Identifiers and Description

Gene Model Identifier

TTHERM_00780530

Standard Name

CSKB1 (CaSein Kinase Beta subunit 1)

Aliases

PreTt01265 | 130.m00075 | 3738.m00011

Description

CSKB1 Casein kinase II (CKII) regulatory beta subunit; Tetrahymena CKII-complex appears to have two alpha subunits and one regulatory beta subunit (Nabeel-Shah et al., 2023); Associated with transcription factor interaction in DNA repair pathway of macronucleus; Casein kinase II, regulatory subunit

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External Links

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

  • ( PF01214 ) Casein kinase II regulatory subunit

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No. Gene Name(s) Paragraph Text
2356 CSKB1, CSKA2, CSKA1 CKII subunits including CSKA1, CSKA2, and CSKB1 co-purified with Cac2 subunit of putative CAF1-complex in Tetrahymena. Tetrahymena appears to contain a single putative homolog of the two regulatory beta subunits of CKII that are found in humans. Affinity purification followed by mass spectrometry (AP-MS) analysis of TTHERM_00780530 (CSKB1) identified a large number of proteins to co-purify, suggesting that CKII clients might include functionally diverse proteins in Tetrahymena (Nabeel-Shah et al., 2023).
2357 CSKB1, CSKA2, CSKA1 CKII subunits including CSKA1, CSKA2, and CSKB1 co-purified with Cac2 subunit of putative CAF1-complex in Tetrahymena. Tetrahymena appears to contain a single putative homolog of the two regulatory beta subunits of CKII that are found in humans. Affinity purification followed by mass spectrometry (AP-MS) analysis of TTHERM_00780530 (CSKB1) identified a large number of proteins to co-purify, suggesting that CKII clients might include functionally diverse proteins in Tetrahymena (Nabeel-Shah et al., 2023).
2358 CSKB1, CSKA2, CSKA1 CKII subunits including CSKA1, CSKA2, and CSKB1 co-purified with Cac2 subunit of putative CAF1-complex in Tetrahymena. Tetrahymena appears to contain a single putative homolog of the two regulatory beta subunits of CKII that are found in humans. Affinity purification followed by mass spectrometry (AP-MS) analysis of TTHERM_00780530 (CSKB1) identified a large number of proteins to co-purify, suggesting that CKII clients might include functionally diverse proteins in Tetrahymena (Nabeel-Shah et al., 2023).

Associated Literature

  1. Ref:37024975: Nabeel-Shah S, Garg J, Ashraf K, Jeyapala R, Lee H, Petrova A, Burns JD, Pu S, Zhang Z, Greenblatt JF, Pearlman RE, Lambert JP, Fillingham J (2023) Multilevel interrogation of H3.3 reveals a primordial role in transcription regulation. Epigenetics & chromatin 16:10

Sequences 

>TTHERM_00780530(coding)
ATGTCAGAGGACTCATAATATTCTGATCTTCCTGGTGGTTGGATTAGCTGGTTTTGTGCT
CTTGAGGATCACTAATTTTTATGTGAAGTTGATGATGATTACATCAGAGATAACTTTAAT
CTTTATGGAATTAAGCAAAAGTTCAATCACTACAACGATACTATTGAAATGATTTTATCC
AGTGAAAGTCCCGATGATGATGATCTTGAAGATGAAAGATTTTTAGAAATCTACTAGGAA
GCAACTGACGTTTATGGTTTAATTCACGCTCGTTTCATTACTTCCCCAAAAGGATTAGCT
TTAATGAGAGAAAAGTTCTTGTTGGGCCGTTTCGGAGTTTGTCCTAGAGTACTTTGTGAA
AGACAAAATGTCTTACCTGTTGGTATGAGTGAAGAGCTTAGAACATCCAGAGTCAAAGTT
TATTGCCCTCGTTGTGAAGATGTATATATTCCTAAGAAAAAATGTCCTGATATCGATGGA
TGTTATTTCGGTGTTTCCTTCCCTCAAATCCTTCTTATGACATACCCTGATTTAGTCCCA
TCAAGAAACAATTCCACTTATATTCCTAGAATTTACGGTTTCAGAATATACAAGAAAAAG
GGATCTAAGTTCCTTGAAGAAGAAAACCCTTTGGTAGAAGTAACACATTATAGTGAAGAG
CTATTAAGACAAATAAGGGGAAAAGTTGATAAAAAAAATGAAGAAAAGAAAGCATTAACC
AACTCAACAACTGCTTAGAGTTACGGAAATACCTAAAATAATAACGCCAATCAAATGAAT
AACTGA



