Identifiers and Description

Gene Model Identifier

TTHERM_00146330

Standard Name

UPFL1 (UP-Frameshift protein-Like 1)

Aliases

PreTt26840 | 11.m00537 | 3702.m00259 | UPF1b

Description

UPFL1 AAA domain protein; One of two paralogs of UPF1; DNA2/NAM7-like helicase

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Cellular Component

• macronucleus (IDA) | GO:0031039
• obsolete integral component of mitochondrial membrane (IEA) | GO:0032592
• P-body (IDA) | GO:0000932
• subrhabdomeral cisterna (IEA) | GO:0016029

Molecular Function

• 11-deoxycorticosterone binding (IEA) | GO:1903878
• amino acid:monoatomic cation symporter activity (IEA) | GO:0005416
• myoinhibitory hormone activity (IEA) | GO:0016085
• obsolete sodium-transporting two-sector ATPase activity (IEA) | GO:0015443
• obsolete zinc, iron permease activity (IEA) | GO:0015342
• pentraxin receptor activity (IEA) | GO:0008029
• phosphatidylinositol-3-phosphate binding (IEA) | GO:0032266
• phosphatidylserine decarboxylase activity (IEA) | GO:0004609
• phosphoenolpyruvate carboxykinase (GTP) activity (IEA) | GO:0004613
• phosphoenolpyruvate carboxykinase activity (IEA) | GO:0004611
• prenyltransferase activity (IEA) | GO:0004659
• prephenate dehydrogenase (NADP+) activity (IEA) | GO:0004665
• protein farnesyltransferase activity (IEA) | GO:0004660
• sphingomyelin phosphodiesterase activity (IEA) | GO:0004767
• tRNA threonylcarbamoyladenosine dehydratase (IEA) | GO:0061503
• type 4 neuropeptide Y receptor binding (IEA) | GO:0031844

Biological Process

• cellular response to cocaine (IEA) | GO:0071314
• coenzyme A biosynthetic process (IEA) | GO:0015937
• diadenosine triphosphate biosynthetic process (IEA) | GO:0015963
• establishment of protein localization to prospore membrane (IEA) | GO:1902658
• glycolytic process from mannose through fructose-6-phosphate (IEA) | GO:0061619
• heme A biosynthetic process (IEA) | GO:0006784
• heme biosynthetic process (IEA) | GO:0006783
• induction of apoptosis by extracellular signals (IEA) | GO:0008624
• inferior colliculus development (IEA) | GO:0061379
• interleukin-19 production (IEA) | GO:0032622
• interleukin-2 production (IEA) | GO:0032623
• lung connective tissue development (IEA) | GO:0060427
• lung saccule development (IEA) | GO:0060430
• mRNA catabolic process (IDA) | GO:0006402
• negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902642
• negative regulation of PERK-mediated unfolded protein response (IEA) | GO:1903898
• negative regulation of steroid hormone biosynthetic process (IEA) | GO:0090032
• neutral lipid metabolic process (IEA) | GO:0006638
• nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (ISO) | GO:0000184
• obsolete modulation by host of symbiont adenylate cyclase activity (IEA) | GO:0075075
• obsolete mRNA endonucleolytic cleavage involved in unfolded protein response (IEA) | GO:0070055
• ommochrome biosynthetic process (IEA) | GO:0006727
• phagocytosis (IEA) | GO:0006909
• plant-type cell wall modification (IEA) | GO:0009827
• polyamine acetylation (IEA) | GO:0032917
• positive regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (IEA) | GO:1902643
• post-chaperonin tubulin folding pathway (IEA) | GO:0007023
• propan-2-ol biosynthetic process (IEA) | GO:1902640
• protein localization to old growing cell tip (IEA) | GO:1903858
• regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process (IEA) | GO:1902646
• sperm aster formation (IEA) | GO:0035044
• visual behavior (IEA) | GO:0007632

