Identifiers and Description

Gene Model Identifier

TTHERM_00688660

Standard Name

REBL1 (Retinoblastoma binding protein 4/7-like 1 (RebL1))

Aliases

PreTt23161 | 105.m00128 | 3737.m00041 | SSCH1

Description

REBL1 Ortholog of histone-binding proteins RBBP4 and RBBP7; Contains WD-40 repeats; Subunit of multiple chromatin-related complexes including CAF1, Hat1, Rpd3 (Sin3), and MuvB (Nabeel-Shah et al., 2021); WD repeat RBAP46/RBAP48/MSI1

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

  • ( PF00400 ) WD domain, G-beta repeat
  • ( PF12265 ) Histone-binding protein RBBP4 or subunit C of CAF1 complex

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No. Gene Name(s) Paragraph Text
2351 REBL1 RebL1 physically interacts with histone H4 and functions in multiple epigenetic regulatory pathways. Genome-wide analyses indicated that RebL1 binds within genic and intergenic regions. RebL1 depletion inhibited cellular growth and reduced the expression levels of multiple genes during Tetrahymena vegetative growth (Nabeel-Shah et al.2021).

Associated Literature

  1. Ref:37024975: Nabeel-Shah S, Garg J, Ashraf K, Jeyapala R, Lee H, Petrova A, Burns JD, Pu S, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J (2023) Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation. Epigenetics & chromatin 16:10
  2. Ref:34086947: Nabeel-Shah S, Garg J, Saettone A, Ashraf K, Lee H, Wahab S, Ahmed N, Fine J, Derynck J, Pu S, Ponce M, Marcon E, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J (2021) Functional characterization of RebL1 highlights the evolutionary conservation of oncogenic activities of the RBBP4/7 orthologue in Tetrahymena thermophila. Nucleic acids research ( ):

Sequences 

>TTHERM_00688660(coding)
ATGAATCAATAAATGGCTGAAGAATTTAATGATGGTTATGAAAACCAAGCTATTAATGAT
GAATATAAGATATGGAAAAAAAATGCTCCTTTCCTATATGATATAGCAATAACACACGAA
TTAGAGTGGCCTTCATTATCTGTATAGTGGCTACCTACTAAAGATATCCCTTAAGAAAGT
GACTATGCAATTCATAAACTGATTTTAGGAACTCATACATCTGGTTAGGATAAAGATTAT
TTGCTTATTGCCAAGGTTAGATTGCCACTTGAAGAAACTGCTACAGATATTAGCGAATAC
CAAAATTAAGCAAAAGAAGTCGGATAAACTGGTTTGTCAGCTGGAGAAAATAGAATAGAA
ATAGAAACAAAAATATTGCATGATGGAGAAATTAATAGAGCTAGATACATGCCTTAAAAG
TATAATGTAATTGCCACAAAAGTAACAAATGGTGAAATCCATGTTTTTGATTACACATAA
CATCCTACTACCCCATAAAATGACTAAGTTCGCCCTTAGCTTAGACTCGTTGGTCATTCA
GCAGAAGGTTATGGTATTTCTTGGAATCCTAAAAAACAAGGTTATATTGTTTCTGGTGGT
TATGATAAAAAAATATGTATTTGGAATGTTGAAGCTGCTTCATAATTAAATTCATCTATT
AGTCCTCTCCATGATATCGAATTTCATAAATCATGTGTAGAAGATGTTGCTTGGCACTAA
ATAAATCCTGATATATTTGGTTCAGTTAGTGATGATCGTACTGTAGCTATATGGGATATG
AGATAAAAATCAAATGCAGGATTAATCAATCCAACTCATTGTACATAAGCTCATACTGGA
GATATTTATTGTTTAGATTTTAATCCTTTCAACGAATATTTATTTATTACAGGCTCAGAA
GATAAAAATATTGGATTTTGGGATATGAGAAACACATCTAAAAGATTACATACTTTTGTA
GGACATACTGATCAAGTTTTGAGATGTGAATGGTCACCTTTCAATGTTGGTGTATTTTCT
AGTTGTTCTGCTGATAGAAGAGTTATTGTTTGGGATATCAGCAAATGTGGTTAGGAAATG
AAAAATGAAGATTTAGTCGATGGACCTCCAGAGCTTCTATTTATGCATGGAGGCCACAGA
GCAAAAGTAAATGATATCAGTTGGAATCAAAAAGAAAATTTAATTTTAGCTTCAGTTGAA
GAAAATAACATATTGCAAGTTTGGCAAATGGCTAGAAATATATATGATGATACTGATGAT
GAAGTAATGAAAGACTGA



