Identifiers and Description

Gene Model Identifier

TTHERM_00526990

Standard Name

THD14 (Tetrahymena Histone Deacetylase 14)

Aliases

PreTt06437 | 66.m00236 | 3722.m00094 | SHD9 | HST2

Description

THD14 SIR2 family histone deacetylase putative; NAD(+)-dependent protein deacetylase; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (IEA) | GO:0016811
• NAD+ binding (IEA) | GO:0070403
• zinc ion binding (IEA) | GO:0008270

Biological Process

• chromatin silencing (IEA) | GO:0006342
• protein deacetylation (IEA) | GO:0006476
• regulation of transcription (IEA) | GO:0045449

Domains

• ( PF01853 ) MOZ/SAS family
• ( PF02146 ) transcriptional regulator, Sir2 family
• ( PF02148 ) Zn-finger in ubiquitin-hydrolases and other

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_13434.1	9.997093137033517e-262
	Description: hypothetical protein (3586 aa)
Oxytricha	Contig9367.0.g58	1.000296925633081e-74
	Description: Sir2 family
DictyBase	DDB_G0283917	9.996907204735647e-62
	Description: sir2A on chromosome: 4 position 1272110 to 1273864
SGD	YPL015C	3.00017180903994e-49
	Description: HST2 Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro
WormBase	WBGene00004800	8.003782782428492e-46
	Description: locus:sir-2.1 NAD-dependent protein deacetylase sir-2.1 status:Partially_confirmed UniProt:Q21921 protein_id:CAA94364.1
Stentor Coeruleus	SteCoe_29687	9.602680054508676e-24
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:21933443: Slade KM, Freggiaro S, Cottrell KA, Smith JJ, Wiley EA (2011) Sirtuin-mediated nuclear differentiation and programmed degradation in Tetrahymena. BMC cell biology 12( ):40
2. Ref:18178773: Smith JJ, Torigoe SE, Maxson J, Fish LC, Wiley EA (2008) A class II histone deacetylase acts on newly synthesized histones in Tetrahymena. Eukaryotic cell 7(3):471-82

Sequences

>TTHERM_00526990(coding)
ATGAGTTCTGAAATTAGTAAAACAGATTTAAGCAATTTAGAATCAAATACAGATTCTATG
AGCGAGGCTTAGAAGGAAGCTTAATTAATTGGGTTTGCTGTAGAACCTAAGCTTGACTGC
CCTCATTTTGAATAGCTTAATGTTATCACTTTGACAGAAGTCTTTAATGATATGACATTA
GAAACTTTAAATAAGCCTTGTAAGACTTGTAACCATATTGGAGAAAACTGGATTTGCTTA
CATTGTACTGACATATTTTGCTCTAGATATATAAATAAAGATATGGCTAAACACGTTGAA
AGCAATTAAGAGCACTGTCTAGTATTTTCTTTTTCTGATGGTAGTTTTTGGTGCTACAAA
TGTGATAATTACATTTCAAATAAAACTATTAAGGATCTTTAGAAAACATTTTCAAAGGTT
AAGCATGGAGGATAAGAATCAAATGAAGAAGAAGAAGAAAAAGAAGATGATATTCATGCA
ATAGCTGCTTAACTTCTTTAGATGCATCTAAACAAAAAAGGTTAAGATGGTATTTAAGAA
GAATTTACCTACTAAAATTTAATTGATGGTTTGAGAGATATTTCTCCTGATTAAGAGAAA
AATTAAGATGACAAATACAATAACAGACAGTTCAATCGAATTGTGTTTTTGACTGGAGCA
GGTATTAGTGTGTCTGCTGGTATTCCAGATTTTAGAACTCCTGGATCTGGTTTATACTCC
CAACTCTAGAAATACAAGTTGCCATATCCTGAAGCAATTTTTGAAATAAATTATTTCAAA
CATCATCCATAGCCATTCTATACTCTTTGTAAAGAATTCTCAAGTTGCGGATCTCACTTT
ACTTCTAGTCACTTCTTTATAGCTGAAACTAATAGAAGAAATCGTCTTTTAATTAATTTT
TCTTAAAATATTGACGGATTAGAACTAGAAGCAGGACTTCCTGAATCAAAACTAGTTTAA
GCTCATGGTCATTTTAGAACAGCAAAGTGTGTTAACTGTAAAAAAGTTGCAGATATTGAA
TTATTCAATGAAGCAGTTAAAAATGATAAAATATGTTATTGCAAAGAATGTGAGGAAGGT
ATTGTAAAACCTGATATTGTTTTCTTTGGTGAGAGTCTTCCATAGAGTTTCTTTTAATAA
ATAGACAGCTTAAATAAGGCTGATTTGGTATTCGTCATGGGAACTTCTCTCAAAGTTTTT
CCATTTGCAGCTTTAGTTGATTTATTCAAAGAAGATGTCCCAATAGTATTGATTAATAGA
GAAAACCCTGGAATAAAAAGAAGAAGATTCCTATTTTTAGAAGGTGAAATAGATGACAAT
GTAGAAAAAATTATGAAGGATATTTCTTGGGATTTTCCTGAAATTAAAAGAACATACCCT
GAAGGAACTGTATTAGAGAAGAAATAAAACCTTTGA

