Identifiers and Description

Gene Model Identifier

TTHERM_00092840

Standard Name

UBA22 (UBA2 Paralog)

Aliases

PreTt16538 | 6.m00612 | 3836.m02198

Description

UBA22 ubiquitin-activating enzyme E1; Ubiquitin activating protein; involved in SUMOylation

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• catalytic activity (IEA) | GO:0003824
• ubiquitin-like modifier activating enzyme activity (IEA) | GO:0008641

Biological Process

• cellular protein modification process (IEA) | GO:0006464

Domains

• ( PF00899 ) ThiF family
• ( PF02134 ) Repeat in ubiquitin-activating (UBA) protein
• ( PF05237 ) MoeZ/MoeB domain
• ( TIGR00136 ) tRNA uridine 5-carboxymethylaminomethyl modification enzyme
• ( TIGR02354 ) thiamine biosynthesis protein ThiF
• ( TIGR02355 ) molybdopterin synthase sulfurylase MoeB
• ( TIGR02356 ) thiazole biosynthesis adenylyltransferase ThiF

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_02543.1	9.997093137033517e-262
	Description: hypothetical protein (578 aa)
Oxytricha	Contig20101.0.g96	2.998830401637127e-79
	Description: ThiF family
DictyBase	DDB_G0286919	3.999627495270728e-67
	Description: uba2 on chromosome: 4 position 5077667 to 5079750
WormBase	WBGene00006700	1.0000310450948521e-65
	Description: locus:uba-2 SUMO-activating enzyme subunit uba-2 status:Partially_confirmed UniProt:Q9NAN1 protein_id:CAB54319.4
SGD	YDR390C	1.0003503620230312e-57
	Description: UBA2 Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability
Stentor Coeruleus	SteCoe_19993	0.0000000000002543665647376923
	Description: None

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00092840(coding)
ATGGAAATAGAGGCTTAAAGGTCTGACAGAAGCTTGAAGCTAATTTATGGTGAAGAAGTT
TACAATAAAATTATCTAATCAAATGTTTTAATTGGAGGAGCAGGTGGTGTTGGATGTGAA
ATAATTAAATCATTAAGTAAAACAGGATTTAGGAAATTTACAATGATCGATTTAGATACA
ATAGAGCTAACCAATTTAAATAGGCAATTCTATTTCAGAAAACATCATGTAGGAAAAGCT
AAATCTGCTTGCGCTAAAGAAGGAGTACTATTAATTGAACCAAATATCTTGTAAGTAGAT
GCTATTTTAGGAAATATTTATGATCCAAAGTTTGATGATTTATTTTATAAATAATTTGAT
ATTGCATTTTGTGCTTTTGATAACTAAGGAGCTAGAAGGCACTTTGGTAAGATGTGTACA
GTGAATAACATTCCTATGGTAGAGGCTGGAACTTCTGCATTTAATGGATAGACATAGACT
AGAATAAAAGATTTATTTGAATGCAGAAATTGCACTCCAGAAGTCAAACAATAAACTAGC
TTTAATGTTTGCTCAATTAGAACTAGACCTTCTGAACCTATTCACTGCATAGTTTGGGCT
TCTAATATGTTTAATTTGATATTTGGGAACCAAGATGATTCAAATTTGTTGGAAAACTAT
ATTTAAGATATTTTCAAAGAGGGAATCAAGAATGTCTAAGACCCAAAAGAAAAAGCTCTT
CAGTTATTTGAAAAGATTTTCAACGAAGACATTTAAAAATGTGATGAAAAAGAAAGATTC
CCAATTTCTTTTGAGCAATCTTTATAAATTGACAACAAAGAAGATGCTGTTTACTTTGAT
GAAAGAAATAATCGCAAATTGTTAGAAGACGAAAAAATCTTCACTATTAAGGAGTATGCA
CAGAAATTTATTTAAGCGTTTTTAGATGTATTTCATCATAGAAAAGAAGCTTTAGGAGAA
CTAAAATTTGATAAAGATGATTAACTGGCTTTGAAATTTGTCGCTGCAATCACTAATTTG
CGTACATTTAATTTCCTTAATAAGGAAAATGAAAAGAATAAGTTGAGATATCTCTCAGAG
CATAAAATAAAATAAATGGTTGGAAATATTATCCCTGCAATAGCATCAACAAACGCTATC
GTTTCTGCTATCCAAGTAAATGAAGCAATTAAAATAATGAAAGGTTATGCCAAAACTAAG
CCTTAACTATTCAGCGAGTATTTAGTCCAAAATGGTGATCAAAGCAAAATAACTCCAGCA
CAGTTATCTCTTCCACAATTATCTTGTCCTGTTTGCTCTCCAGCTAATTGCTACATAAAC
ATAAAAGCAAATTGCACTCAAATAACTTTTGGATAGCTCAAATAAATTTTTGAAGAATAG
TACTTAGCATATAATTAAATTATCAAAATAGATGATAAAGTATATTATGACCCTCATTAG
ATTAGTTTGAGAAAGATATTTGACAACTTACTACTAAAGAAAATTAGCGAACTTCCAAAT
TATAATTAAGACTACACTAAATTTAAGCTATTTAGCATTGATAATTAGATCACTTGGGAG
TTCAATTTAATGCATGATAGCTCTTTATAAGGATAACAAGTAGTTTGTGATCAAAATAGT
GACCCTACTAGAATAAAGTAGCAACAAATTCAATATATAAAACTAAAGCATGAGCAAACT
TTTAAAGAAAAAATAGATATATTTAAGAGATATAAGTATATTTGA

