Identifiers and Description

Gene Model Identifier

TTHERM_00069420

Standard Name

MCM5 (DNA replication licensing factor MCM5)

Aliases

PreTt13232 | 4.m00631 | 3707.m00267

Description

MCM5 DNA replication licensing factor MCM4; Component of the Mcm2-7 complex involved in DNA replication

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• DNA binding (IEA) | GO:0003677
• magnesium chelatase activity (IEA) | GO:0016851

Biological Process

• chlorophyll biosynthetic process (IEA) | GO:0015995
• DNA replication (IEA) | GO:0006260
• photosynthesis (IEA) | GO:0015979

Domains

• ( PF00004 ) ATPase family associated with various cellular activities (AAA)
• ( PF00493 ) MCM P-loop domain
• ( PF01078 ) Magnesium chelatase, subunit ChlI
• ( PF01926 ) 50S ribosome-binding GTPase
• ( PF07726 ) ATPase family associated with various cellular activities (AAA)
• ( PF07728 ) AAA domain (dynein-related subfamily)
• ( TIGR00264 ) alpha-NAC homolog
• ( TIGR00368 ) Mg chelatase homolog

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_21479	0
	Description: None
Tetrahymena borealis	EI9_02143.1	9.997093137033517e-262
	Description: MCM2/3/5 family protein (729 aa)
Oxytricha	Contig1884.0.g10	9.997093137033517e-262
	Description: MCM2/3/5 family
SGD	YLR274W	9.997093137033517e-262
	Description: MCM5 Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
Tetrahymena borealis	EI9_07694.1	9.997093137033517e-262
	Description: oxidoreductase, aldo/keto reductase (348 aa)
DictyBase	DDB_G0292958	7.000463540624081e-176
	Description: mcm5 on chromosome: 6 position 2121500 to 2123946
WormBase	WBGene00003157	1.9993181170755286e-174
	Description: locus:mcm-5 DNA replication licensing factor mcm-5 status:Confirmed UniProt:Q21902 protein_id:CAA90765.1
WormBase	WBGene00008923	1.9993181170755286e-174
	Description: status:Confirmed UniProt:G5EC34 protein_id:CAC35887.1

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00069420(coding)
ATGTACTAAGGAGAGTAAATTAGTTATACATACTAAAATTTGGTTTAAGATGAACCCTAC
AATCAAATCGATAACATGCCTCATGTACCCTAACAAGTCTAAGAAGGTTACAAAAGATTC
TTCTCTGAATTCTTACTCAAGAATCAGAAAGTTTACATTGAAAAAATGAAATAAGCTGTC
GAATCACGTAAGAAATGCTTCGAGCTTGACTTAGAAGATTTGTAATCTTACAACTCTGAC
CATTACTAGCTTCTTATTTAAAAGCCAAACGATTATCTTCCTCTTCTTGAAAAGGCTGCT
TCTGAAGCTTTCTACACAATTACTAATAACCGTAGCAACTTCTAAGTTTTTCTTATCAGT
ACTTAAGACCCTAAGAATCTTCGTGATATTAAGGCTTCTTCTATCTCGAAGCTTATCACT
GTCTCTGGTATTATCACTCAAGCAACTAGACCTTATATTCGTAGTAAAATTTTATACGTA
GAGTGCTCTAAATGCCATCATTAATTGAGTTTAGAAGTTAGCTAAGGTTTGGGTTCAGTA
TCAATTCCTCCTTACTGTAAGAATCCTAACTAAAGTAACGAAAAGTGCCCTGTTGACAGT
TATGTTGTAATTCCAGAAAAGTGCACTCTTATAGATTAGCAAAGAATGAAACTTCAAGAA
TCTCCTGAAGATATTCCTACTGGTGAAATTCCTCGTACTTTTTCTCTTTGTGCTGAACGC
TATTTGGTCAACAGACTTGCTCCAGGTACTCGTGTTGTTTTGACTGGTATTTACTAAGTC
TTAGAGAAAACTTCAATTTCTAACAAAACAATATCTTCTACCAACTCTAAGATAAACTAT
ATTCAAGTTGTTGGTTATAAACTCGAAGATGAAATTAAGAAAAGATCAAGAAGCTTTACT
ACCGAAGAAGAAGAGGCTTTCTAAACTCTTTCCAAAGATCCTAAAATCTTTGAAAAAATA
GGATAATCCATAGCTCCTGCAATATTCGGTTTTGATGATATTAAATAAGCAATAGCATGT
CTTTTATTCGGTGGTTCTAAAAAGATTTTATAAGACGGAATAAGACTTAGAGGAGACATT
AATGTCTTATTGATCGGTGATCCTAGTACTGGTAAATCTTAATTTTTGAAATTCGTCCAA
AGAATAGCCCCTAATGCAGTATATACATCCGGTAAAGGTTCTTCTGCTAGTGGTTTAACA
GCTAGTATTACAAGAGACCCTCTTACTGGTGAATTTTAAATTGAAGGTGGTGCCATGGTT
TTAGCTGATGGTGGAGTTGTGTGTATTGATGAATTTGATAAGATGCGTCCTGAAGACAGA
GTAGCAATTCATGAAGCTATGGAACAATAAACTATCAGTATTGCTAAGGCTGGTATAACA
ACTCGTCTAAACTCTCGTTGCTCTGTTCTAGCTGCTGCCAATCCTATTTTTGGTTCTTAC
AACGACTTGAAGACCATTGAAGATTAAATTGAACTCCAGACTACCATTCTTTCTCGTTTT
GATACAATTTTCGTTGTTAGAGATCCTAAAACCTAGGAACATGATTAACGTCTCGCTGAA
CATGTTCTTAACTTGCACATGATGAATAACTAAAAGAACGGAGGAAGCATTAATGCTGCT
GTCATGGAATAGGAAATGCTTGAATAAAAAGGAGTTGAAATTGAGTTAAATCTCTTAAGA
AAATACATCTCATACGCTCGTGCTAAAATCCATCCTCGTTTGACTGAAAGATCTGCTTAA
AAAATTTAAAATTTATACGTTGAAGATAGAAAGCAATCAAATCAAGGTCACTCATCTAAG
AAGCACCATATTCCTATAACAGTTCGTTAATTAGAAGCCATTATTCGTTTGAGTGAATCA
ATAGCTAAGATTTAATTGAGTGAAGAAGTTACTGATGAACATATCAATAAAGCACATGAA
CTCTTCTAAAATTCTACAATGAACGCCATATAAAACGGTAAAGAATTAGGTTTAGAACTT
CCTTAAGAATTATAGTCTCTATGCTTTAAAATCGAAGAATCTATTCGTCACAATATTCCA
GTAAATGGAAGATACGATTTCACTTCTCTTAAAGATAAATTGTTTTCTAAATTTAACAAT
GCTCGTGCAGTAGATTATGCCTTTTATAAGTTGATTAAAGATGGAGAGTTGCAATAAGTT
GAAGGAAACAGATTTATTGTTCGTAAGAAGTGA