>TTHERM_00526990(gene)
ATGAGTTCTGAAATTAGTAAAACAGATTTAAGCAATTTAGAATCAAATACAGATTCTATG
AGCGAGGCTTAGAAGGAAGCTTAATTAATTGGGTTTGCTGTAGAACCTAAGCTTGACTGC
CCTCATTTTGAATAGCTTAATGTTATCACTTTGACAGAAGTCTTTAATGATATGACATTA
GAAACTTTAAATAAGCCTTGTAAGACTTGTAACCATATTGGAGAAAACTGGATTTGCTTA
CATTGTACTGACATATTTTGCTCTAGATATATAAATAAAGATATGGCTAAACACGTTGAA
AGCAATTAAGAGCACTGTCTAGTATTTTCTTTTTCTGATGGTAGTTTTTGGTGCTACAAA
TGTGATAATTACATTTCAAATAAAACTATTAAGGATCTTTAGAAAACATTTTCAAAGGTT
AAGCATGGAGGATAAGAATCAAATGAAGAAGAAGAAGAAAAAGAAGATGATATTCATGCA
ATAGCTGCTTAACTTCTTTAGATGCATCTAAACAAAAAAGGTTAAGATGGTATTTAAGAA
GAATTTACCTACTAAAATTTAATTGATGGTTTGAGAGATATTTCTCCTGATTAAGAGAAA
AATTAAGATGACAAATACAATAACAGACAGTTCAATCGAATTGTGTTTTTGACTGGAGCA
GGTATTAGTGTGTCTGCTGGTATTCCAGATTTTAGAACTCCTGGATCTGGTTTATACTCC
CAACTCTAGAAATACAAGTTGCCATATCCTGAAGCAATTTTTGAAATAAATTATTTCAAA
CATCATCCATAGCCATTCTATACTCTTTGTAAAGAATTCTCAAGTTGCGGATCTCACTTT
ACTTCTAGTCACTTCTTTATAGCTGAAACTAATAGAAGAAATCGTCTTTTAATTAATTTT
TCTTAAAATATTGACGGATTAGAACTAGAAGCAGGACTTCCTGAATCAAAACTAGTTTAA
GCTCATGGTCATTTTAGAACAGCAAAGTGTGTTAACTGTAAAAAAGTTGCAGATATTGAA
TTATTCAATGAAGCAGTTAAAAATGATAAAATATGTTATTGCAAAGAATGTGAGGAAGGT
ATTGTAAAACCTGATATTGTTTTCTTTGGTGAGAGTCTTCCATAGAGTTTCTTTTAATAA
ATAGACAGCTTAAATAAGGCTGATTTGGTATTCGTCATGGGTAATAAATACAATATTTTT
TTTTAAAGTTATAAATCTTTTAAAATTTAATATAAATAGGAACTTCTCTCAAAGTTTTTC
CATTTGCAGCTTTAGTTGATTTATTCAAAGAAGATGTCCCAATAGTATTGATTAATAGAG
AAAACCCTGGAATAAAAAGAAGAAGATTCCTATTTTTAGAAGGTGAAATAGATGACAATG
TAGAAAAAATTATGAAGGATATTTCTTGGGATTTTCCTGAAATTAAAAGAACATACCCTG
AAGGAACTGTATTAGAGAAGAAATAAAACCTTTGA

>TTHERM_00526990(protein)
MSSEISKTDLSNLESNTDSMSEAQKEAQLIGFAVEPKLDCPHFEQLNVITLTEVFNDMTL
ETLNKPCKTCNHIGENWICLHCTDIFCSRYINKDMAKHVESNQEHCLVFSFSDGSFWCYK
CDNYISNKTIKDLQKTFSKVKHGGQESNEEEEEKEDDIHAIAAQLLQMHLNKKGQDGIQE
EFTYQNLIDGLRDISPDQEKNQDDKYNNRQFNRIVFLTGAGISVSAGIPDFRTPGSGLYS
QLQKYKLPYPEAIFEINYFKHHPQPFYTLCKEFSSCGSHFTSSHFFIAETNRRNRLLINF
SQNIDGLELEAGLPESKLVQAHGHFRTAKCVNCKKVADIELFNEAVKNDKICYCKECEEG
IVKPDIVFFGESLPQSFFQQIDSLNKADLVFVMGTSLKVFPFAALVDLFKEDVPIVLINR
ENPGIKRRRFLFLEGEIDDNVEKIMKDISWDFPEIKRTYPEGTVLEKKQNL