Identifiers and Description

Gene Model Identifier

TTHERM_00684740

Standard Name

FLP5 (FLiPpase)

Aliases

PreTt18187 | 104.m00119 | 3732.m00033

Description

FLP5 phospholipid-translocating P-type ATPase flippase family protein; P-type ATPase, C-terminal

Genome Browser (Macronucleus)

Full Screen View


Genome Browser (Micronucleus)

Full Screen View

External Links

Gene Ontology Annotations

Cellular Component

Molecular Function

Biological Process

  • 1-butanol metabolic process (IEA) | GO:0071270
  • bile acid biosynthetic process (IEA) | GO:0006699
  • cell adhesion involved in multi-species biofilm formation (IEA) | GO:0043710
  • cellular response to magnesium ion (IEA) | GO:0071286
  • cytoplasmic actin-based contraction involved in forward cell motility (IEA) | GO:0060328
  • ferrichrome biosynthetic process, peptide formation (IEA) | GO:0031199
  • galactose to glucose-1-phosphate metabolic process (IEA) | GO:0061612
  • glycolytic process from glycerol (IEA) | GO:0061613
  • heme A biosynthetic process (IEA) | GO:0006784
  • heme biosynthetic process (IEA) | GO:0006783
  • heterophilic cell adhesion involved in cytoadherence to microvasculature, mediated by parasite protein (IEA) | GO:0043706
  • induction of apoptosis by extracellular signals (IEA) | GO:0008624
  • interleukin-19 production (IEA) | GO:0032622
  • interleukin-2 production (IEA) | GO:0032623
  • loss of chromatin silencing (IEA) | GO:0006345
  • mitotic nuclear division (IEA) | GO:0007067
  • negative regulation of brain-derived neurotrophic factor receptor signaling pathway (IEA) | GO:0031549
  • negative regulation of chemokine-mediated signaling pathway (IEA) | GO:0070100
  • negative regulation of interleukin-1 production (IEA) | GO:0032692
  • negative regulation of L-glutamine biosynthetic process (IEA) | GO:0062133
  • negative regulation of PERK-mediated unfolded protein response (IEA) | GO:1903898
  • negative regulation of phospholipid translocation (IEA) | GO:0061093
  • obsolete cellular response to tetrachloromethane (IEA) | GO:1904773
  • obsolete negative regulation of histone H3-K18 acetylation (IEA) | GO:1902030
  • obsolete regulation of transcription from RNA polymerase II promoter involved in response to osmotic stress (IEA) | GO:1902032
  • obsolete reproduction (IEA) | GO:0000003
  • ommochrome biosynthetic process (IEA) | GO:0006727
  • phagocytosis (IEA) | GO:0006909
  • phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene (IEA) | GO:0018956
  • phosphorelay signal transduction system (IEA) | GO:0000160
  • plant-type cell wall modification (IEA) | GO:0009827
  • polyamine acetylation (IEA) | GO:0032917
  • positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902643
  • positive regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation (IEA) | GO:2000704
  • positive regulation of inner ear receptor cell differentiation (IEA) | GO:2000982
  • positive regulation of turning behavior involved in mating (IEA) | GO:0061095
  • propan-2-ol biosynthetic process (IEA) | GO:1902640
  • prostate induction (IEA) | GO:0060514
  • proteasome storage granule disassembly (IEA) | GO:1902907
  • protein localization to old growing cell tip (IEA) | GO:1903858
  • regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902641
  • regulation of antisense RNA transcription (IEA) | GO:0060194
  • regulation of cytokinin dehydrogenase activity (IEA) | GO:1903856
  • regulation of dendrite extension (IEA) | GO:1903859
  • regulation of hematopoietic stem cell proliferation (IEA) | GO:1902033
  • regulation of striated muscle contraction (IEA) | GO:0006942
  • response to osmotic stress (IEA) | GO:0006970
  • response to oxidative stress (IEA) | GO:0006979
  • steroid hormone receptor complex assembly (IEA) | GO:0006463
  • striated muscle contraction (IEA) | GO:0006941
  • tertiary alcohol biosynthetic process (IEA) | GO:1902645

