Identifiers and Description

Gene Model Identifier

TTHERM_00499420

Standard Name

TGP1 (Tetrahymena G-DNA binding Protein )

Aliases

PreTt07985 | 63.m00163 | 3716.m00017

Description

TGP1 G-quartet DNA-binding protein TGP1; G-quartet DNA binding protein; shows preference for binding parallel G-DNAs; activity localized predominantly in the nuclear fraction; knockout strain shows increased occurrence of extra micronuclei; not essential for growth

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• nucleus (IDA) | GO:0005634

Molecular Function

• G-quadruplex DNA binding (IDA) | GO:0051880

Biological Process

• nuclear division (IMP) | GO:0000280

Domains

• ( PF04702 ) Vicilin N terminal region
• ( PF08648 ) Protein of unknown function (DUF1777)

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_09690.1	1.0000509032773212e-171
	Description: hypothetical protein (730 aa)

General Information

No Data fetched for General Information

Associated Literature

1. Ref:10908364: Lu Q, Henderson E (2000) Two Tetrahymena G-DNA-binding proteins, TGP1 and TGP3, share novel motifs and may play a role in micronuclear division. Nucleic acids research 28(15):2993-3001
2. Ref:9512530: Lu Q, Schierer T, Kang SG, Henderson E (1998) Purification, characterization and molecular cloning of TGP1, a novel G-DNA binding protein from Tetrahymena thermophila. Nucleic acids research 26(7):1613-20
3. Ref:7509637: Schierer T, Henderson E (1994) A protein from Tetrahymena thermophila that specifically binds parallel-stranded G4-DNA. Biochemistry 33(8):2240-6

