Identifiers and Description

Gene Model Identifier

TTHERM_00136030

Standard Name

DNA2 (DNA replication ATP-dependent helicase)

Aliases

PreTt24328 | 10.m00377 | 3698.m00096

Description

DNA2 DNA replication helicase Dna2 putative; Homolog of Saccharomyces DNA2; DNA2/NAM7-like helicase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• ascospore wall (IEA) | GO:0005619
• classical-complement-pathway C3/C5 convertase complex (IEA) | GO:0005601
• complement component C1 complex (IEA) | GO:0005602
• endoribonuclease complex (IEA) | GO:1902555
• insulin-responsive compartment (IEA) | GO:0032593
• ionotropic glutamate receptor complex (IEA) | GO:0008328
• obsolete complement component C2 complex (IEA) | GO:0005603
• obsolete integral component of mitochondrial membrane (IEA) | GO:0032592
• phosphatidylinositol transporter complex (IEA) | GO:1902556

Molecular Function

• 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity (IEA) | GO:0008413
• amino acid:monoatomic cation symporter activity (IEA) | GO:0005416
• icosanoid receptor activity (IEA) | GO:0004953
• L-arabinokinase activity (IEA) | GO:0009702
• lactase activity (IEA) | GO:0000016
• obsolete sodium-transporting two-sector ATPase activity (IEA) | GO:0015443
• phosphatidylinositol-3-phosphate binding (IEA) | GO:0032266
• phosphatidylserine decarboxylase activity (IEA) | GO:0004609
• phosphoenolpyruvate carboxykinase (GTP) activity (IEA) | GO:0004613
• sphingomyelin phosphodiesterase activity (IEA) | GO:0004767
• tRNA threonylcarbamoyladenosine dehydratase (IEA) | GO:0061503
• type 4 neuropeptide Y receptor binding (IEA) | GO:0031844

Biological Process

• cell wall modification involved in fruit ripening (IEA) | GO:0009829
• glycolytic process from mannose through fructose-6-phosphate (IEA) | GO:0061619
• heme A biosynthetic process (IEA) | GO:0006784
• heme biosynthetic process (IEA) | GO:0006783
• immunoglobulin heavy chain V-D-J recombination (IEA) | GO:0071707
• induction of apoptosis by extracellular signals (IEA) | GO:0008624
• interleukin-19 production (IEA) | GO:0032622
• interleukin-2 production (IEA) | GO:0032623
• negative regulation of complement-dependent cytotoxicity (IEA) | GO:1903660
• negative regulation of epithelial cell-cell adhesion involved in epithelium migration (IEA) | GO:1903682
• negative regulation of interleukin-1 production (IEA) | GO:0032692
• negative regulation of PERK-mediated unfolded protein response (IEA) | GO:1903898
• obsolete negative regulation of histone H3-K18 acetylation (IEA) | GO:1902030
• obsolete primary charge separation in photosystem I (IEA) | GO:0009770
• ommochrome biosynthetic process (IEA) | GO:0006727
• plant-type cell wall modification (IEA) | GO:0009827
• polyamine acetylation (IEA) | GO:0032917
• positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902643
• positive regulation of catalase activity (IEA) | GO:1902553
• positive regulation of response to water deprivation (IEA) | GO:1902584
• pronuclear fusion (IEA) | GO:0007344
• propan-2-ol biosynthetic process (IEA) | GO:1902640
• protein localization to old growing cell tip (IEA) | GO:1903858
• prothoracic disc morphogenesis (IEA) | GO:0007470
• regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902641
• regulation of complement-dependent cytotoxicity (IEA) | GO:1903659
• regulation of germ cell proliferation (IEA) | GO:1905936
• regulation of phosphorus utilization (IEA) | GO:0006795
• tertiary alcohol biosynthetic process (IEA) | GO:1902645

