Identifiers and Description

Gene Model Identifier

TTHERM_00136210

Standard Name

TTLL1 (Tubulin Tyrosine Ligase-Like )

Aliases

PreTt24346 | 10.m00395 | 3698.m00114

Description

TTLL1 tubulin polyglutamylase putative; Tubulin polyglutamylase; specificity for alpha-tubulin in vitro; knockout shows reduced tubulin polyglutamylation in basal bodies; localizes to subset of MT-rich structures- incl. basal bodies- contractile vacuole pore- deep fiber

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

Gene Ontology Annotations

Cellular Component

• plasma membrane proton-transporting ATP synthase complex, catalytic core F(1) (IMP) | GO:0045262 | Ref:15890843
• protein complex (IDA) | GO:0043234 | Ref:15890843

Molecular Function

• hedgehog receptor activity (IEA) | GO:0008158

Biological Process

• oligosaccharide biosynthetic process (IMp) | GO:0009312 | Ref:15890843
• positive regulation of fast-twitch skeletal muscle fiber contraction (IMP) | GO:0031448 | Ref:15890843
• positive regulation of gibberellic acid mediated signaling pathway (IEA) | GO:0009939
• regulation of slow-twitch skeletal muscle fiber contraction (IMP) | GO:0031449 | Ref:15890843

Domains

• ( PF03133 ) Tubulin-tyrosine ligase family

Gene Expression Profile

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_12084	0
	Description: None
Tetrahymena borealis	EI9_05787.1	9.997093137033517e-262
	Description: tubulin-tyrosine ligase (412 aa)
Oxytricha	Contig19772.0.0.g73	2.0002969069156684e-168
	Description: Tubulin-tyrosine ligase family
WormBase	WBGene00044187	9.001701800865775e-93
	Description: locus:ttll-9 status:Partially_confirmed UniProt:Q564U4 protein_id:CAI79169.1
DictyBase	DDB_G0281541	3.0007793728221555e-22
	Description: DDB_G0281541 on chromosome: 3 position 4627625 to 4629265
SGD	YBR094W	0.00000000000004998767099442072
	Description: PBY1 Putative tubulin tyrosine ligase associated with P-bodies

General Information

No Data fetched for General Information

Associated Literature

1. Ref:15890843: Janke C, Rogowski K, Wloga D, Regnard C, Kajava AV, Strub JM, Temurak N, van Dijk J, Boucher D, van Dorsselaer A, Suryavanshi S, Gaertig J, Eddé B (2005) Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Science (New York, N.Y.) 308(5729):1758-62

Sequences

>TTHERM_00136210(coding)
ATGGCTTCTAAAAAATTAAAATACAAGACAGATTTTGACAAATGTGTTTTAACAGATAAT
TTTGCTGCAAGAGGATGGACTAGATGTGGTGATAAAGATGACGATGATTGGAACATTTAT
TGGGCAACTGTATGGAATGTGAGAAATATTTTCAATCCTAAATCAGGAATTAGATTAAAT
GATATGCAAATTATAAATCATTTCCCAAATCATTATGAATTGACAAGAAAAGATCTTATG
GTAAAAAACTTCAAGAGATATAAAAAAGAATTAGAAAAAGAGAATAGTCCTTATTGCTAG
AAAGACGAAAATGGAAATTATCTATATTTAGATTTTATTCCATAAACATTTACTCTTCCT
GGTGAGTATTCACTCTTTGTTGAAGAATTTCATAGAAATCCTAATGCAACTTGGATTGTT
AAACCAGCATCACGATCTCAAGGAAAAGGTATTTTCTTGCTTAGAAAAATACAGCAGTTG
AAGAAAATAGGAGGAGGAACTAATAGCAATCCTCTGCAGGCATTTTCTCTAAAAGAAGCT
TATGTTGTTTCTAGATATATAGATAATCCATTGCTTGTTGGAGGGAGAAAATTCGATTTA
AGAATATATGCTCTTGTTACCTCTTATCGTCCTCTTAAGGTTTATTTATACGCTATGGGA
TTCGGTCGTTTTTGTAATGAATAGTATACTCAAGATATTGCTGAAATGGATAATATGTTT
ATTCACTTAACAAATGTTGCTATTTAAAAGTTCTCAGATAAGTATTCTGAAAAACACGGA
GGAAAATGGTCATTACAGTCTTTAAGGTATTATCTAGAAATGGTTTATGGTACAGATATG
GCTAATAAATGTTTTGATGATATAAACAATATAATTATAATGAGTTTGAAATCTGTTTAA
AGTATAATAATAAATGATAAGCACTGTTTTGAGATGTATGGCTATGATATATTAATTGAT
GAAAACTGCAAACCATGGCTTATTGAAATAAATGCTTCTCCCTCTTTAACTGTTACAGGT
AAAATTGATAAAGAACTCAAAACTGAACTGATTAAAAATGTATATTAAATTGTCATTCCT
GATGATTGGAATGATGATAGTTCTAAAACTGGTGCAAACACTAGCACATAAACAAAAGTT
GGAGATTTTAATATTCTATATGATGAGGCCTAAGAAAAGAAAATTAGTTAGTAATAATAA
TAATAAAAAAAGAATATAAATAGTAAAACAATTTGGAAATGA

