Identifiers and Description

Gene Model Identifier

TTHERM_00043870

Standard Name

TGP2 (Tetrahymena G-DNA binding Protein )

Aliases

PreTt11064 | 3.m01838 | 3824.m02827

Description

TGP2 dihydrolipoyl dehydrogenase; G-quartet DNA binding protein; has dihydrolipoamide dehydrogenase (DLDH) activity; preferentially binds G4-DNA oligonucleotides with adjacent single-stranded domains

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• cytoplasm (IEA) | GO:0005737

Molecular Function

• flavin adenine dinucleotide binding (IEA) | GO:0050660
• oxidoreductase activity (IEA) | GO:0016491

Biological Process

• cell redox homeostasis (IEA) | GO:0045454
• obsolete oxidation-reduction process (IEA) | GO:0055114
• tRNA processing (IEA) | GO:0008033

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_5695	0
	Description: None
WormBase	WBGene00010794	9.997093137033517e-262
	Description: locus:dld-1 Dihydrolipoyl dehydrogenase, mitochondrial status:Confirmed UniProt:O17953 protein_id:CAB05249.2
Tetrahymena borealis	EI9_01865.1	9.997093137033517e-262
	Description: dihydrolipoamide dehydrogenase (489 aa)
Oxytricha	Contig16905.0.g78	9.997093137033517e-262
	Description: Pyridine nucleotide-disulphide oxidoreductase
DictyBase	DDB_G0291648	4.000089512234839e-180
	Description: lpd on chromosome: 6 position 70728 to 72507
SGD	YFL018C	1.0001465636795248e-178
	Description: LPD1 Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes

General Information

No Data fetched for General Information

Associated Literature

1. Ref:9521745: Kee K, Niu L, Henderson E (1998) A Tetrahymena thermophila G4-DNA binding protein with dihydrolipoamide dehydrogenase activity. Biochemistry 37(12):4224-34

Sequences

>TTHERM_00043870(coding)
ATGTTCAAAACTTTTGTTCCTACTAGAAATCTTACCCATAGTCTTAGATAATTGTTCTCC
ACTAGCACTCAATATGATGTCGTCGTTATTGGTGGTGGTCCTGGTGGTTACGTAGCTGCC
ATTAAGGCTGGTTAATTAGGCTTAAAGACCGCTTGTGTTGAAAAGAGAGGTTCTTTGGGT
GGTACCTGCTTAAATGTTGGTTGCATTCCTTCAAAGGCTCTCTTAAACATCTCTTAAAAA
TATTATGATGCTTCCAAGCACTACAAAGAACTTGGTATCGAAGTTGAAGGTGTTAAAATG
AATTGGGCTCAAGCTTAAACAAAGAAGGCTGAAACAGTTACTGGTTTGACCAGAGGTATC
GAAAGTCTCTTCAAGAAGAATAAGGTTGACTACTTTGTTGGTACTGGTAGACTAAATGAC
AAGAACACTATTGGTATTAATCTTAACAATGGTACTTAGTAGGTTATTAACTCCAAGAAC
ATTATTATTGCTACTGGATCTGAACCTACTCCTTTCCCTGGTCTCAACTTCGACGAAAAG
GTTATCATCTCTTCAACTGGTGCTCTCTCTTTACCCTAGATCCCTAAGAAATTAATCGTT
ATTGGTGCTGGTGTTATTGGTTTAGAAATGGGTTCTGTTTACCAAAGATTAGGTACTCAA
GTTACTGTCATTGAATTTGCTGATTAAATTTGCCCTTTCCTTGATACTGATGTTGCTAAG
GCTTTCCAATAGAGCTTAAAGAAATAAGGTTTACAAATTTTGACTGGCCATAAGGTTGTT
TCTGGTTAAAACTTCGGTACTCACGGTAGCGTAGTTGTTGAACCTGTTAAGGGAGGTCCA
TCTTAGACCTTTGAAGCTGATCATATTTTAGTTTCTACAGGTCGTAGACCTTATGTTGAT
GGCTTAAATGCTAAGGAAATCGGTATTGAGTTTGACAACAAAAATAGAATCATCACTAAC
TCCCACTTACAAACCAACATTCCCAATATTTATGCCATAGGTGATGTCATTCCTGGACCT
ATGTTGGCTCACAAGGGTGAAGAAGAAGGTATTGCTGCTGTTGAATATATTGCTGGAAAG
GGTGGTCATGTTAATTACGATGCTATTCCTAGTGTTATCTATACCCATCCTGAAGTTGCT
TGGGTCGGAAAGACTGAATAAGAACTTAAGGCTGCCAATATTAAGTACAACAAGGGTTCT
TTCCCCATGCTTGCTAACTCTAGAGCTAAAGCTAACAACGACTACGATGGTTTAATTAAG
ATCTTAACTGAAAAGGATACTGATAAACTCTTGGGTGTCCATATTATGAATGCATAAGCT
GGTGAATTAATCGGTGAAGCTACTTTAGCCGTCGAATATGGTGCTGCTGCTGAAGATATA
GGTAGAACTTGCCACGCTCATCCTACTATTTCTGAAGCTCTTAAAGAAGCTTGCATGGCT
GCTTATGACAAGCCCATCCACTTCTGA