Domains

• ( PF08696 ) DNA replication factor Dna2
• ( PF13086 ) AAA domain
• ( PF13087 ) AAA domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00136030(coding)
ATGGATAATAATATGAACAGCTGGAAAAGATTAAACGAAAAAAATCAAGTAGATATAGAA
GATTATAATTAATTATAAAATATTTCAACTGTTCTTAGCAAAGAACCTAAAGCTAAAGTG
AAAGTTAGCTATAGTGAAAGCAGTAGCAGTGATGAAGATGATGATGAAAAATTTTTTATT
TAAAACTTTAGTCAAAAAATGTCTAATTCAACTTCTAAAAATTAAAATCAATCTGATCTT
TAGAAAAATAAGGCTGAATTAGAGACTAAAAAAATGATCAAAAGAGTAGAGAGTTTTTAA
GTTGAAAACTAGCAAACAAAAGATAATTAAGCTATGCATTAAAAAATGGAGTTAAGCTCT
TCTGATGATAGCGATGAAGATGTGGAGTTTATAACAAATCTTTAGAAAGCCTAGTAATAT
TAAAATTTGTTGAAGGAAATTAATGAGGAAAAGTATGTAAGCATAGTTATAACAGAAATT
ATAAAAAAAAATGAAATTCCTTAAGAATACTGGTAAGCCTTTAATCAAATTGCATGTGAT
GATCATGACTTAGCTGAAAAGGATATAAACAAAAATTATACATCAACATACTTAAGAGTA
AGTATTAAGAATAACAAATAACTTGAAGAAAAGTTAAAATTAGTAGAAATAGGTCTGTTG
TTAATAGGGAGTACTTATAATGATATAGAATATGATATAGATGATCAAGCTAACTTTTTG
GGAAAGTTTAATTATTAATTATTGAAGATGTAGAACTAAACAGATTAGCGCGATATACAT
CTTTTCTTCTCTATTTTACACTAGTTTTAGCTATGTGATAACAAGGAAAGAGTTATGAAG
GAGGTATTTTCAAGCTCAAACATCTTGATTATGGAGCCTGATCAGATGCTATATCCAACT
TTGATTGCTTAATCTACGTCTTGTTATAGGATACCTTTGATTAAAATGAAGTTTAAAGTT
ACTGAATCCACTAATTGGAATATGTTAAAGGGTGTTATATTGCATGACATATTCTAACAT
CTGATGACCTTGCATAGCTAAAATCAATAAATAAAAGAAATCATAAAAGAAAAATCAGAT
TCATTTTTAACAGACATAATCAAATAGCTTTACACTAAGTATTTAGAAGAGCTTTTTTTG
TTAGAAAAGTGCATTAACACTTTCGAAAAGGAAATCAAATATATAGCAAAAAATATGATG
GACTTTTTGTAAAATTATTTAATCGAAGGAAAACTTATAGAAACTAAGTATAGTAACAGA
AAAATTAAAATTAAAAAGCTAGTTGAAAATGAAATGGTTGTTAATAATGAGGCTCTAGGA
CTAAAAGGATAAATTGATTGTGTTTTCAAATGTGAAGTTGAAGAATAATTTTCTGATTAA
AAAGAAAAAAAATATGAATGTTTTCTTCCTTTTGAATTAAAAACAGGTGGAAAAAAAAAG
TAAATTTATGAAGATTAAAACCTGTTTTACTGTCTCTTATTAAATCAAAAATATGATCGT
AAATAAAATTTAGAGGGTTTTTTATACTATTTAAGTTTAAATGATCTCACTACATCATGT
CCCACTAAGTAATCTTCTGTGAATTTACTTACTAGAAGAAATAAACTTGCTAAATTTATA
AAGAATATGGAGACTCAAGGTAAAATGCCAGAAATAAATATTGAGAGACCTGATATTTGC
AAATTTTGCTATGAAAAAGAAGCATGCTATGCAAATCAATTAGTTGATGATTATGATAAT
ATTAAAGATATTGAAGATTTACCTGAAAAATATAAAATAGATAAATAATTTGAGTATTTT
CATTAATTTTATGATAGCTTAACGGAAGGATCGAAGCTTTATTTAAAAAAATGGATAGAT
