Identifiers and Description

Gene Model Identifier

TTHERM_00023980

Standard Name

RAN1 (RAN GTPase)

Aliases

Tt-ran | PreTt12011 | 1.m01059

Description

RAN1 GTP-binding nuclear protein Ran-1; Putative Ran GTPase; an evolutionarily conserved small GTPase with roles in nuclear transport- mitotic spindle assembly and nuclear envelope assembly

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• intracellular anatomical structure (IEA) | GO:0005622

Molecular Function

• GTP binding (IEA) | GO:0005525

Biological Process

• small GTPase-mediated signal transduction (IEA) | GO:0007264

Domains

• ( PF00009 ) Elongation factor Tu GTP binding domain
• ( PF00025 ) ADP-ribosylation factor family
• ( PF00071 ) Ras family
• ( PF01926 ) 50S ribosome-binding GTPase
• ( PF08477 ) Ras of Complex, Roc, domain of DAPkinase
• ( TIGR00231 ) small GTP-binding protein domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_13865.1	2.0007442334946695e-153
	Description: Ras family protein (241 aa)
Oxytricha	Contig21120.0.g73	3.001222955304439e-106
	Description: Ras family
SGD	YOR185C	7.003003394656772e-98
	Description: GSP2 GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability
WormBase	WBGene00004302	9.003233894748109e-95
	Description: locus:ran-1 GTP-binding nuclear protein ran-1 status:Confirmed UniProt:O17915 protein_id:CAB07240.1
Tetrahymena borealis	EI9_15807.1	9.003233894748109e-95
	Description: hypothetical protein (236 aa)
DictyBase	DDB_G0291235	9.998285701479858e-93
	Description: ranA on chromosome: 6 position 78789 to 80092
Stentor Coeruleus	SteCoe_37736	5.0345753587649823e-45
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:22594798: Liang H, Xu J, Zhao D, Tian H, Yang X, Liang A, Wang W (2012) Subcellular localization and role of Ran1 in Tetrahymena thermophila amitotic macronucleus. The FEBS journal 279(14):2520-33
2. Ref:12787777: Quimby BB and Dasso M (2003) The small GTPase Ran: interpreting the signs. Curr Opin Cell Biol 15(3):338-44
3. Ref:8026746: Nagata K, Takemasa T, Alam S, Hattori T, Watanabe Y, Nozawa Y (1994) Cloning of cDNAs encoding a cell-cycle-regulatory GTP-binding low-M(r) (GBLM) protein, Ran/TC4, from micronucleated Tetrahymena thermophila and amicronucleated Tetrahymena pyriformis. Gene 144(1):123-5

Sequences

>TTHERM_00023980(coding)
ATGGTTGATAACAAGTAAAACGTTGTTGCTGAATTCAAGCTCGTCTTAGTTGGTGATGGT
GGTGTCGGTAAGACTACTTTCGTCACTAGACATCAAACTGGTGAATTCGAAAAGAGATAT
ATTGCCACCCAAGGTGTCAATGTTTCCAACATGGTCTTATACACCACTAAGGGTCCCATC
AGATTCAACATTTGGGATACTGCTGGTTAAGAAAAGCTCGGTGGTCTCCGTGAAGGTTAC
TACATTGGTGCCAACGCCGCTATCATGATGTTCGATGTCACCTCCAGAATTACTTATAAA
AATATTCCTAAGTGGCACAAGGATTTGACCAGAATCTGCGAAAATATTCCCATCGTTTTG
GTCGGTAACAAGGTTGACTCTAAGGACAGAAAGGTCAAGGCTAGACAAATCACTTTCCAC
AGAAAGAGATCCCTCTAATATTATGATGTCTCTGCTAAATCTAACTATTAATACGAAAAG
CCCTTCCTCTGGATCCTCAGAAAGCTCACCGGTGATCCCACCCTTAACCTCGTCGAAGGT
ATCGCTCTTGTTGCTCCTGATACTGAACACGTCATGACTGAAGATCAAATCAAGCAATTG
GAAATGGAACAAGCTGAAGCTATGAACCTCGCCCAACAAGGTGTCCTTCCTGATGATGAA
GATGATGAATTCAACTGA