>TTHERM_00043870(gene)
ATGTTCAAAACTTTTGTTCCTACTAGAAATCTTACCCATAGTCTTAGATAATTGTTCTCC
ACTAGCACTCAATATGATGTCGTCGTTATTGGTGGTGGTCCTGGTGGTAATAATCCTAAT
TATTTAATCAAAATTTTATACAATACAGCTTCTTCTCCTTCTTTTCGCTTTAAAGCAGTA
GCATTTCAGAGGTTATTCATGAAAACTTTGATTATTTAAAAACTGAGAAAAATTCACATA
GTTAAGCAAATATTCTATAAGAGTTGATCAAATATAAAAGATGCGTACTAAATTAAATTA
CAGTTTGTCTTAAAATATGCCTATAGCTAAGGATAATTTCAAATTATGTTCAATAGCTTT
AAGATAGAAGGAGAAGCAAGTGTTTATAGCTGATATAGCTAAAATTAAGAAAAATAGGTT
TATTTAATTATATTATAAATATAAAAGGTTACGTAGCTGCCATTAAGGCTGGTTAATTAG
GCTTAAAGACCGCTTGTGTTGAAAAGAGAGGTTCTTTGGGTGGTACCTGCTTAAATGTTG
GTTGCATTCCTTCAAAGGCTCTCTTAAACATCTCTTAAAAATATTATGATGCTTCCAAGC
ACTACAAAGAACTTGGTATCGAAGTTGAAGGTGTTAAAATGAATTGGGGTAAAATATTAA
ATTCTTTTTATTTTCATCCTCTTAAGAAAAAAAATTTTATCCACCAAAAATGATTTTTTA
CTCAAAATAAATACTTTTTTTTAATTGAATGCTTTTGTTTCAAACATCTAGCTGTTAGCA
AAATAATTTATTATAACTAAAATATATCTAATAAATAGCTCAAGCTTAAACAAAGAAGGC
TGAAACAGTTACTGGTTTGACCAGAGGTATCGAAAGTCTCTTCAAGAAGAATAAGGTTGA
CTACTTTGTTGGTACTGGTAGACTAAATGACAAGAACACTATTGGTATTAATCTTAACAA
TGGTACTTAGTAGGTTATTAACTCCAAGAACATTATTATTGCTACTGGATCTGAACCTAC
TCCTTTCCCTGGTCTCAACTTCGACGAAAAGGTTATCATCTCTTCAACTGGTAAAATAAA
AGATTTGTGGAAATTTATTTATTTACTTAAGCTATAATGAATTTTGTAGATTGATTAGCA
AATAAATAAATAAATAACAAGATTAGATAAGATTTATAAAAAGATATTTAATGAATGAAA
TAAATTGATTAGTAGCACTATTTAATTAATAAATAAAGCAAATTTTTTATCTTTCAATTT
ATCAAGAAATTTCTCAAAATTTTATTTGATGCTTCAATAATTTTTAAGGATTCTGATCTA
ATCTACTTAATTAATTAATTTATTTATTTATTGTATTATTCGAATCTCCTTTTAATCATT
TTATCATTTTACTATTACTTTAATACAGGTGCTCTCTCTTTACCCTAGATCCCTAAGAAA
