Identifiers and Description
Gene Model Identifier
TTHERM_00294760Standard Name
DNF1 (Drs2 Neo1 Family )Aliases
PreTt15586 | 27.m00246 | 3692.m00049Description
phospholipid-translocating P-type ATPase flippase family proteinGenome Browser (Macronucleus)
Genome Browser (Micronucleus)
Gene Ontology Annotations
Cellular Component
- integral component of membrane (IEA) | GO:0016021
- membrane (IEA) | GO:0016020
Molecular Function
- ATP binding (IEA) | GO:0005524
- ATP hydrolysis activity (IEA) | GO:0016887
- P-type ion transporter activity (IEA) | GO:0015662
Biological Process
- monoatomic cation transport (IEA) | GO:0006812
Domains
- ( PF00122 ) E1-E2 ATPase
- ( PF00702 ) haloacid dehalogenase-like hydrolase
- ( PF08282 ) haloacid dehalogenase-like hydrolase
- ( TIGR00012 ) ribosomal protein L29
- ( TIGR00099 ) Cof-like hydrolase
- ( TIGR01116 ) calcium-translocating P-type ATPase, SERCA-type
- ( TIGR01484 ) HAD-superfamily hydrolase, subfamily IIB
- ( TIGR01494 ) ATPase, P-type (transporting), HAD superfamily,
- ( TIGR01517 ) calcium-translocating P-type ATPase, PMCA-type
- ( TIGR01647 ) plasma-membrane proton-efflux P-type ATPase
- ( TIGR01652 ) phospholipid-translocating P-type ATPase, flippase
Gene Expression Profile
Vegetative Cell Cycle (Zhang et al.,
2023)
GeneMania
Tetrahymena Stock Center
No Data fetched for Tetrahymena Stock Center
Homologs
Source Identifier Score Stentor Coeruleus SteCoe_25323 0 Description: None WormBase WBGene00019166 9.997093137033517e-262 Description: locus:tat-2 status:Partially_confirmed UniProt:U4PRL1 protein_id:CDH93216.1 Tetrahymena borealis EI9_08733.1 9.997093137033517e-262 Description: phospholipid-translocating P-type ATPase, flippase (1229 aa) DictyBase DDB_G0269380 9.997093137033517e-262 Description: DDB_G0269380 on chromosome: 1 position 2645714 to 2650717 Oxytricha Contig10125.0.g35 9.997093137033517e-262 Description: haloacid dehalogenase-like hydrolase SGD YAL026C 9.997093137033517e-262 Description: DRS2 Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease
General Information
No. Gene Name(s) Paragraph Text 19 FLP10, FLP19, FLP18, FLP17, FLP8, FLP16, FLP15, FLP14, FLP6, FLP13, FLP11, FLP2, FLP1, DNF1 , FLP9, FLP12, FLP4, FLP7, FLP5 The phospholipid flippase family of genes in Tetrahymena contains 20 members, FLP1-FLP20. Preliminary studies show that many of these genes are differentially regulated in response to temperature and/or the presence of a polycyclic aromatic hydrocarbon (pyrene).