>TTHERM_00136210(gene)
ATGGCTTCTAAAAAATTAAAATACAAGACAGATTTTGACAAATGTGTTTTAACAGATAAT
TTTGCTGCAAGAGGATGGACTAGGTAATTAAAAATTACTAACATTCTATTCATTTTTATT
TAATTCAATCCAAATATTAAAACTTATTTTTATAAAGATGTGGTGATAAAGATGACGATG
ATTGGAACATTTATTGGGCAACTGTATGGAATGTGAGAAATATTTTCAATCCTAAATCAG
GTAGGCTGACTAAATTTATTATAAAATACTACATACTATTCCTTAAATACTATTATAACT
TTTATACTTCTTTTTAGATAGCTAAGTTGTTTCTAAATCAGATTTTTTATTCTTACAAAA
AAATTTATAAAAACTAGGAATTAGATTAAATGATATGCAAATTATAAATCATTTCCCAAA
TCATTATGAATTGACAAGAAAAGATCTTATGGTAAAAAACTTCAAGAGATATAAAAAAGA
ATTAGAAAAAGAGAATAGTCCTTATTGCTAGAAAGACGAAAATGGAAATTATCTATATTT
AGATTTTATTCCATAAACATTTACTCTTCCTGGTGAGTATTCACTCTTTGTTGAAGAATT
TCATAGAAATCCTAATGCAACTTGGATTGTTAAACCAGCATCACGATCTCAAGGAAAAGG
TATTTTCTTGCTTAGAAAAATACAGCAGTTGAAGAAAATAGGAGGAGGTAATTAATTTTC
TATATATCTATCTTAATAACTTACTAGCAAACTAGCTAATTAATTGACTGATTGATTGAT
TAATTTTGCAAACTAAGATTAGTAATAGAATAAATATCACTTATTGAAAGCAGTAATCAA
TTTAAGTAATTAATATTTCAAAATATTTTATAGGAACTAATAGCAATCCTCTGCAGGCAT
TTTCTCTAAAAGAAGCTTATGTTGTTTCTAGATATATAGATAATCCATTGCTTGTTGGAG
GGAGAAAATTCGATTTAAGAATATATGCTCTTGTTACCTCTTATCGTCCTCTTAAGGTTT
ATTTATACGCTATGGGATTCGGTCGTTTTTGTAATGAATAGTATACTCAAGGTATTATTA
ATTAAAAATATTTTTAGATTGTCAATTAAAATTTTTAAATAGATATTGCTGAAATGGATA
ATATGTTTATTCACTTAACAAATGTTGCTATTTAAAAGTTCTCAGATAAGTATTCTGAAA
AACACGGAGGAAAATGGTCATTACAGTCTTTAAGGTATTATCTAGAAATGGTTTATGGTA
CAGATATGGCTAATAAATGTTTTGATGATATAAACAATATAATTATAATGAGTTTGAAAT
CTGTTTAAAGTATAATAATAAATGATAAGCACTGTTTTGAGATGTATGGCTATGATATAT
TAATTGATGAAAACTGCAAACCATGGCTTATTGAAATAAATGCTTCTCCCTCTTTAACTG
TTACAGGTAAAATAATTAATTTTTTTACCTTCCATATTAAATTCTTTTTATCCTGAAAAA
TCTAATTAAAGGTAAAATTGATAAAGAACTCAAAACTGAACTGATTAAAAATGTATATTA
AATTGTCATTCCTGATGATTGGAATGATGATAGTTCTAAAACTGGTGCAAACACTAGCAC
ATAAACAAAAGTTGGAGATTTTAATATTCTATATGATGAGGCCTAAGAAAAGAAAATTAG
TTAGTAATAATAATAATAAAAAAAGAATATAAATAGTAAAACAATTTGGAAATGA

>TTHERM_00136210(protein)
MASKKLKYKTDFDKCVLTDNFAARGWTRCGDKDDDDWNIYWATVWNVRNIFNPKSGIRLN
DMQIINHFPNHYELTRKDLMVKNFKRYKKELEKENSPYCQKDENGNYLYLDFIPQTFTLP
GEYSLFVEEFHRNPNATWIVKPASRSQGKGIFLLRKIQQLKKIGGGTNSNPLQAFSLKEA
YVVSRYIDNPLLVGGRKFDLRIYALVTSYRPLKVYLYAMGFGRFCNEQYTQDIAEMDNMF
IHLTNVAIQKFSDKYSEKHGGKWSLQSLRYYLEMVYGTDMANKCFDDINNIIIMSLKSVQ
SIIINDKHCFEMYGYDILIDENCKPWLIEINASPSLTVTGKIDKELKTELIKNVYQIVIP
DDWNDDSSKTGANTSTQTKVGDFNILYDEAQEKKISQQQQQQKKNINSKTIWK