Identifiers and Description

Gene Model Identifier

TTHERM_00085600

Standard Name

LIA4 (Localize In macronuclear Anlagen)

Aliases

PreTt16408 | 6.m00482 | 3836.m02076

Description

LIA4 Localize In macronuclear Anlagen 4 protein , involved in macronuclear differentiation; hypothetical protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• macronucleus (IDA) | GO:0031039

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No.	Gene Name(s)	Paragraph Text
2229	LIA4	LIA4 is expressed exclusively during conjugation and Lia4p localizes to developing macronuclei. It is required for completion of conjugation, DNA rearrangement, chromosome breakage, and Pdd1 foci (dumposome) formation (Horrell SA and Chalker DL, unpublished data).

Associated Literature

1. Ref:25084866: Horrell SA, Chalker DL (2014) LIA4 encodes a chromoshadow domain protein required for genomewide DNA rearrangements in Tetrahymena thermophila. Eukaryotic cell 13(10):1300-11
2. Ref:17519286: Yao MC, Yao CH, Halasz LM, Fuller P, Rexer CH, Wang SH, Jain R, Coyne RS, Chalker DL (2007) Identification of novel chromatin-associated proteins involved in programmed genome rearrangements in Tetrahymena. Journal of cell science 120(Pt 12):1978-89

