Identifiers and Description

Gene Model Identifier

TTHERM_00448570

Standard Name

MCM6 (DNA replication licensing factor MCM6)

Aliases

PreTt15376 | 52.m00154 | 3811.m00917

Description

MCM6 DNA replication licensing factor MCM4; Component of the Mcm2-7 complex involved in DNA replication; Mini-chromosome maintenance protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

• ( PF00493 ) MCM P-loop domain
• ( PF14551 ) MCM N-terminal domain
• ( PF17207 ) MCM OB domain
• ( PF17855 ) MCM AAA-lid domain
• ( PF18263 ) MCM6 C-terminal winged-helix domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No.	Gene Name(s)	Paragraph Text
2278	MCM6	Gene Information: MCM6 is a gene coding for a protein product associated with replicative origins in G1 phase during pre-replicative complex assembly. ORC recruits MCM6p on non-rDNA chromosomes. Mcm6p ChIP analysis was performed with affinity-purified rabbit antibodies directed against amino acids 34–51 (GKKIKYYREKALLLKIYE) of the T. thermophila MCM6 protein (Tetrahymena Genome Database gene prediction: TTHERM-00448570, e value versus human MCM6 (NP_005906.2): 1.0e-172. Human MCM6 (NP_005906.2) versus TGD TTHERM-0048570 e value : 1.0e-178.
2280	MCM6	Protein Interaction Partners: Not assessed
2279	MCM6	Nucleic Acid Interactions: Non-rDNA and rDNA origin in cells synchronized at the G1/S border.
2281	MCM6	Biochemical Activities: Predicted helicase activity for dsDNA as a component of MCM2-7 complex

Associated Literature

1. Ref:19153611: Donti TR, Datta S, Sandoval PY, Kapler GM (2009) Differential targeting of Tetrahymena ORC to ribosomal DNA and non-rDNA replication origins. The EMBO journal 28(3):223-33