>TTHERM_00688660(gene)
GTGTAAATATAAAAAATAGATACTGAGTATTAAAAAGCGAAGATAACTAAACAATGAATC
AATAAATGGCTGAAGAATTTAATGATGGTTATGAAAACCAAGCTATTAATGATGAATATA
AGATATGGAAAAAAAATGCTCCTTTCCTATATGATATAGCAATAACACACGAATTAGAGT
GGCCTTCATTATCTGTATAGTGGCTACCTACTAAAGATATCCCTTAAGAAAGTGACTATG
CAATTCATAAACTGATTTTAGGAACTCATACATCTGGTTAGGATAAAGATTATTTGCTTA
TTGCCAAGGTTAGATTGCCACTTGAAGAAACTGCTACAGATATTAGCGAATACCAAAATT
AAGCAAAAGAAGTCGGATAAACTGGTTTGTCAGCTGGAGAAAATAGAATAGAAATAGAAA
CAAAAATATTGCATGATGGAGAAATTAATAGAGCTAGATACATGCCTTAAAAGTATAATG
TAATTGCCACAAAAGTAACAAATGGTGAAATCCATGTTTTTGATTACACATAACATCCTA
CTACCCCATAAAATGACTAAGTTCGCCCTTAGCTTAGACTCGTTGGTCATTCAGCAGAAG
GTTATGGTATTTCTTGGAATCCTAAAAAACAAGGTTATATTGTTTCTGGTGGTTATGATA
AAAAAATATGTATTTGGAATGTTGAAGCTGCTTCATAATTAAATTCATCTATTAGTCCTC
TCCATGATATCGAATTTCATAAATCATGTGTAGAAGATGTTGCTTGGCACTAAATAAATC
CTGATATATTTGGTTCAGTTAGTGATGATCGTACTGTAGCTATATGGGATATGAGATAAA
AATCAAATGCAGGATTAATCAATCCAACTCATTGTACATAAGCTCATACTGGAGATATTT
ATTGTTTAGATTTTAATCCTTTCAACGAATATTTATTTATTACAGGCTCAGAAGATAAAA
ATATTGGATTTTGGGATATGAGAAACACATCTAAAAGATTACATACTTTTGTAGGACATA
CTGATCAAGTTTTGAGATGTGAATGGTCACCTTTCAATGTTGGTGTATTTTCTAGTTGTT
CTGCTGATAGAAGAGTTATTGTTTGGGATATCAGCAAATGTGGTTAGGAAATGAAAAATG
AAGATTTAGTCGATGGACCTCCAGAGCTTCTATTTATGCATGGAGGCCACAGAGCAAAAG
TAAATGATATCAGTTGGAATCAAAAAGAAAATTTAATTTTAGCTTCAGTTGAAGAAAATA
ACATATTGCAAGTTTGGCAAATGGCTAGAAATATATATGATGATACTGATGATGAAGTAA
TGAAAGACTGATTTGATTTACTCAGTTACTTAATTAAAAATGAACTTTTTGAGTAGTATA
AAAATAAAAACCAACAAAGCAAACAAAATATTACAAATTTTTAACTTTATATAAAAATAT
ACAAAATAAATAGATAAATAAATCAATCAATTAATCATATCTAAATAAAATCAATTTAGA
AATAAAATTAATAGGAAAGCTTCATATTGTGTAAAAGAAATTAATTAAAAAAGGGATCAA
ATAAATAAAGTTAAAAAATAAATTATAAAACTAAGTAAG



>TTHERM_00688660(protein)
MNQQMAEEFNDGYENQAINDEYKIWKKNAPFLYDIAITHELEWPSLSVQWLPTKDIPQES
DYAIHKLILGTHTSGQDKDYLLIAKVRLPLEETATDISEYQNQAKEVGQTGLSAGENRIE
IETKILHDGEINRARYMPQKYNVIATKVTNGEIHVFDYTQHPTTPQNDQVRPQLRLVGHS
AEGYGISWNPKKQGYIVSGGYDKKICIWNVEAASQLNSSISPLHDIEFHKSCVEDVAWHQ
INPDIFGSVSDDRTVAIWDMRQKSNAGLINPTHCTQAHTGDIYCLDFNPFNEYLFITGSE
DKNIGFWDMRNTSKRLHTFVGHTDQVLRCEWSPFNVGVFSSCSADRRVIVWDISKCGQEM
KNEDLVDGPPELLFMHGGHRAKVNDISWNQKENLILASVEENNILQVWQMARNIYDDTDD
EVMKD