Domains

• ( PF09416 ) RNA helicase (UPF2 interacting domain)
• ( PF13086 ) AAA domain
• ( PF13087 ) AAA domain

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

No Data fetched for Homologs

General Information

No Data fetched for General Information

Associated Literature

1. Ref:28402567: Tian M, Yang W, Zhang J, Dang H, Lu X, Fu C, Miao W (2017) Nonsense-mediated mRNA decay in Tetrahymena is EJC independent and requires a protozoa-specific nuclease. Nucleic acids research 45(11):6848-6863

Sequences

>TTHERM_00146330(coding)
ATGAAAGGAAACTAGCAAAATCGTCATCTTGTTTGGCAAAAAGTATCTGAAATCAAAGGC
TTCTAGGTTTTATGCTTGGATTGCAGAGTTTTTTTCGATAACTAAAGAAATCCAAATAAC
TCTAATAATTCAAGTAGTATTGTTTCGCACTTAATCTAATCAAAGCATAACAAGGTTCAG
TTACTTATCAATTCAGGCATAGCAGTTTAAAAGCATATTGTTTGCTCATCATGTAAATTA
GGGGATGTTTTTAAACTTTAAATTTATGATTATCCTCAAGGTATTCTACTGCTTTGTAAT
GAGTGTTCTTTTAAATTTATAAATTAAACTAAATTTAAATAAGATTCTGAGGTTAAGCAC
TCAACAGTTATCTAATAAAATGAAATCAATTCCATTCTTTTTGATGCAAAGAGGGTTTAA
TTAAATCCAGATATTCTACAGATAAACTAAAATAAAAAATCTAAAGTTTAATACATCAGA
AAAGTTGATGTAGTAGAAGCAAATGCTGGACCACAAAATATTAGTTAAGCTTAATAATAA
AAATCAACAAATAATTTAAATTAAAATCCCTAATTAATCGGATCAGATAAAATATAAAAT
AAAAATTAAAATGCATCTCAAGAGTAAAAAATTGAAAAACTTTTAAAAATTTAATGCTTA
GATTGCAAATAATATTTTGACAACTAAAAAATAAATGGGTCTCTCAAAACAAGCATCATT
AAGCATCTTACTAAATAGAATCATAATAGAATTACCTGTATATTAAACTAAAATTAATAA
AAAAATATTACTCCAGATTGCTATAAATGCAAGAAAAGAAATGTTTTCGATTTAACAATA
TGTAAAGTTAATAATGAATAGTATTTACTATGCTCTTAATGTTTAAATAAAAGCAACGGC
AGTTTATTTACTAATGATCCAAATATAGCTATGAAATTGGTCAGCACTTTTCCAAATGAA
CCACTTATTACTAATTATTCAATTAATTCTACTTTCCTTGATCAATTAACGAAGAGCGAT
TAACCTAAATAAATTTAATCAGATTAAACCTAATTAAATTAGTAATCTATCCCACAAAAT
ATTTAAATAGGCTTAAATAATAATAATAATTAACTTTTAGTCAGTAATAACAGTAATAAC
GAAGATACATAAGTAAAGTGCCTTTAGTGTAATAATATATTTTAAAACTAAAGAAACAAG
CATGACAGTGTAACTCAAATAGTCAAACATTTAAAAAAGTGTTCCCACAATAAAATAGAA
ATATAAGAAAAGGCAAGAAAAACTTCTTTTTCTACATTTAAATGCCTATCATGCAATTAA
AACAACATTTTTGTTCTATTTATTGTAGAAATTGAATCATTTTACTTTGTTTTATGTAAC
TAATGTATAAATAGTAAGATGATTCAATTTTAAGGTAAAGACTCACAATCAATTGAAAAA
TGTAAGAAGTCTGCTATTGTGTAAAATGGATCAATAAATACTTTATTGATGAACCTGACC
