Identifiers and Description

Gene Model Identifier

TTHERM_00136210

Standard Name

TTLL1 (Tubulin Tyrosine Ligase-Like )

Aliases

PreTt24346 | 10.m00395 | 3698.m00114

Description

TTLL1 tubulin polyglutamylase putative; Tubulin polyglutamylase; specificity for alpha-tubulin in vitro; knockout shows reduced tubulin polyglutamylation in basal bodies; localizes to subset of MT-rich structures, incl; basal bodies, contractile vacuole pore, deep fiber; Tubulin-tyrosine ligase/Tubulin polyglutamylase

Genome Browser (Macronucleus)

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Genome Browser (Micronucleus)

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External Links

Gene Ontology Annotations

Cellular Component

Molecular Function

Biological Process

  • cell wall modification involved in fruit ripening (IEA) | GO:0009829
  • negative regulation of complement-dependent cytotoxicity (IEA) | GO:1903660
  • negative regulation of epithelial cell-cell adhesion involved in epithelium migration (IEA) | GO:1903682
  • negative regulation of fractalkine production (IEA) | GO:0032684
  • negative regulation of hepatocyte growth factor production (IEA) | GO:0032686
  • plant-type cell wall modification (IEA) | GO:0009827
  • positive regulation of peroxisome proliferator activated receptor signaling pathway (IEA) | GO:0035360
  • positive regulation of response to water deprivation (IEA) | GO:1902584
  • positive regulation of wound healing, spreading of epidermal cells (IEA) | GO:1903691
  • priming of cellular response to stress (IEA) | GO:0080136
  • protein polyglutamylation (IMP) | GO:0018095
  • regulation of complement-dependent cytotoxicity (IEA) | GO:1903659
  • regulation of L-arginine import into cell (IEA) | GO:1902826
  • regulation of TRAIL production (IEA) | GO:0032679

Domains

  • ( PF03133 ) Tubulin-tyrosine ligase family

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

  1. Ref:15890843: Janke C, Rogowski K, Wloga D, Regnard C, Kajava AV, Strub JM, Temurak N, van Dijk J, Boucher D, van Dorsselaer A, Suryavanshi S, Gaertig J, Eddé B (2005) Tubulin polyglutamylase enzymes are members of the TTL domain protein family. Science (New York, N.Y.) 308(5729):1758-62

Sequences 

>TTHERM_00136210(coding)
ATGGCTTCTAAAAAATTAAAATACAAGACAGATTTTGACAAATGTGTTTTAACAGATAAT
TTTGCTGCAAGAGGATGGACTAGATGTGGTGATAAAGATGACGATGATTGGAACATTTAT
TGGGCAACTGTATGGAATGTGAGAAATATTTTCAATCCTAAATCAGGAATTAGATTAAAT
GATATGCAAATTATAAATCATTTCCCAAATCATTATGAATTGACAAGAAAAGATCTTATG
GTAAAAAACTTCAAGAGATATAAAAAAGAATTAGAAAAAGAGAATAGTCCTTATTGCTAG
AAAGACGAAAATGGAAATTATCTATATTTAGATTTTATTCCATAAACATTTACTCTTCCT
GGTGAGTATTCACTCTTTGTTGAAGAATTTCATAGAAATCCTAATGCAACTTGGATTGTT
AAACCAGCATCACGATCTCAAGGAAAAGGTATTTTCTTGCTTAGAAAAATACAGCAGTTG
AAGAAAATAGGAGGAGGAACTAATAGCAATCCTCTGCAGGCATTTTCTCTAAAAGAAGCT
TATGTTGTTTCTAGATATATAGATAATCCATTGCTTGTTGGAGGGAGAAAATTCGATTTA
AGAATATATGCTCTTGTTACCTCTTATCGTCCTCTTAAGGTTTATTTATACGCTATGGGA
TTCGGTCGTTTTTGTAATGAATAGTATACTCAAGATATTGCTGAAATGGATAATATGTTT
ATTCACTTAACAAATGTTGCTATTTAAAAGTTCTCAGATAAGTATTCTGAAAAACACGGA
GGAAAATGGTCATTACAGTCTTTAAGGTATTATCTAGAAATGGTTTATGGTACAGATATG
GCTAATAAATGTTTTGATGATATAAACAATATAATTATAATGAGTTTGAAATCTGTTTAA
AGTATAATAATAAATGATAAGCACTGTTTTGAGATGTATGGCTATGATATATTAATTGAT
GAAAACTGCAAACCATGGCTTATTGAAATAAATGCTTCTCCCTCTTTAACTGTTACAGGT
AAAATTGATAAAGAACTCAAAACTGAACTGATTAAAAATGTATATTAAATTGTCATTCCT
GATGATTGGAATGATGATAGTTCTAAAACTGGTGCAAACACTAGCACATAAACAAAAGTT
GGAGATTTTAATATTCTATATGATGAGGCCTAAGAAAAGAAAATTAGTTAGTAATAATAA
TAATAAAAAAAGAATATAAATAGTAAAACAATTTGGAAATGA



