Identifiers and Description

Gene Model Identifier

TTHERM_00627090

Standard Name

SPO11 (Ortholog of budding yeast SPO11)

Aliases

PreTt24634 | 88.m00102 | 3822.m00628

Description

SPO11 type IIB DNA topoisomerase; Type IIB DNA topoisomerase family protein; Required for meiotic DNA DSBs. Required for the elongation of meiotic nuclei and full chromosome pairing in Tetrahymena

Genome Browser (Macronucleus)



Genome Browser (Micronucleus)

External Links

Gene Ontology Annotations

Cellular Component

Molecular Function

Biological Process

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
Tetrahymena borealis EI9_17305.1 1.999126889527329e-167
Description: hypothetical protein (435 aa)
WormBase WBGene00004985 4.998021988471165e-24
Description: locus:spo-11 Meiotic recombination protein spo-11 status:Confirmed UniProt:Q22236 protein_id:CAA92974.1
Oxytricha Contig5159.0.g3 1.9991095569230066e-20
Description: Uncharacterized protein conserved in bacteria C-term(DUF2220)
Stentor Coeruleus SteCoe_32462 8.533047625744066e-17
Description: None
SGD YHL022C 1.000361553249356e-16
Description: SPO11 Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation

General Information

No. Gene Name(s) Paragraph Text
15 SPO11 Spo11p induces DSBs and at the same time triggers the elongation of meiotic nuclei (crescents) via an ATR-dependent response in Tetrahymena. The crescent resembles the conserved bouquet arrangement and the fission yeast horsetail nucleus. It promotes meiotic chromosome pairing. Thus, by nuclear elongation and the ensuing close juxtapositioning of homologous chromosome regions within the tubular nucleus, Spo11p ensures that DSBs formed by its activity can be repaired by homologous recombination.
138 SPO11 The gene model is incorrect. See gene_000008668 in FGD for the correct transcript sequence

Associated Literature

  1. Ref:28621664: Akematsu T, Fukuda Y, Garg J, Fillingham JS, Pearlman RE, Loidl J (2017) Post-meiotic DNA double-strand breaks occur in Tetrahymena, and require Topoisomerase II and Spo11. eLife 6( ):
  2. Ref:20422424: Lukaszewicz A, Howard-Till RA, Novatchkova M, Mochizuki K, Loidl J (2010) MRE11 and COM1/SAE2 are required for double-strand break repair and efficient chromosome pairing during meiosis of the protist Tetrahymena. Chromosoma 119(5):505-18
  3. Ref:19297526: Loidl J, Mochizuki K (2009) Tetrahymena meiotic nuclear reorganization is induced by a checkpoint kinase-dependent response to DNA damage. Molecular biology of the cell 20(9):2428-37
  4. Ref:18522989: Mochizuki K, Novatchkova M, Loidl J (2008) DNA double-strand breaks, but not crossovers, are required for the reorganization of meiotic nuclei in Tetrahymena. Journal of cell science 121(Pt 13):2148-58

Sequences

>TTHERM_00627090(coding)
ATGAATTTCAACCAGTTAAAATCTCTAAATGCTCAAATACTCCAAAGACACTTTGAAGCT
CTCAATTTTCTTGGAATTTAATATTCAATACATGATTTAGATAAAGAAAGTATCATTAAC
AGGTTAAGAGATTTTTTCTTTTAACTTCTGAAAGAGATTATTATTTAGAATTCATGCCTT
AAACTTATGGAAAAAAAAGATATATAATTTGACTACTTTTATTTTATACATGCAGAGTAG
CAATATATCTCCAACTAATCCTTAGAAATAACTAGCTAAAAATATCAAAATTTTTACAGT
CAATTCTAATCATTAAGAAAACTTAACAAAGAAGGAAAAAATAAAACAATGGTTATCCAT
AAGAATAATTTAAAATCATTAGAAAAGTTACTTTTTTGCATAAAATAAATTTTGAATGCC
CTTAAAAATGATTTTTAAATCACAAAAAGAGAAATATTCTACACAAATGTTGAACTTTTT
GACTAAAATTAGTAAAACTTAGAAAAAATTATTCAAATATTGCAAAATTAATTAAGACTG
CCAAGAAATTGTTTAAATATTATTGCTTCAGCTAAAGGTTTAGTAACTGGTAATGTATAA
TTCTAAGTTAGTTCTTAAGCTGAATTTATTGATCTTAGTAAAAATTTTGGAGAAGTCAGG
CAAATATAGCCAAAGGAAGAAATTTTATGGATTGAAACAAACTCTGCATTTATATTGGTT
GTAGAGAAAGAAACTGTTTTTTAAAAAATCATAGCTGAAAAAGACGAATAGCTTTTGAAG
AATTGTATAATGATTACTGGGAAAGGGTATGGCGATTATAGCACCAAATAATATATAAAG
ATGCTAACTGCTAACAATCCAAACTCGCCTTTATTTTATTTAGGGGATTTCGATCCATTT
GGCTTAGATATACTCTTCAATTACACTTTTGGTTCCGAAAATTCTGTCTACTAACAAGAT
AACTTGCCAAATATTCATTTCTTAGGTCTATCAAGCTTTGATATTTTGGATTTTAATTAA
TAATCTGATGAAAAAAAATTCAATGTTGAAAACAATTTAAGCAAACAAGATATTTGTAAG
CTGGATGCCTTAATCGCCAAATTTGAATTTAATAAAATAGACTCAAATAAATTAGATGAT
CTCACTAGTTATCAGATAAATAGATGGAAGAAATGGATTGAAAATGCTGAGTTTATAAGA
CAAAACAATACAAAATATGAAATCGAAGACATTTATCCATTCCTTAGCTAAAAAAATTTA
ACTTTATCATAATTTATTATAAATAAAATCTAATCAAACAAATATTTATGA


