Identifiers and Description

Gene Model Identifier

TTHERM_00726300

Standard Name

UPF1 (UP-Frameshift 1)

Aliases

PreTt21895 | 117.m00147

Description

phage head-tail adaptor family protein putative; An RNA helicase essential for nonsense-mediated mRNA decay (NMD)

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• cytoplasm (IEA) | GO:0005737

Molecular Function

• ATP binding (IEA) | GO:0005524
• DNA binding (IEA) | GO:0003677
• helicase activity (IEA) | GO:0004386
• hydrolase activity (IEA) | GO:0016787
• zinc ion binding (IEA) | GO:0008270

Biological Process

• nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (IEA) | GO:0000184

Domains

• ( PF00004 ) ATPase, AAA family
• ( PF00270 ) DEAD/DEAH box helicase
• ( PF04851 ) type III restriction enzyme, res
• ( TIGR00376 ) DNA helicase, putative
• ( TIGR01447 ) exodeoxyribonuclease V, alpha subunit
• ( TIGR01563 ) phage head-tail adaptor, putative

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_17483	0
	Description: None
WormBase	WBGene00004880	9.997093137033517e-262
	Description: locus:smg-2 Regulator of nonsense transcripts 1 status:Confirmed UniProt:O76512 protein_id:CCD73461.1
Tetrahymena borealis	EI9_04617.1	9.997093137033517e-262
	Description: phage head-tail adaptor, family protein (1081 aa)
DictyBase	DDB_G0288923	9.997093137033517e-262
	Description: upf1 on chromosome: 5 position 2130048 to 2134208
Oxytricha	Contig17825.0.g106	9.997093137033517e-262
	Description: RNA helicase (UPF2 interacting domain)
SGD	YMR080C	9.997093137033517e-262
	Description: NAM7 ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance

General Information

No Data fetched for General Information

Associated Literature

1. Ref:22184018: Lu XY, Xiong J, Yuan DX, Miao W (2011) [Alternative splicing of an ATP-binding cassette transporter ABCC10 in Tetrahymena thermophila]. Dong wu xue yan jiu = Zoological research 32(6):605-10

