Identifiers and Description

Gene Model Identifier

TTHERM_00127000

Standard Name

TMLH1 (Tetrahymena homolog of budding yeast MLH1)

Aliases

PreTt09363 | 9.m00384 | 3699.m00093

Description

TMLH1 DNA mismatch repair protein putative; DNA mismatch repair protein- C-terminal domain containing protein

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• ATP binding (IEA) | GO:0005524
• mismatched DNA binding (IEA) | GO:0030983

Biological Process

• mismatch repair (IEA) | GO:0006298

Domains

• ( PF01119 ) DNA mismatch repair protein, C-terminal domain
• ( PF02518 ) Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
• ( TIGR00585 ) DNA mismatch repair protein MutL

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_09117.1	9.997093137033517e-262
	Description: DNA mismatch repair protein domain-containing protein (747 aa)
SGD	YMR167W	8.999119107228014e-72
	Description: MLH1 Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer
DictyBase	DDB_G0287393	9.999565105288807e-71
	Description: mlh1 on chromosome: 5 position 247623 to 250277
Oxytricha	Contig14864.0.g42	6.9991332754409754e-68
	Description: DNA mismatch repair protein, C-terminal domain
WormBase	WBGene00003373	9.004195835458823e-61
	Description: locus:mlh-1 status:Confirmed UniProt:Q9XU10 protein_id:CAB07283.2
Stentor Coeruleus	SteCoe_23547	2.3802664086944007e-26
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:23935123: Lukaszewicz A, Howard-Till RA, Loidl J (2013) Mus81 nuclease and Sgs1 helicase are essential for meiotic recombination in a protist lacking a synaptonemal complex. Nucleic acids research 41(20):9296-309

Sequences

>TTHERM_00127000(coding)
ATGAATCATTCCTAACCCTTAGAAAATACTGGTCCTCAGATCAAGAAGCTCCCATAAGAG
CTTATCGATAAGATTGCAGCTGGTGAAGTAGTACAACGTCCATCTGCAGCTGTTAAGGAG
CTTATTGAGAACTGTCTTGATGCTGGATCAAGTGAAATTTCAGTAGGGTTAGTATAAGGA
GGGTTAAAGTAGCTTATTGTAGAAGATAATGGTTCTGGAATTCACAAAGACGATTTTCCA
CTTCTCTGCGAAAGGTTTGCTACCTCTAAGATAAATGAGTTTAATGACCTTTAGAGTTTA
GTTTCATTTGGCTTTAGAGGAGAAGCGTTAGCCTCTATTTCTTTTGTCTCCAACTTGAAA
ATCACATCTCGAAAACCTAATTCTGACCTAGGATATAAAGCTAGTTTCAAAAACGGTGTT
ATGCTTGGTGAAGAGCCTGAAGCAGTGAACTGTACTGAAGGGACTACAGTAGATGTCTAG
GATTTATTTTTTAACTATGATGCAAGGAGAAAAAGTTTAAATGTTAACGAAGAAAAAAAA
AGAGTACTCAAATTGATCGGACAATTTGCTATGCATCATGCTAAATTGAGATTTAAATTT
AAAAGTGATAACCAAATTCAATTCTCATCTCACAGTGTGCTTGGCTCTACAGAATTGCAA
AGAAGAGAATAAATTATGTAGCAAATTACTAAGATTGCAGATAAAAGCTTTACTTCATGT
GAAAGTGAGTCGACAGAATATTAAGTTAAATTTAAAGGAACTTTTTCCAACATTGGAGCT
ACTAAAAAATACAAAGAAATCACTCTCTTTATAAATAATCGTTTGGTTGAATGTGAATCT
ATCAAAAAAGCAGTAGAACGCTCTTACCAGTCTTGTTATTAAAGTATTCATGAAGAAGAA
GGTGGATATTTTTGCTACTTGAGCTTAGAAATGAATCCAAAGAACTTGGATCCTAATGTT
CACCCAACAAAAAAAGAAGTCAAATTCTTATTTGAGTACGAAATAGCAAAAGAAATTGAA
TCATGGATTTTCGAAAATTTGAAAAATTGTGGAGTTATCAAACAACTTTCAGCAAATATT
TCATAAAGAACATCTTCATTTGAAACTTCAAATGTGAAAAGAAGTAGCTCAAGTCAATTA
TATTTTGGTTCTTAGAGCAATTTATCTAAGCAAAATTCTGATTACTATCAACCCACCAAG
CAAATTCGTGTAGATCCCAGAGATTAGAAAATTACTAGATTCTTTTCAGTAGAAAGCTCT
GAAGATGGAAATAACAATTCAAATCAAAAAAATTATCAAAGTATTAATTATATTGAAGAG
CAGAAAGAAGAACATCTAAACAGTCAAGATGATATTGCTGAAGAACCTGTTGATATGATT
AAAAAGAAAAAGATGCTCAATGAAGAAAGAAATTAAACTTCAATCAGTAATATAGGAAGC
TCTGACTAATTAGATGCTAATAATGCTCGTTCAAGTGTCATCGATAGGGCAAATTCTTAA
GTTAATGACCCACGTATTTAAGTATAATAATAGTTATTGTCTTTAAGGAATCAAGATATC
CATGATACAACAAGTTCTTTCTTTAAAAATCTTACGTATGTTGGCTGTATTTCTTCTAAT
CACTTTCTAGCTCAATTTAGAGATGATCTCTACCTTATAAACTCTATTCCATTATGTTAA
GAAATATTTAAATTTGAAATTCTGAGAAACTTTGGATAGATTAAGCCTGTAGAGCTAAAT
TAAGCAATAGGTTTGAAGGATATTTTAGAGTATTTTTTATTAAATTTTGATGAGATACCG
AATGAGAAAAAGGAGTTCCATCTGTCAAATATGGATACTTACATCGAGTAATTTGGCTTA
TTGAGTGACTTTTTAAGAGACTCCGTAGGCATAGTCATCAAAGATTAAAAGCTCTTGGCT
TTCCCTAATTTATTTAATTTATTTGAAAATGATAATAACTTTAAAGATATCTCATACATT
CTGTTGAGAATAATCACCAAAGTTAATTTTAGCGAAATACTCTAATCAGGTATGGGCTTA
GCAAACGAATTATCATTCTACTTTGCTTGGCAATTAGAAAAATCGTTTAAAAATTAATTG
TAAAGACAGCATTTCTAGGAAACGCAAAAGCAGAAATGGGACGATTTCTTTGAATAAAAA
ATGCTCCCAATGATTAAAAAAAAACTTTCACTCCCTAAATTAGATATTAGCGAGTTTACA
GTTAAGCTATTTAAGCAAGAAGATGCATACAAGATCTTCGAAAGATGTTGA

