Identifiers and Description

Gene Model Identifier

TTHERM_00316310

Standard Name

NHX1 (Sodium Hydrogen Exchanger 1)

Aliases

PreTt20942 | 31.m00244 | 3687.m00046

Description

NHX1 sodium/hydrogen exchanger family protein; Sodium/hydrogen exchanger family protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• integral component of membrane (IEA) | GO:0016021

Molecular Function

• obsolete solute:proton antiporter activity (IEA) | GO:0015299

Biological Process

• monoatomic cation transport (IEA) | GO:0006812

Domains

• ( PF00027 ) cyclic nucleotide-binding domain
• ( PF00999 ) transporter, monovalent cation:proton antiporter-2 (CPA2)
• ( PF02378 ) Phosphotransferase system, EIIC
• ( PF03023 ) Virulence factor MVIN
• ( PF03547 ) transporter, auxin efflux carrier (AEC)
• ( PF06790 ) Uncharacterised protein family (UPF0259)
• ( PF07674 ) Protein of unknown function (DUF1603)
• ( PF07690 ) transporter, major facilitator family
• ( PF08946 ) Osmosensory transporter coiled coil
• ( TIGR00831 ) Na+/H+ antiporter
• ( TIGR00840 ) sodium/hydrogen exchanger 3
• ( TIGR01726 ) amino ABC transporter, permease protein,

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_08453.1	9.997093137033517e-262
	Description: sodium/hydrogen exchanger family protein (1141 aa)
Stentor Coeruleus	SteCoe_17229	2.820770088460135e-53
	Description: None
WormBase	WBGene00003943	9.002093297142233e-23
	Description: locus:pbo-4 Na(+)/H(+) exchanger protein 7 status:Confirmed UniProt:G5EBK1 protein_id:CAA91995.2
Oxytricha	Contig16604.0.g63	2.0002795641672355e-21
	Description: Sodium/hydrogen exchanger family
DictyBase	DDB_G0275711	8.99902975825788e-19
	Description: nhe1 on chromosome: 2 position 6042281 to 6044641
SGD	YDR456W	0.000000000000006999063783600386
	Description: NHX1 Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion

General Information

No.	Gene Name(s)	Paragraph Text
25	NHX1	NHX1 is an integral membrane protein that shares homology with other proteins containing a sodium hydrogen exchanger domain involved in transporting sodium and hydrogen ions across the concentration gradient between a cell and its surroundings. Functioning as an antiporter for sodium and hydrogen ions, the exchange function characteristic of this domain is highly dependent on pH. Although the exact molecular mechanisms responsible for this behavior are not well understood, a prominent current inference is that these exchanger proteins use ATP to transport ions across membranes. Paragraph by: Samuel Rubin and Owen Foster (undergraduates) Keck Science Deparment, Claremont Colleges

