Identifiers and Description

Gene Model Identifier

TTHERM_00522150

Standard Name

MRNO20 (Membrane Occupation and Recognition Nexus protein other)

Aliases

PreTt12330 | 65.m00148 | 3717.m00027 | TKL1

Description

MRNO20 TKL1 tyrosine kinase family protein; Protein with predicted MORN domains localized throughout the protein and/or associated with other domains having a predicted function; Protein kinase domain; Sequence similarity to the TKL protein kinase family (Eisen et al. 2006); MORN repeat

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No. Gene Name(s) Paragraph Text
2327 MRNO20 Tetrahymena thermophila’s MRNO20 protein is homologous to proteins from the 1APM superfamily, which is associated with transmembrane receptor linked kinases and other cytoplasmic proteins, and the 1B0X superfamily. It contains three domains, the first being composed of six Morn Repeats (E-value= 1E-10 to 1E-22) at the N terminus. The next domain is SAM 1, which functions in protein kinase cascades and RNA binding (E-value= 1.3E-9), and correlates with homologs in the 1B0X family. The eighth domain is tyrosine kinase protein, which transfers a phosphate group from ATP to another protein in signal transduction kinase cascade and homologs with transmembrane receptor linked kinases, specifically in cell division (E-value= 3.3E-66). The closest homologs are I. multifiliis, a disease in freshwater fish, P. tetraurelia, a ciliate common in ponds, and P. persalinus a disease of mariculture fish. MRNO20 is an essential protein that are integral in cell division, in which mutations can lead can lead to Parkinson’s disease and gastric cancer in mammals. Paragraph by: Kate DeMarsh, Ananya Venkatesh, Scripps College

Associated Literature

No Data fetched for Associated Literature

Sequences 

>TTHERM_00522150(coding)
ATGGATTTATTTAAAAAAATCTTTTAATTATAAAATGATGAAGAAAGTAAAAGTAAACAT
AAAAAATTGATAAATTATGACAATAATGAAAAGTATGAAGGTCAAACAAATAAGTAGGGA
GCTAGGCATGGATAAGGTATGATGCACTATAACAATGGAGATAAATATGAAGGTGAATGG
TATAATAATCTGAGATAAGGATAGGGTAAATAATACTATTATAATGGAGATTTTTATACT
GGATCATGGAATAAAGATAAAAAAGAAGGCCATGGTTAATATTTCTATTCAAATAATGAA
AGATATGAAGGTGATTGGTCTAATGATTTAAGACATGGAAAAGGAAAGTATTTTTATAGA
AATGGAGATATTTATGATGGTTCATGGGTGAAAGGGAAAAAAGAGGGTAAAGGAAGAATG
ACATACTACAATAATGAAGAATATGATGGCGATTGGTTAAATGATAAAAAGCACATCAAA
AATAGTACTCAAAATAATGAATCAAAAGAAGAAAATAACCATAAGAGAAGAAAAAATGGA
TAAGAAGATAATTCAAATACTAATTCTTATGAAGAGAAGAATTCAATTGATTAGATAAGA
AAAGTAATCTCTAACGGCTCAGAAAGAAAAAATAGTTCTCCTAAAAATAAAAAGAGTATA
CAAGATGATAAAGATTACGAATATGATTACAATAAGCCTAGCTCTAATAATATAAAAGAA
GAAATTTAAAACAATCTATTTAGCAATAATTAAATAAATTCAAATATTTTAGAAAGCTAG
CAACTGCAATACACAAATCAATATCACAGTAATAGAGACAATGACTTCGCTATAGCTACA
AATGTAGAAGAAAGTGTTTCTAAATCTAATATAATTGCAACTGAGGTTAATGACACATAT
CGAACGAATGGATAGAGTTTATAGATTTCTATAGATGATAACAAGGCTATTGATATATTA
GATATTATGGAGAGCTATGAAATATTAAATAATTTCCCTTAAGATTTAAGAGAATGGAAT
ACGGGACACATTTGCAAGTGGCTAGATTCAATAGGTTTAGGTGAATTCAGCCCTTCTTTT
GAAAGTAATTAAATATGTGGATAGAGTATTTGTATGCTAACCGAGTAAGAATTAGAGCAA
TCAATAGGAATGAAGGCTTTAGGTAAAAGAAAAATCTTTTTGAAGTATTAAGAAATGCTC
AAAAAGTACTATAACAAGAAATTAAGTAAAGACATTAAGCAATTCATCCATAAGCATTAG
TCTAGATTCAAAAAAGGAGAGAAGAGTTTATAGTTTCTCAAGCAAAATTAATAAAACTAC
AGAAGTATAAGGGAAGAGGACGAAAGTATTTCTTCTCACAAAAATTGTAAAAATTTAAAC
CAAATTCATAAATATAATCTCATATAAATTTTCTAATTTATTTATTTAGAAATATAATCA
TTTTATTTTAAATAAAAATATTAGCCTTAAATTCTAATTAAATAAATCAAATGGAAAATT
TTATGCTGCTTGAAGAAGACGAAGATGAAGATCATAGTGGAGGTAAAAAACAGAAGGATA
AAGACAAAAAAAATAACAGCTACAGAAATTCAGATGATGAATAAAATAAAGAAAAAAACG
AAAATAATAAAAAAAATTAAAAAATAAAGAAAAAAAAGAGAGATAAAGGAAGTAACAATA
GTTCATCTAACGATGAAAGCGACTATTCTTAATCAGATAACTAAAAAGTCAGCGGTTTAA
GGAGCAGAGAGAATTCTGGTTCTAATTTAGTAAATGTAAAGGAAGACCAAAAAGAAAAGA
AACAAAAAAGAAATTCTCCTTAGTATTAGTATATCAACAATAACAACAACAATTTTGAAG
AAAATTACAAATACAAATAAAAAGACAAATCTAAAAATTTTGCTGGAGACGAAGATGAAG
AAATTCATAAGTTTTTAAAGTTTTAAAAGAATAAGTCCTAGACAGAGTAACAAAAGCATC
ATAATAATCATATATCTAAAGTTTAATCAGACTCAACATATAACTCACATAAGTTAAAAA
TTCAATAAATAAATAACGTCTACTGTGAAGACAAGCTATTTTAAGATATTAAAGTTGAAA
AAAAATAGAACCATAAATAGTCTGGCGATTATGCTCAAAATATCTAATCAGAATCTTTAC
TCACAGAGTAAAACTAAGAGCTAGCTTACACGATATCCAATGGGAATTATTAAAATTAAG
ATATTCAAACAGCACAAGACTTAAATTAAAATAATATTTAAGAAGAAGAAATAAAAAATT
AAAAATAATTATCAAAAGAGGTAAACAAAACTCAAAGTCTTGACAATTCATATGTTAAAA
AGAAAAAGAAAGATGATAAACTTGGCCCAAGAGATGGTAAATTTAACAATAATAGTATAG
AGTCCATTGATACCTTAGAGCAAAAATAACATAAATCTGATGATGCTGCCTCAGTAAATT
AAATGA