>TTHERM_00127000(gene)
ATGAATCATTCCTAACCCTTAGAAAATACTGGTCCTCAGATCAAGAAGCTCCCATAAGAG
CTTATCGATAAGATTGCAGCTGGTGAAGTAGTACAACGTCCATCTGCAGGTATTTGAATC
CGTCCTTTTCTATTTTTCAATATCCTGATGATAGTTTCTTTCAAATCAAAGCATCACTTC
TTTGATTAAATAATTATCATATATCATTAAGCAGATTATTAATATCAAGAAATAAATATG
GGTTTTTAAAATTAAATTTTGCATTCCATTTTTCCTACGCTAGAAATCTAATTAAAGAAT
TTTTATTGCTGAATATTTTGTAGAAGTTATGATGCATTTTATTTACCCAATAAACTGTTT
GCTCTCATCAGCTTAAATTTAGAGTAAAATTAAGCTGCTTGCTATTCCTGATTATTTTCT
TTAGTATAAATTAGATTTTCAGTAAATTTAGGAATATTGTTTGTTTAGTATTTTAACATA
CAATAAATAATAAGGGCAAATAAATATGTTAGTTAACAAATGAAAGGACATAAAGGAGTT
GATTAAATGAAAGGATAAAATTTTAATTGATCATTTTATTAAATTTTTTTGTTTATTTAT
AATTAATTATAGCTGTTAAGGAGCTTATTGAGAACTGTCTTGATGCTGGATCAAGTGAAA
TTTCAGTAGGGTTAGTATAAGGAGGGTTAAAGTAGCTTATTGTAGAAGATAATGGTTCTG
GAATTCACAAAGACGATTTTCCACTTCTCTGCGAAAGGTTTGCTACCTCTAAGATAAATG
AGTTTAATGACCTTTAGAGTTTAGTTTCATTTGGCTTTAGAGGAGAAGCGTTAGCCTCTA
TTTCTTTTGTCTCCAACTTGAAAATCACATCTCGAAAACCTAATTCTGACCTAGGATATA
AAGCTAGTTTCAAAAACGGTGTTATGCTTGGTGAAGAGCCTGAAGCAGTGAACTGTACTG
AAGGGACTACAGTAGATGTCTAGGATTTATTTTTTAACTATGATGCAAGGTAAATTCAAT
TATAAATTAAAAATATGTTGTTGAAATAACAATTATCGCGTTAAAGCCATTCATTCATTT
ATCATAAAATCAAAATACTAATATATATTTTGATAATTTTCAAGAAAAATTTATAGTTTA
GAAACAAAGGTGTTAAAATTTTGTCATTCAATCAATCAATTTTCATTAATTTGATTACTA
TTTAATGTTTATTTCTCTCTCATTAACATTCATTTTAATGGCAATTAATCATTCATAATT
CTCAAATAAATTCTTCTTAAAGCTACGAAAATATTTAATTCTAGTAAAAGTGTATTGAAA
AAGGCTTGAACATATAAAAATATTTTTAATTCCTTCAAAGATTAACAGAAAGTTAGCAAA
AATAATTTATAGTTTTATACTTTTAAGGTGTTTAATTAATTGAATCAACCATAGCAAAGC
AAAAATAACAGCCCAATTTAGATAGCTTTTTTATTTAAAAATGCAAACAATATTATACAG
TTTATAAATGCTGCTCTGTAGCTATTGAAGAGAAAGAGAGAGATTTATTTTTGGCTGTTA
TGAATTGAATGAAATTGATAATGATAATTGAGATTAGAAAGTAAGTATTATTAAATAAAA
TAGGGGGTCTACGAATATTCGAAAGAATTATAATCAATTGGCTTTACTTTTTTTTTCTTT
TTGATTTAGAAGGTGAAAGTAAATTTACAAAATATGTTAATAGAGATAAAAATTTTTGGT
ATTTCCTTCAGCTTACGTTAATTTATTTAATTTAAATGCAAATAAATTACTAAAACTTAA
TACCTTGCCATTTTTGGAAGTAAAGAAATAAATAAAAAAATATAATTTTGAAGAAATCCT
TTTTATCTTTTTAATTTTCCTAAATTTTATCTTCTAATTCAATAATTTTGAATGAATGAT
TTCTTTGCCACTAATAAAAATTAAGTTTTGAGATAGAAATAAAATAATTAAATTGATTTA
GATTATTATTAAATTAATGAATGCGCACAATTTTTTTTTATAAATGAATTAATATTTGAC
TCAATCAATCAACCTAAACTAAAAACTCTACCCAGTTGATTATTTTTTATATCTACTAAT
TATTAATTTAAATTTCTTGTTCGTTCACCCATAAAACAAACAAAAAAGTTTTTACTTTAA
ACCAAATATTTTAAAATATTGTCCACGTAATTAAATAACAAAGGGTTATTTTAATATTAA
TAATTATAAATATATTCATTGATTAATACACTCATAATAAATACCTTCTACTTTATAAAA