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00316310(coding)
ATGAACAATAGCACTGACACTTCAGCTGCTACATATTAGCCTAATTATTTTAGTACAATG
GCAGCATAAGCCATAGATGATTCAAAAATTAGTACAGAATCGCTTGTAGTGTTTTTCCTT
TTTGGAGGACTTATGATTGCAGGTTTTGTTAGGGAAATTAATAAAAAAACTAGCATTCCT
TACACTCCAATGCTTTTTGTTATTGGAATTTTTTTAGGAAAGTTTTCTGAAAGCATGGGA
ATACTAGGAATAACAATAAGCAAGATAAGTTTAATCAACCCTCATGGTATATTAATTATA
TTCCTCCCTGTGCTTATTTTCGAAAGTGGTTTTAATAGTGATTGGCATACTTTTAAAAAG
TAATCTGGCCAGATATTTTTACTTGCCTTCCCATGTGTACTATTTTCAGCCATATTTTTA
CTCATAAGTATCAAAGTTATTTTGAGATATGATGACTCTTATTACACTTGGAGTGGTGCA
TTTATGTTCGGTTCTATTCTCTCATGTACAGATACAGTAGCCGTCCTAGCTCTTTTAAAA
GAAGTAGGCGCTCCTAAAAAATTTAATTCGCTGATTGAAGGAGAATCATTACTTAACGAT
GGTACCTGTATGGTTCTTTTCCAAATATCAAGTGAATTCGCAAAAAAAGTTGATTAGAAT
ACATAAAATCAGTAATATTTTGATTTGTTTGAAGTGATCAAACTTTTGCTTTCTCTCACT
GTTGGTGGTACACTTCTCGGTATTGTTTTTGGCATGATAGCCTAGTTTTGGATGCGTAGA
ATACATAATGATCCGATATTGACAGTCAATATAACCTTCATTGTTTGCTATCTAACTTAC
TATGTAGCAGAAAATGTAGATATTGGAATAAAAGTCTCAGGAATTATGGCTCTAGTTTCT
CTTGGTATTTATCTCTCTATATTTGGTAAAACTAAAATTTCAAGTGAAGAAAAGAGAACT
GTTTATATTTTCTGGAAGTACGTAACTTATGCTGGTGAATCAATTATTTTTATATTAGCT
GGTGTATTAGTTGGTGTTAAAGTTTTAACATCTAATGGGGATTACGACACTATGTCAGGA
AGCGATAATGTTTCTTCTTCAATTTAAACTAGTGATTATTTTAAACTTTTTGGTCTTTAC
GTTTGTATGATCTTGAGTCGCTTTGGTAGTATTGCTTGCTTTATGTCTTGGTTGAGAAAA
TGGGGTTATGGTCTTACTTGGAAGGAAGTTTATGTCCTTGCTTACGGTGGTCTTAGAGGA
GCTATTGGTATTTCTTTTGCAATGATTGTTGCTAATGATGACTCTTACTCTCAAAAATTA
AGAGATATTATTTTATTCGATATGGCTGGAAATGCAATTTTAACATTAATTATCAATGGA
ACAACTACTGGTCCTTTGATTAAGAGTTTAGGATTATGCGTTACAAGCACAGTTAGAGAA
AGAGTCTTTTTAAATATTTTACAAGATTTGAAGGAAGATACTGAAAAAAAGATTAATTAT
TTGAAATCTAATAACTATCTAAAGATGGTCAATTGGGATAGTGTTAAAGAATATGTAGGA
TTAGCAGATTTGGAGCAAAGAATTACAAGATTAGAGTCAGATCTAACTAAAAGAGAAGAA
ATTGAAGAGTATACAAGAAATATAAGAAATAAAAATGTAATTGATGCTAAGATAGATGAA
CTTAAAAACTCTAATGAATTTTAAGAGTAGTAATCATTTGACTCAGATTCAACAAATCAC
AATCTTGATGAAAATATGATAGTTGAATGTAGAAATAGATTTTTGATGGCTCTCAAAGGA
AATTATTGGGATATTTATGAAAGAAATCAGTGCAGCAGTAATGCTTTATTATTGTTGATT
GATTCAGTAAATTGGGATCTGGATACTGAATAAGAAAGAATGAACTCATGGGAATTTCTT
TCCAATTACTTTTACAATCCTATTTACATCAAAGTGCTCTTTTAATTAAAAGGATGGCCT
ATTGTTGGATCTTATGCTGGTAACCTCCTCTTTAACCATATCTCTAATATTTATGATGTC
ATTGCTGCTTATATTGAAGCTCATGAACAAGCTGAGCAACTTTGCATAGATCAATTCCCT
TTCATTCCCTAAGTTTTAGAAATTATTATCAGAGAAAGCTAAGATAATAGAATGAGTGGC
GAAGAGTATATCAAAAATGATTTAAATGTAAGTTTCCCAGAAATTACTAAACAAATCCAA
ACTAAGAAGGCAACCTACAGTTTATTAGAGTGCTAAAAGAAAATAATAAAGAAGGGTATT
TTGTTAGGTAAGATAGATGAAAAAGAAAGAGATATATTAATGTAATAAATCGATGATAGA
GTAGTTGCTTTAGACAACATCAAACCTTCTTGGAAAGCTCCTCCAATCAAAAATTTCTTA
GAAAATGTTCCATTCTTTAAACTCATCCACAAAGATTTACTTCCATACATCATCAAAGAA
TCTGTTGAGATGATTTTTGAAAAAGATATGTACATCATCAAAGAAGGTGAGAAAGCTAAA
TACTTTTTTGTTATCACTAGAGGTAGTGCTACAGAAACAACATCTTAGAGCTTTTGCACA
TATCAAGAATAAAAGGAAGTTGGCAGTTTAATTTCTCCTCACCACTTGATTGTACCAAGT
TTGAGATACTTGACTTCCTGCATGGCTAATGCAGTTGTATACGTTCTTGCTTTCCCTTTA
AGCTCAATTTAGAAAGTTATCAAAGTTAATTTAGAAATAAAGGAATATGTTTGGATGTAG
AGTCTGAGAGCATTGAGTTAGCTTTTCTATAATGAACTTAAACCTTTAGGAAGTTTAGAT
AGAAACAGTTTTATTAAACTTCAACCAAAGTTGAAATTTGCTAAATATAACAAAGGGAAG
ACTATCTAGTGTGAAAGTGGTGGTATTCTTTTGAAAGGACAAGTTTCGAGAAAGGATTTA
ACAGATGTGATGATGACATAATCTAAAGTAAATAATGACGAGGTAAAAAAATCAGATTTG
ATTGATGGTAGAATTTATAAGGCATTTTGTGTTTTAATGCCAGGATAAGCTTTTTCAGTT
TTCACAGAAAAGAAGTGTACATTTTTGCACTTTGCTGAAGACTGTGAAGAAATTAGGTTT
ATGATTAGTCATATGGACTACAATGTTGGCATTAATTAGTAAACACCTCATACTCTTAAC
ATATTTAGTCCTGTAGCTGTTTCTGGATCTCATAATAAGAGAAACAGTTTTTAAGCTCCC
CACTTAAGTAGATTTGCAGGTAGACATACTTTTAATAATTTAGAAGTAGTTGTGCAAGGT
AGTGAAAATAAAATAAATTCAGGATAATAAATAGAATTGCAAAAGATGAAATCTAAATCA
TACTTAAACGACTAACAAATAAAGAGTGTAAAGAGTGATGATGAAGAATCAGATGATAAT
AAAGAAAAGTGA