Sequences

>TTHERM_00726300(coding)
ATGAGTTAGAATAAGTAAAAGAGAAAAGTTGATTCAAGTAGTGAAGGTGAAGAGAGTGAA
GATGATTCTACAGAATAAAATTAAGATAATGAATCCACATAATAAGGAGGAGAAAATGAA
GATGAAGTATTTGATATTGATTTTAAAAATTTACCCTCACACGCATGCGAATATTGTGGT
GTCCATAATAAGAATAGTGTTATAAAGTGTCTAAATAAAGATTGCAACAAATGGTTTTGC
AATGGTAAACAATAAGGTTAGGGAGCATCTCATATTATTATGCATTTAGTTAAATCTAAA
CACAAAGAAATTTAGGTACACCCTGAGAACTAAAACTCAGATACTACTATTGAATGTTAC
ATTTGTGAGAATAAAAATATATACTTATTAGGTTTAGTTCACTTAAAAAATTAAGAAGAT
CAAGGTTTGATTATTTGTAGACAACCTTGCTTGAATCTAAAAAAGTATAATGAGATGTAA
TGGGAAATTGAAAAATGGAATCCTTTAATTGATGAAAAGATGATTGTTTCTTGGTTAGCT
TCACCACCAAGCGCCAAGCAAATGGAAAAAGGGTTTAAAGTTTCTTAGAAGCAAATTTAC
GAGTACGAGGAGTAAATTAAAACTAACCCCAATTTTAAATTAGCATAAGGTGCTGCTTAA
AGTTAAGTCAAGAAACTAAAACCAGTGTTATTGCGTTATAAAACTGGTAAATAGTATTTC
TAAACATTCTACAACTTAATTGAAGCTGAGGCTAACTATGACAAAGCTTTAAAGGAAAAT
CTTCATTACAACAGCATTACTGTTAAGTGGGATATTTCTTTAAAGAGTAGAAAAGTGGCT
CAATTTGTATTGCCTTAGGGAGAAGATAATGAATTCAACCTTTTGAGTGGTTCTGAATTA
AAGATCACCTACAAAAAGAATAAGAAAGATGAAGAATGGTCTGCCAAGGGTACTATAACT
AAAGTCGGAAATAATGATGAAGTCTTTGTTGAACTAAGTCATAATGTAAAAGATACCCCA
CCATCAGGAAAGGGATACACAATAGAATTTGTATGGAAACATACTGCTGTTAAGCGTATT
AAAAAAGGTATTAAGAAATTCTGGTAAGATGAAAAATGCATTAGCTCGTTCTTATACTTT
TAAATTCTTGGTCATTAGAACGAAGAACAGTAAACACCTACTTTGGATATACAACTTCCT
AAGCATTATTCTTTACCCAAAATGCCTGAGCTCAACTATTATTAAGTTGAAGCAGTTAAA
AAGGCTCTTCAATAACCTCTTTGCTTGATTTAAGGTCCTCCAGGTACTGGTAAAACTTTT
ACAAGTACAGCAATCATTTACCATCTAGTAAAGAACATTTAAAAGAGCGGATAGAGAGGC
CAGGTTTTAGTCTGTGCTCCTTCTAACATCGTTGTAGATTAACTAGCAGAAAGAATACAC
TAGGCTGGTATCAAGGTAGTTAGAATGTGCTCTCGTTCTAGAGAAATGATTTCATCATCA
GTAGAATTCTTAACTTTGCACAATCAAGTAAGAAGTTTAGATTTCGATGAATACAAAGAA
ATGTAAAAGTTACTCGAGCTTAAAGAAGATTAAGGTGAGTTAGACCATGATGATGAAGAC
AAATATTATAGTTTAAAAAGATAAGGTGAAAAGGAAATTTTGAGAAATGCGGAAGTTATT
TGTTCGACTTGTATATCATCAGCAGACCCAAGATTGAAGGATATTAGATTCAAGCATGTT
CTAATTGATGAAGCTACATAAGCTATTGAACCAGAATGTTTGTTACCTATGTTGAAAGGA
GCTAAGCATGTCATTTTAGTAGGAGATCATAGATAATTGGGTCCTGTTGTTACTTGCAGA
GATACTGCAAAGGCTGGTTTGAATAAAAGTCTTTTTGAAAGAATGGTTAGTATGGGTATT
AGACCAATTAGATTGTAAGTTTAGTACAGAATGCATCCTGATCTCTCTATTTTCCCTTCA
AATACTTTCTATGAAGGAACTTTGTAAAATGGTGTAACTTTCAACGATAGACAATTCCAT
GGTGAATTCCCGTGGCCTAATAAAAATAAACCTTTGATGTTTTTAAATTCCTGTGGTGTT
GAAGAAATATCTTCAAGTGGTACCAGTTACTTAAATAGATAAGAAACTGCCTTAATTGAA
GATATTGTATTCAGATTAATAAAAGCTAAGGTAAAACCTGAATAAATAGGTATCATCACT
CCTTATAAAGGTTAAAGATTCTATATTGGCGATTACTTAAGTAAGAACGGACGTTTGAAC
CATGTCTTATATAGATAAATAGAAATTGCCTCTGTTGATGGATTTTAAGGAAGAGAAAAA
GATTATATAATTATTTCTTGTGTAAGAAGCAATGAGTGCTAAGGTATTGGTTTTTTAACA
GACCCACGTCGTCTTAACGTAGCTATTACAAGAGCTAGATACGGACTTATTATTGTCGGT
AATGCTAAGGTACTTGCAAGAGATAATCTTTGGAACAATCTTCTCAATCATATGAAAGAA
AACAAGGTTTTGGTTGATGGAACACTAAATGATCTAAGACAATGCACATTAAAGTTCAGA
TAACCTCAAAAATATGTACCTGAAAGATCAGAATTTTAAGATAACAATAATGACAATGAT
GATGCCAGGTCAACAGTTAGTTACAAAATAGATAACATAAACAACTTTGATCTTGAGTTG
CCTATTGGATTTGGATTTAGAAACAGTGAGTTTGGATTTAACAAAATGCCCTAAACAGAA
TAGTTCAGAAAGATTCAAAAAGATTAAACTCTCAATATGGTAAAGAATTATGGAACTTAG
CTTTACAATAACTAGAATAATTAAGAGATTTTCTTCTTTGGTTAGGACAGAGAATAAAAC
TATTATGATATTCCAAGCTAACAAAAAAATAATGTTCAGCCTAATTAGTTTAGAAACAAT
GGAGGCTTTACTAATTTGAATCCAAATTCTAATAATTAGAATGATTTCAATGGAAGAAAT
AGAGATGACTACAATAATTAAGATGAATAAGCTGAAGATCAAGAAGATGATAACTATACA
AATGGTGGTGATGAAATTTACACAGAAAAGCAAAACGATTACAACAATCCAATAATCTAG
AAGTCATAACCAAAAGATAACTCCTAGAACAGCAAATCAACTTCTTTTGGAGGTATCGGT
ACATTCAGTATAGGTGCTTAGAAATATAGTTAGTTTGATTTAGATTTACCTGATGAATTT
AAATGA