Sequences

>TTHERM_00499420(coding)
ATGACTGATCAAGGTGTCGCTAAAGAACAATACATTACCGTCGGTAGTTTGAAGGAAATT
GCAGATCCCGTCAAGAAATTCCTTAGAAAGGGAAACAGAAAGGGTAGAAATTAGAAGGAA
TTAAAGTTCAGAGCTAAGGTTGTTAACCAATAACTTGCTGACGAAACTGGCTCTATCAAC
TTCACTACTGAAGGTGTTGCCGTAAATAACAACCAAACTTATGAATTCACTGGTTCCTTG
AAGGTTGTCGACTATAAGCTCAACTTAGCTGTTACCTCTGCTACTCCTGCTAAAGATTAA
ATTGCTAATCTTGGTTCTGAATAACTCAGCAAAGCTGATATTGATCAACACTCAGGAAAG
CATATCGTTTTGATCAAGGATCTCATTAATCTTAGAATCGGTCAATCTTTCTTCGCTAGA
CCTAGAGATATTGTTCACAATAACGAATAAAGAAGAATGACAGCTACCTTAGCCGATAAC
ACTGCTGCTATCCAAGCTGAAATTAGTGTTAACAAGAAATCAATCACTTAAGAAGTACTT
GAATCCTTAAACTCTGATAAGGTCTACCTTTTCAGTGATGTTGTTCTCAACTTCAATGAA
AGTAACAAGTTAGTTGCCAGATTCAACTACAGATCAAACATTGTTGAAGCTAATGACCGT
TAGATCTAACAATTATCAAATAACAACTTGAGCGCCAAAGAATACTCAGATGAAACTGAA
AAGAAGGCTCTTACTGATGTCCTCTAAATCCATGAAAAGAAGGAAAGAGTTCACAAATAG
TAAAATAAGAATAAAAATACAAGAAATGCTCACAAGAATCACAACAGATAAAGACCAAAT
TTATAAGAAACTGAACCCGTAAAAATTAGCGGTCTCTAATAATGGAACAATAACTAGACA
GTTATTGGCAAGATTGTCTCTCTCCGCACTGAAGATAAGTCTTTACCAGCTAAGCAAGAC
GGTACCTCAACTACCATGGTCTACCTTAAGGGAACTATTGGTGACGAAACAGGTGTAATT
GATTTCGATATGGCTGAAAAAAGAGATTGCCCTCGTTTCAAAGAAAATGATGTCGTTAAA
TTCACCTCTGTAATGAACAAAGGTAGATAAAGCGCTGAAGGAAAAGTCGGTGGTCACTAC
ATCGAAGTTAAGAAATTCGGTCAATATATTATCCTTTCAGATCATAATATTAACAATGTA
AATTTAAACAATAACTTGTCTAATTTAGAACTCACCGCTCGTCCCAAGAATCCCAACCCA
AGATTCATCAAGGGAGAATTTGTTGGTGTAAAGGAAGAAGAAAAAGATGGAAACATCTAA
TATACTTACACTGTCAGAAGTAAAGAAGGTGAAGAACAATCTATCACTATTAGAAACAAA
ATTACTACACTTAAAGTTGGTGAAATTCACAAAATCGATAGAGAAAGAAAAAGATCAAGT
AGCAGACCTAATCATCAAGGTGGTTAAAGGGGAAATAGATCTCATTCTTAAAATAACAGA
AACCAAAGAAATAGAGATAAGCACCACAATAGCTAAAACAATTAACCCAATAAATACAAC
AAAAACACTTCCGTCTAAAACAATAACAACAACAAAAACTAATAAAGATCTTAATCACAA
AACCAAAGACCTCCTAGAAACTATGATAACAGACAAGGAGGTGAAAATAGAAATAATAGA
TAAAGAAATGAAAATAATAGAAATAATTTCAATGGCAATGGTCATAGAGTCAATAACCAA
AACAATCAAAGAAATAGAAATAGCTCATATCCTAGAAATAATAACTATGATCATCATCAT
AATTAATAAACCGATATTTCTGGCTTAGAACCTGGTAAGAGAGGTCAAAATGTAACTGGT
TAGGTGATTGAAGTTTCTGAATTCTCCAAGTAGATCAATGATAAAACTTTACACTTTGTC
AAGGGTAGAATTGCTGATGAAAATGCTAATATTAGATTTGATATCAAGAAACCTTAAAAC
TTAGAAATTAAGGTTGGTGAAGTCTATAATTTCAAGGACGTTAACAACAAAGTTGATGAT
AATGGTTACCACTATATTGACCTCAATAGATTTGGCAGAGTTTTCCCTTCTCATAAAAAA
TTCTAAAGCATTAATGATAAAAGAAATTGTGATGCTGATCGTTCATCAATTGAATACGTC
AAAAAAACTGTCCCTAACTGA