CTAATTTAAATGGAATAATAATGTGATTCTGATATCAAAAAAGATAAAAAATAAAAGCTA
CTTAATGAGGCTGACAATCAGTTAATTTTTATGACTGAAAATTTCGATTAGTTTTTCTCT
TCTTAAGTTGAGTAGCTCTAAACAAGTGGCTATATCTAATCTTAGTAAAATCTTTCTTCT
AAAGATAGCTCTAGAGATAGTAATGCATCATAAAAAGAATATGAACATATTATTTATTTG
AGAAAAATATGTCCTTCGCTAAGTAAGCTTATTGCTTTAAGCGAATTTTACAAAGAAGGT
GAAAGCTTTGTGCTTTATTAGATGGACATAAAATGCAAATTCAAAGCTATTTTAGAAGAA
AAAACTCTTTAAGAGTAGAGTCACTCTATTATTTTAAAGCTTAAGAGCATACAAGCCCAG
GTTAACTTTGATAAAAAAAAGGTTGAAAAAGTTTTAAATAGTAAAATTGGTAACGGTCTA
TATTGGAGTTTAGAGAGCTATAACAAAGACTAATATCCAGATTAAAGATAGAATGTTTTA
AATTTGATTTTAAATAAACTTGTTATGCAAAGTGAAAGTCATTAGAAATTGAAAGAGGCT
TATAACTTAAAGTTGACCAATAAGGATTTTACATCTGTTATCATAGATAACTTTCCTCCT
AAATTTTAAAATAATGAATTTACTGATGAAAAGATAGAAGAAATTTTAAATAAATATCCA
AATCTTCTCAAAAATGTTGATTAAGCTGATTCTATTAAAAAAATTTTAAAAAGTGAATCA
CTCACATGCATCTTAGGTATGCCAGGAACTGGAAAGACATTTTTAATAGCTCATTTAATC
AAGATTTTAGCTGATTAAAAAAAGAAGGTCTTGGTCACAAGTTTTACTAATTCTGCACTT
GATAACATAATTGTTAAGTTATTAGAGATTTTCCCTGAGATAAAAAATATTTGCTTAAGA
AAAGGATCAAATAAAAATTTGATTCATTCAGTTGCTCAAGAAATTTTATATAATCCTTAC
TCCTTTGAGGAAGAAAGATAATTTTCTGACTACTTAAAAGAAAAATAGATATATTTTGCT
ACCATTATTGGCTCAAATAATAAATTATTTCACAGTGAAAAGATTAAATTTGACTATTGT
ATTATAGATGAAGCCTCCTAGTGTGTAGAGCCTCTTTGCTTAGGTCCTATGCTTATTTGT
GATAAATCTATTTTAATCGGAGATCATTTCTAGCTATAACCTCTAGTTAAAAATGAAGAA
GCTGGCAAATAAGGTCTTTCTATTAGTTTATTTGAAAGAATGTGTAATTAATATCCACTA
TGTTAAGTGAAGCTTAAAAGCCAATTCAGAATGAATAACAAAATTATGGAACTTTCAAAT
ATAATGGTGTATAATAATTAACTAAAGGCATTTGATGATAACATTGGTAATAGAAAAATT
AAAATTAATGAAGATGACTTAAAAAGGATAACAAACAAGAGTTTAAATCATTGTATGTAA
CCTAACAATGAGGTTGTTTTTATAGATACAAGCCTTTTGGAATAAAGCTTCAAAGTTGAA
GGAGCTGCTGAAGAAGATTTAGTTTAGAAATAATCAATTGAAGAAAATAGATTTTAGATT
AAGTTTATTTGTTTGCTGATTAAGAAATTTTAAGAAGTCAATATTTAAAATAAGAGCATG
GCTTTAATTACCCCTTACAACTTTTATAGAGTTCAATTCTTAAAAAATATGAACTAGCTT
CATATTGAATAAAATGACCTTGAACTCTTCACAGTTGACAAAAGTTAAGGAATAGATAAA
GATATTATAATTTTACATATATCTGATAAAATTGGAAATGATCACTTATTATCAAATTGG
AGAAGAACAAATGTTGCTATTACAAGATCAAAAATGAAATTAATCATCGTTGGAAATTAA
AATGTATTAAATCGCTATAAAACCATAGACACTTTAATGACTATACTCTAATAAAAGAAA
TATGTATACCAACTAACTCAACAAGAGATGCAAGAAATACAAGAAGAAGTTCTTTAATTA
TAAAATCCTGAAAATTGA

