Identifiers and Description

Gene Model Identifier

TTHERM_00138080

Standard Name

FIB1 (FIBrillarin 1)

Aliases

FIB | PreTt24434 | PreTt24435 | 10.m00484 | 3698.m00201

Description

FIB1 rRNA 2-prime-O-methyltransferase fibrillarin; Fibrillarin; essential protein localized to nucleoli in the macronucleus of vegetative cells; involved in rRNA processing; associates with U3 snoRNA

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• macronucleus (IDA) | GO:0031039
• nucleolus (IDA) | GO:0005730

Molecular Function

• methyltransferase activity (IEA) | GO:0008168
• RNA binding (IEA) | GO:0003723
• snoRNA binding (IPI) | GO:0030515

Biological Process

• rRNA processing (ISS) | GO:0006364
• rRNA processing (IEA) | GO:0006364
• tRNA processing (IEA) | GO:0008033

Domains

• ( PF01135 ) Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)
• ( PF01269 ) Fibrillarin
• ( PF01391 ) Collagen triple helix repeat (20 copies)
• ( PF08241 ) Methyltransferase domain
• ( PF08704 ) tRNA methyltransferase complex GCD14 subunit
• ( TIGR00080 ) protein-L-isoaspartate O-methyltransferase
• ( TIGR00438 ) ribosomal RNA large subunit methyltransferase

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_05872.1	1.9994249217050915e-157
	Description: fibrillarin (1203 aa)
WormBase	WBGene00006439	1.9994249217050915e-157
	Description: locus:ant-1.1 status:Confirmed UniProt:O45865 protein_id:CAB04874.1
WormBase	WBGene00001423	3.999284652801983e-113
	Description: locus:fib-1 rRNA 2-O-methyltransferase fibrillarin status:Confirmed UniProt:Q22053 protein_id:CAB01657.1
WormBase	WBGene00014200	3.999284652801983e-113
	Description: locus:scrm-2 status:Confirmed UniProt:G5EEQ3 protein_id:CAB04981.1
Oxytricha	Contig11749.0.g117	6.001115222296727e-111
	Description: Fibrillarin
DictyBase	DDB_G0269878	2.998733531465523e-108
	Description: fbl on chromosome: 1 position 3783828 to 3785196
SGD	YDL014W	1.999745369828301e-106
	Description: NOP1 Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin
Stentor Coeruleus	SteCoe_34908	3.392270193026015e-47
	Description: None

General Information

No Data fetched for General Information

Associated Literature

1. Ref:9201715: David E, McNeil JB, Basile V, Pearlman RE (1997) An unusual fibrillarin gene and protein: structure and functional implications. Molecular biology of the cell 8(6):1051-61

Sequences

>TTHERM_00138080(coding)
ATGGGTAAAGATTTCAAGTCAGGTGGTGGCAATGCTGGTGGAAAGCCCTTCAATAAAGGT
CCTGGAGGTCCTGGTGGAAGACCCTTCAATAAGGGTCCTGGTGGTCCCGGTGGTCCTGGT
GGCAAATTCGGTGGTGGCAGACCCGGTGGCCCTGGTGGCAAATTTGGTGCCAAGGGTCCT
AGAGGTCCCAAGACTATTATTGTTAAGCATAGATTAGAAGGTGTTTTCATCTGCAAAGGT
CAATAAGAAGCTTTGGTAACTAAAAATTTCTTCCCTGGTGAATCTGTTTACAATGAAAAA
CGTATGTCCGTTGAAGAAAACGGTGAAAAGATTGAATATCGTGTCTGGAATCCCTACAGA
TCTAAAATTGCTGCTGCTGTTGTTGGTGGTATTTCTGATATTCATATTAAACCTGGCTCC
AAGGTTCTCTATTTGGGTGGTGCCTCTGGTACAACTGTCTCTCACGTTGCTGATATTGTT
GGACCCACTGGTGTTGTCTATGCTGTCGAATTCTCTCACAGAAGTGGTAGAGATTTGGTA
AATATGGCTAAGAAGAGAACCAATGTTGTTCCCATTATCGGTGATGCTAGAAAGCCCCAA
GAATACAGATTCTTAGTCGGTATGGTCGATGTCGTCTTCGCTGATGTTGCCCAACCTGAT
CAAGCTAGAATTATGGGTATGAACTGTTAATACTTCTTAAAGAATGGTGGTCACTTCCTT
ATCTCCATTAAGGCTTGCTGTATTGATTCAACCAACGAACCTGCAGTCGTTTTCGCTGCT
GAAGTACAAAAATTAAAAGAAGAAGGTCTCAAGCCTGAATAATAACTTACTCTTGAACCT
TATGAAAGAGATCACGCTATGGTCCTCGGTTCTTACAGAGCTTGA