>TTHERM_00023980(gene)
ATGGTTGATGTAAATAGTATTTTTTATTCTTTCTTTCTGGCTCAGGAACTGATCTTCAGT
TTTCTTGGATGATGGACACATAGTCTATGAACCTATCATGATTGTTTGTTGATCTCTTTC
CTAAGCCAGAGAGGATTGATTGTTTGCTAATACCTTATTGCTAAACTAACTTTTACAATT
TTAAAATAATAGAACAAGTAAAACGTTGTTGCTGAATTCAAGCTCGTCTTAGTTGGTGAT
GGTGGTGTCGGTAAGACTACTTTCGTCACTAGACATCAAACTGGTGAATTCGAAAAGAGA
TATATTGCCACCCAAGGTGTCAATGTTTCCAACATGGTCTTATACACCACTAAGGGTCCC
ATCAGATTCAACATTTGGGATACTGCTGGTTAAGAAAAGCTCGGTGGTCTCCGTGAAGGT
TACTAGTAATAATTTTTTTCAAACACTTATCATAAAATTTTTATCATTTGGACTAATTGA
TTGACTGACTGACTGATTAACAAGTTTGTTTGCTGAATAATTGCTTACAAGTCTAACTAG
CTCTTACTATAAATATTCCTTTAGGCTCTGTGTTTGTTCATAACATATAAATAGGAATGT
GAGTCATTCTTTCTTTCTATCTATTTTGTTTATGTTATCAAGCTACAAAGCAAGAGTTGA
TTGCTAAAAATAAGCAACAAGAAATAGAAAGATGATTATTAAATGGTATAAAAGGAATAG
CAGAGACCATCTACATTGATTAAGCCATAGCTTCTTACATTATAAGAAATTATAAAGAAA
GTAGGATGCATTTAGAGAAGATTTAGCTAGCGAAAACCCAATCTTTTGTGGTGATTTATT
TAGCGACGCAATTTAATTTAAAAAGAAAATTTAAAAACAAACTCAGTCTGTCAATCAGTC
AATCAATCAGTCAGTCAGTTCTTTGTTCGTTGAGACTCTTTTTTCATTTAAAAATGCTTA
AATCAATCTATTTAACGAATTTCTAATGAATTTATTTTTAACAATAGCATTGGTGCCAAC
GCCGCTATCATGATGTTCGATGTCACCTCCAGAATTACTTATAAAAATATTCCTAAGTGG
CACAAGGATTTGACCAGAATCTGCGAAAATATTCCCATCGTTTTGGTCGGTAACAAGGTT
GACTCTAAGGACAGAAAGGTCAAGGCTAGACAAATCACTTTCCACAGAAAGAGATCCCTC
TAATATTATGATGTCTCTGCTAAATCTAACTATTAATACGAAAAGCCCTTCCTCTGGATC
CTCAGAAAGCTCACCGGTGATCCCACCCTTAACCTCGTCGAAGGTATCGCTCTTGTTGCT
CCTGATACTGAACACGTCATGACTGAAGATCAAATCAAGCAATTGGAAATGGAACAAGCT
GAAGCTATGAACCTCGCCCAACAAGGTGTCCTTCCTGATGATGAAGATGATGAATTCAAC
TGA

>TTHERM_00023980(protein)
MVDNKQNVVAEFKLVLVGDGGVGKTTFVTRHQTGEFEKRYIATQGVNVSNMVLYTTKGPI
RFNIWDTAGQEKLGGLREGYYIGANAAIMMFDVTSRITYKNIPKWHKDLTRICENIPIVL
VGNKVDSKDRKVKARQITFHRKRSLQYYDVSAKSNYQYEKPFLWILRKLTGDPTLNLVEG
IALVAPDTEHVMTEDQIKQLEMEQAEAMNLAQQGVLPDDEDDEFN