>TTHERM_00522150(gene)
TATATAATTTAATTAATATTTAGTTTTCAAACCAGCGTTAAATCTAAATAATCAAGAATT
CTTTTTCAATTATATAAATTTAGGCATAATAATTATATAAATAAAATAGATTTACAAAAA
CTTAACAAATATAAAGAAGTTAGTCTAGAAAAAGCAATCTAGTATAAAAGGTAGCGTTTT
TGCTGGTATTTTTAGAACATAATTAGCTGAAAATAAAAGTTTAGATAGACTACTGATATA
AATTATAGGAATTAAAGCATAAAAATGGATTTATTTAAAAAAATCTTTTAATTATAAAAT
GATGAAGAAAGTAAAAGTAAACATAAAAAATTGATAAATTATGACAATAATGAAAAGTAT
GAAGGTCAAACAAATAAGTAGGGAGCTAGGCATGGATAAGGTATGATGCACTATAACAAT
GGAGATAAATATGAAGGTGAATGGTATAATAATCTGAGATAAGGATAGGGTAAATAATAC
TATTATAATGGAGATTTTTATACTGGATCATGGAATAAAGATAAAAAAGAAGGCCATGGT
TAATATTTCTATTCAAATAATGAAAGATATGAAGGTGATTGGTCTAATGATTTAAGACAT
GGAAAAGGAAAGTATTTTTATAGAAATGGAGATATTTATGATGGTTCATGGGTGAAAGGG
AAAAAAGAGGGTAAAGGAAGAATGACATACTACAATAATGAAGAATATGATGGCGATTGG
TTAAATGATAAAAAGCACATCAAAAATAGTACTCAAAATAATGAATCAAAAGAAGAAAAT
AACCATAAGAGAAGAAAAAATGGATAAGAAGATAATTCAAATACTAATTCTTATGAAGAG
AAGAATTCAATTGATTAGATAAGAAAAGTAATCTCTAACGGCTCAGAAAGAAAAAATAGT
TCTCCTAAAAATAAAAAGAGTATACAAGATGATAAAGATTACGAATATGATTACAATAAG
CCTAGCTCTAATAATATAAAAGAAGAAATTTAAAACAATCTATTTAGCAATAATTAAATA
AATTCAAATATTTTAGAAAGCTAGCAACTGCAATACACAAATCAATATCACAGTAATAGA
GACAATGACTTCGCTATAGCTACAAATGTAGAAGAAAGTGTTTCTAAATCTAATATAATT
GCAACTGAGGTTAATGACACATATCGAACGAATGGATAGAGTTTATAGATTTCTATAGAT
GATAACAAGGCTATTGATATATTAGATATTATGGAGAGCTATGAAATATTAAATAATTTC
CCTTAAGATTTAAGAGAATGGAATACGGGACACATTTGCAAGTGGCTAGATTCAATAGGT
TTAGGTGAATTCAGCCCTTCTTTTGAAAGTAATTAAATATGTGGATAGAGTATTTGTATG
CTAACCGAGTAAGAATTAGAGCAATCAATAGGAATGAAGGCTTTAGGTAAAAGAAAAATC
TTTTTGAAGTATTAAGAAATGCTCAAAAAGTACTATAACAAGAAATTAAGTAAAGACATT
AAGCAATTCATCCATAAGCATTAGTCTAGATTCAAAAAAGGAGAGAAGAGTTTATAGTTT
CTCAAGCAAAATTAATAAAACTACAGAAGTATAAGGGAAGAGGACGAAAGTATTTCTTCT
CACAAAAATTGTAAAAATTTAAACCAAATTCATAAATATAATCTCATATAAATTTTCTAA
TTTATTTATTTAGAAATATAATCATTTTATTTTAAATAAAAATATTAGCCTTAAATTCTA
ATTAAATAAATCAAATGGAAAATTTTATGCTGCTTGAAGAAGACGAAGATGAAGATCATA
GTGGAGGTAAAAAACAGAAGGATAAAGACAAAAAAAATAACAGCTACAGAAATTCAGATG
ATGAATAAAATAAAGAAAAAAACGAAAATAATAAAAAAAATTAAAAAATAAAGAAAAAAA
AGAGAGATAAAGGAAGTAACAATAGTTCATCTAACGATGAAAGCGACTATTCTTAATCAG
ATAACTAAAAAGTCAGCGGTTTAAGGAGCAGAGAGAATTCTGGTTCTAATTTAGTAAATG
TAAAGGAAGACCAAAAAGAAAAGAAACAAAAAAGAAATTCTCCTTAGTATTAGTATATCA
ACAATAACAACAACAATTTTGAAGAAAATTACAAATACAAATAAAAAGACAAATCTAAAA
ATTTTGCTGGAGACGAAGATGAAGAAATTCATAAGTTTTTAAAGTTTTAAAAGAATAAGT
CCTAGACAGAGTAACAAAAGCATCATAATAATCATATATCTAAAGTTTAATCAGACTCAA
