Identifiers and Description

Gene Model Identifier

TTHERM_00030430

Standard Name

PARP3 (Poly [ADP-Ribose] Polymerase 3)

Aliases

PreTt14274 | 2.m02191 | 3825.m02660

Description

PARP3 poly(ADP-ribose) polymerase family WGR domain protein; WGR domain containing protein; highly induced by replication stress; ADP-ribosyltransferase diphtheria toxin-like

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

Cellular Component

Molecular Function

Biological Process

  • aminoacyl-tRNA metabolism involved in translational fidelity (IEA) | GO:0106074
  • basement membrane organization (IEA) | GO:0071711
  • callus formation (IEA) | GO:1990110
  • cell wall modification involved in fruit ripening (IEA) | GO:0009829
  • endoderm development (IEA) | GO:0007492
  • fibrous ring of heart morphogenesis (IEA) | GO:1905285
  • garland cell differentiation (IEA) | GO:0007514
  • general transcription from RNA polymerase II promoter (IEA) | GO:0032568
  • haltere development (IEA) | GO:0007482
  • heme A biosynthetic process (IEA) | GO:0006784
  • heme biosynthetic process (IEA) | GO:0006783
  • imaginal disc-derived genitalia development (IEA) | GO:0007484
  • immunoglobulin heavy chain V-D-J recombination (IEA) | GO:0071707
  • laminaritriose transport (IEA) | GO:2001097
  • mitochondrial fusion (IEA) | GO:0008053
  • negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process (IEA) | GO:1902647
  • negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902642
  • negative regulation of cellular glucuronidation (IEA) | GO:2001030
  • negative regulation of complement-dependent cytotoxicity (IEA) | GO:1903660
  • negative regulation of double-strand break repair via nonhomologous end joining (IEA) | GO:2001033
  • negative regulation of epithelial cell-cell adhesion involved in epithelium migration (IEA) | GO:1903682
  • negative regulation of interleukin-1 beta production (IEA) | GO:0032691
  • negative regulation of macrophage derived foam cell differentiation (IEA) | GO:0010745
  • negative regulation of MyD88-independent toll-like receptor signaling pathway (IEA) | GO:0034128
  • negative regulation of PERK-mediated unfolded protein response (IEA) | GO:1903898
  • negative regulation of renal water transport (IEA) | GO:2001152
  • negative regulation of sprouting angiogenesis (IEA) | GO:1903671
  • notum development (IEA) | GO:0007477
  • obsolete actin filament bundle convergence involved in mitotic contractile ring assembly (IEA) | GO:1903478
  • obsolete lymph gland development (IEA) | GO:0007515
  • obsolete negative regulation by organism of symbiont T-cell mediated immune response (IEA) | GO:0052474
  • obsolete prothoracic morphogenesis (IEA) | GO:0007471
  • obsolete regulation of histone H3-K27 methylation (IEA) | GO:0061085
  • obsolete sodium/potassium transport (IEA) | GO:0006815
  • ommochrome biosynthetic process (IEA) | GO:0006727
  • parathion metabolic process (IEA) | GO:0018952
  • phagocytosis (IEA) | GO:0006909
  • photoreceptor cell morphogenesis (IEA) | GO:0008594
  • plant-type cell wall modification (IEA) | GO:0009827
  • positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902643
  • positive regulation of antifungal innate immune response (IEA) | GO:1905036
  • positive regulation of dipeptide transmembrane transport (IEA) | GO:2001150
  • positive regulation of double-strand break repair via nonhomologous end joining (IEA) | GO:2001034
  • positive regulation of macrophage derived foam cell differentiation (IEA) | GO:0010744
  • positive regulation of mating projection assembly (IEA) | GO:1902917
  • positive regulation of oxidative phosphorylation (IEA) | GO:1903862
  • positive regulation of peroxisome proliferator activated receptor signaling pathway (IEA) | GO:0035360
  • positive regulation of phospholipid translocation (IEA) | GO:0061092
  • positive regulation of renal water transport (IEA) | GO:2001153
  • positive regulation of response to water deprivation (IEA) | GO:1902584
  • positive regulation of wound healing, spreading of epidermal cells (IEA) | GO:1903691
  • prenol metabolic process (IEA) | GO:0016090
  • priming of cellular response to stress (IEA) | GO:0080136
  • pronuclear fusion (IEA) | GO:0007344
  • propan-2-ol biosynthetic process (IEA) | GO:1902640
  • protein localization to old growing cell tip (IEA) | GO:1903858
  • prothoracic disc morphogenesis (IEA) | GO:0007470
  • regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process (IEA) | GO:1902646
  • regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902641
  • regulation of cellular glucuronidation (IEA) | GO:2001029
  • regulation of complement-dependent cytotoxicity (IEA) | GO:1903659
  • regulation of cytokinin dehydrogenase activity (IEA) | GO:1903856
  • regulation of D-xylose catabolic process (IEA) | GO:0043469
  • regulation of dipeptide transmembrane transport (IEA) | GO:2001148
  • regulation of germ cell proliferation (IEA) | GO:1905936
  • regulation of L-arginine import into cell (IEA) | GO:1902826
  • regulation of membrane lipid metabolic process (IEA) | GO:1905038
  • regulation of phosphorus utilization (IEA) | GO:0006795
  • regulation of respiratory gaseous exchange by nervous system process (IEA) | GO:0002087
  • regulation of TOR signaling (IEA) | GO:0032006
  • regulation of TRAIL production (IEA) | GO:0032679
  • tertiary alcohol biosynthetic process (IEA) | GO:1902645
  • vesicle coating (IEA) | GO:0006901
  • visceral mesoderm-endoderm interaction involved in midgut development (IEA) | GO:0007495
  • wing disc morphogenesis (IEA) | GO:0007472

