Identifiers and Description

Gene Model Identifier

TTHERM_01000180

Standard Name

CSKA2 (CaSein Kinase Alpha subunit 2)

Aliases

PreTt15737 | 190.m00047 | 3820.m00272

Description

Casein kinase II alpha subunit; Protein kinase domain containing protein. Sequence similarity to the CK2 protein kinase family (Eisen et al.- 2006). Tetrahymena CKII-complex appears to have two alpha subunits and one regulatory beta subunit (Nabeel-Shah et al., 2023).

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

Molecular Function

Biological Process

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
Tetrahymena borealis EI9_19752.1 9.997093137033517e-262
Description: protein kinase domain-containing protein (345 aa)
Oxytricha Contig13714.0.g6 2.0007864815129413e-165
Description: Protein kinase domain
WormBase WBGene00002191 2.9999444238666675e-148
Description: locus:kin-3 Casein kinase II subunit alpha status:Confirmed UniProt:P18334 protein_id:CCD61302.1
DictyBase DDB_G0276885 5.0011520612761715e-143
Description: casK on chromosome: 2 position 7370887 to 7372679
SGD YOR061W 3.001349705199738e-130
Description: CKA2 Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
Stentor Coeruleus SteCoe_32987 1.7785284761271306e-68
Description: None

General Information

No. Gene Name(s) Paragraph Text
166 CSKA2 CKII subunits including CSKA1, CSKA2, and CSKB1 co-purified with Cac2 subunit of putative CAF1-complex in Tetrahymena. Tetrahymena appears to contain a single putative homolog of the two regulatory beta subunits of CKII that are found in humans. Affinity purification followed by mass spectrometry (AP-MS) analysis of TTHERM_00780530 (CSKB1) identified a large number of proteins to co-purify, suggesting that CKII clients might include functionally diverse proteins in Tetrahymena (Nabeel-Shah et al., 2023).

Associated Literature

  1. Ref:37024975: Nabeel-Shah S, Garg J, Ashraf K, Jeyapala R, Lee H, Petrova A, Burns JD, Pu S, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J (2023) Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation. Epigenetics & chromatin 16:10
  2. Ref:16933976: Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA,

Sequences 

>TTHERM_01000180(coding)
ATGGATTACAAAGTAATAAGCTCAAAACCAAAATTTTATGCAGATGCAAATTTAAAAAAA
TCAGCTGAATACTATGACTATGAAAACTTAGAAATAGAATGGGGTGAATAGGAAAACTAT
GAAGTGATAAGAAAGTTAGGAAGAGGTAAATATTCCGAAGTTTTCGAAGGAATCAACTCT
TTGAATAATGAGAAATGCGTTATTAAAGTCCTTAAGCCAATCAGAAAGAAAAAAATAAAG
AGAGAAATCTCTATTTTAAAGAATCTTAGTGGAGGCCCTAACATTGTTTAACTTCTTGAC
ATAGTAAAGGATCCTGCTTCTAAGTGCACTTCATTTGTTTTTGAGTATGTAAACAATATT
GATTACAGAGAGCTTTATCCAAAGTTAAGCGATTTTGATGTTAGATTTTATATTTTTGAA
GTGCTAAAGGCTTTAGATTTTTGTCATAGTTAAGGTATTATGCATAGAGATGTAAAACCA
CATAATATTATGATAGATCATGAAAAGAAATAACTAAGACTCATAGATTGGGGTTTGGCT
GAGTACTACTTCCCAGGAAAAGATTATAATGTAAGAGTAGCTTCAAGATATTTTAAAGGG
CCTGAATTGTTAGTAGATTACTAATACTATGATTACAGTTTGGATATTTGGAGCTTGGGT
GCTATGTTTGCTGGTATGATTTTCAAAAAAGAACCATTCTTCTAAGGAAACGATAACTAT
GATTAACTTGAAAAGATAGCAAGAGTCCTTGGTACAAATGAATTATATGATTATCTAAAT
ACATATAACCTCGAGTTAGATCCTAAATTTGAAGGAATTTTGGGCAAGCATACAAAGAAA
CCTTGGTCAAAGTTTGTTAATAATGACAATAAGAATTTAGCAGTAAATGAAGCAATTGAC
CTTCTATCAAAGATGCTTGTTTATGATCATGCTTAAAGAATAACACCTAAAGAAGCCATG
CAACATGCTTATTTCTTCCCTATCTTGTAATACCATGAAAAAAACTCTAAGCCTGAAGAA
TCAAATAAAAAATGA