>TTHERM_00138080(gene)
ATGGGTAAAGATTTCAAGTCAGGTGGTGGCAATGCTGGTGGAAAGCCCTTCAATAAAGGT
CCTGGAGGTCCTGGTGGAAGACCCTTCAATAAGGGTCCTGGTGGTCCCGGTGGTCCTGGT
GGCAAATTCGGTGGTGGCAGACCCGGTGGCCCTGGTGGCAAATTTGGTGCCAAGGGTCCT
AGAGGTCCCAAGACTATTATTGTTAAGCATAGATTAGAAGGTGTTTTCATCTGCAAAGGT
CAATAAGAAGCTTTGGTAACTAAAAATTTCTTCCCTGGTGAATCTGTTTACAATGAAAAA
CGTATGTCCGTTGAAGAAAACGGTGAAAAGATTGAATATCGTGTCTGGAATCCCTACAGA
TCTAAAATTGCTGCTGCTGTTGTTGGTGGTATTTCTGATATTCATATTAAACCTGGCTCC
AAGGTTCTCTATTTGGGTATATATTTTAATTCTTTTCAATTAATTGATACAGCTTTGAAT
AGTTTGCATACAGCAAGGCTGTTTAAAAACAAAAATGCTAGATACTAATCAGATGGTTGA
CTTTAAAATATAATCAACTCAATCAATTATTGCAAAATATTAAAAAAGATTGATAGATAG
AAAGTATGTATGTATGTATGGGATACTCTACTTAAAATAAAATAAGTATTTGTTATACAA
ATATAAAGTAGGATTAATTCAATGCAGATAGATAGTTAGCATTTGCAAAAATATAAAATC
CCATAATGAAAATTGTAGCTGATTGTATTGAATAAATAAATACATTTCTATCTACAATAA
AAAGCATTTGAAAGATATATTTATCTTACAACATATACTACTAATATATAAATCGATAAA
TGAATGAATAAATAAATAGAATTTTTAAATTTTGCTTTAATCAATAATCCATATAAAATT
TACGCTGCTATTCTAAATAAATAAGTCAATAGCAATTAATTTTACTAAAATAAAATTTAT
TTTAGGATATTTTTATAACAAACAAACAAAGAAAGAATGATGGTTAAATTCATAGAGATT
TATATCTGAATTTATTTAACATCGATTATATCATTTAATTTCAATCAATTGAGTTAAAAA
TCTCTCATGAATAATGATATATTTTATAAACTTACTTATTTCTTTATTTTTAAGATGTAG
AAATAATTAATTCCCATCGATAATATAATAGAATCATCTAGCAAAATTTTTATTTAAACA
CATATTAAATTAAATTAATTATAAATAGGTGGTGCCTCTGGTACAACTGTCTCTCACGTT
GCTGATATTGTTGGACCCACTGGTGTTGTCTATGCTGTCGAATTCTCTCACAGAAGTGGT
AGAGATTTGGTAAATATGGCTAAGAAGAGAACCAATGTTGTTCCCATTATCGGTGATGCT
AGAAAGCCCCAAGAATACAGATTCTTAGTCGGTATGGTCGATGTCGTCTTCGCTGATGTT
GCCCAACCTGATCAAGCTAGAATTATGGGTATGAACTGTTAATACTTCTTAAAGAATGGT
GGTCACTTCCTTATCTCCATTAAGGCTTGCTGTATTGATTCAACCAACGAACCTGCAGTC
GTTTTCGCTGCTGAAGTACAAAAATTAAAAGAAGAAGGTCTCAAGCCTGAATAATAACTT
ACTCTTGAACCTTATGAAAGAGATCACGCTATGGTCCTCGGTTCTTACAGAGCTTGA

>TTHERM_00138080(protein)
MGKDFKSGGGNAGGKPFNKGPGGPGGRPFNKGPGGPGGPGGKFGGGRPGGPGGKFGAKGP
RGPKTIIVKHRLEGVFICKGQQEALVTKNFFPGESVYNEKRMSVEENGEKIEYRVWNPYR
SKIAAAVVGGISDIHIKPGSKVLYLGGASGTTVSHVADIVGPTGVVYAVEFSHRSGRDLV
NMAKKRTNVVPIIGDARKPQEYRFLVGMVDVVFADVAQPDQARIMGMNCQYFLKNGGHFL
ISIKACCIDSTNEPAVVFAAEVQKLKEEGLKPEQQLTLEPYERDHAMVLGSYRA