Domains

  • ( PF00644 ) Poly(ADP-ribose) polymerase catalytic domain
  • ( PF02877 ) Poly(ADP-ribose) polymerase, regulatory domain
  • ( PF05406 ) WGR domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:30796450: Ashraf K, Nabeel-Shah S, Garg J, Saettone A, Derynck J, Gingras AC, Lambert JP, Pearlman RE, Fillingham J (2019) Proteomic analysis of histones H2A/H2B and variant Hv1 in Tetrahymena thermophila reveals an ancient network of chaperones. Molecular biology and evolution ( ):
  2. Ref:23884606: Gao S, Xiong J, Zhang C, Berquist BR, Yang R, Zhao M, Molascon AJ, Kwiatkowski SY, Yuan D, Qin Z, Wen J, Kapler GM, Andrews PC, Miao W, Liu Y (2013) Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation. Genes & development 27(15):1662-79

Sequences 

>TTHERM_00030430(coding)
ATGCCACCTAAAAAAAATTAAAATAAGAGAAGCGGTAAAGATCGTTCTTTATCTCCTTAA
ACTGCTTCCGATGCAAAATAAGACCCTGTGAAAAAAGTTAAAGATGAAGTTTAAGATTTA
TAAGCTCCAGTTATTGTTAAAAGTAAATGTCCTGTTGACATGTAAGTTCCGGGTGCATCA
TCATACTAAGTATTGTAAATTGGTGACACTGTTTACAGTTTTACACTAAATTAAACTAAC
TGTGGGGCTAATAATAACAAATTTTATCTTGGATAGATACTCTATAATCCTACTGATTAA
AAATTTAGGACATTCTATAAATGGGGTAGAGTAGGAACTCCTGGCTAAAACTCTAATATA
CCATAAAATTCTTTAGAAAAGGCTATTTAAGATTATTAAAAGAAGAAAAATGATAAAATA
AAAGGTGGATATACTGAAATCTTTATAAAATATGGTGATGATGATAAAAATGATGAAGAA
GAAGAATAAAAGCAACAATAGAAACTTGAGGATAAGGAAAGAAAATAAAGTAAACTCTCT
GAGGCTGTTTAAATTATGATCAATGAAATTTTTGATTCTAAAATGATTTAAAATAGTATT
AAAGATATTGGTTTTGATTAAAAAAAGATGCCTTTAGGTAAATTAGCAGAGTAAACAATA
AAATAAGCCTATCTTGTTTTGAACGAACTTATGGAAGCCATCAAAAATAATGAAACTAGT
TAGTTTGAAAGACTTTCGAGCTCATTCTACTCATATATTCCTCATGATTTTGGCTTTTAA
AAAATGAGCCATTTTATTTTAAGATCTGAGGAATAAGTTAAGTAGAAGTTGGAAATGCTT
TAGAACTTAGAAGATCTTAAAATTGCTACTAACTTGTTAAAACTTACAGATACTGAGGAA
GCTATTATAGATGAAAATTATAAAAAACTAAAGTCTAATATTGAAGTTGTTAAAGATCAA
GATACTAGAAACATGATAATCAATTATATTAATGAGGGTTCAACTTATCGCTAACCTTAA
GTGTTAGAAATATACGAAGTAAATAGAGAAGGAGAAGATGAAAGATATACAAAAGATATA
GGAAACGATACACTTCTTTGGCATGGGTCTAGAATTTCTAACTTTGTCGGTATTCTTTCT
TAGGGACTTCGTATAGCACCTCCAGAAGCTCCAGTTTCAGGATATAACTATGGTAAGGGT
ATTTATTTAGCAGATATGTTTGATAAATCAAGATCATATTGCTAAGGAAACAGTCAAGGT
GTAAATTACATTATGCTTATTTAGGCTGCTTTAGGTAACCCGAACAGAATAGAAAGAACA
GATTACAATGCTAGTAATTTACCTTAAGGAACTAATTCCTGTTGGGGCTGGGGAACATTT
GGTCCTGAATAATTTATCACTCATAACGGTGTTAAAGTCCCTCATGGAAAGCCCGTTACG
ACCTAATCTAAGAATTATATGACTCACAATGAATTTATTATTTATAAAGTAGAATAAGCT
AAAATTAAATATTTAATTAGATTTAAATGA