CATATAACTCACATAAGTTAAAAATTCAATAAATAAATAACGTCTACTGTGAAGACAAGC
TATTTTAAGATATTAAAGTTGAAAAAAAATAGAACCATAAATAGTCTGGCGATTATGCTC
AAAATATCTAATCAGAATCTTTACTCACAGAGTAAAACTAAGAGCTAGCTTACACGATAT
CCAATGGGAATTATTAAAATTAAGATATTCAAACAGCACAAGACTTAAATTAAAATAATA
TTTAAGAAGAAGAAATAAAAAATTAAAAATAATTATCAAAAGAGGTAAACAAAACTCAAA
GTCTTGACAATTCATATGTTAAAAAGAAAAAGAAAGATGATAAACTTGGCCCAAGAGATG
GTAAATTTAACAATAATAGTATAGAGTCCATTGATACCTTAGAGCAAAAATAACATAAAT
CTGATGATGCTGCCTCAGTAAATTAAATGAACAGCCCTGATATTAGATAAAACGATTTGA
TTAAATCTTTGCAACCGGATTTTATCAACACAAAGCCATTCATTTTAAATTTTAATTAAT
CTATTAACTAAAATGAAAACACTCTTTTTAAGCTTGGAATATAAAAAGATCTTTTCATAA
GTGACAAAAATGACAGTCAAAAAACTGGATTGACAAAAATTACATCTTCAAACTAATCAG
GTGGTTAAACTTTGATTAATTAATCATCAGGGGCAATTGGAAATCCTACAGCTCAAAATT
CGAGTGTCGAAAATAACTCTGGTTAAAATAAAGGAATGTAAATAAGCAACAATCAGCTTT
CTTCTTCCAGCTCTTCTTCTGATGAGTCTTCAGATAATGAACCTAATAAGCAAGTAGTAA
ATAAGAGATCAAAGGGAGATGGAGGTGCTTCTATATCGAGCTAAGATTCAGATACAAATT
CAAAACTTAAACAAAGATAGACACCTCAATAAAAATTTAAAAAAGAAAATACAAAAGATG
GAAGCAGAAACCCTAGCAAAGATAAAGCTACTCCTCAAATTAAACATAAAGATAAAGATA
AAGATAAAATGAAAGAAGTTAGTAAAGAAAAATCAAGGTTAAGAAGAGAAGAAAAATAAT
AATAGTTGGATTAACTACTGAGAGACATGGGTATCAATAAAAAACTTATTATAAATTACT
AAGAACTTGATTTTGGAAAAAAAATCGGAGAAGGAAGTTATGGTTAAGTATTCAAAGGTA
CATGGGCCAAAACTCAAGTTGCTATTAAAGTATTCATTAAAGAAAATTATTGTTTATTTA
AAAATAAATTTTGTTTTTATAAAAAGTAATTCGGAAAATAAAATTCGAAATTCCACCTTA
GAAAAGTTTAAGATTTTATATCAGAAGTTCGTGTTATAAACAATCTAAGACACCCAAACA
TCGTTTTATATATGGGTGTTTGCTTTTATCAGTCACAATATTTTATGATTACAGAGTAAT
TCATTCATAAGTTAACTTGAAATTATTAATTAATTATTTCAAATTATCATAGATATTTAC
AAGAAGGTTCATTATACGATCATTTACATATCAAGCATACAGCTTTTAGCGAAGCTAAAT
AAATTGATATGATAGAAGATATGGCATTAGGAATGGTATATTTACATGGAAGAAAAGTAA
TGCATTGTGATTTGAAGAGCTCAAACGTTTTAATAGATGAAAATTGGAATGTTAAGCTTT
GCGATTTTGGGCTTTCAAGAATTAAATCAACACTGAATAAAAAGAAAAATGCTCGTAAAA
ATGAAGGCTTAATTGGAACTCCATAATGGATGGCACCAGAAATTATGAGAAGAGAGTAAT
ATTAAGAGCATTCTGACGTCTACTCGTTTGGCATGATTATGTGGGAAATTGCTACGAGAA
AAGTACCTTATTTGGGTCTATCTCATTAGTAAATTTATGGTACTGTAGGATATGATGAAA
ATTATTAAGTAGAAATACCTGTAAGAGGAATACCTAGATATTTGAATCTAATGAAAAAAT
GTTTAAGAAGAAACCCATAAGAAAGACCTACTTTCTAAGAAGTAGTTGAAGAAATTTTTA
AAATAAAAAAAGATCTTAAAGATAATAATAAAAGTAAATAAATTTCTATAAAATAATTAA
AAAAATATTTTCAAACTCATTTTTTTAAAAAAAAAAGAATAAGTAGTAAAAGAAATCATA
AGATTCTTTGATTGATTGATTGATATTTTAATTAATTTAATACAATCTATTGTTAATTCT
AAATATTAGTTTAGTTTGGTATAAATTATATTTTACTTATCCAGTAAAATTTTATTAAAT
TAAAATTTTTAACAAAGTAAATTATAAATTTT