Associated Literature
No Data fetched for Associated Literature
Sequences
>TTHERM_00294760(coding)
ATGCCTAGAAAAAGATGGTAAGACATGCCTGATAGGACTATTGTTAGTAATTGTCCTGAG
CATGTTAAATTTTGTAATAATAGTATCTCAACCACAAAGTACACTCTCTTCACTTTTATT
CCCATGAATCTAGTTGAGTAATTTAGTAAGTTAGCAAATGTCTACTTTTTATTTATTGGA
ATGATGCAAATGATAAATGAAATATCTATTTCGAATGGTTAGCCGGTTATATATGTTCCG
CTTTTTGTTGTTTTGATGATATCTGGAATTAAAGATCTATTTGAAGATATGAAAAGGAAC
AAGTCAGATTAAGAAGAGAATCAAAGATTGGTATGGACTTATAGAAATGGCATGTGGATA
AGAGTATATTGGTAGAGTTTATTAGTAGGAGAAATAGTAAAAGTAGAAAAAAACTAACTC
TTTCCTGCAGATATTTTATGTATGTATACAACTGATTCTAAGGGCCTTTGCTATGTAGAA
ACTAAAAACCTAGATGGCGAAACCAATTTGAAGCGCAAAATATCGAATAAATCTTTATAG
CAATTAGGAGAAGCTGCTATTCTACATTAAAAATTTACTTTTAATTGTGAAAAACCAAAC
CCCTACTTATATAAATTTTAAGGAAACATGGAAATAACAGATGGTTACGATTAATAGTAG
AAAATATCCCTAGATTACAACAATTTTATACTTAGAGGATGCTCTCTGAAAAATACAGAC
TATGTAATTGGCTTGGTTTCTTATACTGGAAGAGATTCTAAAATAATGATGAATACAGTA
AACGCAAGATCAAAGAGATCTCATATAGAAAAAAAAATGAATGTTTTTATTAGTTTGGTC
TTCTTGCTTTAAATAGTAGTATGCTTGTCATTTGCATTAGGTGCTGCAATTTGGTTTAAT
TAAAATAAATCAAGCCTCATTTTTATGCTTGGAGTCAGTAGTACAGCAGAAATAGACAAC
AGTTTTGGTTATTTATTAGTTGTGCAGTGGGGTGCTTGGATTCTTATATTTACTAACTTT
GTTCCTATCAGCTTAATTGTAACCTTGGAAATGGTGAAATTTATGTAAGGAATCAGAATT
ACATAAGATCCAAATACATATTCAAAAACTTATGATATTCAGTGCACTGTGTAATGCAGT
GGATTGAATGAAGAATTAGGATAAGTAGAGTATGTTTTTTCTGATAAAACTGGAACATTA
ACAAGCAACACGATGAAATATAAATGCTTAACAGTGAATGGCGTATCTTATGGTGAGTAA
GATAATATGACTGAATAAGAGTTGATAGATAAGCCTAATGTAACAAATGTTAAATTTTTA
GATAAAAAGTTATTTGAAGACATGTAAGGTAAAAAAGCTATGGGTTCAGAATAGCAACAA
CATCTTTTTACAGCTTTAAAAGTACTCTCTGCTTGCCATACTGTGATTACAGAAAAGACA
TCAGAAGGAATAGAATACAATGCTTCCTCACCAGATGAGCTGGCACTTATAAATTTTGCT
AAATTTTGTGGATTCGAGTATCTTGGAATTGACGAAGACAGTGTTATGAGAATTAAGTAA
GAAAATATAATGCACAGATTTAAGGTATTGAATGTATTAGACTTTAATTCAGTAAGAAAG
CGCATGAGTATTATTGTGGAAGATTCTAATGGCAAGATTTTCTTGTTTTGTAAAGGTGCA
GACAGTGTCTTACAAAAGCTACTTGACTAAAAATTAAATGAAGATCATATAATAGAGTAG
ACATGGATTAACTTAGAAAGGTATGCATCTGTTGGTCTCCGTACTCTTGTTTTAGCATAA