>TTHERM_00316310(gene)
ATGAACAATAGCACTGACACTTCAGCTGCTACATATTAGCCTAATTATTTTAGTACAATG
GCAGCATAAGCCATAGATGATTCAAAAATTAGTACAGAATCGCTTGTAGTGTTTTTCCTT
TTTGGAGGACTTATGATTGCAGGTTTTGTTAGGGAAATTAATAAAAAAACTAGCATTCCT
TACACTCCAATGCTTTTTGTTATTGGAATTTTTTTAGGAAAGTTTTCTGAAAGCATGGGA
ATACTAGGAATAACAATAAGCAAGATAAGTTTAATCAACCCTCATGGTATATTAATTATA
TTCCTCCCTGTGCTTATTTTCGAAAGTGGTTTTAATAGTGATTGGCATACTTTTAAAAAG
TAATCTGGCCAGATATTTTTACTTGCCTTCCCATGTGTACTATTTTCAGCCATATTTTTA
CTCATAAGTATCAAAGTTATTTTGAGATATGATGACTCTTATTACACTTGGAGTGGTGCA
TTTATGTTCGGTTCTATTCTCTCATGTACAGATACAGTAGCCGTCCTAGCTCTTTTAAAA
GAAGTAGGCGCTCCTAAAAAATTTAATTCGCTGATTGAAGGAGAATCATTACTTAACGAT
GGTACCTGTATGGTTCTTTTCCAAATATCAAGTGAATTCGCAAAAAAAGTTGATTAGAAT
ACATAAAATCAGGTATTAAATTAAATCTTTTATATATAAACATTAGCTAAGATAGACAGA
TAATTATAGTTTATAGCTTAATTTTTATATTATTTTAAAATAAAACCTTAGCTTATATAT
TTTATTACTCAAAAAAAAAAGTAATTAGAGTACCCAAATAGTAATTTTAGTCTACATTTA
AAAAGCTATTAATTTTAAATAAATAAAATATGATGAGAATATTTAATATTTATATGAATT
AAATTAGTAATATTTTGATTTGTTTGAAGTGATCAAACTTTTGCTTTCTCTCACTGTTGG
TGGTACACTTCTCGGTATTGTTTTTGGCATGATAGCCTAGTTTTGGATGCGTAGAATACA
TAATGATCCGATATTGACAGTCAATATAACCTTCATTGTTTGCTATCTAACTTACTATGT
AGCAGAAAATGTAGATATTGGAATAAAAGTCTCAGGAATTATGGCTCTAGTTTCTCTTGG
TATTTATCTCTCTATATTTGGTAAAACTAAAATTTCAAGTGAAGAAAAGAGAACTGTTTA
TATTTTCTGGAAGTACGTAACTTATGCTGGTGAATCAATTATTTTTATATTAGCTGGTGT
ATTAGTTGGTGTTAAAGTTTTAACATCTAATGGGGATTACGACACTATGTCAGGAAGCGA
TAATGTTTCTTCTTCAATTTAAACTAGTGATTATTTTAAACTTTTTGGTCTTTACGTTTG
TATGATCTTGAGTCGCTTTGGTAGTATTGCTTGCTTTATGTCTTGGTTGAGAAAATGGGG
TTATGGTCTTACTTGGAAGGAAGTTTATGTCCTTGCTTACGGTGGTCTTAGAGGAGCTAT
TGGTAATTTTATAAGTAAGTTAAATAAAAATAATATTTTAAATTTTATTTAGGTATTTCT
TTTGCAATGATTGTTGCTAATGATGACTCTTACTCTCAAAAATTAAGAGATATTATTTTA
TTCGATATGGCTGGAAATGCAATTTTAACATTAATTATCAATGGAACAACTACTGGTAAT
TTGTTTAATTTTAAATAAAGTATTTATTACAAATTTTATGATATTTTTAGGTCCTTTGAT
TAAGAGTTTAGGATTATGCGTTACAAGCACAGTTAGAGAAAGAGTCTTTTTAAATATTTT
ACAAGATTTGAAGGAAGATACTGAAAAAAAGATTAATTATTTGAAATCTAATAACTATCT
AAAGATGGTCAATTGGGATAGTGTTAAAGAATATGTAGGATTAGCAGATTTGGAGCAAAG
AATTACAAGATTAGAGTCAGATCTAACTAAAAGAGAAGAAATTGAAGAGTATACAAGAAA
TATAAGAAATAAAAATGTAATTGATGCTAAGATAGATGAACTTAAAAACTCTAATGAATT