>TTHERM_00030430(gene)
GCTAGTTAGAATTTATCAAAAATTAATTAGATTTTATACAATCTCATTAGTTATTTAATT
AGAAATGAAAAGATATTAGATTTTTTGTATATTAAATAGGTAGGTAAGTAGATATCTGAT
TGATATTAAAAAAAATTAAAATAATCAAAAATTACATTCAACCAATAACAGAAAAAATGC
CACCTAAAAAAAATTAAAATAAGAGAAGCGGTAAAGATCGTTCTTTATCTCCTTAAACTG
CTTCCGATGCAAAATAAGACCCTGTGAAAAAAGTTAAAGATGAAGTTTAAGATTTATAAG
CTCCAGTTATTGTTAAAAGTAAATGTCCTGTTGACATGTAAGTTCCGGGTGCATCATCAT
ACTAAGTATTGTAAATTGGTGACACTGTTTACAGTTTTACACTAAATTAAACTAACTGTG
GGGCTAATAATAACAAATTTTATCTTGGATAGATACTCTATAATCCTACTGATTAAAAAT
TTAGGACATTCTATAAATGGGGTAGAGTAGGAACTCCTGGCTAAAACTCTAATATACCAT
AAAATTCTTTAGAAAAGGCTATTTAAGATTATTAAAAGAAGAAAAATGATAAAATAAAAG
GTGGATATACTGAAATCTTTATAAAATATGGTGATGATGATAAAAATGATGAAGAAGAAG
AATAAAAGCAACAATAGAAACTTGAGGATAAGGAAAGAAAATAAAGTAAACTCTCTGAGG
CTGTTTAAATTATGATCAATGAAATTTTTGATTCTAAAATGATTTAAAATAGTATTAAAG
ATATTGGTTTTGATTAAAAAAAGATGCCTTTAGGTAAATTAGCAGAGTAAACAATAAAAT
AAGCCTATCTTGTTTTGAACGAACTTATGGAAGCCATCAAAAATAATGAAACTAGTTAGT
TTGAAAGACTTTCGAGCTCATTCTACTCATATATTCCTCATGATTTTGGCTTTTAAAAAA
TGAGCCATTTTATTTTAAGATCTGAGGAATAAGTTAAGTAGAAGTTGGAAATGCTTTAGA
ACTTAGAAGATCTTAAAATTGCTACTAACTTGTTAAAACTTACAGATACTGAGGAAGCTA
TTATAGATGAAAATTATAAAAAACTAAAGTCTAATATTGAAGTTGTTAAAGATCAAGATA
CTAGAAACATGATAATCAATTATATTAATGAGGGTTCAACTTATCGCTAACCTTAAGTGT
TAGAAATATACGAAGTAAATAGAGAAGGAGAAGATGAAAGATATACAAAAGATATAGGAA
ACGATACACTTCTTTGGCATGGGTCTAGAATTTCTAACTTTGTCGGTATTCTTTCTTAGG
GACTTCGTATAGCACCTCCAGAAGCTCCAGTTTCAGGATATAACTATGGTAAGGGTATTT
ATTTAGCAGATATGTTTGATAAATCAAGATCATATTGCTAAGGAAACAGTCAAGGTGTAA
ATTACATTATGCTTATTTAGGCTGCTTTAGGTAACCCGAACAGAATAGAAAGAACAGATT
ACAATGCTAGTAATTTACCTTAAGGAACTAATTCCTGTTGGGGCTGGGGAACATTTGGTC
CTGAATAATTTATCACTCATAACGGTGTTAAAGTCCCTCATGGAAAGCCCGTTACGACCT
AATCTAAGAATTATATGACTCACAATGAATTTATTATTTATAAAGTAGAATAAGCTAAAA
TTAAATATTTAATTAGATTTAAATGATAAATAACTTAATAAATTTATTATAACTTGCAAT
AAATCTAAATATTTTGTAGATATTTTATTTTTTTATACTTTGTATTACATTTATTTTTAA
TATAATTAAAAATATTTTGACAAATATAAAA



>TTHERM_00030430(protein)
MPPKKNQNKRSGKDRSLSPQTASDAKQDPVKKVKDEVQDLQAPVIVKSKCPVDMQVPGAS
SYQVLQIGDTVYSFTLNQTNCGANNNKFYLGQILYNPTDQKFRTFYKWGRVGTPGQNSNI
PQNSLEKAIQDYQKKKNDKIKGGYTEIFIKYGDDDKNDEEEEQKQQQKLEDKERKQSKLS
EAVQIMINEIFDSKMIQNSIKDIGFDQKKMPLGKLAEQTIKQAYLVLNELMEAIKNNETS
QFERLSSSFYSYIPHDFGFQKMSHFILRSEEQVKQKLEMLQNLEDLKIATNLLKLTDTEE
AIIDENYKKLKSNIEVVKDQDTRNMIINYINEGSTYRQPQVLEIYEVNREGEDERYTKDI
GNDTLLWHGSRISNFVGILSQGLRIAPPEAPVSGYNYGKGIYLADMFDKSRSYCQGNSQG
VNYIMLIQAALGNPNRIERTDYNASNLPQGTNSCWGWGTFGPEQFITHNGVKVPHGKPVT
TQSKNYMTHNEFIIYKVEQAKIKYLIRFK