ATCAAAAAAAAAGAATACTATCCAGTAAACAATGAGCACAAAAATTAACCTGACTAAAAC
TAAATAGAATAAGATAATAATGATGATGATTATGATTTTTGCCTAAATGGAGGTAATGAC
AATCAAGTTTAAGTAGGTATGTTGAATGACCCTAAAACCTAAAATATCAATAATTAAGAT
AGAAATTTTGACTAGTCTCGCAATCTCCAATCAATCCAAGTTAATTCTAGAGAGGAAAAA
AAAATTGAAATATTTAAAAATGTTGAAGCTTATTAACATTTTTTTAAAAAGATCTTAAAT
TAAGAATAATATGAAATATCTAAGTAGATATAATAAAGTGTTTTAACAACTAAAGCACTT
ATCTTATCAGAAAATCAGTTGTAAATATAAGTTTCCTCCAACCATCTATTAAAATAGGGT
AAAGAATTAAAAATTAAATGGGGTAATTTTAAATCCAAATTTTATGTAGAGAGTATTGAT
GATCATAAAATCGTTATTAAAATTTAAGATTCTAATAAATCTTTAAGTCGTTTCAAAGTA
GGAAATGTAGTAGAAAATGTTTAAATAAAATTAATCAATCCTAAATAGATTTTTGAAAGA
ATACTGTAGGGAATTAACAAATTTTCAAGTCTAGAAGAATCTTTGTAAAAAAAAATACTT
GGTTAATTTGAAAAGGATGATAAATCTATTAAAAGTGATGATTCATTAGAAATAATTGAC
GAATAAGCTCAATAAGATATAGCTTAGCTAAATTAAAGTTAGCTGTAAGCAATTTAGTCA
TCTCTCTCAAAAAATATTTCGCTGATTTAAGGTCCTCCAGGAACAGGAAAAACTGAAACA
GCAGCTCAGCTAGTTTTAGAAATATGGTATAAAATTAACAAAAATTAACAAAACGAAAAG
ATTTTAGTTTGTGCTCCATCAAACTTAGCTGCAGATAACATTTCAGATAGGATTCATGCA
TAAAATAGAGAAATAAAAGTAATAAGAATAGTTTCTTAAGCTAGGTAAAGAGTAAAAGTT
TCATATTAATTTCAAGATATAGTTCTGCATAAAGTACTAAAGAAAGAAGGTTTCTTTAAT
AAAAATAGTGTATTGAAAAGAGCAAAATAATTAATTGAAAATGCTGACGTCATTTGTACT
ACTTGCATTAATTCTGTAGATAAGTTTATAAAAGGTATTAGTTTTTCAACAGTAGTAATA
GATGAAGCAAACTAGGCAATAGAACCAGAAACAATAATACCTCTTTAGCATTAAGCTAAA
AAATTAATTTTGATAGGTGATCATAAATAATTGCCACCCATCATCTTAAGCATTTAAGCT
TCAAAAGATGGGTTAAAAAGAAGTTTATTTTCAAGACTTGTTTAAGCTGGTCTTATCCCT
TAATTTTTATCAATTCAGTATAGGATGCATCCAGAAATAAGAAAGTTAGCATCTTCTATA
TTCTATCAAAACTAGCTTAAAGATGGAGTTAATGAATAAGATAGAACTCCTACTCCGAAG
TTCAATTGGCTAAATAATAAAATTCCTATCTAATTTTATGATGTCTAAGGTTAAGAAATT
ACTTTGTAAGATGGTAAAAGTTTTATAAACGAAGAAGAAGCAAAGCTTGTAAAAAGTTTA
GTTTCTTAGCTTATATAAGCAGGTGTTAAAGATAATGATATTGGGATAATAACGCCTTAT
TTATCTTAATCTAATTATATAAGTTAATTAATAAAAAATAGCAATATTTTAATTGATACA
ACATACAGTTTCTAAGGACAAGAAAGAGACTACATAATAATTTCATGTGTAAGGATCAAT
AATTTTTAAAACTTAGGAATTTTAAGGACACCATAGCTGATTAACGTATCTATAACAAGA
GCTAAGAGAGGTTTACTAATAGTTGGAAACAAGAAACATGTGAGTTATTCAAGATGGTGG
AAACAAATCATTGATTATTTGGATAAATTAAAACTTATTTAAGAAATTAAAAAAGAGCCT
ATCGAAAATATTTATTCTATTGAGAACAATAAAATCATAAATAAAATTGATGAAAGGCTA
TGCTTCCATAAAAAAAGTTGA