>TTHERM_00726300(gene)
ATGAGTTAGAATAAGTAAAAGAGAAAAGTTGATTCAAGTAGTGAAGGTGAAGAGAGTGAA
GATGATTCTACAGAATAAAATTAAGATAATGAATCCACATAATAAGGAGGAGTATATATT
TATGCTTAATTTCATTTATTATTACTTCGAATTAAATATCGAAGAATATTTTTAAATCTA
ACTTTTAAAAAAAGGAAAATGAAGATGAAGTATTTGATATTGATTTTAAAAATTTACCCT
CACACGCATGCGAGTATGTTAATGAAATAAAATATTGGTTTTTGATTAAATTAAATAATA
TAAAATTAAAGATATTGTGGTGTCCATAATAAGAATAGTGTTATAAAGTGTCTAAATAAA
GATTGCAACAAAGTAAATATTAAATTTTAGCCTTATAGATTGTTTTAAATATTTTTTATA
AAAATAAATCATTAGTGGTTTTGCAATGGTAAACAATAAGGTTAGGGAGCATCTCATATT
ATTATGCATTTAGTTAAATCTAAACACAAAGTATGTTTGTTGATTATTAAATAGCAAATA
TCAATTTATCTTTAGATTTAAAAATGTTTTAGAGCAAAAGATAAAATTGGCTAAAAAAGT
AGAATATTAATTTTCATTTATCTAAAATTAGGAAATTTAGGTACACCCTGAGAACTAAAA
CTCAGATACTACTATTGAATGTTACATTTGTGAGAATAAAAATATATACTTATTAGGTTT
AGTTCACTTAAAAAATTAAGAAGATCAAGTAATAATTTAGCTTTGTTAGTTTTATTTTAA
AATTTTCGAAAAATAAACAACTTTAATTGTTTTCCAAAATGAATGTTAAAATAGGGTTTG
ATTATTTGTAGACAACCTTGCTTGAATCTAAAAAAGTATAATGAGATGTAATGGGAAATT
GAAAAATGGAATCCTTTAATTGATGAAAAGATGATTGTTTCTTGGTTAGCTTCACCACCA
AGCGCCAAGCAAATGGAAAAAGGGTTTAAAGTTTCTTAGAAGCAAATTTACGAGTACGAG
GAGTAAATTAAAACTAACCCCAATTTTAAAGTAAATCTATTGAAAAAAATCTTCAAAATT
TAATTTATTGCTTTTTAAATCTTCAAATTTAGTTAGCATAAGGTGCTGCTTAAAGTTAAG
TCAAGAAACTAAAACCAGTGTTATTGCGTTATAAAACTGGTAAATAGTATTTCTAAACAT
TCTACAACTTAATTGAAGCTGAGGCTAACTATGACAAAGCTTTAAAGGAAAATCTTCATT
ACAACAGCATTACTGTTAAGTAAATCTTTGTTATTTTTTTAAATTATATTGAATCTCATT
TCGTGTGCGTTTAATAGGTGGGATATTTCTTTAAAGAGTAGAAAAGTGGCTCAATTTGTA
TTGCCTTAGGGAGAAGATAATGAATTCAACCTTTTGAGTGGTTCTGAATTAAAGATCACC
TACAAAAAGAATAAGAAAGATGAAGAATGGTCTGCCAAGGGTACTATAACTAAAGTCGGA
AATAATGATGAAGTCTTTGTTGAACTAAGTCATAATGTAAAAGATACCCCACCATCAGGA
AAGGGATACACAATAGAATTTGTATGGAAACATACTGCTGTTAAGCGTATTAAAAAAGGT
ATTAAGAAATTCTGGTAAGATGAAAAATGCATTAGCTCGTTCTTATACTTTTAAATTCTT
GGTCATTAGAACGAAGAACAGTAAACACCTACTTTGGATATACAACTTCCTAAGCATTAT
TCTTTACCCAAAATGCCTGAGCTCAACTATTATTAAGTTGAAGCAGTTAAAAAGTAAATG
CTTTATTTGATGATTCTAGTTTCTATTGATATTTTTTAATAAAAGGGCTCTTCAATAACC
TCTTTGCTTGATTTAAGGTCCTCCAGGTACTGGTAAAACTTTTACAAGTACAGCAATCAT
TTACCATCTAGTAAAGAACATTTAAAAGAGCGGATAGAGAGGCCAGGTTTTAGTCTGTGC
TCCTTCTAACATCGTTGTAGATTAACTAGCAGAAAGAATACACTAGGCTGGTATCAAGGT
AGTTAGAATGTGCTCTCGTTCTAGAGAAATGATTTCATCATCAGTAGAATTCTTAACTTT
GCACAATCAAGTAAAATATTATTTATCGCGAATATAGCTATTTGATTTAAAGAGCTATTT