>TTHERM_00499420(gene)
ATGACTGATCAAGGTGTCGCTAAAGAACAATGTATAATTTTAAATGTCTATTGATGATTA
AATTCATTATAAATTTAATCTTCTTACCATTCAAAATTTATTAATTTGTCTTTGTTTTTA
CAAAAAGACATTACCGTCGGTAGTTTGAAGGAAATTGCAGATCCCGTCAAGAAATTCCTT
AGAAAGGGAAACAGAAAGGGTAGAAATTAGAAGGAATTAAAGTTCAGAGCTAAGGTATGA
AATTAAATTAACATTCTCCCTTAACTTGAAAATACCATTTTTACAGAGTGATTAAAAATC
TGCCTATTTATAAATCAATAAAGTTGATTTTAAAGCTGTATTGGTAGGTCTAGCATAGGC
TGGACATTATCAAATATTTATTTTTTAAGCTTTTACATTCCAAGTTAATTATTCTAAATT
ATTTAATATATTCAATAGGTTGTTAACCAATAACTTGCTGACGAAACTGGCTCTATCAAC
TTCACTACTGAAGGTAATTTCAAAAATGAATATTGTATATAAAATTAATTTTATATATTT
TTATAATTTATAGGTGTTGCCGTAAATAACAACCAAACTTATGAATTCACTGGTTCCTTG
AAGGTTGTCGACTATAAGCTCAACTTAGCTGTTACCTCTGCTACTCCTGCTAAAGATTAA
GTACGATTGTTTGATAAAATAAGCTAATTTTTGAAAATTAAATAAAATTTATTAGATTGC
TAATCTTGGTTCTGAATAACTCAGCAAAGCTGATATTGATCAACACTCAGGAAAGCATAT
CGTTTTGATCAAGGATCTCATTAATCTTAGAATCGGTCAATCTTTCTTCGCTAGAGTAAT
TTTTAAAATAGTTTGTAGATTTTATATTAATATTTATCATTTTTTATAATTTTAATCTTA
AAGCCTAGAGATATTGTTCACAATAACGAATAAAGAAGAATGACAGCTACCTTAGCCGAT
AACACTGCTGCTATCCAAGCTGAAATTAGTGTTAACAAGAAATGTAAACAATAAAATTTA
TTTTAACTAGATATATAGAAAGGCAAAATATTATTGCATCATGAAAAAAGTTAGCATTTG
TAGAGTAAAAGGATATAGATAAATAAACAAATCTATACATATATAGTTAGCCATAAGTAT
TAGAAGTTTTAAATTAATTTTTCAATAAATATATCAAATAGATACTTTTGTTTAGGAAAA
ATAAAGTATATTGTGGCTATCATTATAAGAATTAAATAAATCAAATTAATTATTTGTTTA
GACATTTTAAATCTAAATGAATAAATTTATTACAAGTTAATAAATACCCTTTTTTAATTA
AAGCATCTTATAAAAGTTAAAGAATAAATAAACATTTGCAAATTTATTTATTTATTTACT
TTAAACTAAATTATTAAATCACAAAGAGATTATTTAAATGATAATTTATTCTTATTTTTA
AAATCAAATCACATCTCCAATTTTGCGCCTTAATATCTTTCAACACTAATTCAAATTTGG
GTTAAATTAATTTTAATTAATATCTATTTATTGATAAATAAATAGCAATCACTTAAGAAG
TACTTGAATCCTTAAACTCTGATAAGGTCTACCTTTTCAGTGATGTTGTTCTCAACTTCA
ATGAAAGTAACAAGTTAGTTGCCAGATTCAACTACAGATCAAACATTGTTGAAGCTAATG
ACCGTTAGATCTAACAATTATCAAATAACAACTTGAGCGCCAAAGAATACTCAGATGAAA
CTGAAAAGAAGGCTCTTACTGATGTCCTCTAAATCCATGAAAAGAAGGAAAGAGTTCACA
AATAGTAAAATAAGAATAAAAATACAAGAAATGCTCACAAGAATCACAACAGATAAAGAC
CAAATTTATAAGAAACTGAACCCGTAAAAATTAGCGGTCTCTAATAATGGAACAATAACT
AGACAGTTATTGGCAAGGTAATAGTTTAACTATTCTAAATATTTTTTTTATTTTAAAATA
TATTAAAAATGTAGATTGTCTCTCTCCGCACTGAAGATAAGTCTTTACCAGCTAAGCAAG
ACGGTACCTCAACTACCATGGTCTACCTTAAGGGAACTATTGGTGACGAAACAGGTGTAA
TTGATTTCGATATGGCTGAAAAAAGAGATTGCCCTCGTTTCAAAGAAAATGATGTCGTTA
AATTCACCTCTGTAATGAACAAAGGTAGATAAAGCGCTGAAGGAAAAGTCGGTGGTCACT
ACATCGAAGTTAAGAAATTCGGTCAATATATTATCCTTTCAGATGTAATCACTTTAAATA
ATTTTCATTTAGGAATATCACTAAATAATTTATATTATTAATAAAGCATAATATTAACAA
TGTAAATTTAAACAATAACTTGTCTAATTTAGAACTCACCGCTCGTCCCAAGAATCCCAA
CCCAAGATTCATCAAGGGAGAAGTAAAAGATTATTTTTCTTAAAATTTTTAATATTCTTT
ATAATAAAGATGAATTAAAATTAAATATCAATTTTATTAGTTTGTTGGTGTAAAGGAAGA
AGAAAAAGATGGAAACATCTAATATACTTACACTGTCAGAAGTAAAGAAGGTGAAGAACA
ATCTATCACTATTAGAAACAAAATTACTACACTTAAAGTTGGTGAAATTCACAAAATCGA
TAGAGAAAGAAAAAGAGTAAATAATTTATTATAACAAATTAAAACATTTTTGTTAATTTT
TATTCTATTTTAGTCAAGTAGCAGACCTAATCATCAAGGTGGTTAAAGGGGAAATAGATC
TCATTCTTAAAATAACAGTAATTCCAAACTAATTATTAATAAAAGTATTTATCTTAGCAT
TTTTTACTTAAATAATAAAAGGAAACCAAAGAAATAGAGATAAGCACCACAATAGCTAAA
ACAATTAACCCAATAAATACAACAAAAACACTTCCGTCTAAAACAATAACAACAACAAAA
ACTAATAAAGATCTTAATCACAAAACCAAAGACCTCCTAGAAACTATGATAACAGACAAG
GAGGTGAAAATAGAAATAATAGATAAAGAAATGAAAATAATAGAAATAATTTCAATGGCA
ATGGTCATAGAGTCAATAACCAAAACAATCAAAGAAATAGAAATAGCTCATATCCTAGAA
ATAATAACTATGATCATCATCATAATTAATAAACCGATATTTCTGGCTTAGAACCTGGTA
AGAGAGGTCAAAATGTAACTGGTTAGGTAAAGATAAATTTAAAATTAAATAAAAAAATGA
TATATCTAAATAACTATAATTAGGTGATTGAAGTTTCTGAATTCTCCAAGTAGATCAATG
ATAAAACTTTACACTTTGTCAAGGGTAGAATTGCTGATGAAAATGCTAATATTAGATTTG
ATATCAAGAAACCTTAAAACTTAGAAATTAAGGTTGGTGAAGTCTATAATTTCAAGGACG
TTAACAACAAAGTTGATGATAATGGTTACCACTATATTGACCTCAATAGATTTGGCAGAG
TTTTCCCTTCTCATAAAGTAAATAATTATTTTTAAAAATATTTTATTCATATAATTATTT
GTTAAAAAATTAGAAATTCTAAAGCATTAATGATAAAAGAAATTGTGATGCTGATCGTTC
ATCAATTGAATACGTCAAAAAAACTGTCCCTAACTGA

