Identifiers and Description

Gene Model Identifier

TTHERM_00136210

Standard Name

TTLL1 (Tubulin Tyrosine Ligase-Like )

Aliases

PreTt24346 | 10.m00395 | 3698.m00114

Description

TTLL1 tubulin polyglutamylase putative; Tubulin polyglutamylase; specificity for alpha-tubulin in vitro; knockout shows reduced tubulin polyglutamylation in basal bodies; localizes to subset of MT-rich structures- incl. basal bodies- contractile vacuole pore- deep fiber

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• contractile vacuole pore (IMP) | GO:0031913
• microtubule basal body (IMp) | GO:0005932
• oral apparatus (IMP) | GO:0031912

Molecular Function

• acid-amino acid ligase activity (IDA) | GO:0016881
• tubulin-tyrosine ligase activity (IEA) | GO:0004835

Biological Process

• cellular protein modification process (IEA) | GO:0006464
• protein polyglutamylation (IMP) | GO:0018095

Domains

• ( PF03133 ) Tubulin-tyrosine ligase family

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Stentor Coeruleus	SteCoe_12084	0
	Description: None
Tetrahymena borealis	EI9_05787.1	9.997093137033517e-262
	Description: tubulin-tyrosine ligase (412 aa)
Oxytricha	Contig19772.0.0.g73	2.0002969069156684e-168
	Description: Tubulin-tyrosine ligase family
WormBase	WBGene00044187	9.001701800865775e-93
	Description: locus:ttll-9 status:Partially_confirmed UniProt:Q564U4 protein_id:CAI79169.1
DictyBase	DDB_G0281541	3.0007793728221555e-22
	Description: DDB_G0281541 on chromosome: 3 position 4627625 to 4629265
SGD	YBR094W	0.00000000000004998767099442072
	Description: PBY1 Putative tubulin tyrosine ligase associated with P-bodies

General Information

No Data fetched for General Information

Associated Literature

1. Ref:15890843: Janke C, Rogowski K, Wloga D, Regnard C, Kajava AV, Strub JM, Temurak N, van Dijk J, Boucher D, van Dorsselaer A, Suryavanshi S, Gaertig J, Eddé B (2005) Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Science (New York, N.Y.) 308(5729):1758-62

Sequences

>TTHERM_00136210(coding)
ATGGCTTCTAAAAAATTAAAATACAAGACAGATTTTGACAAATGTGTTTTAACAGATAAT
TTTGCTGCAAGAGGATGGACTAGATGTGGTGATAAAGATGACGATGATTGGAACATTTAT
TGGGCAACTGTATGGAATGTGAGAAATATTTTCAATCCTAAATCAGGAATTAGATTAAAT
GATATGCAAATTATAAATCATTTCCCAAATCATTATGAATTGACAAGAAAAGATCTTATG
GTAAAAAACTTCAAGAGATATAAAAAAGAATTAGAAAAAGAGAATAGTCCTTATTGCTAG
AAAGACGAAAATGGAAATTATCTATATTTAGATTTTATTCCATAAACATTTACTCTTCCT
GGTGAGTATTCACTCTTTGTTGAAGAATTTCATAGAAATCCTAATGCAACTTGGATTGTT
AAACCAGCATCACGATCTCAAGGAAAAGGTATTTTCTTGCTTAGAAAAATACAGCAGTTG
AAGAAAATAGGAGGAGGAACTAATAGCAATCCTCTGCAGGCATTTTCTCTAAAAGAAGCT
TATGTTGTTTCTAGATATATAGATAATCCATTGCTTGTTGGAGGGAGAAAATTCGATTTA
AGAATATATGCTCTTGTTACCTCTTATCGTCCTCTTAAGGTTTATTTATACGCTATGGGA
TTCGGTCGTTTTTGTAATGAATAGTATACTCAAGATATTGCTGAAATGGATAATATGTTT
ATTCACTTAACAAATGTTGCTATTTAAAAGTTCTCAGATAAGTATTCTGAAAAACACGGA
GGAAAATGGTCATTACAGTCTTTAAGGTATTATCTAGAAATGGTTTATGGTACAGATATG
GCTAATAAATGTTTTGATGATATAAACAATATAATTATAATGAGTTTGAAATCTGTTTAA
AGTATAATAATAAATGATAAGCACTGTTTTGAGATGTATGGCTATGATATATTAATTGAT
GAAAACTGCAAACCATGGCTTATTGAAATAAATGCTTCTCCCTCTTTAACTGTTACAGGT
AAAATTGATAAAGAACTCAAAACTGAACTGATTAAAAATGTATATTAAATTGTCATTCCT
GATGATTGGAATGATGATAGTTCTAAAACTGGTGCAAACACTAGCACATAAACAAAAGTT
GGAGATTTTAATATTCTATATGATGAGGCCTAAGAAAAGAAAATTAGTTAGTAATAATAA
TAATAAAAAAAGAATATAAATAGTAAAACAATTTGGAAATGA