Sequences

>TTHERM_00085600(coding)
ATGGTTGATATTGTTGATGATAGTATGCATAATATGCCTAATATTGATATAAAAGAAGAA
GAGGAAGTTGATTTTAATTTAAATGAAGCTGGAAATAAGAAAAAGCTTTACAGCTCTGAT
GATTCAAAAGATTAAAATGATAATTAAAATAATGTTCTTGAGCCTTCTGTTTTGAATGTA
GAAGCTACAAACGGTAATATACCAGAAAGTGATATTCTATAATAAGTAAACGAAACTATG
GACATCGAATAAAAAGAAAAAGCAAGTGAAAGCAAACAAAAAAAATAATAAAAAGACAAC
AACAAAGATATGTCAGAAGGTAGCTAATTAGAAAATGAAGATTATAAAGATGCTGAGTCA
AGCTAAAGCAAAACAACTTCAGATGAAGATTACTAAAATCCCTTAGAAAAGGGAATGGTA
ATGGAAGAATATGAAGATGATGATGAGTTTATTGGTGTAGAAGAAGAGATTCCTTCCACT
CAATTAGAGCAAAGGAAGAATTCTAGGAAATCAAATGAGAAAAGAGGGCAGAGAAAGAAA
AAAATGATTGAATCTGAAGAAGGAGATGAGGAAGATTCTTCTAATTCAAGTTCTGGTTTT
TCATAAAGAAAAAACTAACTTAATTAAAAGAGAAATACTTCTACAAGAACTAGGAGAAGA
AGAAGATAAAACAGTTAAATTAATGATTCTACTTTTAGTGAAATAAAACCATAGAAAAGA
ACTCGTAGAAAAAAAACAAATGTAGATGAATCAGGATTAAGTTTCAATAATAAAGAAGAT
AATCAACTCATACAAGATGCAATAGATTTTATTAAAAGTAAACCGAGAAGAAGAAGGACA
AGCAAAAAAGAAAATGTAAAATTGGATTCTGAATTTTTAGAAAAAATACAAAAAAAAGCA
AAATCAAATGAAAAAGAAGTTCCTAATAATTTATAGCAAATTAATTTAAATTAAAATGGC
TAAGGACAACAAAATGGGAATATACCATAATAATTCATTGATCTAAATAAGACAATCTCA
AATGAAATTTAATTTTAACAAATAAATCCTTAATTGATACAGTAATAGTTATAATTTTAA
AACTTAGCCTAGCTCTAGTTATAAGCAATGCAGCAATTACCATTTATATTATAGAAATAA
CAGCAATAATAATAATAATAGTAGTAATAGTAGAATTAACAATAAAATGGCTAATTACAA
GCAGCTTTAGCTAATCCACTTTTACTTTAGAATTACTAAAATTAATTTCTTTTGTAAGCT
TAAAGAAACGCTGAAATGCTCATGAATGTTAAAAAGGAGGATCTTTCAAATTAACCACTA
CTAAATCTAGGTTTGCAGTAACAAAATTTAGAGGATAATAAAAATTTACCAAAGTAAACA
ACTCAACTTGTACAATAGAATTCTAACAGCAACCAAACAAACGGAAGACATAGAACTGGA
AGGAGAGGAAGAGGTAGTGTTTAATCTAACTAAACTAGTGGGAAAAATTCTAAAGTAGAT
GAAAGTTTTACTGTAGATGATTTAGGAAGAAGAAAGAAGTATAATACGAGAAGGAAGATT
CAAAAATAGAACTATGCTGAAAGTCCTTTGAATGAAGATAGAGATAAGGAGGAGAATAAA
ACCTCTGAATAAAAAGAGAAATCTGGAAATAAAGATTAAAGAAGTTTAGAAGAAGTTGGT
AATGCTGCAATAGATGAGTCAAATATAGAGTTAATTGAGAAAATTCAAAAGAAAGCTGAA
GAAAAAAAATTAGGAAAGGAAATTGAATAATAGTTAAAAGATTTGTTGAGCAAAATAGAA
AATGAAAAGTAAAATTAAATTCTTAGTCAGATAGTGAATAAATACAACTTAAACACTGAA
AAAATAAAAGAATCATAACCTCCAAAGTAAAACAGTAAAACTAAAGAAGATGTAAAGAAA
AAAGGAACTACAAAAGAAATAATATTGAATCCTCATTAAACTCTTACATAATAACTTGAA
GTTATTGATAATATATCTGTTGATAGTGCAAACGGTGTTAACATTAATTACAGAGAGTCA
GGTTCGTCAGATGAAAATCTGAATCAAATTAAAAATGTTGTAGATCTTGATAAAGAAAAA
GAGCTGAAAAAACCAAAATAGTTATAAACATCATACAAGTTGTTGAATTATGATAAGTTA
GAATAAAAAGGTAATATTTGTTCAAAAGGAAGACAAGATGACAAAAAGACTGCTTAGCCT
GCGAATAATCTAGATTAAGCATCTTAAAATGAAGAAAGTGATGAAGAAGATGATTATATT
AGAGATGAAGTAATTCCAATTACAGGTCATTTTAAATATAAAGATAAAGCTGCTGGAGTC
CTTTCATCAAAAATATTAAATAAAAATATATATCTTGAAATATAATGGGAAAAAAGAAAA
AATGGTGTGACACCAACTCCTACCATCATTAATACTCATGAAGTAAAAGCATATGACACT
GATTTCTTAATAGATTTTTATGAATCTAAAATATTAAAAACAAATGAATCAAAAGCCTAA
AGACTACCTAATCAATAAGTTAGTGGTTCTAAGAATTCACATATTGAGTAACTCAGATAA
GATGTTCATAAAAACTAAATGCAAGTATCTTTACAGCAAAAAGATAAATATTATAAATTA
GTAGAACCCAAAGAAAACTAAGCACTCTCTTTACTTGATAGCCAGACAAATTAATCTAAA
AATACAGAAAATAAAACTGTGAGTAACAATTAAGGTAACACCAGCAACGTTCTAAACCAA
AACAAAAAGTAAATCGACCTTGATTAGTAAAGTGATAACGAAAGCGGTGATGAGGAAATT
ACCCAAAAAGATAAAAATAAAATCTATTAAATAGATACACCATCTAGTAAATCAAGTGAA
GAATTTTGCATTGATCCTTACAGAAAATTCATAGAGGATGAAGGTCTTCTCCCAGAATAA
TTACAATAAGAATTAAAAGAAAAACTCGTTTTTTGA