>TTHERM_00522150(protein)
MDLFKKIFQLQNDEESKSKHKKLINYDNNEKYEGQTNKQGARHGQGMMHYNNGDKYEGEW
YNNLRQGQGKQYYYNGDFYTGSWNKDKKEGHGQYFYSNNERYEGDWSNDLRHGKGKYFYR
NGDIYDGSWVKGKKEGKGRMTYYNNEEYDGDWLNDKKHIKNSTQNNESKEENNHKRRKNG
QEDNSNTNSYEEKNSIDQIRKVISNGSERKNSSPKNKKSIQDDKDYEYDYNKPSSNNIKE
EIQNNLFSNNQINSNILESQQLQYTNQYHSNRDNDFAIATNVEESVSKSNIIATEVNDTY
RTNGQSLQISIDDNKAIDILDIMESYEILNNFPQDLREWNTGHICKWLDSIGLGEFSPSF
ESNQICGQSICMLTEQELEQSIGMKALGKRKIFLKYQEMLKKYYNKKLSKDIKQFIHKHQ
SRFKKGEKSLQFLKQNQQNYRSIREEDESISSHKNCKNLNQIHKYNLIQIFQFIYLEIQS
FYFKQKYQPQILIKQIKWKILCCLKKTKMKIIVEVKNRRIKTKKITATEIQMMNKIKKKT
KIIKKIKKQRKKREIKEVTIVHLTMKATILNQITKKSAVQGAERILVLIQQMQRKTKKKR
NKKEILLSISISTITTTILKKITNTNKKTNLKILLETKMKKFISFQSFKRISPRQSNKSI
IIIIYLKFNQTQHITHISQKFNKQITSTVKTSYFKILKLKKNRTINSLAIMLKISNQNLY
SQSKTKSQLTRYPMGIIKIKIFKQHKTQIKIIFKKKKQKIKNNYQKRQTKLKVLTIHMLK
RKRKMINLAQEMVNLTIIVQSPLIPQSKNNINLMMLPQQIK