Identifiers and Description

Gene Model Identifier

TTHERM_01087780

Standard Name

PCP2 (PARP Correlated Protein 2)

Aliases

PreTt05179 | 227.m00035

Description

Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger family protein putative. Vertebrate PARPs contain PADR and zinc finger (zf)–PARP domains. None of the Tetrahymena putative PARPs carry these domains. Instead, Tetrahymena has at least six additional proteins carrying PADR1 and zf–PARP domains(Kanwal Ashraf et al., 2019)

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• macronucleus (IDA) | GO:0031039

Molecular Function

• DNA binding (IEA) | GO:0003677
• zinc ion binding (IEA) | GO:0008270

Domains

• ( PF00645 ) Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger
• ( PF02037 ) SAP domain
• ( PF08063 ) PADR1 (NUC008) domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_20055.1	2.0008734984431652e-95
	Description: poly polymerase and DNA-Ligase Zn-finger region family protein (255 aa)
WormBase	WBGene00004049	0.0000007001298633766835
	Description: locus:pme-1 Poly(ADP-ribose) polymerase pme-1 status:Confirmed UniProt:Q9N4H4 protein_id:CCD73512.1
DictyBase	DDB_G0291872	0.0000029996948234116693
	Description: DDB_G0291872 on chromosome: 6 position 855161 to 857960

General Information

No Data fetched for General Information

Associated Literature

1. Ref:30796450: Ashraf K, Nabeel-Shah S, Garg J, Saettone A, Derynck J, Gingras AC, Lambert JP, Pearlman RE, Fillingham J (2019) Proteomic analysis of histones H2A/H2B and variant Hv1 in Tetrahymena thermophila reveals an ancient network of chaperones. Molecular biology and evolution ( ):

Sequences

>TTHERM_01087780(coding)
ATGGTCCAATTATCAATAGAAAAAGCCAAATCAGCAAGATCTTCTTGCAAATAATGCAAA
TAGAAGATCGCAAAAGATGAAGTGCGTGTAGGAATAAGTATTTCTAAAGGAGACTATGAT
GAAACTTCTTGGTATCATGTTTCATGCTTTTCTAAGACTAAATTTGCAGGATCTAAAGAC
ATCGAAGATTTAGATGGCTACAGTGCCTTATCAGGAACAGAACAAGCAGAAGCCAAAAAG
AATTTTGATAAGGGAGCCAAAGCTGCTAAAGGTAAAGCAAAGGGTAAAAAAGGATCAAAA
AGTGAATCAGATGAGCCTGAAAGCGGAGACGAAAGTGATGAAGACTCTGGAAAAGGTAAA
AATGGTGCAAAAAAAGGAGCTGCCAAAAAGGGAAGCTCTGGAGGTGCCTTAGCAGGCTAT
ACAGCAGCTGAAAAAGCAAAATATGAAAAGTATTATGAAGAAGCTTTAAAATTATCTGTT
GCTGCTATCAAATAAGCTCTCAAAAAGAATGGTATGACTCAAAATGGAAATAAACAAGAA
ATCGCTTCAAGAATGGCTGATTGCTAAACTATGGGAACTCTCCCAAATTGCTCAAAATGT
GGAGGAGGTAGACTTAGATTTAACTAACAGGATGGTACTTACTTCTGCAAGGGCTACATG
GATGATGCAGATTTTGTCAACTGCTCAGCAAAATATCCCAAAAGTGAAATCACTCGTGGC
ACTTGGACTGATTGA

>TTHERM_01087780(gene)
ATGGTCCAATTATCAATAGAAAAAGCCAAATCAGCAAGATCTTCTTGCAAATAATGCAAA
TAGAAGATCGCAAAAGATGAAGTGCGTGTAGGAATAAGTATTTCTAAAGGAGACTATGAT
GAAACTTCTTGGTATCATGTTTCATGCTTTTCTAAGACTAAATTTGCAGGATCTAAAGAC
ATCGAAGATTTAGATGGCTACAGTGCCTTATCAGGAACAGAACAAGCAGAAGCCAAAAAG
AATTTTGATAAGGGAGCCAAAGCTGCTAAAGGTAAAGCAAAGGGTAAAAAAGGATCAAAA
AGTGAATCAGATGAGCCTGAAAGCGGAGACGAAAGTGATGAAGACTCTGGAAAAGGTAAA
AATGGTGCAAAAAAAGGAGCTGCCAAAAAGGGAAGCTCTGGAGGTGCCTTAGCAGGCTAT
ACAGCAGCTGAAAAAGCAAAATATGAAAAGTATTATGAAGAAGCTTTAAAATTATCTGTT
GCTGCTATCAAATAAGCTCTCAAAAAGAATGGTATGACTCAAAATGGAAATAAACAAGAA
ATCGCTTCAAGAATGGCTGATTGCTAAACTATGGGAACTCTCCCAAATTGCTCAAAATGT
GGAGGAGGTAGACTTAGATTTAACTAACAGGATGGTACTTACTTCTGCAAGGGCTACATG
GATGATGCAGATTTTGTCAACTGCTCAGCAAAATATCCCAAAAGTGAAATCACTCGTGGC
ACTTGGACTGATTGA

>TTHERM_01087780(protein)
MVQLSIEKAKSARSSCKQCKQKIAKDEVRVGISISKGDYDETSWYHVSCFSKTKFAGSKD
IEDLDGYSALSGTEQAEAKKNFDKGAKAAKGKAKGKKGSKSESDEPESGDESDEDSGKGK
NGAKKGAAKKGSSGGALAGYTAAEKAKYEKYYEEALKLSVAAIKQALKKNGMTQNGNKQE
IASRMADCQTMGTLPNCSKCGGGRLRFNQQDGTYFCKGYMDDADFVNCSAKYPKSEITRG
TWTD