TAGAATATTTAACTAATAAACTAAACATTAATAGGTAAGAAGTTTAGATTTCGATGAATA
CAAAGAAATGTAAAAGTTACTCGAGCTTAAAGAAGATTAAGGTGAGTTAGACCATGATGA
TGAAGACAAATATTATAGTTTAAAAAGATAAGGTGAAAAGGAAATTTTGGTAAATATTTT
ATTATTTCTAAAGAGAAACTAAAAAACTTTTAAAATAAAGAGAAATGCGGAAGTTATTTG
TTCGACTTGTATATCATCAGCAGACCCAAGATTGAAGGATATTAGATTCAAGCATGTTCT
AATTGATGAAGCTACATAAGCTATTGAACCAGAATGTTTGTTACCTATGTTGAAAGGAGC
TAAGCATGTAGATTTAAAAATACTTTATTCATCCATCTTATTAATTAATTATGTAATTAG
GTCATTTTAGTAGGAGATCATAGATAATTGGGTCCTGTTGTTACTTGCAGAGATACTGCA
AAGGCTGGTTTGAATAAAAGTCTTTTTGAAAGAATGGTTAGTATGGGTATTAGACCAATT
AGATTGTAAGTTTAGTACAGAATGCATCCTGATCTCTCTATTTTCCCTTCAAATACTTTC
TATGAAGGAACTTTGTAAAATGGTGTAACTTTCAACGATAGACAATTCCATGGTGAATTC
CCGTGGCCTAATAAAAGTATATAATAATAATTTAAAAGAAATAAAAGTAATAAATAAGCT
TTTTTTAAAAAAAGATAAACCTTTGATGTTTTTAAATTCCTGTGGTGTTGAAGAAATATC
TTCAAGTGGTACCAGTTACTTAAATAGATAAGAAACTGCCTTAATTGAAGATATTGTATT
CAGATTAATAAAAGCTAAGGTAAAACCTGAATAAATAGGTATCATCACTCCTTATAAAGG
TTAAAGATTCTATATTGGCGATTACTTAAGTAAGAACGGACGTTTGAACCATGTCTTATA
TAGATAAATAGAAGTAAAATCTTAAAATTTTTAATTCTATATTAAAAAAATCCTCAATTT
AAATTATTAAAGATTGCCTCTGTTGATGGATTTTAAGGAAGAGAAAAAGATTATATAATT
ATTTCTTGTGTAAGAAGCAATGAGTGCTAAGGTATTGGTTTTTTAACAGACCCACGTCGT
CTTAACGTAGCTATTACAAGAGCTAGGTAAAAATTATTTAAATTAAAAAAATCATTAATT
TTTATTTCTAAATAAAAGATACGGACTTATTATTGTCGGTAATGCTAAGGTACTTGCAAG
AGATAATCTTTGGAACAATCTTCTCAATCATATGAAAGAAAACAAGGTTTTGGTTGATGG
AACACTAAATGATCTAAGACAATGCACATTAAAGTTCAGATAACCTCAAAAATATGTACC
TGAAAGATCAGAATTTTAAGATAACAATAATGACAATGATGATGCCAGGTCAACAGTTAG
TTACAAAATAGGTAATTTCACAACAACAAAAAACAAAAAAGGTTAATTAATATAATAAAA
TATAAAAAGATAACATAAACAACTTTGATCTTGAGTTGCCTATTGGATTTGGATTTAGAA
ACAGTGAGTTTGGATTTAACAAAATGCCCTAAACAGAATAGTTCAGAAAGATTCAAAAAG
GTAAATTTAAATTTAAAAAGAAATAAAATCAAAATAAAATATAAAAATGATAAATAATTA
AATTATAAAACACTCTAGATTAAACTCTCAATATGGTAAAGAATTATGGAACTTAGCTTT
ACAATAACTAGAATAATTAAGAGATTTTCTTCTTTGGTTAGGACAGAGAATAAAACTATT
ATGATATTCCAAGCTAACAAAAAAATAATGTTCAGCCTAATTAGTTTAGAAACAATGGAG
GCTTTACTAATTTGAATCCAAATTCTAATAATTAGAATGATTTCAATGGAAGAAATAGAG
ATGACTACAATAATTAAGATGAATAAGCTGAAGATCAAGAAGATGATAACTATACAAATG
GTGGTGATGAAATTTACACAGAAAAGCAAAACGATTACAACAATCCAATAATCTAGAAGT
CATAACCAAAAGATAACTCCTAGAACAGCAAATCAACTTCTTTTGGAGGTATCGGTACAT
TCAGTATAGGTGCTTAGAAATATAGTTAGTTTGATTTAGATTTACCTGATGAATTTAAAT
GA