AAAGAAATTTAAAAAGATGAGTACCATTTATGGAATGAACAGTACTAAGTAGCATGCTGC
AGCCTTAAAGACAGAGAAGAAGAAATGGAAAGGTTACAAAAAAAGATAGAAAAAAATCTT
ATCTTAGTAGGAGCTACTGCGATAGAAGATTAATTACAAGACGAAGTTTCTTCAACTATC
TAGCTTATGAAGAAAGCTGGAATAAAAGTTTGGGTGCTGACAGGAGATAAAGTTGAAACA
GCAGTTAATATAGGCTACGCTTGCTCACTTTTGAATGATTAGTTAAGGAGAATTCTTGTT
GATGGTTATAGTTTAGAAGAAGTATAAAAATCTTTACAGGCAGCTTACAAGTCTATCCTA
AATGAAGTTGAAAATCATAACTAAACTATCCTTTAAAGCAATAGAAAAAAGTCATAAAAG
AACGAAATGATAAAGAACTTTAGTTTAGATCTCGCTCTAATCCTGACAGGAGATGCTTTG
ATACACTGTACAGAAAATAAAGAGAATAATGAAACTCTAATGAAAATATCAGAACATTGT
AAAGTAGTTCTTGCTTGTAGAGTTTCGCCTAAACAGAAGTAAGAAATTGTGCATTTAGTT
AGAGTTGCTAAACCAGAGTCAACAACTTTAGCAATTGGAGATGGAGCTAATGATGTGAAT
ATGATAAGTGCTGCTCATGTTGGTGTTGGCATTAGAGGAAAAGAAGGATAACAAGCAGCT
AGAGCAAGCGATTTTGCTGTTGGAGAATTTAAAATATTAAAATCCTTACTTTTTAATCAT
GGAAGAGAATCTTATAGAAAAAATTCAACTTTGATATGCTACAATTTTTACAAAAATATG
CTATTAGTCTTACCATAGTGGTGGTATGCCTTCATTAGTGGGTATTCGGGTTCTTCCATG
TATGACCCTTGGATTTATTAACTTTATAATATGTGTTACACTTCTCTTCCAATTGTTGTA
TATGCTATTTTTGACCAAGAGTTTAGTGATGAATATTTGGTTGAAAATCCTGATCTTTAT
GTCCAAGGTATAAAAGGTTTACTTTTTAATCAAAGAGAATACTGGCTTTGGATAATAAAT
GGATCTTGGCATGCTTTCTTAAGTTGTTTCATAAGCTTTGTAGGTTTAGATGGAACATTT
TAGGTTAATGGAAAAGATTTCTTTTTCTAAGCCACAGGAACTGTTACTTTCGGAGCTACT
GTCTTCATTGGAAATTTAAAAGTTTATATTTTCAGCAACACTTACAACCCAGCTTTATTG
ATAAGTGTTTTTGGAAGTATTATCTTCTATATTTCAAATCATGGGCTGGCAAGCTATTTC
TATGTCACATCTGATATATTCAATACTTTTTCAAACACTTATTCAAGCCCTTACTTTTGG
TTTTGTTCAATAATAATTATAGGAATCGCTACTATATTTGATTCTACTGATAGAAGATGG
GAATATTTTAGCTAAGTACTTAAAAGACAAGATGAAAAGAAATTAGCTTTACTTAATGAG
GCTCTAACATATTAATAAAATGAAGGATTAAATCTTGAAGGTTCAAAAAGTAATTCAGCA
GAAAATAAAAATTATTAACAAGAAAACAGAGACGAGATTATAACGTGTGTTGGGATGCTC
AAAAATGGATACTAAACTTAAGAACCAATAAATCTAAAGTAGCACAAGCCTCTATATGGA
GAAGAAGAAAAGGTGCCTTCCAGCGAATCTCTTAGCAATCCTCCTTATCCAAATAAATCC
GCTAAGACTGTATCTAACCATTAAAATTCCCACATGAATTCTAATTATCTTACTAGCACT
AAGCCATACACAGGATATGCTTTTTCTCAAATAGAGCCCATCACAGAAGCTTAATAAAAG
