Identifiers and Description

Gene Model Identifier

TTHERM_00402050

Standard Name

COI12 (COnjugation-Induced 12)

Aliases

PreTt12749 | 43.m00267 | 3713.m00093

Description

anaphase-promoting complex cyclosome subunit 3; A Hsp90 co-chaperone required for the loading of scnRNAs to Twi1p

Genome Browser (Macronucleus)



Genome Browser (Micronucleus)

External Links

Gene Ontology Annotations

No Data fetched for Gene Ontology Annotations

Domains

  • ( PF00515 ) tetratricopeptide repeat
  • ( PF02071 ) Aromatic-di-Alanine (AdAR) repeat
  • ( PF07337 ) DC-EC Repeat
  • ( PF07719 ) tetratricopeptide repeat
  • ( PF08180 ) B melanoma antigen family

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source Identifier Score
Tetrahymena borealis EI9_13976.1 1.999872053281847e-142
Description: hypothetical protein (544 aa)

General Information

No. Gene Name(s) Paragraph Text
103 COI12 The Tetrahymena Hsp90 co-chaperone Coi12p promotes scnRNA loading into the Argonaute protein Twi1p in both ATP-dependent and ATP-independent manners.
105 GIW1, COI12, TWI1 ATP-dependent and ATP-independent activities of Coi12p facilitate scnRNA loading by counteracting the Twi1p-binding protein Giw1p, which is important for sorting scnRNAs to Twi1p (Woehrer et al. 2015).

Associated Literature

  1. Ref:29021213: Noto T, Mochizuki K (2017) Whats, hows and whys of programmed DNA elimination in Tetrahymena. Open biology 7(10):
  2. Ref:26688337: Kataoka K, Mochizuki K (2015) Phosphorylation of an HP1-like Protein Regulates Heterochromatin Body Assembly for DNA Elimination. Developmental cell 35(6):775-88
  3. Ref:25588944: Woehrer SL, Aronica L, Suhren JH, Busch CJ, Noto T, Mochizuki K (2015) A Tetrahymena Hsp90 co-chaperone promotes siRNA loading by ATP-dependent and ATP-independent mechanisms. The EMBO journal 34(4):559-77

Sequences

>TTHERM_00402050(coding)
ATGTATTACTTGCCTAAAAGATACTTTTCCAAATAAATCAAATTTCAAATCAAACTCAAA
TTTGGTAGGAAATTAAATTTTCAAGCTAAATAAACTGCCCTCCCCAATAACTTTAATATT
TACATGTAAATCTATTTGATTGATTTTTAATTATTTCGTTCAATATATATAGCTAGCTAG
CTAGATAGATTGCTTTAAAGTAATTCAATCAATTTCAACAAAAAGATAATTACTTTAATT
AGCAAGGCTATTTTAAATATTAAAACAAACACTATTATATTAAAAATTAAATAAATTATA
ATTAAGCATTATTTCATTAAAAAATAAATAAAAGACATTAAAATGGATTCATCTAATGAA
AACACAAGGAGCTCTTCTTGTAATGAGTAGGAAACTAATTCAGAACTTTAGTAAAGTGTT
AATGAGAGTTGTACCAGCCTAGAAGAGTAGTAATTCAGCACTCCTTTTTTATCCAGCCAA
GAAACTGTATAGGTAGACTAAGCATTCTAAGAATCCACTAAATAGAATGAAGGAACTTCT
TCTTTCTTAAACGAGACCTAATGCTATCAAGATTGTAAGCCCAATTTAATTTCTAAAGGA
GAGTCAAATCAACAGTAATACAAAGAGTAAACTCAAGAAATTAGTGAGATTTTAGAAAAC
CCTTTTGCTTAAAATACACCAACTGATTAATGGAGCATTGTAGAAGAAAAAGATGGTAAT
AAACAAGCAGATAGTTTTGATATTTTATAAGACAAATTGATTAAAGAGGAAACATATAAC
ATCCCTAGTTGGAATTATGAGCCTTAAGATTTTAAAGCAGATATTGACTTTGAAAAATAT
GACAAAGAAAATCTAGATCACCTAAAGAAAGTCTACAAGCCTCCATAAATTGAAGACGTC
GTCGAAAAAGTAGAATAAGATGAAAATGGGCTTAAAATCTAAACTTTATCTTAATTCAAT
ATACCTAAATGCAATATACTGAAGCTTGATATGAGTTTTCTCTAAACTTGGCAATCAAAA
GAAATAGTACCATGCTTTACTATGTTTTCAGAACCAAAAACTAACAACGGGGAAAGTCTA
AATTGTGATGAAGAAGAAACTAATCCTTAGATTGATAAGAAATGGTGCAGAGATGTTTAA
GTTGTCTTTGAAGAAAGAGATTAGAATGGTGAGCTTATTGATAAATATAGAGTTGTCAAA
GAAAAAAGAACAGTTAAATTATAAGGAGATATATCAGCAAAGTGGTATATTTGTCTAGAG
CAGATGAAGCCAAATGAAACTAAGTGGTTTAAAATGGAATAAAAACTTCTTTGGCAGATT
GGACAAAAAAATTTAGCTTAATATGAGTGTATTTATCTAAAAATATAAATTGTTGGAGTA
AAGGCTCTTGCTCTTTCTGAAATGAAAGATAAACTTGAAAAAAATAACTTACAACCCTAA
CAGTAAAATATAATCTATGAGGATTATAGTTAAATAGCTCAGAAATCAGAAGAGTTTAAC
AATGAAGGAAAAATTCTATTCTCTATTATGAATTATGAAAAAGCTGCAAAATGGTTTAAC
AAAGCATTTAGTATTTGGAGAGGAATGAGCAAAAAGCTTAGAAAAACTTTAAATTCTGAA
TAGGAATAGAATTATATTGATAAGAGTAACTAGTTTGGTGCTAATTATGCATAATGCCTT
ATTAACCTCAAAAAATATTAAGAGTGTGTGGATTTTTACTAAAAAAACAAGCTTTCTTCT
AATAAGAACATTTATAAACTTGTAAAAAGTTTATATGAATTACATAACTATGAAAAAGCT
ATTTAAGTAATAGATAAACAGTTTCCTTAAAATGATGAAAACTCAGTTGATAAATTTATG
AACGGTAATCAAGAAAGTTTACTTCCAGCTGAATTCTAAAAGCTTAAAAGTCAGTGTTAA
GTAAAGCTAAAAATGTTAGAAAATCAATCAATAAATACATTTTATAGAAAATTGTTTTAA
TGA