AATATAATTAATTAATTAATTAATTAAATAAATAAATTTCTCACTTTAACTTATAATTCT
ATTTTAAATAATTAGGAGAAAAAGTTTAAATGTTAACGAAGAAAAAAAAAGAGTACTCAA
ATTGATCGGACAATTTGCTATGCATCATGCTAAATTGAGATTTAAATTTAAAAGTGATAA
CCAAATTCAATTCTCATCTCACAGTGTGCTTGGCTCTACAGAATTGCAAGTAAACTTTCG
TAAACATTAAATACATTTTAATTAATTCTAATTAAATTCTAGAGAAGAGAATAAATTATG
TAGCAAATTACTAAGATTGCAGATAAAAGCTTTACTTCATGTGAAAGTGAGTCGACAGAA
TATTAAGTTAAATTTAAAGGAACTTTTTCCAACATTGGAGCTACTAAAAAATACAAAGAA
ATCACTCTCTTTATAAATAATCGTTTGGTTGAATGTGAATCTATCAAAAAAGCAGTAGAA
CGCTCTTACCAGTCTTGTTATTAAGTAAAACCTTTTTACCTAATTAACTAATGAGATTTA
ATCAACAATTTTAATTATCATTAGAACTGCTTTAAATTTAATTTTATATAATAATTACAT
AACAATAATAATAATATATATATAGAGTATTCATGAAGAAGAAGGTGGATATTTTTGCTA
CTTGAGCTTAGAAATGAATCCAAAGAACTTGGATCCTAATGTTCACCCAACAAAAAAAGA
AGTCAAATTCTTATTTGAGTACGAAATAGCAAAAGAAATTGAATCATGGATTTTCGAAAA
TTTGAAAAATTGTGGAGTTATCAAACAACTTTCAGCAAATATTTCATAAAGAACATCTTC
ATTTGAAACTTCAAATGTGAAAAGAAGTAGCTCAAGTCAATTATATTTTGGTTCTTAGAG
CAATTTATCTAAGCAAAATTCTGATTACTATCAACCCACCAAGCAAATTCGTGTAGATCC
CAGAGATTAGAAAATTACTAGATTCTTTTCAGTAGAAAGCTCTGAAGATGGAAATAACAA
TTCAAATCAAAAAAATTATCAAAGTATTAATTATATTGAAGAGCAGAAAGAAGAACATCT
AAACAGTCAAGATGATATTGCTGAAGAACCTGTTGATATGATTAAAAAGAAAAAGATGCT
CAATGAAGAAAGAAATTAAACTTCAATCAGTAATATAGGAAGCTCTGACTAATTAGATGC
TAATAATGCTCGTTCAAGTGTCATCGATAGGGCAAATTCTTAAGTTAATGACCCACGTAT
TTAAGTATAATAATAGTTATTGTCTTTAAGGAATCAAGATATCCATGATACAACAAGTTC
TTTCTTTAAAAATCTTACGTATGTTGGCTGTATTTCTTCTAATCACTTTCTAGCTCAATT
TAGAGATGATCTCTACCTTATAAACTCTATTCCATTATGGTAAATTCATCTTTAAATCAT
TCGCTCTTTCTTTTAAATTTTAATGGAAACAAAAAAATAAACCAAAATATTTATTTATCA
TTTTAGAAACATTTTTTTGATTTTAATAACCAAAATATTTATTTTAAAAAAAGTTAAGAA
ATATTTAAATTTGAAATTCTGAGAAACTTTGGATAGATTAAGCCTGTAGAGCTAAATTAA
GCAATAGGTTTGAAGGATATTTTAGAGTATTTTTTATTAAATTTTGATGAGATACCGAAT
GAGAAAAAGGAGTTCCATCTGTCAAATATGGATGTATGTTAGTTATTTGTTAATTTTATC
AATAAATAAAATATTTTGATTAAAATTAGACTTACATCGAGTAATTTGGCTTATTGAGTG
ACTTTTTAAGAGACTCCGTAGGCATAGTCATCAAAGATTAAAAGCTCTTGGCTTTCCCTA
ATTTATTTAATTTATTTGAAAATGATAATAACTTTAAAGATATCTCATACATTCTGTTGA
GAATAATCACCAAAGTAAATAAATAAATAAAAAGCTATTTGCTTATTTACAAACAATATA
TAATAAACTTTTTAAATTCAAAGGTTAATTTTAGCGAAATACTCTAATCAGGTATGGGCT
TAGCAAACGAATTATCATTCTACTTTGCTTGGCAATTAGAAAAATCGTTTAAAAATTAAT
TGTAAAGACAGCATTTCTAGGAAACGCAAAAGCAGAAATGGGACGATTTCTTTGAATAAA
AAATGCTCCCAATGATTAAAAAAAAACTTTCACTCCCTAAATTAGATATTAGCGAGTTTA
CAGTTAAGCTATTTAAGCAAGAAGATGCATACAAGATCTTCGAAAGATGTTGA