TATACTTACTGA>TTHERM_00294760(gene)
ATGCCTAGAAAAAGATGGTAAGACATGCCTGATAGGACTATTGTTAGTAATTGTCCTGAG
CATGTTAAATTTTGTAATAATAGTATCTCAACCACAAAGTACACTCTCTTCACTTTTATT
CCCATGAATCTAGTTGAGTAATTTAGTAAGTTAGCAAATGTCTACTTTTTATTTATTGGA
ATGATGCAAATGATAAATGAAATATCTATTTCGAATGGTTAGCCGGTTATATATGTTCCG
CTTTTTGTTGTTTTGATGATATCTGGAATTAAAGATCTATTTGAAGATATGAAAAGGAAC
AAGTCAGATTAAGAAGAGAATCAAAGATTGGTAAATTTTTGTTTCAACTTAAAATCTAAT
TTCCTCCAATTAGCAATTAAGTTTATTTAGATGCATAAGGAGGAATTTATTCATAAATTC
ATTTATTTATATGATATTTCTACGAAAAAATTACTTTTTTAATAATATTTGGCAATTTAT
TAATAGGTATGGACTTATAGAAATGGCATGTGGATAAGAGTATATTGGTAGAGTTTATTA
GTAGGAGAAATAGTAAAAGTAGAAAAAAACTAACTCTTTCCTGCAGATATTTTATGTATG
TATACAACTGATTCTAAGGGCCTTTGCTATGTAGAAACTAAAAACCTAGATGGCGAAACC
AATTTGAAGCGCAAAATATCGAATAAATCTTTATAGCAATTAGGAGAAGCTGCTATTCTA
CATTAAAAATTTACTTTTAATTGTGAAAAACCAAACCCCTACTTATATAAATTTTAAGGA
AACATGGAAATAACAGATGGTTACGATTAATAGTAGAAAATATCCCTAGATTACAACAAT
TTTATACTTAGAGGATGCTCTCTGAAAAATACAGACTATGTAATTGGCTTGGTTTCTTAT
ACTGGAAGAGATTCTAAAATAATGATGAATACAGTAAACGCAAGATCAAAGAGATCTCAT
ATAGAAAAAAAAATGAATGTTTTTATTAGTTTGGTCTTCTTGCTTTAAATAGTAGTATGC
TTGTCATTTGCATTAGGTGCTGCAATTTGGTTTAATTAAAATAAATCAAGCCTCATTTTT
ATGCTTGGAGTCAGTAGTACAGCAGAAATAGACAACAGTTTTGGTTATTTATTAGTTGTG
CAGTGGGGTGCTTGGATTCTTATATTTACTAACTTTGTTCCTATCAGTAACTTACTTTTA
GTTATTAATTTAAATCATTCAAATTTGAATGAATGCTGTGTTACATTATTATTTTATAAT
TAATTAAATTAAAAGAAATCATAAAATTCTTTTTTCTTCAAATTTAATTAAATTCATTTG
CACACATACACTCAAGCAAATAAACAAATATTGGCTATTTTATTAATTCTAATTTTATTC
GTTTCTTGCTGACTCTATTCTTTTCTGGCTTTTTTTTTATTTTTATTAAAAATCAAATTA
ACTTCAATTTTTTTTTTTGAAAAATATTAATAGGCTTAATTGTAACCTTGGAAATGGTGA
AATTTATGTAAGGAATCAGAATTACATAAGATCCAAATACATATTCAAAAACTTATGATA
TTCAGTGCACTGTGTAATGCAGTGGATTGAATGAAGAATTAGGATAAGTAGAGTATGTTT
TTTCTGATAAAACTGGAACATTAACAAGCAACACGATGAAATATAAATGCTTAACAGTGA
ATGGCGTATCTTATGGTGAGTAAGATAATATGACTGAATAAGAGTTGATAGATAAGCCTA
ATGTAACAAATGTTAAATTTTTAGATAAAAAGTTATTTGAAGACATGTAAGGTAAAAAAG
CTATGGGTTCAGAATAGCAACAACATCTTTTTACAGCTTTAAAAGTACTCTCTGCTTGCC