>TTHERM_00146330(gene)
CTAAAATAATCTTCACATACTATAAAAAAATAAGTGAAAAAAAGTTAATTAAAAATAATA
TTAGAAAAAACTTAGCTTAAGCTAAAGAAAAATATAATTACAAACAATTTTTAAATTTTT
CTAAAAAAGGAAATCTAAAAATAAGTAAAGGTATAAGGAAAGATATTTATGAAAGGAAAC
TAGCAAAATCGTCATCTTGTTTGGCAAAAAGTATCTGAAATCAAAGGCTTCTAGGTTTTA
TGCTTGGATTGCAGAGTTTTTTTCGATAACTAAAGAAATCCAAATAACTCTAATAATTCA
AGTAGTATTGTTTCGCACTTAATCTAATCAAAGCATAACAAGGTTCAGTTACTTATCAAT
TCAGGCATAGCAGTTTAAAAGCATATTGTTTGCTCATCATGTAAATTAGGGGATGTTTTT
AAACTTTAAATTTATGATTATCCTCAAGGTATTCTACTGCTTTGTAATGAGTGTTCTTTT
AAATTTATAAATTAAACTAAATTTAAATAAGATTCTGAGGTTAAGCACTCAACAGTTATC
TAATAAAATGAAATCAATTCCATTCTTTTTGATGCAAAGAGGGTTTAATTAAATCCAGAT
ATTCTACAGATAAACTAAAATAAAAAATCTAAAGTTTAATACATCAGAAAAGTTGATGTA
GTAGAAGCAAATGCTGGACCACAAAATATTAGTTAAGCTTAATAATAAAAATCAACAAAT
AATTTAAATTAAAATCCCTAATTAATCGGATCAGATAAAATATAAAATAAAAATTAAAAT
GCATCTCAAGAGTAAAAAATTGAAAAACTTTTAAAAATTTAATGCTTAGATTGCAAATAA
TATTTTGACAACTAAAAAATAAATGGGTCTCTCAAAACAAGCATCATTAAGCATCTTACT
AAATAGAATCATAATAGAATTACCTGTATATTAAACTAAAATTAATAAAAAAATATTACT
CCAGATTGCTATAAATGCAAGAAAAGAAATGTTTTCGATTTAACAATATGTAAAGTTAAT
AATGAATAGTATTTACTATGCTCTTAATGTTTAAATAAAAGCAACGGCAGTTTATTTACT
AATGATCCAAATATAGCTATGAAATTGGTCAGCACTTTTCCAAATGAACCACTTATTACT
AATTATTCAATTAATTCTACTTTCCTTGATCAATTAACGAAGAGCGATTAACCTAAATAA
ATTTAATCAGATTAAACCTAATTAAATTAGTAATCTATCCCACAAAATATTTAAATAGGC
TTAAATAATAATAATAATTAACTTTTAGTCAGTAATAACAGTAATAACGAAGATACATAA
GTAAAGTGCCTTTAGTGTAATAATATATTTTAAAACTAAAGAAACAAGCATGACAGTGTA
ACTCAAATAGTCAAACATTTAAAAAAGTGTTCCCACAATAAAATAGAAATATAAGAAAAG
GCAAGAAAAACTTCTTTTTCTACATTTAAATGCCTATCATGCAATTAAAACAACATTTTT
GTTCTATTTATTGTAGAAATTGAATCATTTTACTTTGTTTTATGTAACTAATGTATAAAT
AGTAAGATGATTCAATTTTAAGGTAAAGACTCACAATCAATTGAAAAATGTAAGAAGTCT
GCTATTGTGTAAAATGGATCAATAAATACTTTATTGATGAACCTGACCATCAAAAAAAAA
GAATACTATCCAGTAAACAATGAGCACAAAAATTAACCTGACTAAAACTAAATAGAATAA
GATAATAATGATGATGATTATGATTTTTGCCTAAATGGAGGTAATGACAATCAAGTTTAA
GTAGGTATGTTGAATGACCCTAAAACCTAAAATATCAATAATTAAGATAGAAATTTTGAC
TAGTCTCGCAATCTCCAATCAATCCAAGTTAATTCTAGAGAGGAAAAAAAAATTGAAATA