Domains

  • ( PF00702 ) haloacid dehalogenase-like hydrolase
  • ( PF13246 ) Cation transport ATPase (P-type)
  • ( PF16209 ) Phospholipid-translocating ATPase N-terminal
  • ( PF16212 ) Phospholipid-translocating P-type ATPase C-terminal

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No. Gene Name(s) Paragraph Text
2226 FLP6, FLP16, FLP19, FLP2, FLP8, FLP15, FLP4, FLP9, FLP12, FLP11, FLP13, FLP5, FLP14, FLP1, FLP18, FLP10, FLP17, FLP7, DNF1 The phospholipid flippase family of genes in Tetrahymena contains 20 members, FLP1-FLP20. Preliminary studies show that many of these genes are differentially regulated in response to temperature and/or the presence of a polycyclic aromatic hydrocarbon (pyrene).

Associated Literature

No Data fetched for Associated Literature

Sequences 

>TTHERM_00684740(coding)
ATGGCTTATAAAGGAATCAACGGAGAAAATTCATATAACAATAAGGAATCTCTAATCGAG
GAGTAGAAGGATGTAGTAGACTAACCCTCATTAATATTTCGAAATAATAGTTCTCGAGCA
GGAGTTCGCAATAATAAAGACAATAATAATATCTCTCTTGATATAGAGGGAAATAAATCT
AATTCAGGAAACTCTTTTAGCAGTTAAAGCAAATAAAATTAAAGATAAAAAGATAACAGC
CAAATAAAAATGCATAATTCCTCTTAATCTAGTAGCTTCCTTACAATACCAAGAGATGAT
ACGAGTTAAATAGTTGTAAATGAAAAATATAAATAAAATGTAATTAGAAATGAATAATGT
ATACACGTCAAAGAACCTTTACTCAAAGTGAGACCAAAATAAGAAGCAAACTATAAATTG
ACATTCTTCCAAAAATTAAAAAATTTAATTGGCAATCCAGATCCTTAGAAAGTTGAGAGA
TAAATATACATAAATGGAGATATATTTCCACAGAACTATTAAATAAATTAAATTAAAAAT
TCAAAATATTCTCTTTTAACATTCTTGCCACTAGTTTTATGGAATCACTTCTAAAATTTT
ATGAACCTTCTATACCTTATAATCACTATATCTTAGTTTATATACGACTTAAAGGTAGGA
TATGTCTATACTTATCTCTCGCCTGTCATTTTTATTGTTTTTCTAGTCATGGCTCGAGAA
GTATATGATAATATTAAAATATTCGTGCAAGATAGTAAATACAACCAGACAGTTTTTAAA
GTGCTCAATTATTAAAATTAATTTCAAGAAGTTAAAATCCAAGAACTAAAAATCGGTTAG
ATAATTGAGCTGTAAGAAGGATAACCAGCTCCAGCAGATTTACTAATTTTGTATTCTAGC
AATATAAATGGTAATATTTTAATCAAGACTGACCATTTTGATGGAAAAACAAAATAAATT
TCAAGAAAGGCTATTAATTATTTTTAGTAAGATATAAAAAAACGTTAAAATGATTATCTT
CAACTAATTGATACAGATGGTTATGTTGAAATTCCACCACCATCAGCAAACTATAGCTAA
TTCGAAGCTACTTTCTATCTTAATGATGGATATAGTAAGTATAATGAAAAAATTACAATT
GAAAATGCAATATGGCAAAATAGTACAGTATCAAATGGATTTATTTTAGGTTTGATTATT
TACACAGGATCTGAAACAAAAACAAACATGAACATGAAATCGCCAAGATTTAAAATAGGA
AAATTTGACTTAGAAGCCAACTTTTTAATGAAAATATTTTTCTTAATAGTTATTTTTTAT
TCATGCTTGATTGTGATTATTAAAGGAAACATAATGAGTTCTATAAGAATAGTAATTGAT