ATACTGTGATTACAGAAAAGACATCAGAAGGAATAGAATACAATGCTTCCTCACCAGATG
AGCTGGCACTTATAAATTTTGCTAAATTTTGTGGATTCGAGTATCTTGGAATTGACGAAG
ACAGTGTTATGAGAATTAAGTAAGAAAATATAATGCACAGATTTAAGGTATTGAATGTAT
TAGACTTTAATTCAGTAAGAAAGCGCATGAGTATTATTGTGGAAGATTCTAATGGCAAGA
TTTTCTTGTTTTGTAAAGGTGCAGACAGTGTCTTACAAAAGCTACTTGACTAAAAATTAA
ATGAAGATCATATAATAGAGTAGACATGGATTAACTTAGAAAGGTATTTATTTATTTATT
TATAATAAATAATTACCAATTTTTTTATTTCTAATTAATTTAAAAATATAATTTTATTAG
GTATGCATCTGTTGGTCTCCGTACTCTTGTTTTAGCATAAAAAGAAATTTAAAAAGATGA
GTACCATTTATGGAATGAACAGTACTAAGTAGCATGCTGCAGCCTTAAAGACAGAGAAGA
AGAAATGGAAAGGTTACAAAAAAAGATAGAAAAAAATCTTATCTTAGTAGGAGCTACTGC
GATAGAAGATTAATTACAAGACGAAGTTTCTTCAACTATCTAGCTTATGAAGAAAGCTGG
AATAAAAGTAAGATAATTATATAAATATAGATTTAGATTAATATTTAATAAATCATAAAA
GGTTTGGGTGCTGACAGGAGATAAAGTTGAAACAGCAGTTAATATAGGCTACGCTTGCTC
ACTTTTGAATGATTAGTTAAGGAGAATTCTTGTTGATGGTTATAGTTTAGAAGAAGTATA
AAAATCTTTACAGGCAGCTTACAAGTCTATCCTAAATGAAGTTGAAAATCATAACTAAAC
TATCCTTTAAAGCAATAGAAAAAAGTCATAAAAGAACGAAATGATAAAGAACTTTAGTTT
AGATCTCGCTCTAATCCTGACAGGAGATGCTTTGATACACTGTACAGAAAATAAAGAGAA
TAATGAAACTCTAATGAAAATATCAGAACATTGTAAAGTAGTTCTTGCTTGTAGAGTTTC
GCCTAAACAGAAGTAAGAAATTGTGCATTTAGTTAGAGTTGCTAAACCAGAGTCAACAAC
TTTAGCAATTGGAGATGGAGCTAATGATGTGAATATGATAAGTGCTGCTCATGTTGGTGT
TGGCATTAGAGGAAAAGAAGGATAACAAGCAGCTAGAGCAAGCGATTTTGCTGTTGGAGA
ATTTAAAATATTAAAATCCTTACTTTTTAATCATGGAAGAGAATCTTATAGAAAAAATTC
AACTTTGATATGCTACAATTTTTACAAAAATATGCTATTAGTCTTACCATAGTGGTGGTA
TGCCTTCATTAGTGGGTATTCGGGTTCTTCCATGTATGACCCTTGGATTTATTAACTTTA
TAATATGTGTTACACTTCTCTTCCAATTGTTGGTAAATAATAAATAAATTAACTTATTAA
TTCCTTTATTATTGAATAAGCTTTTAATAAATCAAAATAGAATTATTATTAATATTCAAT
TTATAAAAAAACAAATTTAATATTATTTATAATAAAGTATATGCTATTTTTGACCAAGAG
TTTAGTGATGAATATTTGGTTGAAAATCCTGATCTTTATGTCCAAGGTATAAAAGGTTTA
CTTTTTAATCAAAGAGAATACTGGCTTTGGATAATAAATGGATCTTGGCATGCTTTCTTA
AGTTGTTTCATAAGCTTTGTAGGTTTAGATGGAACATTTTAGGTTAATGGAAAAGATTTC
TTTTTCTAAGCCACAGGAACTGTTACTTTCGGAGCTACTGTCTTCATTGGAAATTTAAAA