Sequences

>TTHERM_00448570(coding)
ATGAGGAATATTGCGCGGATTTTATTTTAGATTGTGGCGTATTTTTTGAAAAGAAATTTT
ATTATATTTAGATTTTTTTATATTTATTTATAATTCAAAAGTCAATCAAACTTTAAAGAT
ACACTTTCTAAAATTAAAATTATCAACGAATATTAACAAAAAAGCAAAAAAAAAAAAGGT
GTATTGCTTATTAAACAAAAAAAATAATTAAGTAAAAGCAAAATCCAATAAAATAGCTAA
ACACTGAACAATAATAAAGAAATGAGCTAGATGAACTTTTCCTAAACAATCTAACTTAAG
ATTGAAACAGTAAAGACCTAATTCCTTAACTTCTTAAACAACTTTGAAGTAGTTGAAAAT
GGAAAAAAAATCAAGTATTACAGAGAAAAGGCACTTTTGTTGAAGATTTATGAAAAGAAT
ACACTTTTTATTGACTTTAATCACTTATTAGATTTTATTGATGACAACGATATTTCAGAT
GTCATTTTAAACGACTACTACAAAATTGAACCTCACTTAAGAAAAATTGTTTCAAATTTC
ATCTTTAGTCTAACCAACACAAACGATAGCCAGGAAAGTTACTACCTTAGCTTTTACAAC
TTACCAACTGAAAAGAAAATTAGAGAATTGGGAACTTAAGAAATAGGTAAATTGAATAGT
ATTAAGGGTTTAGTTACTAGATCAAGTGAAGTACGTCCTGAATTACTTTATGGTACATTT
ATTTGCCAATTGTGTAATAGTGAAGTGCGTGATATTGAGTAGCAATTTAAATACACTGAA
CCTAAAATATGTTCAAACCCTGGCTGTAACAACCATACTAAGTGGATGTTAAAACCCTAA
TCATCAGTATTTTCTGATTTTTAGAAACTTAGAGTTCAAGAAGAATCTACTGACATTCCT
GCAGGAGGTATGCCTCGTTCTATTGATATTGTTTGTAGAGGTGAAGTTGTTGACACCGCT
AAGCCTGGTGATAAATGTATTTTCACTGGTTATTTAATTGTTGTTCCTGATATAGCAGCT
CTTACTAAACCAGGTGAAAAAACTGAAATGGGTATTAAATCTGATGCCGTTAGAGTCAAA
GGAGAAGGAAATAATGATGGTATTACTGGTCTCTCTCAACTAGGTCAAAGAGATTTGAAC
TACAGACTTGTTTTCTTAGCTATTAACATTGAAGCAAAAAAGAGTAGATTCAACTTATGG
AATTAAGATGAAGAAGAAAATCAGGATTTAACTGAAGAAGAAGAAAGACAAAAAATTATG
GAAAATTTCTCTGAAAGAGAACTTGAAGACATTTTTAAAATAAGCAGAAGTTCTAATGTT
TATGAAAGATTAGCATCTAGTTTGTGTCCTACTGTACATGGTCACTTGGAAGTTAAAAAG
GGTATTTTACTCATGCTTTTTGGTGGTGTCAACAAAAAAACAGAAGAAGGTATTAACTTG
AGAGGTGATATCAACATTTGCATGGTAGGTGATCCATCTACTGCTAAGTCTCAATTCCTT
AAATATGTTAATAAGCTTATTCCTCGTTCAGTCTATACTTCTGGTAAAGCATCAACATCT
GCTGGTTTGACTGCAAGTGTTTCTAAAGATCCTGAAACTGGAGAAAATTGCATTGAAGCT
GGTGCTTTGATGCTTTCTGACTAAGGTATTTGCTGTATCGATGAATTTGATAAGATGGAT
AAAAGAGATTAAGTCGCCATCCACGAAGCTATGGAACAATAAACAATTTCTATTTCAAAG
GCAGGTATTCAAGCTACCTTGAATTCAAGAGCCAGTATTTTAGCTGCTGCAAACCCTGTT
TTTGGTAGATACGATAAATCCAAGGGTTTAAAATACAACTTAGATATAAGCGCTCCCATT
CTTTCTCGTTTCGATTTATTCTTTGTCATTTTGGATGAGTGCAACGAATAATCAGATAGA
ATGATTGCATAACATATTGTTAATATTCATTAAAGCTGTGGAAGAAATATCAATCCTGAA
ATCAGTACTGAAGATTTGTCTAAGTATATACGTTTTGCTAGAACTATAAAGCCAATTTTC
ACTCGTGAAGCTGCCCTCGAATTGCAAAAATGCTATGTAAAACTTAGATAAAATGATTCA
AGCTCTTAAAATACTTCATACAGAATTACAGTCAGACAGCTTGAATCTCTTATTAGATTA
AGTGAAGCTTTGGCTAGAGTTCACATTCAATCAGAAGTTACTGCTGAATTTGTATAGGAA
GCCGCAAGATTACTCAGCAATTCTATTCTTAAAATAGAAAAGGGATAATTGGACATCTAA
GATGAAGAAGAGCAAAAGATAGACCTCAACTAATAAAAAGAATAAGGCTAAAACATTATT
TAAGAAGATATTGAAAAAAAACAACAATAATAAAGAAAGAAGGAAGGTAAAATCTCAATT
ACTTATGAGGAATACTTAAACATGAGAAAGATAATCATTCAAACAGTCAAAGATTTAGAA
ATAGAAGATAGTCTTAGAGTTTCCACAGAAGGAGAAGACGGAATGGAAGTTGAAAGACAA
AATGGTTTCGAATAAAGAGTTATTATAGAATAAATTCTTAAGCAATTATTAGAAAATGAC
CTTATCCAAACAGAAGAAGATGCTACTAAATTAAAAAAAATATATTCTCAAATTATTAAA
AAGTTAGTAGATGTAGACTAAGTTTTAATTGTTGTCGAAGAGGCCTCAAATTTAGACGAA
CGTAGATTATAACTTCATGCTAACTACTGCGAACCTAGTTGA