>TTHERM_00726300(protein)
MSQNKQKRKVDSSSEGEESEDDSTEQNQDNESTQQGGENEDEVFDIDFKNLPSHACEYCG
VHNKNSVIKCLNKDCNKWFCNGKQQGQGASHIIMHLVKSKHKEIQVHPENQNSDTTIECY
ICENKNIYLLGLVHLKNQEDQGLIICRQPCLNLKKYNEMQWEIEKWNPLIDEKMIVSWLA
SPPSAKQMEKGFKVSQKQIYEYEEQIKTNPNFKLAQGAAQSQVKKLKPVLLRYKTGKQYF
QTFYNLIEAEANYDKALKENLHYNSITVKWDISLKSRKVAQFVLPQGEDNEFNLLSGSEL
KITYKKNKKDEEWSAKGTITKVGNNDEVFVELSHNVKDTPPSGKGYTIEFVWKHTAVKRI
KKGIKKFWQDEKCISSFLYFQILGHQNEEQQTPTLDIQLPKHYSLPKMPELNYYQVEAVK
KALQQPLCLIQGPPGTGKTFTSTAIIYHLVKNIQKSGQRGQVLVCAPSNIVVDQLAERIH
QAGIKVVRMCSRSREMISSSVEFLTLHNQVRSLDFDEYKEMQKLLELKEDQGELDHDDED
KYYSLKRQGEKEILRNAEVICSTCISSADPRLKDIRFKHVLIDEATQAIEPECLLPMLKG
AKHVILVGDHRQLGPVVTCRDTAKAGLNKSLFERMVSMGIRPIRLQVQYRMHPDLSIFPS
NTFYEGTLQNGVTFNDRQFHGEFPWPNKNKPLMFLNSCGVEEISSSGTSYLNRQETALIE
DIVFRLIKAKVKPEQIGIITPYKGQRFYIGDYLSKNGRLNHVLYRQIEIASVDGFQGREK
DYIIISCVRSNECQGIGFLTDPRRLNVAITRARYGLIIVGNAKVLARDNLWNNLLNHMKE
NKVLVDGTLNDLRQCTLKFRQPQKYVPERSEFQDNNNDNDDARSTVSYKIDNINNFDLEL
PIGFGFRNSEFGFNKMPQTEQFRKIQKDQTLNMVKNYGTQLYNNQNNQEIFFFGQDREQN
YYDIPSQQKNNVQPNQFRNNGGFTNLNPNSNNQNDFNGRNRDDYNNQDEQAEDQEDDNYT
NGGDEIYTEKQNDYNNPIIQKSQPKDNSQNSKSTSFGGIGTFSIGAQKYSQFDLDLPDEF
K