TTTAAAAATGTTGAAGCTTATTAACATTTTTTTAAAAAGATCTTAAATTAAGAATAATAT
GAAATATCTAAGTAGATATAATAAAGTGTTTTAACAACTAAAGCACTTATCTTATCAGAA
AATCAGTTGTAAATATAAGTTTCCTCCAACCATCTATTAAAATAGGGTAAAGAATTAAAA
ATTAAATGGGGTAATTTTAAATCCAAATTTTATGTAGAGAGTATTGATGATCATAAAATC
GTTATTAAAATTTAAGATTCTAATAAATCTTTAAGTCGTTTCAAAGTAGGAAATGTAGTA
GAAAATGTTTAAATAAAATTAATCAATCCTAAATAGATTTTTGAAAGAATACTGTAGGGA
ATTAACAAATTTTCAAGTCTAGAAGAATCTTTGTAAAAAAAAATACTTGGTTAATTTGAA
AAGGATGATAAATCTATTAAAAGTGATGATTCATTAGAAATAATTGACGAATAAGCTCAA
TAAGATATAGCTTAGCTAAATTAAAGTTAGCTGTAAGCAATTTAGTCATCTCTCTCAAAA
AATATTTCGCTGATTTAAGGTCCTCCAGGAACAGGAAAAACTGAAACAGCAGCTCAGCTA
GTTTTAGAAATATGGTATAAAATTAACAAAAATTAACAAAACGAAAAGATTTTAGTTTGT
GCTCCATCAAACTTAGCTGCAGATAACATTTCAGATAGGATTCATGCATAAAATAGAGAA
ATAAAAGTAATAAGAATAGTTTCTTAAGCTAGGTAAAGAGTAAAAGTTTCATATTAATTT
CAAGATATAGTTCTGCATAAAGTACTAAAGAAAGAAGGTTTCTTTAATAAAAATAGTGTA
TTGAAAAGAGCAAAATAATTAATTGAAAATGCTGACGTCATTTGTACTACTTGCATTAAT
TCTGTAGATAAGTTTATAAAAGGTATTAGTTTTTCAACAGTAGTAATAGATGAAGCAAAC
TAGGCAATAGAACCAGAAACAATAATACCTCTTTAGCATTAAGCTAAAAAATTAATTTTG
ATAGGTGATCATAAATAATTGCCACCCATCATCTTAAGCATTTAAGCTTCAAAAGATGGG
TTAAAAAGAAGTTTATTTTCAAGACTTGTTTAAGCTGGTCTTATCCCTTAATTTTTATCA
ATTCAGTATAGGATGCATCCAGAAATAAGAAAGTTAGCATCTTCTATATTCTATCAAAAC
TAGCTTAAAGATGGAGTTAATGAATAAGATAGAACTCCTACTCCGAAGTTCAATTGGCTA
AATAATAAAATTCCTATCTAATTTTATGATGTCTAAGGTTAAGAAATTACTTTGTAAGAT
GGTAAAAGTTTTATAAACGAAGAAGAAGCAAAGCTTGTAAAAAGTTTAGTTTCTTAGCTT
ATATAAGCAGGTGTTAAAGATAATGATATTGGGATAATAACGCCTTATTTATCTTAATCT
AATTATATAAGTTAATTAATAAAAAATAGCAATATTTTAATTGATACAACATACAGTTTC
TAAGGACAAGAAAGAGACTACATAATAATTTCATGTGTAAGGATCAATAATTTTTAAAAC
TTAGGAATTTTAAGGACACCATAGCTGATTAACGTATCTATAACAAGAGCTAAGAGAGGT
TTACTAATAGTTGGAAACAAGAAACATGTGAGTTATTCAAGATGGTGGAAACAAATCATT
GATTATTTGGATAAATTAAAACTTATTTAAGAAATTAAAAAAGAGCCTATCGAAAATATT
TATTCTATTGAGAACAATAAAATCATAAATAAAATTGATGAAAGGCTATGCTTCCATAAA
AAAAGTTGACAGATACAATAATAATTTTTATTAAAACATATTTAAATTTTTTTAACAAAC
ACCTATTTAATTTTATAGTTTCAAAAATGTCTGCTTTATAGTTAGTTAGTTTCTAATAAA
TATTGAAATTTATAAATTATTTTCTTTAA