>TTHERM_00136210(gene)
ATTCATCAAAATTAATTAATTAATCACTGCTTAAATATCAAAAATTTTATATTTTTAAAT
AATAATTTTACACCAACAAGTAAATAAATAAATAAATGGCTTCTAAAAAATTAAAATACA
AGACAGATTTTGACAAATGTGTTTTAACAGATAATTTTGCTGCAAGAGGATGGACTAGAT
GTGGTGATAAAGATGACGATGATTGGAACATTTATTGGGCAACTGTATGGAATGTGAGAA
ATATTTTCAATCCTAAATCAGGAATTAGATTAAATGATATGCAAATTATAAATCATTTCC
CAAATCATTATGAATTGACAAGAAAAGATCTTATGGTAAAAAACTTCAAGAGATATAAAA
AAGAATTAGAAAAAGAGAATAGTCCTTATTGCTAGAAAGACGAAAATGGAAATTATCTAT
ATTTAGATTTTATTCCATAAACATTTACTCTTCCTGGTGAGTATTCACTCTTTGTTGAAG
AATTTCATAGAAATCCTAATGCAACTTGGATTGTTAAACCAGCATCACGATCTCAAGGAA
AAGGTATTTTCTTGCTTAGAAAAATACAGCAGTTGAAGAAAATAGGAGGAGGAACTAATA
GCAATCCTCTGCAGGCATTTTCTCTAAAAGAAGCTTATGTTGTTTCTAGATATATAGATA
ATCCATTGCTTGTTGGAGGGAGAAAATTCGATTTAAGAATATATGCTCTTGTTACCTCTT
ATCGTCCTCTTAAGGTTTATTTATACGCTATGGGATTCGGTCGTTTTTGTAATGAATAGT
ATACTCAAGATATTGCTGAAATGGATAATATGTTTATTCACTTAACAAATGTTGCTATTT
AAAAGTTCTCAGATAAGTATTCTGAAAAACACGGAGGAAAATGGTCATTACAGTCTTTAA
GGTATTATCTAGAAATGGTTTATGGTACAGATATGGCTAATAAATGTTTTGATGATATAA
ACAATATAATTATAATGAGTTTGAAATCTGTTTAAAGTATAATAATAAATGATAAGCACT
GTTTTGAGATGTATGGCTATGATATATTAATTGATGAAAACTGCAAACCATGGCTTATTG
AAATAAATGCTTCTCCCTCTTTAACTGTTACAGGTAAAATTGATAAAGAACTCAAAACTG
AACTGATTAAAAATGTATATTAAATTGTCATTCCTGATGATTGGAATGATGATAGTTCTA
AAACTGGTGCAAACACTAGCACATAAACAAAAGTTGGAGATTTTAATATTCTATATGATG
AGGCCTAAGAAAAGAAAATTAGTTAGTAATAATAATAATAAAAAAAGAATATAAATAGTA
AAACAATTTGGAAATGAAACACATCTTAAGAATAAGAACAATAAATATTTCTATTTATCT
AATTAATTAATTTTATTTATTTATTAAACATATTTTTAAACCTTTCCCTGAAAAAGCATT
TTAACTGAAGTCTAATTTCGTAACTTTAACAATCAAAAATATAAAAAACCTATGCAAATC
TTTTATTATTAAATGTTCTCAAT



>TTHERM_00136210(protein)
MASKKLKYKTDFDKCVLTDNFAARGWTRCGDKDDDDWNIYWATVWNVRNIFNPKSGIRLN
DMQIINHFPNHYELTRKDLMVKNFKRYKKELEKENSPYCQKDENGNYLYLDFIPQTFTLP
GEYSLFVEEFHRNPNATWIVKPASRSQGKGIFLLRKIQQLKKIGGGTNSNPLQAFSLKEA
YVVSRYIDNPLLVGGRKFDLRIYALVTSYRPLKVYLYAMGFGRFCNEQYTQDIAEMDNMF
IHLTNVAIQKFSDKYSEKHGGKWSLQSLRYYLEMVYGTDMANKCFDDINNIIIMSLKSVQ
SIIINDKHCFEMYGYDILIDENCKPWLIEINASPSLTVTGKIDKELKTELIKNVYQIVIP
DDWNDDSSKTGANTSTQTKVGDFNILYDEAQEKKISQQQQQQKKNINSKTIWK