Identifiers and Description

Gene Model Identifier

TTHERM_00106890

Standard Name

RFA1 (Homolog of budding yeast RFA1 and mouse RPA1)

Aliases

PreTt23083 | 7.m00532

Description

RFA1 replication protein complex A largest subunit; Encodes Replication Protein A (RPA). Protein involved in recombination and DNA repair

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Biological Process

• DNA recombination (ISA) | GO:0006310
• DNA repair (ISA) | GO:0006281

Domains

• ( PF01336 ) OB-fold nucleic acid binding domain
• ( PF04057 ) Replication factor-A protein 1, N-terminal domain
• ( PF07975 ) TFIIH C1-like domain
• ( PF08646 ) Replication factor-A C terminal domain
• ( TIGR00617 ) replication factor-a protein 1 (rpa1)

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_00409.1	9.997093137033517e-262
	Description: hypothetical protein (659 aa)
Oxytricha	Contig5713.0.g13	4.000054831110256e-33
	Description: Replication factor-A C terminal domain
SGD	YAR007C	6.001249495680822e-29
	Description: RFA1 Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
WormBase	WBGene00017546	1.9993007828132465e-27
	Description: locus:rpa-1 Probable replication factor A 73 kDa subunit status:Confirmed UniProt:Q19537 protein_id:CCD62042.1
DictyBase	DDB_G0289513	0.0000000000599805963605737
	Description: rfa1 on chromosome: 5 position 2891660 to 2893699
Stentor Coeruleus	SteCoe_15423	0.0000000001026187963170189
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:20363756: Min B, Collins K (2010) Multiple mechanisms for elongation processivity within the reconstituted tetrahymena telomerase holoenzyme. The Journal of biological chemistry 285(22):16434-43

Sequences

>TTHERM_00106890(coding)
ATGGTTACTCAATTAACAAAAAATGCTATTGATTCTCTAATAAATAGCACTAATCCTGAT
GAATAGTATGTTATTCAAGTTTTAAAAGCTCCTCAATCTGTTGCTGAAAATCTTTTCAAG
ATTTGCATTTCTGATGGCTTTTGCAAATTCAAGAAAGGATATTTCGTTAGTGATGCTGCT
ACCAAATGCCAAGATTTGAAGGATCTCTGTATTATCAAATGCAAAAAATATATTGATGAC
TCAAACCACGATAAGGAAAGAATTATTATCTCTAACTACGAATTAATATATTCTAATATC
TAAGAGCAAATTGGAAAACCAATCGAATACAAATAATACAAGTCAAGTGGATTCTCTAAT
CCAGAAGGATCAACTGTAATTCCCTCATAATACTTGAGCAGAAACGCTTAAATACTTCAA
TAAAATTAAGTTTCTTAACCTAAGCAAATGGTAACTCCTCCAGTTAGCAACATAAATAAG
CCTACTCCTGCTGTAAATAACACATTTGCTTAAAAACCAGCAGTTACAAACTAAAACATT
TAAAGAGTAAACTAGAATCCATAACAAATGAACAAAACTGCACCTGTAAAGCAAAATAAT
AATAATAACAATAATAACAATGGCAACAACAAAAATAATTCTAGTTTGTAGATTTCTACT
GATGGAGATGAGTAAAATTTGGAATACATTAGAAACTTATAGCCAAATGGTTAACCATAA
ACAATCAAAGTTAGAATCACCAAAAAGGGTGATTTGAAAAGCTTTAAGGAAAAGTAAGGA
AAACTCTTTTCAATAGATGTTATTGATAAGTTTGGAGACGAATGTAGTATTTCTTTCTTC
AACGAAATAGCTGAATAGTATGATGGCTTATTTAAAGTAGGTTAAGTTATAGTCTTGAAA
TAATTTTCAGTGAAAGTCAACAATAATCATCAATACAATAAGGGAGATCACACTGTAACT
GTCAATAAAGAGAGTAAAATATTGATATGTCAAGAAGATCCATCTATTCCTATGATCAAA
TTAAATAGATAATTCATTTAAGATATGTAGAATAAATAGAAAGGAGATTTAATCGATTTG
ATTGTTGTTGTAAAGGCAGACACAGAAGTTAAAACCATGATCTTAAAGAAAGATAATTAA
TAATAATCTAAAAGAGACATAATATCATTTGATGAATCTCTAATTGAAACAGAAATCACA
CTCTGGGGAGAAACTGCTAAAGACTATGATGCAAAGTAGGGAGATATCATTGTATTTAAA
GATGCCAAAATAGGTGAATTTAAAGATAAAAAGTAAATTAATATCGGATATGGAACATAA
ATCTTCATGAATCCAGATGAATAACTCTTCCCATAGATCCATGATGTCAAAAAATGGTAC
CTAAGCTTAAATTCCGACTAATTAAGCACTATTCAAAAGGCATAAGGAAATGATACTGGT
CCTAGAGAAGTAACTAGCTTTGAATCTTCTCTAAACATTTTGAAAGAAGAAATTAAAAAC
CTTTAAACTGACCCAGAAATGAAAATTTGGAAAGAAATTCGTGGTTAAATTATGTACATT
AAAGATACTCCTCTTTATTATAATGCTTGTTTTAGTTGCAAAAAGAAAATCGCACGTAAT
AACGAAGTATGGACTTGCATAAATTGCAATAAAGATTTTAATGAACCTGACTCTAGATAT
ATTCTCTCCCTCAATATAAGTGACTCTACAGATACTATTTGGGTAAGTGCATTCGATGAA
GTAGGTCAAAAAATTCTTGGTAAATTTATTTTTTAAAAGTTAAACTAAGTTAATTTATTT
TTATCATATTTAATTAACTTATTAATTAAACAGGTGTTAAGGGTGATGTATTTAGATATG
CTGATGAAGATACAGAACACGGTACAGAAACAAAAAAGAAATTGCTTATGGCTGCCTAAA
ATAAGGAATATAGATTCCTGTTACTTACTAAATAAGAAAGAGACTAAAATGGCAACGCCA
GAGATAAGACAGTTATTCATGCTATAAAAGACTTTTAACCTGCTTATGAGGCCAAAAAGA
TCATCAATTCTTTGGAGAAATTTATGGTGA