TTAATCGTTATTGGTGCTGGTGTTATTGGTTTAGAAATGGGTTCTGTTTACCAAAGATTA
GGTACTCAAGTTACTGTCATTGAATTTGCTGATTAAATTTGCCCTTTCCTTGATACTGAT
GTTGCTAAGGCTTTCCAATAGAGCTTAAAGAAATAAGGTTTACAAATTTTGACTGGCCAT
AAGGTTGTTTCTGGTTAAAACTTCGGTACTCACGGTAGCGTAGTTGTTGAACCTGTTAAG
GGAGGTCCATCTTAGACCTTTGAAGCTGATCATATTTTAGTTTCTACAGGTCGTAGACCT
TATGTTGATGGCTTAAATGCTAAGGAAATCGGTATTGAGTTTGACAACAAAAATAGAATC
ATCACTAACTCCCACTTACAAACCAACATTCCCAATATTTATGCCATAGGTGATGTCATT
CCTGGACCTATGTTGGCTCACAAGGGTGAAGAAGAAGGTATTGCTGCTGTTGAATATATT
GCTGGAAAGGGTGGTCATGTTAATTACGATGCTATTCCTAGTGTTATCTATACCCATCCT
GAAGTTGCTTGGGTCGGAAAGACTGAATAAGAACTTAAGGCTGCCAGTAAATATTATTTT
TATTATTAATTTAAAATTAAATTAATCTAAATATTTAAACCAAATTTAATAGATATTAAG
TACAACAAGGGTTCTTTCCCCATGCTTGCTAACTCTAGAGCTAAAGCTAACAACGACTAC
GATGGTTTAATTAAGATCTTAACTGAAAAGGATACTGATAAACTCTTGGGTGTCCATATT
ATGAATGCATAAGCTGGTGAATTAATCGGTGAAGCTACTTTAGCCGTCGAATATGGTGCT
GCTGCTGAAGATATAGGTAGAACTTGCCACGCTCATCCTACTATTTCTGAAGCTCTTAAA
GAAGCTTGCATGGCTGCTTATGACAAGCCCATCCACTTCTGA

>TTHERM_00043870(protein)
MFKTFVPTRNLTHSLRQLFSTSTQYDVVVIGGGPGGYVAAIKAGQLGLKTACVEKRGSLG
GTCLNVGCIPSKALLNISQKYYDASKHYKELGIEVEGVKMNWAQAQTKKAETVTGLTRGI
ESLFKKNKVDYFVGTGRLNDKNTIGINLNNGTQQVINSKNIIIATGSEPTPFPGLNFDEK
VIISSTGALSLPQIPKKLIVIGAGVIGLEMGSVYQRLGTQVTVIEFADQICPFLDTDVAK
AFQQSLKKQGLQILTGHKVVSGQNFGTHGSVVVEPVKGGPSQTFEADHILVSTGRRPYVD
GLNAKEIGIEFDNKNRIITNSHLQTNIPNIYAIGDVIPGPMLAHKGEEEGIAAVEYIAGK
GGHVNYDAIPSVIYTHPEVAWVGKTEQELKAANIKYNKGSFPMLANSRAKANNDYDGLIK
ILTEKDTDKLLGVHIMNAQAGELIGEATLAVEYGAAAEDIGRTCHAHPTISEALKEACMA
AYDKPIHF