>TTHERM_00085600(gene)
ATGTTTTTCACAATGATTTAATTAATCTCTTATTATTATTTAATTTATAAAAAACTTTTC
ATTATTTAAACTTCTAAAAAGAGGAAAATACATTTTAAAATTATTTTTCGTTATTTTGCC
TTCAAATGGTTGATATTGTTGATGATAGTATGCATAATATGCCTAATATTGATATAAAAG
AAGAAGAGGAAGTTGATTTTAATTTAAATGAAGCTGGAAATAAGAAAAAGCTTTACAGCT
CTGATGATTCAAAAGATTAAAATGATAATTAAAATAATGTTCTTGAGCCTTCTGTTTTGA
ATGTAGAAGCTACAAACGGTAATATACCAGAAAGTGATATTCTATAATAAGTAAACGAAA
CTATGGACATCGAATAAAAAGAAAAAGCAAGTGAAAGCAAACAAAAAAAATAATAAAAAG
ACAACAACAAAGATATGTCAGAAGGTAGCTAATTAGAAAATGAAGATTATAAAGATGCTG
AGTCAAGCTAAAGCAAAACAACTTCAGATGAAGATTACTAAAATCCCTTAGAAAAGGGAA
TGGTAATGGAAGAATATGAAGATGATGATGAGTTTATTGGTGTAGAAGAAGAGATTCCTT
CCACTCAATTAGAGCAAAGGAAGAATTCTAGGAAATCAAATGAGAAAAGAGGGCAGAGAA
AGAAAAAAATGATTGAATCTGAAGAAGGAGATGAGGAAGATTCTTCTAATTCAAGTTCTG
GTTTTTCATAAAGAAAAAACTAACTTAATTAAAAGAGAAATACTTCTACAAGAACTAGGA
GAAGAAGAAGATAAAACAGTTAAATTAATGATTCTACTTTTAGTGAAATAAAACCATAGA
AAAGAACTCGTAGAAAAAAAACAAATGTAGATGAATCAGGATTAAGTTTCAATAATAAAG
AAGATAATCAACTCATACAAGATGCAATAGATTTTATTAAAAGTAAACCGAGAAGAAGAA
GGACAAGCAAAAAAGAAAATGTAAAATTGGATTCTGAATTTTTAGAAAAAATACAAAAAA
AAGCAAAATCAAATGAAAAAGAAGTTCCTAATAATTTATAGCAAATTAATTTAAATTAAA
ATGGCTAAGGACAACAAAATGGGAATATACCATAATAATTCATTGATCTAAATAAGACAA
TCTCAAATGAAATTTAATTTTAACAAATAAATCCTTAATTGATACAGTAATAGTTATAAT
TTTAAAACTTAGCCTAGCTCTAGTTATAAGCAATGCAGCAATTACCATTTATATTATAGA
AATAACAGCAATAATAATAATAATAGTAGTAATAGTAGAATTAACAATAAAATGGCTAAT
TACAAGCAGCTTTAGCTAATCCACTTTTACTTTAGAATTACTAAAATTAATTTCTTTTGT
AAGCTTAAAGAAACGCTGAAATGCTCATGAATGTTAAAAAGGAGGATCTTTCAAATTAAC
CACTACTAAATCTAGGTTTGCAGTAACAAAATTTAGAGGATAATAAAAATTTACCAAAGT
AAACAACTCAACTTGTACAATAGAATTCTAACAGCAACCAAACAAACGGAAGACATAGAA
CTGGAAGGAGAGGAAGAGGTAGTGTTTAATCTAACTAAACTAGTGGGAAAAATTCTAAAG
TAGATGAAAGTTTTACTGTAGATGATTTAGGAAGAAGAAAGAAGTATAATACGAGAAGGA
AGATTCAAAAATAGAACTATGCTGAAAGTCCTTTGAATGAAGATAGAGATAAGGAGGAGA
ATAAAACCTCTGAATAAAAAGAGAAATCTGGAAATAAAGATTAAAGAAGTTTAGAAGAAG
TTGGTAATGCTGCAATAGATGAGTCAAATATAGAGTTAATTGAGAAAATTCAAAAGAAAG
CTGAAGAAAAAAAATTAGGAAAGGAAATTGAATAATAGTTAAAAGATTTGTTGAGCAAAA
TAGAAAATGAAAAGTAAAATTAAATTCTTAGTCAGATAGTGAATAAATACAACTTAAACA
CTGAAAAAATAAAAGAATCATAACCTCCAAAGTAAAACAGTAAAACTAAAGAAGATGTAA
AGAAAAAAGGAACTACAAAAGAAATAATATTGAATCCTCATTAAACTCTTACATAATAAC
TTGAAGTTATTGATAATATATCTGTTGATAGTGCAAACGGTGTTAACATTAATTACAGAG
AGTCAGGTTCGTCAGATGAAAATCTGAATCAAATTAAAAATGTTGTAGATCTTGATAAAG
AAAAAGAGCTGAAAAAACCAAAATAGTTATAAACATCATACAAGTTGTTGAATTATGATA
AGTTAGAATAAAAAGGTAATATTTGTTCAAAAGGAAGACAAGATGACAAAAAGACTGCTT
AGCCTGCGAATAATCTAGATTAAGCATCTTAAAATGAAGAAAGTGATGAAGAAGATGATT
ATATTAGAGATGAAGTAATTCCAATTACAGGTCATTTTAAATATAAAGATAAAGCTGCTG
GAGTCCTTTCATCAAAAATATTAAATAAAAATATATATCTTGAAATATAATGGGAAAAAA
GAAAAAATGGTGTGACACCAACTCCTACCATCATTAATACTCATGAAGTAAAAGCATATG
ACACTGATTTCTTAATAGATTTTTATGAATCTAAAATATTAAAAACAAATGAATCAAAAG
CCTAAAGACTACCTAATCAATAAGTTAGTGGTTCTAAGAATTCACATATTGAGTAACTCA
GATAAGATGTTCATAAAAACTAAATGCAAGTATCTTTACAGCAAAAAGATAAATATTATA
AATTAGTAGAACCCAAAGAAAACTAAGCACTCTCTTTACTTGATAGCCAGACAAATTAAT
CTAAAAATACAGAAAATAAAACTGTGAGTAACAATTAAGGTAACACCAGCAACGTTCTAA
ACCAAAACAAAAAGTAAATCGACCTTGATTAGTAAAGTGATAACGAAAGCGGTGATGAGG
AAATTACCCAAAAAGATAAAAATAAAATCTATTAAATAGATACACCATCTAGTAAATCAA
GTGAAGAATTTTGCATTGATCCTTACAGAAAATTCATAGAGGATGAAGGTCTTCTCCCAG
AATAATTACAATAAGAATTAAAAGAAAAACTCGTTTTTTGAAAAATAAGTCTATGTTACT
TTGTATTTACAGTTTTATTTTCATAA