>TTHERM_00092840(gene)
ATGGAAATAGAGGCTTAAAGGTCTGACAGAAGCTTGAAGCTAATTTATGGTGAAGAAGTT
TACAATAAAATTATCTAATCAAATGTTTTAATTGGAGGAGCAGGTGGTGTTGGATGTGAA
ATAATTAAATCATTAAGTAAAACAGGATTTAGGAAATTTACAATGATCGATTTAGATACA
ATAGAGCTAACCAATTTAAATAGGCAATTCTATTTCAGAAAACATCATGTAGGAAAAGCT
AAATCTGCTTGCGCTAAAGAAGGAGTACTATTAATTGAACCAAATATCTTGTAAGTAGAT
GCTATTTTAGGAAATATTTATGATCCAAAGTTTGATGATTTATTTTATAAATAATTTGAT
ATTGCATTTTGTGCTTTTGATAACTAAGGAGCTAGAAGGCACTTTGGTAAGATGTGTACA
GTGAATAACATTCCTATGGTAGAGGCTGGAACTTCTGCATTTAATGGTAATAATTAATTT
TAACAATAAATTGAAAATTATTGTATTTTTCAAAGTCTACTCAATATTTTAACCCTTAAA
AATTTAAAGAATATATTTTTCAAGTAAATTAGGAGTAAAATATAATTTTATTGCTTTGAA
AATTTCAAATAAAATAAGAATTTTAATGTTTTAAAAAATTTATTCAAACAGGATAGACAT
AGACTAGAATAAAAGATTTATTTGAATGCAGAAATTGCACTCCAGAAGTCAAACAATAAA
CTAGCTTTAATGTTTGCTCAATTAGAACTAGACCTTCTGAACCTATTCACTGCATAGTTT
GGGCTTCTAATATGTTTAATTTGATATTTGGGAACCAAGATGATTCAAATTTGTTGGAAA
ACTATATTTAAGATATTTTCAAAGAGGGAATCAAGAATGTCTAAGACCCAAAAGAAAAAG
CTCTTCAGTTATTTGAAAAGATTTTCAACGAAGACATTTAAAAATGTGATGAAAAAGAAA
GATTCCCAATTTCTTTTGAGCAATCTTTATAAATTGACAACAAAGAAGATGCTGTTTACT
TTGATGAAAGAAATAATCGCAAATTGTTAGAAGACGAAAAAATCTTCACTATTAAGGAGT
ATGCACAGAAATTTATTTAAGCGTTTTTAGATGTATTTCATCATAGAAAAGAAGCTTTAG
GAGAACTAAAATTTGATAAAGATGATTAACTGGCTTTGAAATTTGTCGCTGCAATCACTA
ATTTGCGTACATTTAATTTCCTTAATAAGGAAAATGAAAAGAATAAGTTGAGATATCTCT
CAGAGCATAAAATAAAATAAATGGTTGGAAATATTATCCCTGCAATAGGTATTTATTTAA
TTTAAAAATATAAATAAATTATTAAATATCAATTAAACTATAGCATCAACAAACGCTATC
GTTTCTGCTATCCAAGTAAATGAAGCAATTAAAATAATGAAAGGTTATGCCAAAACTAAG
CCTTAACTATTCAGCGAGTATTTAGTCCAAAATGGTGATCAAAGCAAAATAACTCCAGCA
CAGTTATCTGTAAATTATCCATATTAAATAAGCACATTTTTTTAAACTATAAATTTAATT
TAAAAGCTTCCACAATTATCTTGTCCTGTTTGCTCTCCAGCTAATTGCTACATAAACATA
AAAGCAAATTGCACTCAAATAACTTTTGGATAGCTCAAATAAATTTTTGAAGAATAGTAC
TTAGCATATAATTAAATTATCAAAATAGATGATAAAGTATATTATGACCCTCATTAGATT
AGTTTGAGAAAGATATTTGACAACTTACTACTAAAGAAAATTAGCGAACTTCCAAATTAT
AATTAAGACTACACTAAATTTAAGCTATTTAGCATTGATAATTAGATCACTTGGGAGTTC
AATTTAATGCATGATAGCTCTTTATAAGGATAACAAGTAGTTTGTGATCAAAATAGTGAC
CCTACTAGAATAAAGTAGCAACAAATTCAATATATAAAACTAAAGCATGAGCAAACTTTT
AAAGAAAAAATAGATATATTTAAGAGATATAAGTATATTTGA

>TTHERM_00092840(protein)
MEIEAQRSDRSLKLIYGEEVYNKIIQSNVLIGGAGGVGCEIIKSLSKTGFRKFTMIDLDT
IELTNLNRQFYFRKHHVGKAKSACAKEGVLLIEPNILQVDAILGNIYDPKFDDLFYKQFD
IAFCAFDNQGARRHFGKMCTVNNIPMVEAGTSAFNGQTQTRIKDLFECRNCTPEVKQQTS
FNVCSIRTRPSEPIHCIVWASNMFNLIFGNQDDSNLLENYIQDIFKEGIKNVQDPKEKAL
QLFEKIFNEDIQKCDEKERFPISFEQSLQIDNKEDAVYFDERNNRKLLEDEKIFTIKEYA
QKFIQAFLDVFHHRKEALGELKFDKDDQLALKFVAAITNLRTFNFLNKENEKNKLRYLSE
HKIKQMVGNIIPAIASTNAIVSAIQVNEAIKIMKGYAKTKPQLFSEYLVQNGDQSKITPA
QLSLPQLSCPVCSPANCYINIKANCTQITFGQLKQIFEEQYLAYNQIIKIDDKVYYDPHQ
ISLRKIFDNLLLKKISELPNYNQDYTKFKLFSIDNQITWEFNLMHDSSLQGQQVVCDQNS
DPTRIKQQQIQYIKLKHEQTFKEKIDIFKRYKYI