Identifiers and Description

Gene Model Identifier

TTHERM_00105430

Standard Name

PRF1 (PRoFilin)

Aliases

PreTt23043 | 7.m00567

Description

PRF1 profilin; Profilin family protein; both inhibits and enhances actin polymerization; co-localizes with actin in the division furrow

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

Gene Ontology Annotations

Molecular Function

• lipid kinase activity (IMP) | GO:0001727 | Ref:15132168
• peptide transporter activity (IMP) | GO:0015197 | Ref:15132168
• polyamine:proton antiporter activity (IEA) | GO:0015312
• protein-arginine C-methyltransferase activity (IEA) | GO:0035244
• xylitol oxidase activity (ISS) | GO:0050582 | Ref:15132168

Biological Process

• histidine catabolic process (IEA) | GO:0006548
• interleukin-35 secretion (IMP) | GO:0072626 | Ref:15132168
• lysine catabolic process (ISS) | GO:0006554 | Ref:10767551
• post-embryonic ectodermal digestive tract morphogenesis (IDA) | GO:0048614 | Ref:1478923
• pyrimidine ribonucleoside triphosphate metabolic process (IDA) | GO:0009208 | Ref:1478923

Domains

• ( PF00235 ) Profilin

Gene Expression Profile

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_00377.1	3.999498296699862e-96
	Description: profilin family protein (153 aa)
Oxytricha	Contig22514.0.g15	9.995317835403734e-19
	Description: Profilin
WormBase	WBGene00003990	0.0000000400154582995175
	Description: locus:pfn-2 Profilin-2 status:Confirmed UniProt:Q20025 protein_id:CCD62785.1
DictyBase	DDB_G0271142	0.00000009004106436083642
	Description: proC on chromosome: 2 position 57583 to 57963
SGD	YOR122C	0.00003998524687536623
	Description: PFY1 Profilin, binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress

General Information

No Data fetched for General Information

Associated Literature

1. Ref:15132168: Wilkes DE, Otto JJ (2004) Profilin functions in cytokinesis, nuclear positioning, and stomatogenesis in Tetrahymena thermophila. The Journal of eukaryotic microbiology 50(4):252-62
2. Ref:11942614: Numata O, Gonda K (2001) Determination of division plane and organization of contractile ring in Tetrahymena. Cell structure and function 26(6):593-601
3. Ref:10767551: Wilkes DE, Otto JJ (2000) Molecular cloning of profilin from Tetrahymena thermophila. Gene 246(1-2):295-301
4. Ref:1478923: Edamatsu M, Hirono M, Watanabe Y (1992) Tetrahymena profilin is localized in the division furrow. Journal of biochemistry 112(5):637-42
5. Ref:1902095: Edamatsu M, Hirono M, Takemasa T, Watanabe Y (1991) The primary structure of Tetrahymena profilin. Biochemical and biophysical research communications 175(2):543-50
6. Ref:2383275: Edamatsu M, Hirono M, Watanabe Y (1990) Purification and characterization of Tetrahymena profilin. Biochemical and biophysical research communications 170(2):957-62

Sequences

>TTHERM_00105430(coding)
ATGTCTGGTTGGGATCAATATATCTAATATCTTTTGGCTGATAAGAAGTGCGAATCTGCC
TACATCCTCGGTAAGGATCATGCTAACATTTGGGCTTGCTCTACTGGTATTGCTGCTCTT
CCTACTTACTAAATCAATGTCGAAGGTAAAAACTTCAATGTTAACGAAGCTGAGCTCTTG
GTTAAGGCTTTGAAGAACAACGGTGTTCCCACTGATCCTAATGTTGGTTTAAGAATTAAG
AATGAAAAGTACTACACTGTCAGATTCGACGCTGATGCTGGTACCTGGTATCTTAAGAAG
GATTAAGGTGGTGCTTGCATTGCCGTTACCAAGTAAGCTTTAGTTATTGGTACTTTCAAA
AACGACATCAAAATGACTAACGGTCAACCTCAAAATCCTGGTGCCGTCAACGCTGCTTGT
GAAAAGCTCGCTGAATCCTTAAAGTCCGCTAACTACTGA

>TTHERM_00105430(gene)
ATGTCTGGTTGGGATCAATATATCTAATATCTTTTGGCTGATAAGAAGTGCGAATCTGCC
TACATCCTCGGTAAGGATCATGCTAACATTTGGGCTTGCTCTACTGGTATTGCTGCTGTA
AGATATATTAGATTTTGCTTCTTTTTGGCCTTTTTTGCCATTTTAGTCACTCTATGATTT
TGTGACTTCAATATTAATTTCATGTATTAATTTTCCTTTTTACTAAACAATCTAGCTTCC
TACTTACTAAATCAATGTCGAAGGTAAAAACTTCAATGTTAACGAAGCTGAGCTCTTGGT
TAAGGGTAATTTTTCTTTTAATTCATTAACTATCTCATATAATTGGCTGATTATCTTCAA
GCTTCTTCTCTCAAAAACTCTTTCATTCCTATGAAAATTATTAGTGTTTAATATTTTTAA
GATCCGAAGAACAATAAATAAATAAATAATATCCTTCGAACAAAAATTAGCAAACCTTCA
AATCATTTAATCAATAAATAAATAAATATATAAGTACATAGCAACTATGCAACTAACTAA
TAAGGAATGAAGTACTCAATTTTTAACAAATATTTGCCAATATTCATCAAATTTTGATTA
GCTTTCCTCTTTAATATTTACTAATATTAATAATAATATTCTCTTTCGTTAAATATTTTA
GCTTTGAAGAACAACGGTGTTCCCACTGATCCTAATGTTGGTTTAAGAATTAAGAATGAA
AAGTACTACACTGTCAGATTCGACGCTGATGCTGGTACCTGGTATCTTAAGAAGGTATAT
AATTTATTATTATTTAAGTTAGCAAATTATTCAAAGCTATAGCTATTAGGTGTCTTAAAA
AAATAAACTAGCCAGCCATTTATTTATAATATTTGTTTTCATGACTGATATTAAGATATT
TTAGAAAATAAAGCACCAAGCACTCAAAAAATAAAATAATGCAAAAATTAATATTATTTT
TCAAAAAATAATTTAGGATTAAGGTGGTGCTTGCATTGCCGTTACCAAGTAAGCTTTAGT
TATTGGTACTTTCAAAAACGACATCAAAATGACTAACGGTCAACCTCAAAATCCTGGTGC
CGTCAACGCTGCTTGTGAAAAGCTCGCTGAATCCTTAAAGTCCGCTAACTACTGA

>TTHERM_00105430(protein)
MSGWDQYIQYLLADKKCESAYILGKDHANIWACSTGIAALPTYQINVEGKNFNVNEAELL
VKALKNNGVPTDPNVGLRIKNEKYYTVRFDADAGTWYLKKDQGGACIAVTKQALVIGTFK
NDIKMTNGQPQNPGAVNAACEKLAESLKSANY