>TTHERM_00127000(protein)
MNHSQPLENTGPQIKKLPQELIDKIAAGEVVQRPSAAVKELIENCLDAGSSEISVGLVQG
GLKQLIVEDNGSGIHKDDFPLLCERFATSKINEFNDLQSLVSFGFRGEALASISFVSNLK
ITSRKPNSDLGYKASFKNGVMLGEEPEAVNCTEGTTVDVQDLFFNYDARRKSLNVNEEKK
RVLKLIGQFAMHHAKLRFKFKSDNQIQFSSHSVLGSTELQRREQIMQQITKIADKSFTSC
ESESTEYQVKFKGTFSNIGATKKYKEITLFINNRLVECESIKKAVERSYQSCYQSIHEEE
GGYFCYLSLEMNPKNLDPNVHPTKKEVKFLFEYEIAKEIESWIFENLKNCGVIKQLSANI
SQRTSSFETSNVKRSSSSQLYFGSQSNLSKQNSDYYQPTKQIRVDPRDQKITRFFSVESS
EDGNNNSNQKNYQSINYIEEQKEEHLNSQDDIAEEPVDMIKKKKMLNEERNQTSISNIGS
SDQLDANNARSSVIDRANSQVNDPRIQVQQQLLSLRNQDIHDTTSSFFKNLTYVGCISSN
HFLAQFRDDLYLINSIPLCQEIFKFEILRNFGQIKPVELNQAIGLKDILEYFLLNFDEIP
NEKKEFHLSNMDTYIEQFGLLSDFLRDSVGIVIKDQKLLAFPNLFNLFENDNNFKDISYI
LLRIITKVNFSEILQSGMGLANELSFYFAWQLEKSFKNQLQRQHFQETQKQKWDDFFEQK
MLPMIKKKLSLPKLDISEFTVKLFKQEDAYKIFERC