>TTHERM_00627090(gene)
ATGAATTTCAACCAGTTAAAATCTCTAAATGCTCAAATACTCCAAAGACACTTTGAAGCT
CTCAATTTTCTTGGAATTTAATATTCAATACATGATTTAGATAAAGAAAGTATCATTAAC
AGGTTAAGAGATTTTTTCTTTTAACTTCTGAAAGAGATTATTATTTAGAATTCATGCCTT
AAACTTATGGAAAAAAAAGATATATAATTTGACTACTTTTATTTTATACATGCAGAGTAG
CAATATATCTCCAACTAATCCTTAGAAATAACTAGCTAAAAATATCAAAATTTTTACAGT
CAATTCTAATCATTAAGAAAACTTAACAAAGAAGGAAAAAATAAAACAATGGTTATCCAT
AAGAATAATTTAAAATCATTAGAAAAGTTACTTTTTTGCATAAAATAAATTTTGAATGCC
CTTAAAAATGATTTTTAAATCACAAAAAGAGAAATATTCTACACAAATGTTGAACTTTTT
GACTAAAATTAGTAAAACTTAGAAAAAATTATTCAAATATTGCAAAATTAATTAAGACTG
CCAAGAAATTGTTTAAATATTATTGCTTCAGCTAAAGGTTTAGTAACTGGTAATGTATAA
TTCTAAGTTAGTTCTTAAGCTGAAGTAAAATTCCTTTATGTATTTCCTTGATTTAACTCA
CAAAAATTCTTTAATAGTTTATTGATCTTAGTAAAAATTTTGGAGAAGTCAGGCAAATAT
AGCCAAAGGAAGAAATTTTATGGATTGAAACAAACTCTGCATTTATATTGGTTGTAGAGA
AAGAAACTGTTTTTTAAAAAATCATAGCTGAAAAAGACGAGTAAGTTCCTATTAATTTAT
TTATTAGTTTTATGATTTTTAATATTTTGATTTATATAATTAGATAGCTTTTGAAGAATT
GTATAATGATTACTGGGAAAGGGTATGGCGATTATAGCACCAAATAATATATAAAGATGC
TAACTGCTAACAATCCAAACTCGCCTTTATTTTATTTAGGGGATTTCGATCCATTTGGCT
TAGATATACTCTTCAATTACACTTTTGGTTCCGAAAATTCTGTCTACTAACAAGATAACT
TGCCAAATATTCATTTCTTAGGTCTATCAAGCTTTGATATTTTGGATTTTAATTAATAAT
CTGATGAAAAAAAATTCAATGTTGAAAACAATTTAAGCAAACAAGATATTTGTAAGCTGG
ATGCCTTAATCGCCAAATTTGAATTTAGTAAATTGAATTAACTTAAAAATAATTATTTAT
AAATACCAAAAGATAAAATAGACTCAAATAAATTAGATGATCTCACTAGTTATCAGATAA
ATAGATGGAAGAAATGGATTGAAAATGCTGAGTTTATAAGACAAAACAATACAAAATATG
AAATCGAAGACATTTATCCATTCCTTAGCTAAAAAAATTTAACTTTATCATAATTTATTA
TAAATAAAATCTAATCAAACAAATATTTATGA


>TTHERM_00627090(protein)
MNFNQLKSLNAQILQRHFEALNFLGIQYSIHDLDKESIINRLRDFFFQLLKEIIIQNSCL
KLMEKKDIQFDYFYFIHAEQQYISNQSLEITSQKYQNFYSQFQSLRKLNKEGKNKTMVIH
KNNLKSLEKLLFCIKQILNALKNDFQITKREIFYTNVELFDQNQQNLEKIIQILQNQLRL
PRNCLNIIASAKGLVTGNVQFQVSSQAEFIDLSKNFGEVRQIQPKEEILWIETNSAFILV
VEKETVFQKIIAEKDEQLLKNCIMITGKGYGDYSTKQYIKMLTANNPNSPLFYLGDFDPF
GLDILFNYTFGSENSVYQQDNLPNIHFLGLSSFDILDFNQQSDEKKFNVENNLSKQDICK
LDALIAKFEFNKIDSNKLDDLTSYQINRWKKWIENAEFIRQNNTKYEIEDIYPFLSQKNL
TLSQFIINKIQSNKYL