>TTHERM_00136030(gene)
TTTATCAAAAAAAGATATTGTAAAAACAAAGGTAGAAATTTTACTTTATTTAGAGATGGA
TAATAATATGAACAGCTGGAAAAGATTAAACGAAAAAAATCAAGTAGATATAGAAGATTA
TAATTAATTATAAAATATTTCAACTGTTCTTAGCAAAGAACCTAAAGCTAAAGTGAAAGT
TAGCTATAGTGAAAGCAGTAGCAGTGATGAAGATGATGATGAAAAATTTTTTATTTAAAA
CTTTAGTCAAAAAATGTCTAATTCAACTTCTAAAAATTAAAATCAATCTGATCTTTAGAA
AAATAAGGCTGAATTAGAGACTAAAAAAATGATCAAAAGAGTAGAGAGTTTTTAAGTTGA
AAACTAGCAAACAAAAGATAATTAAGCTATGCATTAAAAAATGGAGTTAAGCTCTTCTGA
TGATAGCGATGAAGATGTGGAGTTTATAACAAATCTTTAGAAAGCCTAGTAATATTAAAA
TTTGTTGAAGGAAATTAATGAGGAAAAGTATGTAAGCATAGTTATAACAGAAATTATAAA
AAAAAATGAAATTCCTTAAGAATACTGGTAAGCCTTTAATCAAATTGCATGTGATGATCA
TGACTTAGCTGAAAAGGATATAAACAAAAATTATACATCAACATACTTAAGAGTAAGTAT
TAAGAATAACAAATAACTTGAAGAAAAGTTAAAATTAGTAGAAATAGGTCTGTTGTTAAT
AGGGAGTACTTATAATGATATAGAATATGATATAGATGATCAAGCTAACTTTTTGGGAAA
GTTTAATTATTAATTATTGAAGATGTAGAACTAAACAGATTAGCGCGATATACATCTTTT
CTTCTCTATTTTACACTAGTTTTAGCTATGTGATAACAAGGAAAGAGTTATGAAGGAGGT
ATTTTCAAGCTCAAACATCTTGATTATGGAGCCTGATCAGATGCTATATCCAACTTTGAT
TGCTTAATCTACGTCTTGTTATAGGATACCTTTGATTAAAATGAAGTTTAAAGTTACTGA
ATCCACTAATTGGAATATGTTAAAGGGTGTTATATTGCATGACATATTCTAACATCTGAT
GACCTTGCATAGCTAAAATCAATAAATAAAAGAAATCATAAAAGAAAAATCAGATTCATT
TTTAACAGACATAATCAAATAGCTTTACACTAAGTATTTAGAAGAGCTTTTTTTGTTAGA
AAAGTGCATTAACACTTTCGAAAAGGAAATCAAATATATAGCAAAAAATATGATGGACTT
TTTGTAAAATTATTTAATCGAAGGAAAACTTATAGAAACTAAGTATAGTAACAGAAAAAT
TAAAATTAAAAAGCTAGTTGAAAATGAAATGGTTGTTAATAATGAGGCTCTAGGACTAAA
AGGATAAATTGATTGTGTTTTCAAATGTGAAGTTGAAGAATAATTTTCTGATTAAAAAGA
AAAAAAATATGAATGTTTTCTTCCTTTTGAATTAAAAACAGGTGGAAAAAAAAAGTAAAT
TTATGAAGATTAAAACCTGTTTTACTGTCTCTTATTAAATCAAAAATATGATCGTAAATA
AAATTTAGAGGGTTTTTTATACTATTTAAGTTTAAATGATCTCACTACATCATGTCCCAC
TAAGTAATCTTCTGTGAATTTACTTACTAGAAGAAATAAACTTGCTAAATTTATAAAGAA
TATGGAGACTCAAGGTAAAATGCCAGAAATAAATATTGAGAGACCTGATATTTGCAAATT
TTGCTATGAAAAAGAAGCATGCTATGCAAATCAATTAGTTGATGATTATGATAATATTAA
AGATATTGAAGATTTACCTGAAAAATATAAAATAGATAAATAATTTGAGTATTTTCATTA
ATTTTATGATAGCTTAACGGAAGGATCGAAGCTTTATTTAAAAAAATGGATAGATCTAAT
TTAAATGGAATAATAATGTGATTCTGATATCAAAAAAGATAAAAAATAAAAGCTACTTAA
TGAGGCTGACAATCAGTTAATTTTTATGACTGAAAATTTCGATTAGTTTTTCTCTTCTTA