TTTATAAGATATTTAATTTTACTCTGTAATATTATTCCGGTTTGCTTAAAAATAAATCTT
GAAATGGTCAAAATCTATTTTACATTTAGAATCAATAATGACCCAGACATGGAAGGAGTT
AACTTTAAGGATTAAAATATACCTGAAGAATTAGGGCGAGTTTAATTCTTATTAGCAGAT
AAAACAGGAACTTTAACAAAGAATGAAATGATTTTTAATAGAGTTGCTTTAGAATAAGCA
ACTTACACTCATGAAGATATGATTGTCATGCAGTCTATTATTATCAATTAGTGTTAAAGA
TACTTAGAGCCTCTGGCAAATTATCAGCTCACTTCTTCAAATAAGCGTGCTAAAGAAGAA
ATATTTAGAGATTTAGTTAATGCAATGTGTATTTGTAACACTGTATCACCTGGGATAGAG
CTAATATCAAGATAGAGTAAATATTTAGGTGAATCATAAGAAGAAGTGGCATTTGTAGAA
TTTGCTGAGTAATTAGGTATTAAATTGGTGACAAGGAATGAAGATACTATAGGGATAGAA
AACTGTAGAGAAAATAAAGATTACTATTAAATACTAGACTTATTTGAGTTCTCTTCAGAA
AAAAACAGGATGGGAATCATAGTTAAGCATTTGAGTAGCTAAAAAATTATATATTATGTA
AAAGGATCAGCTAGAGAGATGTCAGAACTTGTAATTGAGTCATCAAGAAAATTCATAAAT
GAAGAAAGCTCAAATATCGGAAGTGAAGGAATTAGAGTCATGGTATTTGCATAAAAGTAA
ATAGACTAAAATGATTACAATAAATGGAAATAAGCATAACTAAATAAGAACATAAACGTT
AACATGAGCTCTCCTTTAATGAGAAATAATATTTAAAACGCTTCCCAAATGTTTGATTAA
TTTGAAAAAGATATGGAATTTTTAGGTATAGTTGGTGTAGAAGATTAGCTTAGAGATGGT
GTTTAATAAACTATAGAAACTCTAACATTAGCAGGTATTTCAGTTTGGATTGTATCTGGT
GACAGTATGCAAACAACTATAAGTGCAGCTATTTAATCTGGAATCAAATAAAATGATTAA
CATTTTAACATAGTCAAGAAAGTTTACGACGATATAGATATAAAAGCAAAGCTTATGTAC
ATAAATAGTGACAGAAACTCTAAAAAATAAATATTAGTTATGGATGGATAATCTCTAAGT
GTAGCAATGGAAGTTGATAAAAAGTAGCTTGTTAATGTATGCACAAGGGCTGCATCTGTC
CTTTTATGCGAATGCACTCCTCAATAGAAGCACTAGATAATAGATCTAATTAAATAGTAT
ACTGATTATAGAATTGCGGCTATAGGAGATGGAGCAAATGATGTTGGAATGATATAAAGT
GCTCACTTAGGAATTGGAATAAGTGATTCTGATAATAAATTGGCATAGCTGGCTGCAGAT
GTAACTATTCCTGAGTTTTATTACTTAAATCAGCTATTATTATGGCATGGAAGGTGTTAC
AAAAAAGCTGTCTCTTTGTGTTCTTTTGTATATTAAAGAGGGTTAGTAATTGCTTTCATC
GAATTGATTTTTGTCGGAGTATTTTACACTATTACAATATAAATATTTAATGCTTAATTA
CTACTCTGTTATGCTACCATATTTACTATTTTCCCAGTGCTAACACTAGTTATGGACTCA
GATATAGATATAAACACATGTATCTCATTTCCTCAACTTTACAAATCAGCTTTAAAAGGA
AGACATTTAAATCTAAGAACATTCTTTTCATGGATCTGGAAAGCTGTTTATCAAGCTACC
GTTTTGATGATGCTAATATTCACTTTCTTCTAAAGATAATACTTTTTGAATATAGAAACA
TTTGTTCTTTTTGAATTAATATTCACAGAGTATTTTATGATTTTCTCTAAAATTTACTAG
ATCAAAAAGATAAAATGGATCCAGGCATTATTTATAGGTATTTCGCTGATAATCTATCTT
TTAATACTAATTTTCTTATAGCCTTAGTTTGATATAGGAAACATATGGACTTTATAAACA
ATTGGAATACTTTTATTGATAATTTTAATAGCATTAATCCCTATGCTTGTAATTCACCTC
TTAAGAATGAAAATAGAGCCCACAGATGATGAGAAGGTTTTAAGAAGTGCACTTAATAGA
GCTAGCTCAGAGTAACTATCTCAATGA



