATTGGCTTCAGGT
AGCTGTGATGGCAAAATATTTATTTATAATGCTAAGAATTTTGCCTTTAACGATTGGGAG
AGAGATCAACACCCTTATGTTTACCACGAAGGATCTGTCGAAGATCTTTAGTTCTCTCCT
GTTGAAGAATACAGTCTTGCTTCATGTTCAACTGATGGAACAATTAGAGTAGTTGATTTA
AGAGTAGGTAATAAAAAATAAGCTCAATTACTTGTTAAAGCCCACGAATGTGATGTAAAT
GTTATTTCTTGGAACCACAAGAATCCTTTCCTCATAGCATCAGGAGCAGATGATGGTTGC
TTTAAAGTTTGGGATTTACGTTATCCTGACACTGCATTTACAGAAATTTAATACCATCAA
GAACCAATTACTTCTATACAATGGTAACCAAATGAAGAATCTGTTTTATCAGTTACATCT
GCTGATAACAGACTAACTATTTGGGACTTTTCAGTTGAAAATGATGAAAACGTTGAAGAT
TACGGAGAAGAAATTCCTGATTAACTTATGTTTGTTCATTAAGGTTAATAAGACATGAAA
GAATTAAGATATCATCCTAAATATTATGAAATGATAGTAAGCACAGCTGCAGATGGTTTC
CACATATTCAAACCTGCATTAAACGACGAAGAAGAAAATGAAAAAGAAAAGGAAGATTTA
GAAAATGAAGATTTAAGCAAAATTCCTAAGATAAAAGAATCTGATTTAAATGCTTATTTA
GCTAAAATGAGCTTAAATTGA

>TTHERM_00467910(gene)
ATGAGTGACAATAAAAAGATAAGTTAAAAGAGAAAGCTTGAAACTGCTGAAGATGTTTCA
CTTAATATTAAAGAACAAAACTAGAAAAAAAATCCTAATAAGAAGAAAGGGGATTAAGCA
GTAGTTGACGAATTCGAAAAAAATGAAAATTTTGAAGAGGAAGAAGGATCTGAATTAGAA
TTTGAAGATTGTGAAGATGATATAGGTAATTTATACTTTTTTACAGCTTTTTACTAATTC
AGTTTTAAAAAATATGATTTTAATTATGTAGAGTTTATTTATTTATTATGATAAAAATAT
AATTTTGATAAAAATATATTCAAATTACAATAAAACAAATGATTATATTTTAATTATATA
GATGATGAATATGTTGATGAAAAGACATACAAAAAGATTATGTAAGGAAATTTCTAAGAA
GATGAAGAGGAATGGGAAGACGATGGAGATGATGACGATGATGAAAATGAAGAAATTGGT
AATGAAGAAGAAAAATAAGACATAAATGCAAAGAAGAGAAATAAAAAAAATAAAAACTAA
AAAGTTGAATTTATTGATGTTTAATAAAAGCCTTTCATGGGTACTGAAAAGAATTTAGAA
GAAGATGAAATTCTAGATTTCGATAATAAGGCATACGAAATGCTTCATAGAGCTAACACT
GAATGGTAATTTAAATTAACTACTTTTTACATCTTAAATATGAAGCATTTACATATATAA
ACAATCAAACCTCTTGAAAAATTTTTAAGTTTTTAGTTAGTTAAACACACAATTGATAAA
ATAAGTATTTAAGGTTAGTAAAATTCTACATGAAACTATCTATGTAGTTAGTTTTTTAGC
CAAAAATTACAATTGATCTAAAAATACAATAAACAAACAATGCACCTAAACAAAGATATT
AAATTGTTTTAAATATATTTAACAGGCCTTGCTTGTCATGTGATTTTGTAACTGGAGAAC
CTCATAATATTAATAACCCTGGCTTCTAAGAAATGAAAAAGTATCCTTATGATGTTTATG
TAGTAGCAGGTACCTAAAGCAAGTAATAAAATTTCATATACTTAATGAGATGGTCCAAAT