>TTHERM_01000180(gene)
ATGGATTACAAAGTAATAAGCTCAAAACCAAAATTTTATGCAGATGCAAATTTAAAAAAA
TCAGCTGAATACTATGACTATGAAAACTTAGAAATAGAATGGGGGTAAACCTTTTTTAGC
AAATAGTTACTTCCTTAATTTGATAATCCATAAAATAATCATTACCAATTTAGTTTTTTT
ACAATAGCTTCTATTAAAAAAATATTTTTATGGAAATGCCTTCTCTTTCAAATGTTTAAT
TTAAAGGCATAAGTTGGATTGAGAGAAAATTTTAAGATTTATATTATTAGCATGAATGAA
ATTTATGTAAAATAACTAAGAATTTTTTAAATTTATTAGTGAATAGGAAAACTATGAAGT
GATAAGAAAGTTAGGAAGAGGTAAATATTCCGAAGTTTTCGAAGGAATCAACTCTTTGAA
TAATGAGAAATGCGTTATTAAAGTCCTTAAGCCAAGTATTATTTATTAATTTCACCTTGT
TTATCAATATAACTGTTTATTATGTATTTATTTTAGTCAGAAAGAAAAAAATAAAGAGAG
AAATCTCTATTTTAAAGAATCTTAGTGGAGGCCCTAACATTGTTTAACTTCTTGACATAG
TAAAGGATCCTGCTTCTAAGTGCACTTCATTTGTAGAATAGATTATCGTTAGGCAAATAA
TAATTAACTTTATTCTATATTTAAATAGGTTTTTGAGTATGTAAACAATATTGATTACAG
AGAGCTTTATCCAAAGTTAAGCGATTTTGATGTTAGATTTTATATTTTTGAAGTGCTAAA
GGTAACAAAAATATAATATAATATGATTTATAGTTTTTAAATTTCATTTATTATCTATTT
ATAGGCTTTAGATTTTTGTCATAGTTAAGGTATTATGCATAGAGATGTAAAACCACATAA
TATTATGATAGATCATGAAAAGAAATAACTAAGACTCATAGATTGGGGTTTGGCTGAGTA
CTACTTCCCAGGAAAAGATTATAATGTAATGGTTTTTTTTTAGAATTTAGCATGAAATTC
TTATTCAATATTTTTAAAATAGGTAAGAGTAGCTTCAAGATATTTTAAAGGGCCTGAATT
GTTAGTAGATTACTAATACTATGATTACAGTTTGGATATTTGGAGCTTGGGTGCTATGTT
TGCTGGTATGATTTTCAAAAAAGAACCATTCTTCTAAGGAAACGATAACTATGATTAACT
TGAAAAGATAGCAAGAGTCCTTGGTACAAATGAATTATATGATTATCTAAATACATATAA
CCTCGAGTTAGATCCTAAATTTGAAGGAATTTTGGGCAAGCATACAAAGAAACCTTGGTC
AAAGTTTGTTAATAATGACAATAAGAATTTAGCAGTAAATGAAGCAATTGACCTTCTATC
AAAGATGCTTGTTTATGATCATGTATTTTTTAAATTCATAATAAATATAATTAGTTACTA
TATCTTAAATTTTAAAATAGGCTTAAAGAATAACACCTAAAGAAGCCATGCAACATGCTT
ATTTCTTCCCTATCTTGTAATACCATGAAAAAAACTCTAAGCCTGAAGAATCAAATAAAA
AATGA


>TTHERM_01000180(protein)
MDYKVISSKPKFYADANLKKSAEYYDYENLEIEWGEQENYEVIRKLGRGKYSEVFEGINS
LNNEKCVIKVLKPIRKKKIKREISILKNLSGGPNIVQLLDIVKDPASKCTSFVFEYVNNI
DYRELYPKLSDFDVRFYIFEVLKALDFCHSQGIMHRDVKPHNIMIDHEKKQLRLIDWGLA
EYYFPGKDYNVRVASRYFKGPELLVDYQYYDYSLDIWSLGAMFAGMIFKKEPFFQGNDNY
DQLEKIARVLGTNELYDYLNTYNLELDPKFEGILGKHTKKPWSKFVNNDNKNLAVNEAID
LLSKMLVYDHAQRITPKEAMQHAYFFPILQYHEKNSKPEESNKK