>TTHERM_00684740(gene)
GGATTTATAAAATACATAAACAGATGCATGCTGATCATCAATACAATATAAAGCTAATTT
AGCCAATTTATAAATTGCAAACAAATAAATTATTAGCGAAAATTATAATATTAGGGTTTT
AATTCTTATACAAATATCAACAAATTAGCAACAGGAATTTAAGGATACCTTGAAATTTGG
CATTTAGGAGTAATTCTATCAATAAATAGTTGCAAATGGCTTATAAAGGAATCAACGGAG
AAAATTCATATAACAATAAGGAATCTCTAATCGAGGAGTAGAAGGATGTAGTAGACTAAC
CCTCATTAATATTTCGAAATAATAGTTCTCGAGCAGGAGTTCGCAATAATAAAGACAATA
ATAATATCTCTCTTGATATAGAGGGAAATAAATCTAATTCAGGAAACTCTTTTAGCAGTT
AAAGCAAATAAAATTAAAGATAAAAAGATAACAGCCAAATAAAAATGCATAATTCCTCTT
AATCTAGTAGCTTCCTTACAATACCAAGAGATGATACGAGTTAAATAGTTGTAAATGAAA
AATATAAATAAAATGTAATTAGAAATGAATAATGTATACACGTCAAAGAACCTTTACTCA
AAGTGAGACCAAAATAAGAAGCAAACTATAAATTGACATTCTTCCAAAAATTAAAAAATT
TAATTGGCAATCCAGATCCTTAGAAAGTTGAGAGATAAATATACATAAATGGAGATATAT
TTCCACAGAACTATTAAATAAATTAAATTAAAAATTCAAAATATTCTCTTTTAACATTCT
TGCCACTAGTTTTATGGAATCACTTCTAAAATTTTATGAACCTTCTATACCTTATAATCA
CTATATCTTAGTTTATATACGACTTAAAGGTAGGATATGTCTATACTTATCTCTCGCCTG
TCATTTTTATTGTTTTTCTAGTCATGGCTCGAGAAGTATATGATAATATTAAAATATTCG
TGCAAGATAGTAAATACAACCAGACAGTTTTTAAAGTGCTCAATTATTAAAATTAATTTC
AAGAAGTTAAAATCCAAGAACTAAAAATCGGTTAGATAATTGAGCTGTAAGAAGGATAAC
CAGCTCCAGCAGATTTACTAATTTTGTATTCTAGCAATATAAATGGTAATATTTTAATCA
AGACTGACCATTTTGATGGAAAAACAAAATAAATTTCAAGAAAGGCTATTAATTATTTTT
AGTAAGATATAAAAAAACGTTAAAATGATTATCTTCAACTAATTGATACAGATGGTTATG
TTGAAATTCCACCACCATCAGCAAACTATAGCTAATTCGAAGCTACTTTCTATCTTAATG
ATGGATATAGTAAGTATAATGAAAAAATTACAATTGAAAATGCAATATGGCAAAATAGTA
CAGTATCAAATGGATTTATTTTAGGTTTGATTATTTACACAGGATCTGAAACAAAAACAA
ACATGAACATGAAATCGCCAAGATTTAAAATAGGAAAATTTGACTTAGAAGCCAACTTTT
TAATGAAAATATTTTTCTTAATAGTTATTTTTTATTCATGCTTGATTGTGATTATTAAAG
GAAACATAATGAGTTCTATAAGAATAGTAATTGATTTTATAAGATATTTAATTTTACTCT
GTAATATTATTCCGGTTTGCTTAAAAATAAATCTTGAAATGGTCAAAATCTATTTTACAT
TTAGAATCAATAATGACCCAGACATGGAAGGAGTTAACTTTAAGGATTAAAATATACCTG
AAGAATTAGGGCGAGTTTAATTCTTATTAGCAGATAAAACAGGAACTTTAACAAAGAATG
AAATGATTTTTAATAGAGTTGCTTTAGAATAAGCAACTTACACTCATGAAGATATGATTG
TCATGCAGTCTATTATTATCAATTAGTGTTAAAGATACTTAGAGCCTCTGGCAAATTATC
AGCTCACTTCTTCAAATAAGCGTGCTAAAGAAGAAATATTTAGAGATTTAGTTAATGCAA