>TTHERM_00402050(gene)
ATGTATTACTTGCCTAAAAGATACTTTTCCAAATAAATCAAATTTCAAATCAAACTCAAA
TTTGGTAGGAAATTAAATTTTCAAGCTAAATAAACTGCCCTCCCCAATAACTTTAATATT
TACATGTAAATCTATTTGATTGATTTTTAATTATTTCGTTCAATATATATAGCTAGCTAG
CTAGATAGATTGCTTTAAAGTAATTCAATCAATTTCAACAAAAAGATAATTACTTTAATT
AGCAAGGCTATTTTAAATATTAAAACAAACACTATTATATTAAAAATTAAATAAATTATA
ATTAAGCATTATTTCATTAAAAAATAAATAAAAGACATTAAAATGGATTCATCTAATGAA
AACACAAGGAGCTCTTCTTGTAATGAGTAGGAAACTAATTCAGAACTTTAGTAAAGTGTT
AATGAGAGTTGTACCAGCCTAGAAGAGTAGTAATTCAGCACTCCTTTTTTATCCAGCCAA
GAAACTGTATAGGTAGACTAAGCATTCTAAGAATCCACTAAATAGAATGAAGGAACTTCT
TCTTTCTTAAACGAGACCTAATGCTATCAAGATTGTAAGCCCAATTTAATTTCTAAAGGA
GAGTCAAATCAACAGTAATACAAAGAGTAAACTCAAGAAATTAGTGAGATTTTAGAAAAC
CCTTTTGCTTAAAATACACCAACTGATTAATGGAGCATTGTAGAAGAAAAAGATGGTAAT
AAACAAGCAGATAGTTTTGATATTTTATAAGACAAATTGATTAAAGAGGAAACATATAAC
ATCCCTAGTTGGAATTATGAGCCTTAAGATTTTAAAGCAGATATTGACTTTGAAAAATAT
GACAAAGAAAATCTAGATCACCTAAAGAAAGTCTACAAGCCTCCATAAATTGAAGACGTC
GTCGAAAAAGTAGAATAAGATGAAAATGGGCTTAAAATCTAAACTTTATCTTAATTCAAT
ATACCTAAATGCAATATACTGAAGCTTGATATGAGTTTTCTCTAAACTTGGCAATCAAAA
GAAATAGTACCATGCTTTACTATGTTTTCAGAACCAAGTAAGATTCATTCCAGTTTTAAA
CTACTTCTACTTACTTACTTACTTATTATTATTTTTAATTAATTAGATTTAGTTTTAATT
TTGTAATTTTTGAATTTTCTGAATCTTTTTTTTTCAGTTTTTAAAATTTAAAATGAATAA
ATTTAATTAATTTACAATAAATTAAAAAATTTTTAAACATTTTATTTGAAAATTGGCTAA
AATTTGTTATATAGAAATAAAAAATATTCCAAAATTGTTTATTTCATGAAATATTTTATT
TAAAAATTAATCTAGAAACTAACAACGGGGAAAGTCTAAATTGTGATGAAGAAGAAACTA
ATCCTTAGATTGATAAGAAATGGTGCAGAGATGTTTAAGTTGTCTTTGAAGAAAGAGATT
AGAATGGTGAGCTTATTGATAAATATAGAGTTGTCAAAGAAAAAAGAACAGTTAAATTAT
AAGGAGATATATCAGCAAAGTGGTATATTTGTCTAGAGCAGATGAAGCCAAATGAAACTA
AGTGGTTTAAAATGGAATAAAAACTTCTTTGGCAGATTGGACAAAAAAATTTAGCTTAAT
ATGAGTGTATTTATCTAAAAATATAAATTGTTGGAGTAAAGGCTCTTGCTCTTTCTGAAA
TGAAAGATAAACTTGAAAAAAATAACTTACAACCCTAACAGTAAAATATAATCTATGAGG
ATTATAGTTAAATAGCTCAGAAATCAGAAGAGTTTAACAATGAAGGAAAAATTCTATTCT
CTATTATGAATTATGAAAAAGCTGCAAAATGGTTTAACAAAGCATTTAGTATTTGGAGAG
GAATGAGCAAAAAGCTTAGAAAAACTTTAAATTCTGAATAGGAATAGAATTATATTGATA
AGAGTAACTAGTTTGGTGCTAATTATGCATAATGCCTTATTAACCTCAAAAAATATTAAG
AGTGTGTGGATTTTTACTAAAAAAACAAGCTTTCTTCTAATAAGAACATTTATAAACTTG
TAAAAAGTTTATATGAATTACATAACTATGAAAAAGCTATTTAAGTAATAGATAAACAGT
TTCCTTAAAATGATGAAAACTCAGTTGATAAATTTATGAACGGTAATCAAGAAAGTTTAC
TTCCAGCTGAATTCTAAAAGCTTAAAAGTCAGTGTTAAGTAAAGCTAAAAATGTTAGAAA
ATCAATCAATAAATACATTTTATAGAAAATTGTTTTAATGA


