Identifiers and Description

Gene Model Identifier

TTHERM_01345800

Standard Name

CSKA1 (CaSein Kinase Alpha subunit 1)

Aliases

PreTt01649 | 337.m00014 | 3805.m00068

Description

Casein kinase II alpha subunit; Protein kinase domain containing protein. Sequence similarity to a protein kinase family unique to Tetrahymena thermophila (Eisen et al.- 2006).Tetrahymena CKII-complex appears to have two alpha subunits and one regulatory beta subunit (Nabeel-Shah et al., 2023)

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

Molecular Function

Biological Process

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
Tetrahymena borealis EI9_21113.1 9.997093137033517e-262
Description: protein kinase domain-containing protein (383 aa)
Oxytricha Contig13714.0.g6 2.0009356157506544e-160
Description: Protein kinase domain
SGD YOR061W 1.999489510516749e-128
Description: CKA2 Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
DictyBase DDB_G0276885 8.997006431083756e-128
Description: casK on chromosome: 2 position 7370887 to 7372679
WormBase WBGene00002191 4.999344532016006e-127
Description: locus:kin-3 Casein kinase II subunit alpha status:Confirmed UniProt:P18334 protein_id:CCD61302.1
Stentor Coeruleus SteCoe_32987 1.1677812485237086e-60
Description: None

General Information

No. Gene Name(s) Paragraph Text
165 CSKA1 CKII subunits including CSKA1, CSKA2, and CSKB1 co-purified with Cac2 subunit of putative CAF1-complex in Tetrahymena. Tetrahymena appears to contain a single putative homolog of the two regulatory beta subunits of CKII that are found in humans. Affinity purification followed by mass spectrometry (AP-MS) analysis of TTHERM_00780530 (CSKB1) identified a large number of proteins to co-purify, suggesting that CKII clients might include functionally diverse proteins in Tetrahymena (Nabeel-Shah et al., 2023).

Associated Literature

  1. Ref:37024975: Nabeel-Shah S, Garg J, Ashraf K, Jeyapala R, Lee H, Petrova A, Burns JD, Pu S, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J (2023) Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation. Epigenetics & chromatin 16:10

Sequences 

>TTHERM_01345800(coding)
ATGTTAAAAAATTTAATAAAAAATATATTTATAAGTGGAAAAAGCAGCTTCCAATAAATA
TATAAAAATAATAGAATACAATATAATTTCTGTCAAGCAACAACTACAATGAACTAGTAG
TAAAAAAGTGTACTTCCAAAGTATTATGCTAATGTGAATGAATTCATGCCAAAGGATTAT
TCAAATTACGAAGACTATGAAAACGAATGGGGAAATCAAGACGATTATGAAGTAATCCGC
AAATTAGGAAGAGGTAAATACTCTGAAGTCTTTGATGGAATTAGCGTTGTAACAAAGAAA
AGAGTAGTTATTAAGGTCCTCAAGCCAGTTAAAAAGCGCAAAATTAAAAGAGAAATCAAG
ATTTTATAGATTTTGAAGGGAGGTCCAAATATTGTTGAATTGTTAGACGTAGTTCGTGAC
CCTGCCTCAAAAACTCCTTCACTTATCTTTGAATAAATTGAAAATGTCGACTTTAGAAGC
TAGTTCCCAAACTTGACAGACTTAGAAATTAAATTCTATATGTTCGAAATTTTGAAAGCA
TTAGATTATTGTCATAGCAAAGGTATTATGCATAGAGATGTTAAGCCATAGAATATAATT
GTAGATCCCAAAAATAAAATTCTCAAATTAATTGATTGGGGTCTAGCTGAATTCTATCAC
CCTGGAACAGATTATAATGTTAGAGTTGCTTCTCGTTATTTCAAGGGTCCTGAATTGCTT
GTTGATCAAAATTACTATGATTATTCACTCGATATTTGGAGTACAGGAACTATGTTTGCA
TCTATGATTTTCAAGAAAGAGCCTTTCTTCTAAGGTGCAGACAACTAAGACTAATTAATA
AAAATTGCTAAAGTTTTAGGTACAGAAGACTTACATAAATATCTTAGAAAATACGATTTA
ACATTAGATGTTAGTTATCATAAGATTCTTGGAAGTTACGCTAAGAAGCCTTGGGTCAAA
TTCATTACAGAAGAAAATAAACATCTTTGCCATGAATAAGCTATTGATCTTCTTTCTAAG
ATGTTAATCTATGATAATGCTTTAAGAATTACACCTAAGGATGCTATGGAACACCCTTAT
TTTGATTAAGTTCGTACTCTCACTCCTACTGGTCTTATTAATCTATTAAAACAATAATAA
AATCAATAGTGA