>TTHERM_00136210(gene)
ATGGCTTCTAAAAAATTAAAATACAAGACAGATTTTGACAAATGTGTTTTAACAGATAAT
TTTGCTGCAAGAGGATGGACTAGGTAATTAAAAATTACTAACATTCTATTCATTTTTATT
TAATTCAATCCAAATATTAAAACTTATTTTTATAAAGATGTGGTGATAAAGATGACGATG
ATTGGAACATTTATTGGGCAACTGTATGGAATGTGAGAAATATTTTCAATCCTAAATCAG
GTAGGCTGACTAAATTTATTATAAAATACTACATACTATTCCTTAAATACTATTATAACT
TTTATACTTCTTTTTAGATAGCTAAGTTGTTTCTAAATCAGATTTTTTATTCTTACAAAA
AAATTTATAAAAACTAGGAATTAGATTAAATGATATGCAAATTATAAATCATTTCCCAAA
TCATTATGAATTGACAAGAAAAGATCTTATGGTAAAAAACTTCAAGAGATATAAAAAAGA
ATTAGAAAAAGAGAATAGTCCTTATTGCTAGAAAGACGAAAATGGAAATTATCTATATTT
AGATTTTATTCCATAAACATTTACTCTTCCTGGTGAGTATTCACTCTTTGTTGAAGAATT
TCATAGAAATCCTAATGCAACTTGGATTGTTAAACCAGCATCACGATCTCAAGGAAAAGG
TATTTTCTTGCTTAGAAAAATACAGCAGTTGAAGAAAATAGGAGGAGGTAATTAATTTTC
TATATATCTATCTTAATAACTTACTAGCAAACTAGCTAATTAATTGACTGATTGATTGAT
TAATTTTGCAAACTAAGATTAGTAATAGAATAAATATCACTTATTGAAAGCAGTAATCAA
TTTAAGTAATTAATATTTCAAAATATTTTATAGGAACTAATAGCAATCCTCTGCAGGCAT
TTTCTCTAAAAGAAGCTTATGTTGTTTCTAGATATATAGATAATCCATTGCTTGTTGGAG
GGAGAAAATTCGATTTAAGAATATATGCTCTTGTTACCTCTTATCGTCCTCTTAAGGTTT
ATTTATACGCTATGGGATTCGGTCGTTTTTGTAATGAATAGTATACTCAAGGTATTATTA
ATTAAAAATATTTTTAGATTGTCAATTAAAATTTTTAAATAGATATTGCTGAAATGGATA
ATATGTTTATTCACTTAACAAATGTTGCTATTTAAAAGTTCTCAGATAAGTATTCTGAAA
AACACGGAGGAAAATGGTCATTACAGTCTTTAAGGTATTATCTAGAAATGGTTTATGGTA
CAGATATGGCTAATAAATGTTTTGATGATATAAACAATATAATTATAATGAGTTTGAAAT
CTGTTTAAAGTATAATAATAAATGATAAGCACTGTTTTGAGATGTATGGCTATGATATAT
TAATTGATGAAAACTGCAAACCATGGCTTATTGAAATAAATGCTTCTCCCTCTTTAACTG
TTACAGGTAAAATAATTAATTTTTTTACCTTCCATATTAAATTCTTTTTATCCTGAAAAA
TCTAATTAAAGGTAAAATTGATAAAGAACTCAAAACTGAACTGATTAAAAATGTATATTA
AATTGTCATTCCTGATGATTGGAATGATGATAGTTCTAAAACTGGTGCAAACACTAGCAC
ATAAACAAAAGTTGGAGATTTTAATATTCTATATGATGAGGCCTAAGAAAAGAAAATTAG
TTAGTAATAATAATAATAAAAAAAGAATATAAATAGTAAAACAATTTGGAAATGA

>TTHERM_00136210(protein)
MASKKLKYKTDFDKCVLTDNFAARGWTRCGDKDDDDWNIYWATVWNVRNIFNPKSGIRLN
DMQIINHFPNHYELTRKDLMVKNFKRYKKELEKENSPYCQKDENGNYLYLDFIPQTFTLP
GEYSLFVEEFHRNPNATWIVKPASRSQGKGIFLLRKIQQLKKIGGGTNSNPLQAFSLKEA
YVVSRYIDNPLLVGGRKFDLRIYALVTSYRPLKVYLYAMGFGRFCNEQYTQDIAEMDNMF
IHLTNVAIQKFSDKYSEKHGGKWSLQSLRYYLEMVYGTDMANKCFDDINNIIIMSLKSVQ
SIIINDKHCFEMYGYDILIDENCKPWLIEINASPSLTVTGKIDKELKTELIKNVYQIVIP
DDWNDDSSKTGANTSTQTKVGDFNILYDEAQEKKISQQQQQQKKNINSKTIWK