>TTHERM_00780530(gene)
AAAAAAACTTAAGTAATTAAATAAAGGAAATTAGTAAGAAGAAAGAAGAAAAATTAAATT
AATAAAAAGAATCAAATAAATATGTCAGAGGACTCATAATATTCTGATCTTCCTGGTGGT
TGGATTAGCTGGTTTTGTGCTCTTGAGGATCACTAATTTTTATGTGAAGTTGATGATGAT
TACATCAGAGATAACTTTAATCTTTATGGAATTAAGCAAAAGTTCAATCACTACAACGAT
ACTATTGAAATGATTTTATCCAGTGAAAGTCCCGATGATGATGATCTTGAAGATGAAAGA
TTTTTAGAAATCTACTAGGAAGCAACTGACGTTTATGGTTTAATTCACGCTCGTTTCATT
ACTTCCCCAAAAGGATTAGCTTTAATGAGAGAAAAGTTCTTGTTGGGCCGTTTCGGAGTT
TGTCCTAGAGTACTTTGTGAAAGACAAAATGTCTTACCTGTTGGTATGAGTGAAGAGCTT
AGAACATCCAGAGTCAAAGTTTATTGCCCTCGTTGTGAAGATGTATATATTCCTAAGAAA
AAATGTCCTGATATCGATGGATGTTATTTCGGTGTTTCCTTCCCTCAAATCCTTCTTATG
ACATACCCTGATTTAGTCCCATCAAGAAACAATTCCACTTATATTCCTAGAATTTACGGT
TTCAGAATATACAAGAAAAAGGGATCTAAGTTCCTTGAAGAAGAAAACCCTTTGGTAGAA
GTAACACATTATAGTGAAGAGCTATTAAGACAAATAAGGGGAAAAGTTGATAAAAAAAAT
GAAGAAAAGAAAGCATTAACCAACTCAACAACTGCTTAGAGTTACGGAAATACCTAAAAT
AATAACGCCAATCAAATGAATAACTGATTATGATAATTAAAACATATTTTTTTCTTAAAC
TAAAAATTAATAAATCTTTCTTAATACACTTAAAATATCTATCTCAATCATCTTATCAAG
TATACGCATGAATGATATTATTATCGATTTTTATCACATGAATATTATAAATATATAAAG
ACTGTTAAGCTTAGTTTCAAATATCAGAATCTGTAAGTAAGTAAGCAAATGAATCAATAA
ATCAATCAGCAAAATAAAACTCCTATCTTCCTTTATTTCTTCAGCTTGCTGAAGTTTCTG
AATTTGAGTATTATTAATCCCACTTTTTTAGTAATTGATACATGTACTAAACTATTTTGC
TTGTTAGTATTATTCTATCGCATTAGTTAAGCTGATTTGGCAACTCATGATTTGATTTGA
TTTAATGATAATCATAGCATAATAAAAAGGAAATGTTTATTTTTTTAAATAATACTTTCT
TTTTTTGTGTTATTTTTCATAACATTTCTAATAAATTGAATTATAATAATTTTAAATTAA
AGTCTTGATTTCATTACTTAACAATTTATTTATTTATTTTTTTATTCATGTAAAAATTAT
AATTTTTTGTAAAAATAAATAAAAATCTGCTAATTTTTTTATTGAT



>TTHERM_00780530(protein)
MSEDSQYSDLPGGWISWFCALEDHQFLCEVDDDYIRDNFNLYGIKQKFNHYNDTIEMILS
SESPDDDDLEDERFLEIYQEATDVYGLIHARFITSPKGLALMREKFLLGRFGVCPRVLCE
RQNVLPVGMSEELRTSRVKVYCPRCEDVYIPKKKCPDIDGCYFGVSFPQILLMTYPDLVP
SRNNSTYIPRIYGFRIYKKKGSKFLEEENPLVEVTHYSEELLRQIRGKVDKKNEEKKALT
NSTTAQSYGNTQNNNANQMNN