Identifiers and Description

Gene Model Identifier

TTHERM_00105430

Standard Name

PRF1 (PRoFilin)

Aliases

PreTt23043 | 7.m00567

Description

PRF1 profilin; Profilin family protein; both inhibits and enhances actin polymerization; co-localizes with actin in the division furrow; hypothetical protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• actomyosin contractile ring (IDA) | GO:0005826
• cleavage furrow (IDA) | GO:0032154

Molecular Function

• actin monomer binding (ISS) | GO:0003785

Biological Process

• cytokinesis (IMP) | GO:0000910
• nucleus localization (IMP) | GO:0051647
• phagocytosis (IMP) | GO:0006909
• regulation of actin filament polymerization (ISS) | GO:0030833

Domains

No Data fetched for Domains

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

1. Ref:15132168: Wilkes DE, Otto JJ (2004) Profilin functions in cytokinesis, nuclear positioning, and stomatogenesis in Tetrahymena thermophila. The Journal of eukaryotic microbiology 50(4):252-62
2. Ref:11942614: Numata O, Gonda K (2001) Determination of division plane and organization of contractile ring in Tetrahymena. Cell structure and function 26(6):593-601
3. Ref:10767551: Wilkes DE, Otto JJ (2000) Molecular cloning of profilin from Tetrahymena thermophila. Gene 246(1-2):295-301
4. Ref:1478923: Edamatsu M, Hirono M, Watanabe Y (1992) Tetrahymena profilin is localized in the division furrow. Journal of biochemistry 112(5):637-42
5. Ref:1902095: Edamatsu M, Hirono M, Takemasa T, Watanabe Y (1991) The primary structure of Tetrahymena profilin. Biochemical and biophysical research communications 175(2):543-50
6. Ref:2383275: Edamatsu M, Hirono M, Watanabe Y (1990) Purification and characterization of Tetrahymena profilin. Biochemical and biophysical research communications 170(2):957-62

Sequences

>TTHERM_00105430(coding)
ATGTCTGGTTGGGATCAATATATCTAATATCTTTTGGCTGATAAGAAGTGCGAATCTGCC
TACATCCTCGGTAAGGATCATGCTAACATTTGGGCTTGCTCTACTGGTATTGCTGCTCTT
CCTACTTACTAAATCAATGTCGAAGGTAAAAACTTCAATGTTAACGAAGCTGAGCTCTTG
GTTAAGGCTTTGAAGAACAACGGTGTTCCCACTGATCCTAATGTTGGTTTAAGAATTAAG
AATGAAAAGTACTACACTGTCAGATTCGACGCTGATGCTGGTACCTGGTATCTTAAGAAG
GATTAAGGTGGTGCTTGCATTGCCGTTACCAAGTAAGCTTTAGTTATTGGTACTTTCAAA
AACGACATCAAAATGACTAACGGTCAACCTCAAAATCCTGGTGCCGTCAACGCTGCTTGT
GAAAAGCTCGCTGAATCCTTAAAGTCCGCTAACTACTGA

>TTHERM_00105430(gene)
GTAATTAATATGCATTGCCATGCGCTGATAAATTATAAAAGCTGACAGTGTACTTTAAAA
TTTACATAAAAAATAATATCTTTAGTAAATAAAAATCTAAAAAGAAAAAAAAAGTTTAAG
AAAATCAAAAATAAAGAAATACAATTAAAATGTCTGGTTGGGATCAATATATCTAATATC
TTTTGGCTGATAAGAAGTGCGAATCTGCCTACATCCTCGGTAAGGATCATGCTAACATTT
GGGCTTGCTCTACTGGTATTGCTGCTCTTCCTACTTACTAAATCAATGTCGAAGGTAAAA
ACTTCAATGTTAACGAAGCTGAGCTCTTGGTTAAGGCTTTGAAGAACAACGGTGTTCCCA
CTGATCCTAATGTTGGTTTAAGAATTAAGAATGAAAAGTACTACACTGTCAGATTCGACG
CTGATGCTGGTACCTGGTATCTTAAGAAGGATTAAGGTGGTGCTTGCATTGCCGTTACCA
AGTAAGCTTTAGTTATTGGTACTTTCAAAAACGACATCAAAATGACTAACGGTCAACCTC
AAAATCCTGGTGCCGTCAACGCTGCTTGTGAAAAGCTCGCTGAATCCTTAAAGTCCGCTA
ACTACTGATTTGATTATTAATAGTTAAATAAATGATAATAAATTTATAAAAATAATTTAA
ATTGATAAACTTGTCATGATGATTTTTGTGTGATTTCATAGAAATATTATTCATTCATTT
AGCTTTTTTTTAGATTATTCTTCTCAATA

>TTHERM_00105430(protein)
MSGWDQYIQYLLADKKCESAYILGKDHANIWACSTGIAALPTYQINVEGKNFNVNEAELL
VKALKNNGVPTDPNVGLRIKNEKYYTVRFDADAGTWYLKKDQGGACIAVTKQALVIGTFK
NDIKMTNGQPQNPGAVNAACEKLAESLKSANY