Identifiers and Description

Gene Model Identifier

TTHERM_00085220

Standard Name

MRK1 (MAP-related kinase )

Aliases

MRK | PreTt16370 | 6.m00444 | 3836.m02037

Description

MRK1 MEK kinase; MAP-related kinase; recombinant MRK autophosphorylates, and phosphorylates myelin basic protein (MBP); transcription increases with temperature downshift from 35 to 15 degrees C, or with osmotic shock; Mitogen-activated protein kinase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• MAP kinase activity (ISS) | GO:0004707

Biological Process

• response to cold (IEP) | GO:0009409
• response to osmotic stress (IDA) | GO:0006970

Domains

• ( PF00069 ) Protein kinase domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

1. Ref:16933976: Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, Smith RK, Garg J, Pearlman RE, Karrer KM, Sun L, Manning G, Elde NC, Turkewitz AP, Asai DJ, Wilkes DE, Wang Y, Cai H, Collins K, Stewart BA, Lee SR, Wilamowska K, Weinberg Z, Ruzzo WL, Wloga D, Gaertig J, Frankel J, Tsao CC, Gorovsky MA, Keeling PJ, Waller RF, Patron NJ, Cherry JM, Stover NA,
2. Ref:10735176: Nakashima S, Nozawa Y (1999) Stress-responsive gene expression in Tetrahymena. Acta biologica Hungarica 50(4):413-24
3. Ref:10187773: Nakashima S, Wang S, Hisamoto N, Sakai H, Andoh M, Matsumoto K, Nozawa Y (1999) Molecular cloning and expression of a stress-responsive mitogen-activated protein kinase-related kinase from Tetrahymena cells. The Journal of biological chemistry 274(15):9976-83

Sequences

>TTHERM_00085220(coding)
ATGGACAAAAAGTTATCTTCCAAGAATTTTTCCGACTGGGAGGTTGGTGATAGATATGAT
CTTATTAAGGTTGTAGGTAGTGGTTCTTATGGTTCTGTAGCTGAAGCTACTGACAAGAAA
TCAGGCAAGAAAGTTGCCATTAAGAGATTGAATGGTATCTTCGAAGACAATGTTGACTGC
AAACGTATTCTTAGAGAAATTCACTTGTTACGTATTTTAAATCACCCTAACCTTATTAGA
ATCAATGAAATTATTGAACCTAAGGACTTATAGAACTTCGACACTCTTTATGTCGTTACT
GAATATTGCTAATCCGACCTTAAAAAGCTCTTCAAGTCACCTATTCACTTGTGCATGATC
CAAGTTTAAACATTAACCTACAACATTCTCACTGGTATTAAATATCTCCACTCTGCTGAA
GTACTTCATAGAGATCTCAAGCCTGCTAACGTCCTTATCAATGAAGATTGCTCTGTCAAG
ATTTGTGACTTTGGTCTCGCCAGATCTGTAGAAGGTATTGAAGGTGCACATATTTATGAT
GATAGAAATAGCAACAGCCCTCAAAAGTAATAAACCAGTAGCCAAAGCCCTGAAAAGCCT
GCAGCTACCAGCAGTGGAAGACCTAAACTTTCTAAAGAAAAGGGAATTAACTCTAAAACC
ACTAAGAGAGAATTGACTGGCCACGTAGTTACTCGTTGGTACAGAGCTCCCGAATTGATT
CTTTTGGAAAAAGATTACACTGCTGCCATTGATATCTGGAGTATTGGTTGTATCTTCGCT
GAATTGATGAATATGATCAAGGAAAACTCCCCCACCTTCTTAGATAGATCTCCTCTTTTC
CCTGGTAGCAGCTGCTTCCCCCTCTCACCTGATAGAAACAACACAGTTAAGTAGGGTGGA
TTCCCCCACAGCCACAGTGATTAATTGAATGTCATCTTCTCAGTCTTGGGTACCCCTAAT
GAAGAAGATATGGACTTCGTCACTGATGCTAAGGCTATCGAATATTTAAAGAGCTTCAAG
CAAAAGAAGAGAGTCGACTTCAAGGATTTATTCCCAGCTGCCACCCCTGAATGTATTGAT
TTCTTGAACAAAACCCTTGTCTTCAACCCTCGTAAAAGAATTACTATTGATGCTGCCCTC
AACCATCCTCTCTTTACCCCTGTCAGAGATATCAAGAAAGAAGTATTTGCTGATGGCTCC
GTTGTTCTTCCCTTTGAAAAAGAAGGAGACATGGCTATACCTAGACTCCGTGAACTCTTC
ATCGAAGAAATCAAGCGTTATCACACTAAGTGA