TACATAAGACAAAATATGACGATGATTCTGATTACTAAGATGATGATGAAGATGATATCA
ATAACGACGATGAACCTGAGCTTGCTTTACAAAGTATTTAAATTAAAGACCCTGTTAATC
GTATTAGAGCTATGTAAAACTCACCACTTGTTGCATATTGGACTGAAAATGGAGATGTCA
CTATTGCTGATTTGTCATCTCGTTATGATATACTTAACTAATGGGATCCAAAAATTTTAG
CTTCAAAACCCAAAAACAATCCTAAAGACAAAGTTTTTACCAAAACTTTCCATAATTAAG
TTGAAGGTTTTGCTCTTGATTGGAGTCCTATTAAGCCTGGCAGATTGGCTTCAGGTAGCT
GTGATGGCAAAATATTTATTTATAATGCTAAGAATTTTGCCTTTAACGATTGGGAGAGAG
ATCAACACCCTTATGTTTACCACGAAGGATCTGTCGAAGATCTTTAGTTCTCTCCTGTTG
AAGAATACAGTCTTGCTTCATGTAAAAATAATTTATATTTAGAAAATTAAAAGTTATTAA
ATTTTAACTTAAAATCAAGGTTCAACTGATGGAACAATTAGAGTAGTTGATTTAAGAGTA
GGTAATAAAAAATAAGCTCAATTACTTGTTAAAGCCCACGAATGTGATGTAAATGTTATT
TCTTGGAACCACAAGAATCCTTTCCTCATAGCATCAGGAGCAGATGATGGTTGCTTTAAA
GTTTGGGATTTACGTTATCCTGACACTGCATTTACAGAAATTTAATACCATCAAGAACCA
ATTACTTCTATACAATGGTAACCAAATGAAGAATCTGTTTTATCAGTTACATCTGCTGAT
AACAGACTAACTATTTGGGACTTTTCAGTTGAAAATGATGAAAACGTTGAAGATTACGGA
GAAGAAATTCCTGATTAACTTATGTTTGTTCATTAAGGTAATATATATTTTGAAATTTAA
AATATCATTTTACTAAATCAAAATTCAAAAATTTAGGTTAATAAGACATGAAAGAATTAA
GATATCATCCTAAATATTATGAAATGATAGTAAGCACAGCTGCAGATGGTTTCCACATAT
TCAAACCTGCATTAAACGACGAAGAAGAAAATGAAAAAGAAAAGGAAGATTTAGAAAATG
AAGATTTAAGCAAAATTCCTAAGATAAAAGAATCTGATTTAAATGCTTATTTAGCTAAAA
TGAGCTTAAATTGA

>TTHERM_00467910(protein)
MSDNKKISQKRKLETAEDVSLNIKEQNQKKNPNKKKGDQAVVDEFEKNENFEEEEGSELE
FEDCEDDIDDEYVDEKTYKKIMQGNFQEDEEEWEDDGDDDDDENEEIGNEEEKQDINAKK
RNKKNKNQKVEFIDVQQKPFMGTEKNLEEDEILDFDNKAYEMLHRANTEWPCLSCDFVTG
EPHNINNPGFQEMKKYPYDVYVVAGTQSKQQNFIYLMRWSKLHKTKYDDDSDYQDDDEDD
INNDDEPELALQSIQIKDPVNRIRAMQNSPLVAYWTENGDVTIADLSSRYDILNQWDPKI
LASKPKNNPKDKVFTKTFHNQVEGFALDWSPIKPGRLASGSCDGKIFIYNAKNFAFNDWE
RDQHPYVYHEGSVEDLQFSPVEEYSLASCSTDGTIRVVDLRVGNKKQAQLLVKAHECDVN
VISWNHKNPFLIASGADDGCFKVWDLRYPDTAFTEIQYHQEPITSIQWQPNEESVLSVTS
ADNRLTIWDFSVENDENVEDYGEEIPDQLMFVHQGQQDMKELRYHPKYYEMIVSTAADGF
HIFKPALNDEEENEKEKEDLENEDLSKIPKIKESDLNAYLAKMSLN