>TTHERM_00499420(protein)
MTDQGVAKEQYITVGSLKEIADPVKKFLRKGNRKGRNQKELKFRAKVVNQQLADETGSIN
FTTEGVAVNNNQTYEFTGSLKVVDYKLNLAVTSATPAKDQIANLGSEQLSKADIDQHSGK
HIVLIKDLINLRIGQSFFARPRDIVHNNEQRRMTATLADNTAAIQAEISVNKKSITQEVL
ESLNSDKVYLFSDVVLNFNESNKLVARFNYRSNIVEANDRQIQQLSNNNLSAKEYSDETE
KKALTDVLQIHEKKERVHKQQNKNKNTRNAHKNHNRQRPNLQETEPVKISGLQQWNNNQT
VIGKIVSLRTEDKSLPAKQDGTSTTMVYLKGTIGDETGVIDFDMAEKRDCPRFKENDVVK
FTSVMNKGRQSAEGKVGGHYIEVKKFGQYIILSDHNINNVNLNNNLSNLELTARPKNPNP
RFIKGEFVGVKEEEKDGNIQYTYTVRSKEGEEQSITIRNKITTLKVGEIHKIDRERKRSS
SRPNHQGGQRGNRSHSQNNRNQRNRDKHHNSQNNQPNKYNKNTSVQNNNNNKNQQRSQSQ
NQRPPRNYDNRQGGENRNNRQRNENNRNNFNGNGHRVNNQNNQRNRNSSYPRNNNYDHHH
NQQTDISGLEPGKRGQNVTGQVIEVSEFSKQINDKTLHFVKGRIADENANIRFDIKKPQN
LEIKVGEVYNFKDVNNKVDDNGYHYIDLNRFGRVFPSHKKFQSINDKRNCDADRSSIEYV
KKTVPN