>TTHERM_00085600(protein)
MVDIVDDSMHNMPNIDIKEEEEVDFNLNEAGNKKKLYSSDDSKDQNDNQNNVLEPSVLNV
EATNGNIPESDILQQVNETMDIEQKEKASESKQKKQQKDNNKDMSEGSQLENEDYKDAES
SQSKTTSDEDYQNPLEKGMVMEEYEDDDEFIGVEEEIPSTQLEQRKNSRKSNEKRGQRKK
KMIESEEGDEEDSSNSSSGFSQRKNQLNQKRNTSTRTRRRRRQNSQINDSTFSEIKPQKR
TRRKKTNVDESGLSFNNKEDNQLIQDAIDFIKSKPRRRRTSKKENVKLDSEFLEKIQKKA
KSNEKEVPNNLQQINLNQNGQGQQNGNIPQQFIDLNKTISNEIQFQQINPQLIQQQLQFQ
NLAQLQLQAMQQLPFILQKQQQQQQQQQQQQNQQQNGQLQAALANPLLLQNYQNQFLLQA
QRNAEMLMNVKKEDLSNQPLLNLGLQQQNLEDNKNLPKQTTQLVQQNSNSNQTNGRHRTG
RRGRGSVQSNQTSGKNSKVDESFTVDDLGRRKKYNTRRKIQKQNYAESPLNEDRDKEENK
TSEQKEKSGNKDQRSLEEVGNAAIDESNIELIEKIQKKAEEKKLGKEIEQQLKDLLSKIE
NEKQNQILSQIVNKYNLNTEKIKESQPPKQNSKTKEDVKKKGTTKEIILNPHQTLTQQLE
VIDNISVDSANGVNINYRESGSSDENLNQIKNVVDLDKEKELKKPKQLQTSYKLLNYDKL
EQKGNICSKGRQDDKKTAQPANNLDQASQNEESDEEDDYIRDEVIPITGHFKYKDKAAGV
LSSKILNKNIYLEIQWEKRKNGVTPTPTIINTHEVKAYDTDFLIDFYESKILKTNESKAQ
RLPNQQVSGSKNSHIEQLRQDVHKNQMQVSLQQKDKYYKLVEPKENQALSLLDSQTNQSK
NTENKTVSNNQGNTSNVLNQNKKQIDLDQQSDNESGDEEITQKDKNKIYQIDTPSSKSSE
EFCIDPYRKFIEDEGLLPEQLQQELKEKLVF