>TTHERM_01345800(gene)
ATGTTAAAAAATTTAATAAAAAATATATTTATAAGTGGAAAAAGCAGCTTCCAATAAATA
TATAAAAATAATAGAATACAATATAATTTCTGTCAAGCAACAACTACAATGAACTAGTAG
TAAAAAAGTGTACTTCCAAAGTATTATGCTAATGTGAATGAATTCATGCCAAAGGATTAT
TCAAATTACGAAGACTATGAAAACGAATGGGGGTAAACTATTTTAATCGCAAGACATTTA
AGCATTTTTTCCTGCAAAATCTATTTAATTTCAAAATTATCCTCGATAATTGCAAACTCA
AAAAAGTCAAAAGTTGTCTACTAAAAACAAGATTTAAAAAAGGAAGAATATAAGTGATTT
AGAAGTAATATAAAATGTTAAAAGAGTTAACGATAAGCCCAATAAGCAGCTTTTAATTAA
TAAACAAACATATTTTCTGCTTTGCTGACTCTCCTGGCGACAGTTTAATTTAAAATTTTT
AAATTATTTGTTTCTTAGGAAAAGAAATACTTGAAAAGGAAAGAAAAAAAAATGTTTTTA
TTAAGCAATTAAAAAAATAAGCAATTAAATTTGATAGTTAAAGAAAGCTATTCAAGAAAA
GACTCATTAAATATGAATTAATGAACAATATATTTAGCTGAATGTAATAAATATTTTCAA
AAATTATATAGAAATCAAGACGATTATGAAGTAATCCGCAAATTAGGAAGAGGTAAATAC
TCTGAAGTCTTTGATGGAATTAGCGTTGTAACAAAGAAAAGAGTAGTTATTAAGGTCCTC
AAGCCAGTTAAAAAGCGCAAAATTAAAAGAGAAATCAAGATTTTATAGATTTTGAAGGGA
GGTCCAAATATTGTTGAATTGTTAGACGTAGTTCGTGACCCTGCCTCAAAAACTCCTTCA
CTTGTATAGCTACTTTATATATTAATTAATTCATGATCTTATTTCCTATCTATTTATTTT
GGCTCAATTAATCCATATTTCAAAAGCTAAACGAAATATATTAAATAAAATAACTATCTA
ACTAACTAACAATAAATAGATCTTTGAATAAATTGAAAATGTCGACTTTAGAAGCTAGTT
CCCAAACTTGACAGACTTAGAAATTAAATTCTATATGTTCGAAATTTTGAAAGTAAATTA
AATTAATATTCTATTTTATTCACTTACTTACTTACTTCTTTCTTTCAACCCAGTTTATTT
ATTATTAATTAATTATTAATTTCATTCATTTTAAAAATAATTTTTATTAAACTGCAATAA
AATAAATAAATAGGCATTAGATTATTGTCATAGCAAAGGTATTATGCATAGAGATGTTAA
GCCATAGAATATAATTGTAGATCCCAAAAATAAAATTCTCAAATTAATTGATTGGGGTCT
AGCTGAATTCTATCACCCTGGAACAGATTATAATGTTAGAGTAATTAATTAGCTATTTTT
TTATAATTGACTCATTTATTTATTTATGCTAATCGATTAAATTTAAAAATACATTTTTAG
AAATTCACTTCATTGCTAAAATTTCTGAAAATCAAATCAGCTTGAATATAAAATGTTTAC
TCTAACATGATAAATTAATTTGTTAATTAACTGAGTTACCAAAATTAAAACTATCAATTA
TATAATAACTTTATTAATTAAATTAACTTTGTTAAAAAGGTTGCTTCTCGTTATTTCAAG
GGTCCTGAATTGCTTGTTGATCAAAATTACTATGATTATTCACTCGATATTTGGAGTACA
GGAACTATGTTTGCATCTATGGTAATAAATTATTTTAAAATCAATTAATTTTACAATAGC
AATAAACATAAACATAAATTATTAAGATTTTCAAGAAAGAGCCTTTCTTCTAAGGTGCAG
ACAACTAAGACTAATTAATAAAAATTGCTAAAGTTTTAGGTACAGAAGACTTACATAAAT
ATCTTAGAAAATACGATTTAACATTAGATGTTAGTTATCATAAGATTCTTGGAAGGTAAG
AATTATTTTGAATTAAATGAATTTATTTAAAAATAAATATAAAAATAAATTAGTTACGCT
AAGAAGCCTTGGGTCAAATTCATTACAGAAGAAAATAAACATCTTTGCCATGAATAAGCT
ATTGATCTTCTTTCTAAGATGTTAATCTATGATAATGTAACTTAGATTAATTATAAGATA
GCATAATTTTTATTAATAAATATACTTTTAAATAAACAGGCTTTAAGAATTACACCTAAG
GATGCTATGGAACACCCTTATTTTGATTAAGTTCGTACTCTCACTCCTACTGGTCTTATT
AATCTATTAAAACAATAATAAAATCAATAGTGA


>TTHERM_01345800(protein)
MLKNLIKNIFISGKSSFQQIYKNNRIQYNFCQATTTMNQQQKSVLPKYYANVNEFMPKDY
SNYEDYENEWGNQDDYEVIRKLGRGKYSEVFDGISVVTKKRVVIKVLKPVKKRKIKREIK
ILQILKGGPNIVELLDVVRDPASKTPSLIFEQIENVDFRSQFPNLTDLEIKFYMFEILKA
LDYCHSKGIMHRDVKPQNIIVDPKNKILKLIDWGLAEFYHPGTDYNVRVASRYFKGPELL
VDQNYYDYSLDIWSTGTMFASMIFKKEPFFQGADNQDQLIKIAKVLGTEDLHKYLRKYDL
TLDVSYHKILGSYAKKPWVKFITEENKHLCHEQAIDLLSKMLIYDNALRITPKDAMEHPY
FDQVRTLTPTGLINLLKQQQNQQ