>TTHERM_00402050(protein)
MYYLPKRYFSKQIKFQIKLKFGRKLNFQAKQTALPNNFNIYMQIYLIDFQLFRSIYIASQ
LDRLLQSNSINFNKKIITLISKAILNIKTNTIILKIKQIIIKHYFIKKQIKDIKMDSSNE
NTRSSSCNEQETNSELQQSVNESCTSLEEQQFSTPFLSSQETVQVDQAFQESTKQNEGTS
SFLNETQCYQDCKPNLISKGESNQQQYKEQTQEISEILENPFAQNTPTDQWSIVEEKDGN
KQADSFDILQDKLIKEETYNIPSWNYEPQDFKADIDFEKYDKENLDHLKKVYKPPQIEDV
VEKVEQDENGLKIQTLSQFNIPKCNILKLDMSFLQTWQSKEIVPCFTMFSEPKTNNGESL
NCDEEETNPQIDKKWCRDVQVVFEERDQNGELIDKYRVVKEKRTVKLQGDISAKWYICLE
QMKPNETKWFKMEQKLLWQIGQKNLAQYECIYLKIQIVGVKALALSEMKDKLEKNNLQPQ
QQNIIYEDYSQIAQKSEEFNNEGKILFSIMNYEKAAKWFNKAFSIWRGMSKKLRKTLNSE
QEQNYIDKSNQFGANYAQCLINLKKYQECVDFYQKNKLSSNKNIYKLVKSLYELHNYEKA
IQVIDKQFPQNDENSVDKFMNGNQESLLPAEFQKLKSQCQVKLKMLENQSINTFYRKLFQ