>TTHERM_00448570(gene)
AAGGAGATTGAGTTAAGGTAGAAGTTAATTTTGATATTGATAGAAATTATATAAAAAGTT
AATTTTATAAATTTGAATTATTTATGAAGCTTAGCTCGCTCCAATTTAAAGTCACTTAAA
AAGAGGCGCCATTTAATGAGGAATATTGCGCGGATTTTATTTTAGATTGTGGCGTATTTT
TTGAAAAGAAATTTTATTATATTTAGATTTTTTTATATTTATTTATAATTCAAAAGTCAA
TCAAACTTTAAAGATACACTTTCTAAAATTAAAATTATCAACGAATATTAACAAAAAAGC
AAAAAAAAAAAAGGTGTATTGCTTATTAAACAAAAAAAATAATTAAGTAAAAGCAAAATC
CAATAAAATAGCTAAACACTGAACAATAATAAAGAAATGAGCTAGATGAACTTTTCCTAA
ACAATCTAACTTAAGATTGAAACAGTAAAGACCTAATTCCTTAACTTCTTAAACAACTTT
GAAGTAGTTGAAAATGGAAAAAAAATCAAGTATTACAGAGAAAAGGCACTTTTGTTGAAG
ATTTATGAAAAGAATACACTTTTTATTGACTTTAATCACTTATTAGATTTTATTGATGAC
AACGATATTTCAGATGTCATTTTAAACGACTACTACAAAATTGAACCTCACTTAAGAAAA
ATTGTTTCAAATTTCATCTTTAGTCTAACCAACACAAACGATAGCCAGGAAAGTTACTAC
CTTAGCTTTTACAACTTACCAACTGAAAAGAAAATTAGAGAATTGGGAACTTAAGAAATA
GGTAAATTGAATAGTATTAAGGGTTTAGTTACTAGATCAAGTGAAGTACGTCCTGAATTA
CTTTATGGTACATTTATTTGCCAATTGTGTAATAGTGAAGTGCGTGATATTGAGTAGCAA
TTTAAATACACTGAACCTAAAATATGTTCAAACCCTGGCTGTAACAACCATACTAAGTGG
ATGTTAAAACCCTAATCATCAGTATTTTCTGATTTTTAGAAACTTAGAGTTCAAGAAGAA
TCTACTGACATTCCTGCAGGAGGTATGCCTCGTTCTATTGATATTGTTTGTAGAGGTGAA
GTTGTTGACACCGCTAAGCCTGGTGATAAATGTATTTTCACTGGTTATTTAATTGTTGTT
CCTGATATAGCAGCTCTTACTAAACCAGGTGAAAAAACTGAAATGGGTATTAAATCTGAT
GCCGTTAGAGTCAAAGGAGAAGGAAATAATGATGGTATTACTGGTCTCTCTCAACTAGGT
CAAAGAGATTTGAACTACAGACTTGTTTTCTTAGCTATTAACATTGAAGCAAAAAAGAGT
AGATTCAACTTATGGAATTAAGATGAAGAAGAAAATCAGGATTTAACTGAAGAAGAAGAA
AGACAAAAAATTATGGAAAATTTCTCTGAAAGAGAACTTGAAGACATTTTTAAAATAAGC
AGAAGTTCTAATGTTTATGAAAGATTAGCATCTAGTTTGTGTCCTACTGTACATGGTCAC
TTGGAAGTTAAAAAGGGTATTTTACTCATGCTTTTTGGTGGTGTCAACAAAAAAACAGAA
GAAGGTATTAACTTGAGAGGTGATATCAACATTTGCATGGTAGGTGATCCATCTACTGCT
AAGTCTCAATTCCTTAAATATGTTAATAAGCTTATTCCTCGTTCAGTCTATACTTCTGGT
AAAGCATCAACATCTGCTGGTTTGACTGCAAGTGTTTCTAAAGATCCTGAAACTGGAGAA
AATTGCATTGAAGCTGGTGCTTTGATGCTTTCTGACTAAGGTATTTGCTGTATCGATGAA
TTTGATAAGATGGATAAAAGAGATTAAGTCGCCATCCACGAAGCTATGGAACAATAAACA
ATTTCTATTTCAAAGGCAGGTATTCAAGCTACCTTGAATTCAAGAGCCAGTATTTTAGCT
GCTGCAAACCCTGTTTTTGGTAGATACGATAAATCCAAGGGTTTAAAATACAACTTAGAT
ATAAGCGCTCCCATTCTTTCTCGTTTCGATTTATTCTTTGTCATTTTGGATGAGTGCAAC
GAATAATCAGATAGAATGATTGCATAACATATTGTTAATATTCATTAAAGCTGTGGAAGA
AATATCAATCCTGAAATCAGTACTGAAGATTTGTCTAAGTATATACGTTTTGCTAGAACT
ATAAAGCCAATTTTCACTCGTGAAGCTGCCCTCGAATTGCAAAAATGCTATGTAAAACTT
AGATAAAATGATTCAAGCTCTTAAAATACTTCATACAGAATTACAGTCAGACAGCTTGAA
TCTCTTATTAGATTAAGTGAAGCTTTGGCTAGAGTTCACATTCAATCAGAAGTTACTGCT
GAATTTGTATAGGAAGCCGCAAGATTACTCAGCAATTCTATTCTTAAAATAGAAAAGGGA
TAATTGGACATCTAAGATGAAGAAGAGCAAAAGATAGACCTCAACTAATAAAAAGAATAA
GGCTAAAACATTATTTAAGAAGATATTGAAAAAAAACAACAATAATAAAGAAAGAAGGAA
GGTAAAATCTCAATTACTTATGAGGAATACTTAAACATGAGAAAGATAATCATTCAAACA
GTCAAAGATTTAGAAATAGAAGATAGTCTTAGAGTTTCCACAGAAGGAGAAGACGGAATG
GAAGTTGAAAGACAAAATGGTTTCGAATAAAGAGTTATTATAGAATAAATTCTTAAGCAA
TTATTAGAAAATGACCTTATCCAAACAGAAGAAGATGCTACTAAATTAAAAAAAATATAT
TCTCAAATTATTAAAAAGTTAGTAGATGTAGACTAAGTTTTAATTGTTGTCGAAGAGGCC
TCAAATTTAGACGAACGTAGATTATAACTTCATGCTAACTACTGCGAACCTAGTTGAAAT
GCATGCAAATATAGTTACTAACTAACTATCTATCATTCAATTCAAAGAATAAATAAAAAA
ATAAATTTTACTATCATAATCAAACAAATAAATAAATATAAAATAACCCTATAACATATA
TAAATAAATAAATAATTTTCAAAATTATAATTCTTTATATAAATAATTTAATTAATTATT
ATAATCTATCTATACATTAATTTTTACATATAAATTGTATATTTTATATAAAATCTCCTT
AAAAGACTTACATCCAATCATTTTTAAATTCAACTCAAATCAAATATATAAATAAATAAA
TAAATAAATAAATAAAGAAAATTTCAAATTCTATCAGCTATAAACTAATTT