>TTHERM_00106890(gene)
ATGGTTACTCAATTAACAAAAAATGCTATTGATTCTCTAATAAATAGCACTAATCCTGAT
GAATAGTATGTTATTCAAGTTTTAAAAGCTCCTCAATCTGTTGCTGAAAATCTTTTCAAG
TAATTTAATTGATTGATCGATTGAAAAAAACTAATTTTATTCATTTCTTTTTTTTGTTGA
CAAATAGGATTTGCATTTCTGATGGCTTTTGCAAATTCAAGAAAGGATATTTCGTTAGTG
ATGCTGCTACCAAATGCCAAGATTGTAATTAATTTTTCTTAATTTTTTGTGAAGAATTGT
ATATGGAAAAGTACTATCATTTTTAACTCTACTTTAATAATTTAATAGTGAAGGATCTCT
GTATTATCAAATGCAAAAAATATATTGATGACTCAAACCACGATAAGGAAAGAATTATTA
TCTCTAACTACGAATTAATATATTCTAATATCTAAGAGCAAATTGGAAAACCAATCGAAT
ACAAATAATACAAGTCAAGTGTAATAAAATATTTCTAAAGTTCTATATAATTTATTTTAT
TCTTTGCTACTTGATCAAAAATGCTCTTTAAAGGGAGTTTTCAAGATATGGCAAAAAAAT
AAAAATATGTTCTTGAAAATTAATAATTTTTAAATTAAATATAAAAGGGATTCTCTAATC
CAGAAGGATCAACTGTAATTCCCTCATAATACTTGAGCAGAAACGCTTAAATACTTCAAT
AAAATTAAGTTTCTTAACCTAAGCAAATGGTAACTCCTCCAGTTAGCAACATAAATAAGC
CTACTCCTGCTGTAAATAACACATTTGCTTAAAAACCAGCAGTTACAAACTAAAACATTT
AAAGAGTAAACTAGAATCCATAACAAATGAACAAAACTGCACCTGTAAAGCAAAATAATA
ATAATAACAATAATAACAATGGCAACAACAAAAATAATTCTAGTTTGTAGATTTCTACTG
ATGGAGATGAGTAAAATTTGGAATACATTAGAAACTTATAGCCAAATGGTTAACCATAAA
CAATCAAAGTTAGAATCACCAAAAAGGGTGATTTGAAAAGCTTTAAGGAAAAGTAAGGAA
AACTCTTTTCAATAGATGTTATTGATAAGTTTGGAGACGAATGTAGTATTTCTTTCTTCA
ACGAAATAGCTGAATAGTATGATGGCTTATTTAAAGTAGGTTAAGTTATAGTCTTGAAAT
AATTTTCAGTGAAAGTCAACAATAATCATCAATAGTAAATTAATTTATTTAAGTTTTAGC
AATTACTATTACATAATATTTAATAAATAGCAATAAGGGAGATCACACTGTAACTGTCAA
TAAAGAGAGTAAAATATTGATATGTCAAGAAGATCCATCTATTCCTATGATCAAATTAAA
TAGATAATTCATTTAAGATATGTAGAATAAATAGAAAGGAGATTTAATCGATTTGATTGT
TGTTGTAAAGGCAGACACAGAAGTTAAAACCATGATCTTAAAGAAAGATAATTAATAATA
ATCTAAAAGAGACATAATATCATTTGATGAATCTCTAATTGAAACAGAAATCACACTCTG
GGGAGAAACTGCTAAAGACTATGATGCAAAGTAGGGAGATATCATTGTATTTAAAGATGC
CAAAATAGGTGAATTTAAAGATAAAAAGTAAATTAATATCGGATATGGAACATAAATCTT
CATGAATCCAGATGAATAACTCTTCCCATAGATCCATGATGTCAAAAAATGGTACCTAAG
CTTAAATTCCGACTAATTAAGCACTATTCAAAAGGCATAAGGAAATGATACTGGTCCTAG
AGAAGTAACTAGCTTTGAATCTTCTCTAAACATTTTGAAAGAAGAAATTAAAAACCTTTA
AACTGACCCAGAAATGAAAATTTGGAAAGAAATTCGTGGTTAAATTATGTACATTAAAGA
TACTCCTCTTTATTATAATGCTTGTTTTAGTTGCAAAAAGAAAATCGCACGTAATAACGA
AGTATGGACTTGCATAAATTGCAATAAAGATTTTAATGAAGTAATATTTTTTCTTATTCA
TCTTTAAAATTTTAGTTAATAAAATTAATTTTATTAAAATATAATTGAATTTATTTTAAA
TAATAATTTTATTAGCCTGACTCTAGATATATTCTCTCCCTCAATATAAGTGACTCTACA
GATACTATTTGGGTAAGTGCATTCGATGAAGTAGGTCAAAAAATTCTTGGTAAATTTATT
TTTTAAAAGTTAAACTAAGTTAATTTATTTTTATCATATTTAATTAACTTATTAATTAAA
CAGGTGTTAAGGGTGATGTATTTAGATATGCTGATGAAGATACAGAACACGGTACAGAAA
CAAAAAAGAAATTGCTTATGGCTGCCTAAAATAAGGAATATAGATTCCTGTTACTTACTA
AATAAGAAAGAGACTAAAATGGCAACGCCAGAGATAAGACAGTTATTCATGCTATAAAAG
ACTTTTAACCTGCTTATGAGGCCAAAAAGATCATCAATTCTTTGGAGAAATTTATGGTGA