TGTGTATTTGTAACACTGTATCACCTGGGATAGAGCTAATATCAAGATAGAGTAAATATT
TAGGTGAATCATAAGAAGAAGTGGCATTTGTAGAATTTGCTGAGTAATTAGGTATTAAAT
TGGTGACAAGGAATGAAGATACTATAGGGATAGAAAACTGTAGAGAAAATAAAGATTACT
ATTAAATACTAGACTTATTTGAGTTCTCTTCAGAAAAAAACAGGATGGGAATCATAGTTA
AGCATTTGAGTAGCTAAAAAATTATATATTATGTAAAAGGATCAGCTAGAGAGATGTCAG
AACTTGTAATTGAGTCATCAAGAAAATTCATAAATGAAGAAAGCTCAAATATCGGAAGTG
AAGGAATTAGAGTCATGGTATTTGCATAAAAGTAAATAGACTAAAATGATTACAATAAAT
GGAAATAAGCATAACTAAATAAGAACATAAACGTTAACATGAGCTCTCCTTTAATGAGAA
ATAATATTTAAAACGCTTCCCAAATGTTTGATTAATTTGAAAAAGATATGGAATTTTTAG
GTATAGTTGGTGTAGAAGATTAGCTTAGAGATGGTGTTTAATAAACTATAGAAACTCTAA
CATTAGCAGGTATTTCAGTTTGGATTGTATCTGGTGACAGTATGCAAACAACTATAAGTG
CAGCTATTTAATCTGGAATCAAATAAAATGATTAACATTTTAACATAGTCAAGAAAGTTT
ACGACGATATAGATATAAAAGCAAAGCTTATGTACATAAATAGTGACAGAAACTCTAAAA
AATAAATATTAGTTATGGATGGATAATCTCTAAGTGTAGCAATGGAAGTTGATAAAAAGT
AGCTTGTTAATGTATGCACAAGGGCTGCATCTGTCCTTTTATGCGAATGCACTCCTCAAT
AGAAGCACTAGATAATAGATCTAATTAAATAGTATACTGATTATAGAATTGCGGCTATAG
GAGATGGAGCAAATGATGTTGGAATGATATAAAGTGCTCACTTAGGAATTGGAATAAGTG
ATTCTGATAATAAATTGGCATAGCTGGCTGCAGATGTAACTATTCCTGAGTTTTATTACT
TAAATCAGCTATTATTATGGCATGGAAGGTGTTACAAAAAAGCTGTCTCTTTGTGTTCTT
TTGTATATTAAAGAGGGTTAGTAATTGCTTTCATCGAATTGATTTTTGTCGGAGTATTTT
ACACTATTACAATATAAATATTTAATGCTTAATTACTACTCTGTTATGCTACCATATTTA
CTATTTTCCCAGTGCTAACACTAGTTATGGACTCAGATATAGATATAAACACATGTATCT
CATTTCCTCAACTTTACAAATCAGCTTTAAAAGGAAGACATTTAAATCTAAGAACATTCT
TTTCATGGATCTGGAAAGCTGTTTATCAAGCTACCGTTTTGATGATGCTAATATTCACTT
TCTTCTAAAGATAATACTTTTTGAATATAGAAACATTTGTTCTTTTTGAATTAATATTCA
CAGAGTATTTTATGATTTTCTCTAAAATTTACTAGATCAAAAAGATAAAATGGATCCAGG
CATTATTTATAGGTATTTCGCTGATAATCTATCTTTTAATACTAATTTTCTTATAGCCTT
AGTTTGATATAGGAAACATATGGACTTTATAAACAATTGGAATACTTTTATTGATAATTT
TAATAGCATTAATCCCTATGCTTGTAATTCACCTCTTAAGAATGAAAATAGAGCCCACAG
ATGATGAGAAGGTTTTAAGAAGTGCACTTAATAGAGCTAGCTCAGAGTAACTATCTCAAT
GAAAATTTTCTCAAGTTGGAGTAATATAATAAACTATCAATTAAAACTAAAGAAGATATT
AAATTTAATAAAATAAACTAATTAATAAAAATAAATAGTATTTAAATATATATATAAATA
TTCGACTGTGTTTTAGAGCAAATATTTTAATTTTTCT