AGTTGAGTAGCTCTAAACAAGTGGCTATATCTAATCTTAGTAAAATCTTTCTTCTAAAGA
TAGCTCTAGAGATAGTAATGCATCATAAAAAGAATATGAACATATTATTTATTTGAGAAA
AATATGTCCTTCGCTAAGTAAGCTTATTGCTTTAAGCGAATTTTACAAAGAAGGTGAAAG
CTTTGTGCTTTATTAGATGGACATAAAATGCAAATTCAAAGCTATTTTAGAAGAAAAAAC
TCTTTAAGAGTAGAGTCACTCTATTATTTTAAAGCTTAAGAGCATACAAGCCCAGGTTAA
CTTTGATAAAAAAAAGGTTGAAAAAGTTTTAAATAGTAAAATTGGTAACGGTCTATATTG
GAGTTTAGAGAGCTATAACAAAGACTAATATCCAGATTAAAGATAGAATGTTTTAAATTT
GATTTTAAATAAACTTGTTATGCAAAGTGAAAGTCATTAGAAATTGAAAGAGGCTTATAA
CTTAAAGTTGACCAATAAGGATTTTACATCTGTTATCATAGATAACTTTCCTCCTAAATT
TTAAAATAATGAATTTACTGATGAAAAGATAGAAGAAATTTTAAATAAATATCCAAATCT
TCTCAAAAATGTTGATTAAGCTGATTCTATTAAAAAAATTTTAAAAAGTGAATCACTCAC
ATGCATCTTAGGTATGCCAGGAACTGGAAAGACATTTTTAATAGCTCATTTAATCAAGAT
TTTAGCTGATTAAAAAAAGAAGGTCTTGGTCACAAGTTTTACTAATTCTGCACTTGATAA
CATAATTGTTAAGTTATTAGAGATTTTCCCTGAGATAAAAAATATTTGCTTAAGAAAAGG
ATCAAATAAAAATTTGATTCATTCAGTTGCTCAAGAAATTTTATATAATCCTTACTCCTT
TGAGGAAGAAAGATAATTTTCTGACTACTTAAAAGAAAAATAGATATATTTTGCTACCAT
TATTGGCTCAAATAATAAATTATTTCACAGTGAAAAGATTAAATTTGACTATTGTATTAT
AGATGAAGCCTCCTAGTGTGTAGAGCCTCTTTGCTTAGGTCCTATGCTTATTTGTGATAA
ATCTATTTTAATCGGAGATCATTTCTAGCTATAACCTCTAGTTAAAAATGAAGAAGCTGG
CAAATAAGGTCTTTCTATTAGTTTATTTGAAAGAATGTGTAATTAATATCCACTATGTTA
AGTGAAGCTTAAAAGCCAATTCAGAATGAATAACAAAATTATGGAACTTTCAAATATAAT
GGTGTATAATAATTAACTAAAGGCATTTGATGATAACATTGGTAATAGAAAAATTAAAAT
TAATGAAGATGACTTAAAAAGGATAACAAACAAGAGTTTAAATCATTGTATGTAACCTAA
CAATGAGGTTGTTTTTATAGATACAAGCCTTTTGGAATAAAGCTTCAAAGTTGAAGGAGC
TGCTGAAGAAGATTTAGTTTAGAAATAATCAATTGAAGAAAATAGATTTTAGATTAAGTT
TATTTGTTTGCTGATTAAGAAATTTTAAGAAGTCAATATTTAAAATAAGAGCATGGCTTT
AATTACCCCTTACAACTTTTATAGAGTTCAATTCTTAAAAAATATGAACTAGCTTCATAT
TGAATAAAATGACCTTGAACTCTTCACAGTTGACAAAAGTTAAGGAATAGATAAAGATAT
TATAATTTTACATATATCTGATAAAATTGGAAATGATCACTTATTATCAAATTGGAGAAG
AACAAATGTTGCTATTACAAGATCAAAAATGAAATTAATCATCGTTGGAAATTAAAATGT
ATTAAATCGCTATAAAACCATAGACACTTTAATGACTATACTCTAATAAAAGAAATATGT
ATACCAACTAACTCAACAAGAGATGCAAGAAATACAAGAAGAAGTTCTTTAATTATAAAA
TCCTGAAAATTGATATAAATTACTTCATTCATAAAATTTTATTTAAATAAAATGTAAATT
ATCTAAATTTATCTCAAATATTTTTATTACAATATGAAAAAATAAAATAAAT