GTTTATATTTTCAGCAACACTTACAACCCAGCTTTATTGATAAGTGTTTTTGGAAGTATT
ATCTTCTATATTTCAAATCATGGGCTGGCAAGCTATTTCTATGTCACATCTGATATATTC
AATACTTTTTCAAACACTTATTCAAGCCCTTACTTTTGGTTTTGTTCAATAATAATTATA
GGAATCGCTACTATATTTGATTCTACTGATAGAAGATGGGAATATTTTAGCTAAGTACTT
AAAAGACAAGATGAAAAGAAATTAGCTTTACTTAATGAGGCTCTAACATATTAATAAAAT
GAAGGATTAAATCTTGAAGGTTCAAAAAGTAATTCAGCAGAAAATAAAAATTATTAACAA
GAAAACAGAGACGAGATTATAACGTGTGTTGGGATGCTCAAAAATGGATACTAAACTTAA
GAACCAATAAATCTAAAGTAGCACAAGCCTCTATATGGAGAAGAAGAAAAGGTGCCTTCC
AGCGAATCTCTTAGCAATCCTCCTTATCCAAATAAATCCGCTAAGACTGTATCTAACCAT
TAAAATTCCCACATGAATTCTAATTATCTTACTAGCACTAAGCCATACACAGGATATGCT
TTTTCTCAAATAGAGCCCATCACAGAAGCTTAATAAAAGTATACTTACTGA>TTHERM_00294760(protein)
MPRKRWQDMPDRTIVSNCPEHVKFCNNSISTTKYTLFTFIPMNLVEQFSKLANVYFLFIG
MMQMINEISISNGQPVIYVPLFVVLMISGIKDLFEDMKRNKSDQEENQRLVWTYRNGMWI
RVYWQSLLVGEIVKVEKNQLFPADILCMYTTDSKGLCYVETKNLDGETNLKRKISNKSLQ
QLGEAAILHQKFTFNCEKPNPYLYKFQGNMEITDGYDQQQKISLDYNNFILRGCSLKNTD
YVIGLVSYTGRDSKIMMNTVNARSKRSHIEKKMNVFISLVFLLQIVVCLSFALGAAIWFN
QNKSSLIFMLGVSSTAEIDNSFGYLLVVQWGAWILIFTNFVPISLIVTLEMVKFMQGIRI
TQDPNTYSKTYDIQCTVQCSGLNEELGQVEYVFSDKTGTLTSNTMKYKCLTVNGVSYGEQ
DNMTEQELIDKPNVTNVKFLDKKLFEDMQGKKAMGSEQQQHLFTALKVLSACHTVITEKT
SEGIEYNASSPDELALINFAKFCGFEYLGIDEDSVMRIKQENIMHRFKVLNVLDFNSVRK
RMSIIVEDSNGKIFLFCKGADSVLQKLLDQKLNEDHIIEQTWINLERYASVGLRTLVLAQ
KEIQKDEYHLWNEQYQVACCSLKDREEEMERLQKKIEKNLILVGATAIEDQLQDEVSSTI
QLMKKAGIKVWVLTGDKVETAVNIGYACSLLNDQLRRILVDGYSLEEVQKSLQAAYKSIL
NEVENHNQTILQSNRKKSQKNEMIKNFSLDLALILTGDALIHCTENKENNETLMKISEHC
KVVLACRVSPKQKQEIVHLVRVAKPESTTLAIGDGANDVNMISAAHVGVGIRGKEGQQAA
RASDFAVGEFKILKSLLFNHGRESYRKNSTLICYNFYKNMLLVLPQWWYAFISGYSGSSM
YDPWIYQLYNMCYTSLPIVVYAIFDQEFSDEYLVENPDLYVQGIKGLLFNQREYWLWIIN
GSWHAFLSCFISFVGLDGTFQVNGKDFFFQATGTVTFGATVFIGNLKVYIFSNTYNPALL
ISVFGSIIFYISNHGLASYFYVTSDIFNTFSNTYSSPYFWFCSIIIIGIATIFDSTDRRW
EYFSQVLKRQDEKKLALLNEALTYQQNEGLNLEGSKSNSAENKNYQQENRDEIITCVGML
KNGYQTQEPINLKQHKPLYGEEEKVPSSESLSNPPYPNKSAKTVSNHQNSHMNSNYLTST
KPYTGYAFSQIEPITEAQQKYTY