>TTHERM_00069420(gene)
ATGTACTAAGGAGAGTAAATTAGTTATACATACTAAAATTTGGTTTAAGATGAACCCTAC
AATCAAATCGATAACATGCCTCATGTACCCTAACAAGTCTAAGAAGGTTACAAAAGATTC
TTCTCTGAATTCTTACTCAAGAATCAGAAAGTTTACATTGAAAAAATGAAATAAGCTGTC
GAATCACGTAAGAAATGCTTCGAGCTTGACTTAGAAGATTTGTAATCTTACAACTCTGAC
CATTACTAGCTTCTTATTTAAAAGCCAAACGATTATCTTCCTCTTCTTGAAAAGGCTGCT
TCTGAAGCTTTCTACACAATTACTAATAACCGTAGCAACTTCTAAGTTTTTCTTATCAGT
ACTTAAGACCCTAAGAATCTTCGTGATATTAAGGCTTCTTCTATCTCGAAGCTTATCACT
GTCTCTGGTATTATCACTCAAGTAATTTTTGCATGCTTCACATTTATCATATATCATCTC
TTTTAACATTTTGAAAATCGCTTTTATTAATAAAACTAATTATCATAATAATAAAATAGG
CAACTAGACCTTATATTCGTAGTAAAATTTTATACGTAGAGTGCTCTAAATGCCATCATT
AATTGAGTTTAGAAGTTAGCTAAGGTTTGGGTTCAGTATCAATTCCTCCTTACTGTAAGA
ATCCTAACTAAAGTAACGAAAAGTGCCCTGTTGACAGTTATGTTGTAATTCCAGAAAAGT
GCACTCTTATAGATTAGCAAAGAATGAAACTTCAAGAATCTCCTGAAGATATTCCTACTG
GTGAAATTCCTCGTACTTTTTCTCTTTGTGCTGAACGCTATTTGGTCAACAGACTTGCTC
CAGGTACTCGTGTTGTTTTGACTGGTATTTACTAAGTCTTAGAGAAAACTTCAATTTCTA
ACAAAACAATATCTTCTACCAACTCTAAGATAAACTATATTCAAGTTGTTGGTTATAAAC
TCGAAGATGAAATTAAGAAAAGATCAAGAAGCTTTACTACCGAAGAAGAAGAGGCTTTCT
AAACTCTTTCCAAAGATCCTAAAATCTTTGAAAAAATAGGATAATCCATAGCTCCTGCAA
TATTCGGTTTTGATGATATTAAATAAGCAATAGCATGTCTTTTATTCGGTGGTTCTAAAA
AGATTTTATAAGACGGAATAAGACTTAGAGGAGACATTAATGTCTTATTGGTAATTAATT
TTTAAATGTTTTAATCTAAATTTTAAACAGTCAAGCAAAAGCAAACTTTTTGAAGATGAA
AATAGCAAAAATATTTTGAAAATTTCCATGCAATAAAAACTTTATTTATTAAATTTAAAT
TTATAAAATAGATCGGTGATCCTAGTACTGGTAAATCTTAATTTTTGAAATTCGTCCAAA
GAATAGCCCCTAATGCAGTATATACATCCGGTAAAGGTTCTTCTGCTAGTGGTTTAACAG
CTAGTATTACAAGAGACCCTCTTACTGGTGAATTTTAAATTGAAGGTGGTGCCATGGTTT
TAGCTGATGGTGGAGTTGTGTGTATTGATGAATTTGATAAGATGCGTCCTGAAGACAGAG
TAGCAATTCATGAAGCTATGGAACAATAAACTATCAGTATTGCTAAGGCTGGTATAACAA
CTCGTCTAAACTCTCGTTGCTCTGTTCTAGCTGCTGCCAATCCTATTTTTGGTTCTTACA
ACGACTTGAAGACCATTGAAGATTAAATTGAACTCCAGACTACCATTCTTTCTCGTTTTG
ATACAATTTTCGTTGTTAGAGATCCTAAAACCTAGGAACATGATTAACGTCTCGCTGAAC
ATGTTCTTAACTTGCACATGATGAATAACTAAAAGAACGGAGGAAGCATTAATGCTGCTG
TCATGGAATAGGAAATGCTTGAATAAAAAGGAGTTGAAATTGAGTTAAATCTCTTAAGAA
AATACATCTCATACGCTCGTGCTAAAATCCATCCTCGTTTGACTGAAAGATCTGCTTAAA
AAATTTAAAATTTATACGTTGAAGATAGAAAGCAATCAAATCAAGGTCACTCATCTAAGA
AGCACCATATTCCTATAACAGTTCGTTAATTAGAAGCCATTATTCGTTTGAGTGAATCAA
TAGCTAAGATTTAATTGAGTGAAGAAGTTACTGATGAACATATCAATAAAGCACATGAAC
TCTTCTAAAATTCTACAATGAACGCCATATAAAACGGTAAAGAATTAGGTTTAGAACTTC
CTTAAGAATTATAGTCTCTATGCTTTAAAATCGAAGAATCTATTCGTCACAATATTCCAG
TAAATGGAAGATACGATTTCACTTCTCTTAAAGATAAATTGTTTTCTAAATTTAACAATG
CTCGTGCAGTAGATTATGCCTTTTATAAGTTGATTAAAGATGGAGAGTTGCAATAAGTTG
AAGGAAACAGATTTATTGTTCGTAAGAAGTGA