>TTHERM_00136030(protein)
MDNNMNSWKRLNEKNQVDIEDYNQLQNISTVLSKEPKAKVKVSYSESSSSDEDDDEKFFI
QNFSQKMSNSTSKNQNQSDLQKNKAELETKKMIKRVESFQVENQQTKDNQAMHQKMELSS
SDDSDEDVEFITNLQKAQQYQNLLKEINEEKYVSIVITEIIKKNEIPQEYWQAFNQIACD
DHDLAEKDINKNYTSTYLRVSIKNNKQLEEKLKLVEIGLLLIGSTYNDIEYDIDDQANFL
GKFNYQLLKMQNQTDQRDIHLFFSILHQFQLCDNKERVMKEVFSSSNILIMEPDQMLYPT
LIAQSTSCYRIPLIKMKFKVTESTNWNMLKGVILHDIFQHLMTLHSQNQQIKEIIKEKSD
SFLTDIIKQLYTKYLEELFLLEKCINTFEKEIKYIAKNMMDFLQNYLIEGKLIETKYSNR
KIKIKKLVENEMVVNNEALGLKGQIDCVFKCEVEEQFSDQKEKKYECFLPFELKTGGKKK
QIYEDQNLFYCLLLNQKYDRKQNLEGFLYYLSLNDLTTSCPTKQSSVNLLTRRNKLAKFI
KNMETQGKMPEINIERPDICKFCYEKEACYANQLVDDYDNIKDIEDLPEKYKIDKQFEYF
HQFYDSLTEGSKLYLKKWIDLIQMEQQCDSDIKKDKKQKLLNEADNQLIFMTENFDQFFS
SQVEQLQTSGYIQSQQNLSSKDSSRDSNASQKEYEHIIYLRKICPSLSKLIALSEFYKEG
ESFVLYQMDIKCKFKAILEEKTLQEQSHSIILKLKSIQAQVNFDKKKVEKVLNSKIGNGL
YWSLESYNKDQYPDQRQNVLNLILNKLVMQSESHQKLKEAYNLKLTNKDFTSVIIDNFPP
KFQNNEFTDEKIEEILNKYPNLLKNVDQADSIKKILKSESLTCILGMPGTGKTFLIAHLI
KILADQKKKVLVTSFTNSALDNIIVKLLEIFPEIKNICLRKGSNKNLIHSVAQEILYNPY
SFEEERQFSDYLKEKQIYFATIIGSNNKLFHSEKIKFDYCIIDEASQCVEPLCLGPMLIC
DKSILIGDHFQLQPLVKNEEAGKQGLSISLFERMCNQYPLCQVKLKSQFRMNNKIMELSN
IMVYNNQLKAFDDNIGNRKIKINEDDLKRITNKSLNHCMQPNNEVVFIDTSLLEQSFKVE
GAAEEDLVQKQSIEENRFQIKFICLLIKKFQEVNIQNKSMALITPYNFYRVQFLKNMNQL
HIEQNDLELFTVDKSQGIDKDIIILHISDKIGNDHLLSNWRRTNVAITRSKMKLIIVGNQ
NVLNRYKTIDTLMTILQQKKYVYQLTQQEMQEIQEEVLQLQNPEN