>TTHERM_00085220(gene)
ATCGCAGACAAATAAAAAATAAATAATTTTTATAAAAACAAAACATTCATTTTCAAAGAA
AAACCTAAGTAAAAAAACTTTAAAAAATAAATAAATAAATAAACAAAATAAATGGACAAA
AAGTTATCTTCCAAGAATTTTTCCGACTGGGAGGTTGGTGATAGATATGATCTTATTAAG
GTTGTAGGTAGTGGTTCTTATGGTTCTGTAGCTGAAGCTACTGACAAGAAATCAGGCAAG
AAAGTTGCCATTAAGAGATTGAATGGTATCTTCGAAGACAATGTTGACTGCAAACGTATT
CTTAGAGAAATTCACTTGTTACGTATTTTAAATCACCCTAACCTTATTAGAATCAATGAA
ATTATTGAACCTAAGGACTTATAGAACTTCGACACTCTTTATGTCGTTACTGAATATTGC
TAATCCGACCTTAAAAAGCTCTTCAAGTCACCTATTCACTTGTGCATGATCCAAGTTTAA
ACATTAACCTACAACATTCTCACTGGTATTAAATATCTCCACTCTGCTGAAGTACTTCAT
AGAGATCTCAAGCCTGCTAACGTCCTTATCAATGAAGATTGCTCTGTCAAGATTTGTGAC
TTTGGTCTCGCCAGATCTGTAGAAGGTATTGAAGGTGCACATATTTATGATGATAGAAAT
AGCAACAGCCCTCAAAAGTAATAAACCAGTAGCCAAAGCCCTGAAAAGCCTGCAGCTACC
AGCAGTGGAAGACCTAAACTTTCTAAAGAAAAGGGAATTAACTCTAAAACCACTAAGAGA
GAATTGACTGGCCACGTAGTTACTCGTTGGTACAGAGCTCCCGAATTGATTCTTTTGGAA
AAAGATTACACTGCTGCCATTGATATCTGGAGTATTGGTTGTATCTTCGCTGAATTGATG
AATATGATCAAGGAAAACTCCCCCACCTTCTTAGATAGATCTCCTCTTTTCCCTGGTAGC
AGCTGCTTCCCCCTCTCACCTGATAGAAACAACACAGTTAAGTAGGGTGGATTCCCCCAC
AGCCACAGTGATTAATTGAATGTCATCTTCTCAGTCTTGGGTACCCCTAATGAAGAAGAT
ATGGACTTCGTCACTGATGCTAAGGCTATCGAATATTTAAAGAGCTTCAAGCAAAAGAAG
AGAGTCGACTTCAAGGATTTATTCCCAGCTGCCACCCCTGAATGTATTGATTTCTTGAAC
AAAACCCTTGTCTTCAACCCTCGTAAAAGAATTACTATTGATGCTGCCCTCAACCATCCT
CTCTTTACCCCTGTCAGAGATATCAAGAAAGAAGTATTTGCTGATGGCTCCGTTGTTCTT
CCCTTTGAAAAAGAAGGAGACATGGCTATACCTAGACTCCGTGAACTCTTCATCGAAGAA
ATCAAGCGTTATCACACTAAGTGAGAGAAAAACTTTTATGCATCTATATTGGATTTGTAG
ATATCTGAAGCAAGCAATAACTACTAATTTTGATAACTTTATTAATAAATCACAAATATT
ATCTAAATACCATCTATTTATATGACTTGCTCAGATATAACATATAGGCAGTAAGTAGCC
TGCGTGCTCAAGAAAAACAATATAGATCTCCTTTAAAAAATCCTTCACATAAATAACAAT
CTTACTTCTCCAAAACCACACATTTATTCATTAAATCAATATATCTATTACTAAATATAT
TTTTTGTTTTATTTACTCTAACTAAACAAACATGTCAGTCAGTCAGTTTATCATCTTTTT
ATTTCTTATAAATTAAA

>TTHERM_00085220(protein)
MDKKLSSKNFSDWEVGDRYDLIKVVGSGSYGSVAEATDKKSGKKVAIKRLNGIFEDNVDC
KRILREIHLLRILNHPNLIRINEIIEPKDLQNFDTLYVVTEYCQSDLKKLFKSPIHLCMI
QVQTLTYNILTGIKYLHSAEVLHRDLKPANVLINEDCSVKICDFGLARSVEGIEGAHIYD
DRNSNSPQKQQTSSQSPEKPAATSSGRPKLSKEKGINSKTTKRELTGHVVTRWYRAPELI
LLEKDYTAAIDIWSIGCIFAELMNMIKENSPTFLDRSPLFPGSSCFPLSPDRNNTVKQGG
FPHSHSDQLNVIFSVLGTPNEEDMDFVTDAKAIEYLKSFKQKKRVDFKDLFPAATPECID
FLNKTLVFNPRKRITIDAALNHPLFTPVRDIKKEVFADGSVVLPFEKEGDMAIPRLRELF
IEEIKRYHTK