>TTHERM_00684740(protein)
MAYKGINGENSYNNKESLIEEQKDVVDQPSLIFRNNSSRAGVRNNKDNNNISLDIEGNKS
NSGNSFSSQSKQNQRQKDNSQIKMHNSSQSSSFLTIPRDDTSQIVVNEKYKQNVIRNEQC
IHVKEPLLKVRPKQEANYKLTFFQKLKNLIGNPDPQKVERQIYINGDIFPQNYQINQIKN
SKYSLLTFLPLVLWNHFQNFMNLLYLIITISQFIYDLKVGYVYTYLSPVIFIVFLVMARE
VYDNIKIFVQDSKYNQTVFKVLNYQNQFQEVKIQELKIGQIIELQEGQPAPADLLILYSS
NINGNILIKTDHFDGKTKQISRKAINYFQQDIKKRQNDYLQLIDTDGYVEIPPPSANYSQ
FEATFYLNDGYSKYNEKITIENAIWQNSTVSNGFILGLIIYTGSETKTNMNMKSPRFKIG
KFDLEANFLMKIFFLIVIFYSCLIVIIKGNIMSSIRIVIDFIRYLILLCNIIPVCLKINL
EMVKIYFTFRINNDPDMEGVNFKDQNIPEELGRVQFLLADKTGTLTKNEMIFNRVALEQA
TYTHEDMIVMQSIIINQCQRYLEPLANYQLTSSNKRAKEEIFRDLVNAMCICNTVSPGIE
LISRQSKYLGESQEEVAFVEFAEQLGIKLVTRNEDTIGIENCRENKDYYQILDLFEFSSE
KNRMGIIVKHLSSQKIIYYVKGSAREMSELVIESSRKFINEESSNIGSEGIRVMVFAQKQ
IDQNDYNKWKQAQLNKNINVNMSSPLMRNNIQNASQMFDQFEKDMEFLGIVGVEDQLRDG
VQQTIETLTLAGISVWIVSGDSMQTTISAAIQSGIKQNDQHFNIVKKVYDDIDIKAKLMY
INSDRNSKKQILVMDGQSLSVAMEVDKKQLVNVCTRAASVLLCECTPQQKHQIIDLIKQY
TDYRIAAIGDGANDVGMIQSAHLGIGISDSDNKLAQLAADVTIPEFYYLNQLLLWHGRCY
KKAVSLCSFVYQRGLVIAFIELIFVGVFYTITIQIFNAQLLLCYATIFTIFPVLTLVMDS
DIDINTCISFPQLYKSALKGRHLNLRTFFSWIWKAVYQATVLMMLIFTFFQRQYFLNIET
FVLFELIFTEYFMIFSKIYQIKKIKWIQALFIGISLIIYLLILIFLQPQFDIGNIWTLQT
IGILLLIILIALIPMLVIHLLRMKIEPTDDEKVLRSALNRASSEQLSQ