TTAAGAGTAGTAATCATTTGACTCAGATTCAACAAATCACAATCTTGATGAAAATATGAT
AGTTGAATGTAGAAATAGATTTTTGATGGCTCTCAAAGGAAATTATTGGTACAAAAATTT
CAAAAAAATTTATTTTTTTTATTTCTAACTTTAAATAATTTTGAATAAAGGGATATTTAT
GAAAGAAATCAGTGCAGCAGTAATGCTTTATTATTGTTGATTGATTCAGTAAATTGGGAT
CTGGATACTGAATAAGAAAGAATGAACTCATGGGAATTTCTTTCCAATTACTTTTACAAT
CCTATTTACATCAAAGTGCTCTTTTAATTAAAAGGATGGCCTATTGTTGGATCTTATGCT
GGTAACCTCCTCTTTAACCATATCTCTAATATTTATGATGTCATTGCTGCTTATATTGAA
GCTCATGAACAAGCTGAGCAACTTTGCATAGATCAATTCCCTTTCATTCCCTAAGTAAAT
AAATACATTTACAAGAGCATAAAAAAGAATTGTATTTTTTACAAATTAATATTAAAAATA
GGTTTTAGAAATTATTATCAGAGAAAGCTAAGATAATAGAATGAGTGGCGAAGAGTATAT
CAAAAATGATTTAAATGTAAGTTTCCCAGAAATTACTAAACAAATCCAAACTAAGAAGGC
AACCTACAGTTTATTAGAGTGCTAAAAGAAAATAATAAAGAAGGGTATTTTGTTAGGTAA
GATAGATGAAAAAGAAAGAGATATATTAATGTAATAAATCGATGATAGAGTAGTTGCTTT
AGACAACATCAAACCTTCTTGGAAAGCTCCTCCAATCAAAAATTTCTTAGAAAATGTAAT
ATTTTTATTTATAGTAAAATTTTTTAAAACAAAATAAAAAATAAAGGTTCCATTCTTTAA
ACTCATCCACAAAGATTTACTTCCATACATCATCAAAGAATCTGTTGAGATGATTTTTGA
AAAAGATATGTACATCATCAAAGAAGGTGAGAAAGCTAAATACTTTTTTGTTATCACTAG
AGGTAGTGCTACAGAAACAACATCTTAGAGCTTTTGCACGTAAATTTATAATTATTTATT
CAGTAAATGTTATGTCTTTTTAGATATCAAGAATAAAAGGAAGTTGGCAGTTTAATTTCT
CCTCACCACTTGATTGTACCAAGTTTGAGATACTTGACTTCCTGCATGGCTAATGCAGTT
GTATACGTTCTTGCTTTCCCTTTAAGCTCAATTTAGAAAGTTATCAAAGTTAATTTAGAA
ATAAAGGAATATGTTTGGATGTAGAGTCTGAGAGCATTGAGTTAGCTTTTCTATAATGAA
CTTAAACCTTTAGGAAGTTTAGATAGAAACAGTTTTATTAAACTTCAACCAAAGTTGAAA
TTTGCTAAATATAAGTAAACATTTTTAATAAATTAAATTTTTCTAGTTATGCTTAATTGA
TGGCTTAAAAAAATAGCAAAGGGAAGACTATCTAGTGTGAAAGTGGTGGTATTCTTTTGA
AAGGACAAGTTTCGAGAAAGGATTTAACAGATGTGATGATGACATAATCTAAAGTAAATA
ATGACGAGGTAAAAAAATCAGATTTGATTGATGGTAGAATTTATAAGGTAAATAAAATAT
TTATTAGTTATGAAAATATCATTTATTTTTAATCTTAAAAAAATAGGCATTTTGTGTTTT
AATGCCAGGATAAGCTTTTTCAGTTTTCACAGAAAAGAAGTGTACATTTTTGCACTTTGC
TGAAGACTGTGAAGAAATTAGGTTTATGATTAGTCATATGGACTACAATGTTGGCATTAA
TTAGTAAACACCTCATACTCTTAACATATTTAGTCCTGTAGCTGTTTCTGGATCTCATAA
TAAGAGAAACAGTTTTTAAGCTCCCCACTTAAGTAGATTTGCAGGTAGACATACTTTTAA
TAATTTAGAAGTAGTTGTGCAAGGTAGTGAAAATAAAATAAATTCAGGATAATAAATAGA
ATTGCAAAAGATGAAATCTAAATCATACTTAAACGACTAACAAATAAAGAGTGTAAAGAG
TGATGATGAAGAATCAGATGATAATAAAGAAAAGTGA