>TTHERM_00069420(protein)
MYQGEQISYTYQNLVQDEPYNQIDNMPHVPQQVQEGYKRFFSEFLLKNQKVYIEKMKQAV
ESRKKCFELDLEDLQSYNSDHYQLLIQKPNDYLPLLEKAASEAFYTITNNRSNFQVFLIS
TQDPKNLRDIKASSISKLITVSGIITQATRPYIRSKILYVECSKCHHQLSLEVSQGLGSV
SIPPYCKNPNQSNEKCPVDSYVVIPEKCTLIDQQRMKLQESPEDIPTGEIPRTFSLCAER
YLVNRLAPGTRVVLTGIYQVLEKTSISNKTISSTNSKINYIQVVGYKLEDEIKKRSRSFT
TEEEEAFQTLSKDPKIFEKIGQSIAPAIFGFDDIKQAIACLLFGGSKKILQDGIRLRGDI
NVLLIGDPSTGKSQFLKFVQRIAPNAVYTSGKGSSASGLTASITRDPLTGEFQIEGGAMV
LADGGVVCIDEFDKMRPEDRVAIHEAMEQQTISIAKAGITTRLNSRCSVLAAANPIFGSY
NDLKTIEDQIELQTTILSRFDTIFVVRDPKTQEHDQRLAEHVLNLHMMNNQKNGGSINAA
VMEQEMLEQKGVEIELNLLRKYISYARAKIHPRLTERSAQKIQNLYVEDRKQSNQGHSSK
KHHIPITVRQLEAIIRLSESIAKIQLSEEVTDEHINKAHELFQNSTMNAIQNGKELGLEL
PQELQSLCFKIEESIRHNIPVNGRYDFTSLKDKLFSKFNNARAVDYAFYKLIKDGELQQV
EGNRFIVRKK