>TTHERM_00106890(protein)
MVTQLTKNAIDSLINSTNPDEQYVIQVLKAPQSVAENLFKICISDGFCKFKKGYFVSDAA
TKCQDLKDLCIIKCKKYIDDSNHDKERIIISNYELIYSNIQEQIGKPIEYKQYKSSGFSN
PEGSTVIPSQYLSRNAQILQQNQVSQPKQMVTPPVSNINKPTPAVNNTFAQKPAVTNQNI
QRVNQNPQQMNKTAPVKQNNNNNNNNNGNNKNNSSLQISTDGDEQNLEYIRNLQPNGQPQ
TIKVRITKKGDLKSFKEKQGKLFSIDVIDKFGDECSISFFNEIAEQYDGLFKVGQVIVLK
QFSVKVNNNHQYNKGDHTVTVNKESKILICQEDPSIPMIKLNRQFIQDMQNKQKGDLIDL
IVVVKADTEVKTMILKKDNQQQSKRDIISFDESLIETEITLWGETAKDYDAKQGDIIVFK
DAKIGEFKDKKQINIGYGTQIFMNPDEQLFPQIHDVKKWYLSLNSDQLSTIQKAQGNDTG
PREVTSFESSLNILKEEIKNLQTDPEMKIWKEIRGQIMYIKDTPLYYNACFSCKKKIARN
NEVWTCINCNKDFNEPDSRYILSLNISDSTDTIWVSAFDEVGQKILGKFIFQKLNQVNLF
LSYLINLLIKQVLRVMYLDMLMKIQNTVQKQKRNCLWLPKIRNIDSCYLLNKKETKMATP
EIRQLFMLQKTFNLLMRPKRSSILWRNLW