>TTHERM_00316310(protein)
MNNSTDTSAATYQPNYFSTMAAQAIDDSKISTESLVVFFLFGGLMIAGFVREINKKTSIP
YTPMLFVIGIFLGKFSESMGILGITISKISLINPHGILIIFLPVLIFESGFNSDWHTFKK
QSGQIFLLAFPCVLFSAIFLLISIKVILRYDDSYYTWSGAFMFGSILSCTDTVAVLALLK
EVGAPKKFNSLIEGESLLNDGTCMVLFQISSEFAKKVDQNTQNQQYFDLFEVIKLLLSLT
VGGTLLGIVFGMIAQFWMRRIHNDPILTVNITFIVCYLTYYVAENVDIGIKVSGIMALVS
LGIYLSIFGKTKISSEEKRTVYIFWKYVTYAGESIIFILAGVLVGVKVLTSNGDYDTMSG
SDNVSSSIQTSDYFKLFGLYVCMILSRFGSIACFMSWLRKWGYGLTWKEVYVLAYGGLRG
AIGISFAMIVANDDSYSQKLRDIILFDMAGNAILTLIINGTTTGPLIKSLGLCVTSTVRE
RVFLNILQDLKEDTEKKINYLKSNNYLKMVNWDSVKEYVGLADLEQRITRLESDLTKREE
IEEYTRNIRNKNVIDAKIDELKNSNEFQEQQSFDSDSTNHNLDENMIVECRNRFLMALKG
NYWDIYERNQCSSNALLLLIDSVNWDLDTEQERMNSWEFLSNYFYNPIYIKVLFQLKGWP
IVGSYAGNLLFNHISNIYDVIAAYIEAHEQAEQLCIDQFPFIPQVLEIIIRESQDNRMSG
EEYIKNDLNVSFPEITKQIQTKKATYSLLECQKKIIKKGILLGKIDEKERDILMQQIDDR
VVALDNIKPSWKAPPIKNFLENVPFFKLIHKDLLPYIIKESVEMIFEKDMYIIKEGEKAK
YFFVITRGSATETTSQSFCTYQEQKEVGSLISPHHLIVPSLRYLTSCMANAVVYVLAFPL
SSIQKVIKVNLEIKEYVWMQSLRALSQLFYNELKPLGSLDRNSFIKLQPKLKFAKYNKGK
TIQCESGGILLKGQVSRKDLTDVMMTQSKVNNDEVKKSDLIDGRIYKAFCVLMPGQAFSV
FTEKKCTFLHFAEDCEEIRFMISHMDYNVGINQQTPHTLNIFSPVAVSGSHNKRNSFQAP
HLSRFAGRHTFNNLEVVVQGSENKINSGQQIELQKMKSKSYLNDQQIKSVKSDDEESDDN
KEK