>TTHERM_00146330(protein)
MKGNQQNRHLVWQKVSEIKGFQVLCLDCRVFFDNQRNPNNSNNSSSIVSHLIQSKHNKVQ
LLINSGIAVQKHIVCSSCKLGDVFKLQIYDYPQGILLLCNECSFKFINQTKFKQDSEVKH
STVIQQNEINSILFDAKRVQLNPDILQINQNKKSKVQYIRKVDVVEANAGPQNISQAQQQ
KSTNNLNQNPQLIGSDKIQNKNQNASQEQKIEKLLKIQCLDCKQYFDNQKINGSLKTSII
KHLTKQNHNRITCILNQNQQKNITPDCYKCKKRNVFDLTICKVNNEQYLLCSQCLNKSNG
SLFTNDPNIAMKLVSTFPNEPLITNYSINSTFLDQLTKSDQPKQIQSDQTQLNQQSIPQN
IQIGLNNNNNQLLVSNNSNNEDTQVKCLQCNNIFQNQRNKHDSVTQIVKHLKKCSHNKIE
IQEKARKTSFSTFKCLSCNQNNIFVLFIVEIESFYFVLCNQCINSKMIQFQGKDSQSIEK
CKKSAIVQNGSINTLLMNLTIKKKEYYPVNNEHKNQPDQNQIEQDNNDDDYDFCLNGGND
NQVQVGMLNDPKTQNINNQDRNFDQSRNLQSIQVNSREEKKIEIFKNVEAYQHFFKKILN
QEQYEISKQIQQSVLTTKALILSENQLQIQVSSNHLLKQGKELKIKWGNFKSKFYVESID
DHKIVIKIQDSNKSLSRFKVGNVVENVQIKLINPKQIFERILQGINKFSSLEESLQKKIL
GQFEKDDKSIKSDDSLEIIDEQAQQDIAQLNQSQLQAIQSSLSKNISLIQGPPGTGKTET
AAQLVLEIWYKINKNQQNEKILVCAPSNLAADNISDRIHAQNREIKVIRIVSQARQRVKV
SYQFQDIVLHKVLKKEGFFNKNSVLKRAKQLIENADVICTTCINSVDKFIKGISFSTVVI
DEANQAIEPETIIPLQHQAKKLILIGDHKQLPPIILSIQASKDGLKRSLFSRLVQAGLIP
QFLSIQYRMHPEIRKLASSIFYQNQLKDGVNEQDRTPTPKFNWLNNKIPIQFYDVQGQEI
TLQDGKSFINEEEAKLVKSLVSQLIQAGVKDNDIGIITPYLSQSNYISQLIKNSNILIDT
TYSFQGQERDYIIISCVRINNFQNLGILRTPQLINVSITRAKRGLLIVGNKKHVSYSRWW
KQIIDYLDKLKLIQEIKKEPIENIYSIENNKIINKIDERLCFHKKS