>TTHERM_00448570(protein)
MRNIARILFQIVAYFLKRNFIIFRFFYIYLQFKSQSNFKDTLSKIKIINEYQQKSKKKKG
VLLIKQKKQLSKSKIQQNSQTLNNNKEMSQMNFSQTIQLKIETVKTQFLNFLNNFEVVEN
GKKIKYYREKALLLKIYEKNTLFIDFNHLLDFIDDNDISDVILNDYYKIEPHLRKIVSNF
IFSLTNTNDSQESYYLSFYNLPTEKKIRELGTQEIGKLNSIKGLVTRSSEVRPELLYGTF
ICQLCNSEVRDIEQQFKYTEPKICSNPGCNNHTKWMLKPQSSVFSDFQKLRVQEESTDIP
AGGMPRSIDIVCRGEVVDTAKPGDKCIFTGYLIVVPDIAALTKPGEKTEMGIKSDAVRVK
GEGNNDGITGLSQLGQRDLNYRLVFLAINIEAKKSRFNLWNQDEEENQDLTEEEERQKIM
ENFSERELEDIFKISRSSNVYERLASSLCPTVHGHLEVKKGILLMLFGGVNKKTEEGINL
RGDINICMVGDPSTAKSQFLKYVNKLIPRSVYTSGKASTSAGLTASVSKDPETGENCIEA
GALMLSDQGICCIDEFDKMDKRDQVAIHEAMEQQTISISKAGIQATLNSRASILAAANPV
FGRYDKSKGLKYNLDISAPILSRFDLFFVILDECNEQSDRMIAQHIVNIHQSCGRNINPE
ISTEDLSKYIRFARTIKPIFTREAALELQKCYVKLRQNDSSSQNTSYRITVRQLESLIRL
SEALARVHIQSEVTAEFVQEAARLLSNSILKIEKGQLDIQDEEEQKIDLNQQKEQGQNII
QEDIEKKQQQQRKKEGKISITYEEYLNMRKIIIQTVKDLEIEDSLRVSTEGEDGMEVERQ
NGFEQRVIIEQILKQLLENDLIQTEEDATKLKKIYSQIIKKLVDVDQVLIVVEEASNLDE
RRLQLHANYCEPS