Identifiers and Description

Gene Model Identifier

TTHERM_00193230

Standard Name

PDA1 (Pyruvate Dehydrogenase Alpha 1)

Aliases

PreTt06606 | 16.m00262

Description

PDA1 pyruvate dehydrogenase E1 alpha subunit; Pyruvate dehydrogenase complex E1 component; catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA

Genome Browser (Macronucleus)

Full Screen View

No Genome Browser Data Present

Genome Browser (Micronucleus)

Full Screen View

No Genome Browser Data Present

External Links

• Uniprot
• Alphafold

Gene Ontology Annotations

Molecular Function

• oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (IEA) | GO:0016624

Biological Process

• metabolic process (IEA) | GO:0008152

Domains

• ( PF00676 ) Dehydrogenase E1 component
• ( PF02775 ) Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
• ( TIGR03181 ) pyruvate dehydrogenase (acetyl-transferring) E1 component,
• ( TIGR03182 ) pyruvate dehydrogenase (acetyl-transferring) E1 component,

Gene Expression Profile

Vegetative Cell Cycle (Zhang et al., 2023)

GeneMania

No results were calculated for this gene in GeneMania.

Tetrahymena Stock Center

No Data fetched for Tetrahymena Stock Center

Homologs

Source	Identifier	Score
Tetrahymena borealis	EI9_03605.1	9.997093137033517e-262
	Description: pyruvate dehydrogenase E1 component (388 aa)
Tetrahymena borealis	EI9_03443.1	9.997093137033517e-262
	Description: hypothetical protein (211 aa)
Oxytricha	Contig9079.0.0.g83	2.998923500611476e-144
	Description: Dehydrogenase E1 component
DictyBase	DDB_G0292994	9.995516318087232e-125
	Description: pdhA on chromosome: 6 position 2563001 to 2564757
WormBase	WBGene00011510	1.000211181581171e-120
	Description: locus:pdha-1 Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial status:Confirmed UniProt:P52899 protein_id:CAA87793.1
WormBase	WBGene00020369	1.000211181581171e-120
	Description: status:Confirmed UniProt:Q22352 protein_id:CCD72269.1
SGD	YER178W	1.0001900614163146e-108
	Description: PDA1 E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose
Stentor Coeruleus	SteCoe_7851	1.7785284761271306e-68
	Description: None

General Information

No Data fetched for General Information

Associated Literature

No Data fetched for Associated Literature

Sequences

>TTHERM_00193230(coding)
ATGAGGTACTAAAGAGTATAATTATTCCTTGCTCAAATCAAAAGAAAGGAAAGAAAGAAA
GAAGAAAAGAAAGAAAAAAAATAAAAATAAAATACAAATAAATAAAATAATCATCAAAAA
GCTAAACTAATGATATCTAAGTTCTTCAATCCTGTTGCTGGTAAGACCTTCAACAGACTT
AACAAGTATGCCTTCTCTTCAGTCACTATTAACCTTGAAGGATACTAGACTAAGATGTTA
GACGGATTCAAATTGCCCACCTAATCAACTGCTACCAAGGAAGAATTATTGAAGCTCTAC
AAAGATATGAACGTTATGAGAAAGATCGAACTTGCATGCGATAAGCTTTATAAGCAAAGA
GAAATTAGAGGTTTCTGCCATCTCTACGACGGTTAAGAAGCTGTTATCTCAGGTATTGAA
GCTGCTTGCAATCTTGAGGATGCAATAATCACTGCCTATAGATGCCATTGTCACGCTTAC
ACAAGAGGTGACACTCCCCATTAAATTATTGCTGAACTTATGGGAAGAAAGACTGGTTCT
ACAGGTGGTAAGGGTGGTTCTATGCACTTCTACAGAAAGAAAACTCACTTCTATGGTGGT
CACGGTATTGTCGGTGCTCAAGTTCCCATGGGTGCTGGATTAGCCTTTGCTTTGAAATAT
GAAAAGAAGCCCAACGTTTCTATCACTATGTACGGTGACGGTGCTGCCAATCAAGGTTAA
ATTGCTGAAGCTGCCAACATGGCTGGTTTATGGAATTTACCATGCTTGTTTGTTTGTGAA
AACAATCTTTACGGTATGGGTACCTCTACTGCAAGAGCTTCTCACAATACTGATTTCTAC
ACCAGAGGTGACAAGATTCCTGGTATCAGAATGGACGGTAATAACTATTTCCATGTTAAG
GAAGGTTTCAAGTTTGCTAAGCAATATGCCTTAGAACATGGTCCTCTCTTCATTGAATTG
AGAACTTACAGATATCACGGTCACTCTATGTCTGACTCCGGTACTACTTATAGAACTCAA
GAAGAAATCAAAGAATTCAGATAAAAGAAGGATTGCATATAATTTATTGCTAATACCATT
TTATAAAATAACTTTGCTACTCAAGAATAACTCGAAGCTATCCAAGATGAAACTAGAGAA
ATTGTTGATAAAGCCGTTGAACAAGCTCTTAAAGACCCATTACCTGATGATCACGAATTG
TGCACCGATGTTTACATTAACAACGATAAATACTACATCAGAGGTATTGAATACGAATAA
GGTTACTTCCCTGAAGGCAAGCCCTACTGA

>TTHERM_00193230(gene)
ATGAGGTACTAAAGAGTATAATTATTCCTTGCTCAAATCAAAAGAAAGGAAAGAAAGAAA
GAAGAAAAGAAAGAAAAAAAATAAAAATAAAATACAAATAAATAAAATAATCATCAAAAA
GCTAAACTAATGATATCTAAGTTCTTCAATCCTGTTGCTGGTAAGACCTTCAACAGACTT
AACAAGTATGCCTTCTCTTCAGTCACTATTAACCTTGTAATTCAATTATTTATTTAATCT
TTTGCTAAGAATATAAATTTAGATAGAAATAGTTTATATTTTTCATTTTTTGACAGAATA
ACTAACTAACTCTCCAATGTTCGAATATTTGATTATATGGCGATAACTACTAAAATATTT
CAAATTCTTGCAAACATTCAACAAAAAAGCTTATAAACTTTAATTTAAATTTACAAAATA
TTTAAGAAAAATAACTTAAATATGATACCAAGCATTTCTTTAGTTAAATATTGCAGTATC
CCACGAATATCCTTATTGTCTAATTTCTGTTTTAAGAAATCTATTTCTACCTAATTATTT
AGCAATCCTAAAACAAAAAAATAGAAAAAAATGATTGCAACTAGAATTTAAATGAAATAA
ATAGTGCTTAACAACCCTTACTTAATCTGATTTTTTTATGAATGATATATGATAGGAAGG
ATACTAGACTAAGATGTTAGACGGATTCAAATTGCCCACCTAATCAACTGCTACCAAGGA
AGAATTATTGAAGCTCTACAAAGATATGAACGTTATGAGAAAGATCGAACTTGCATGCGA
TAAGCTTTATAAGCAAAGAGAAATTAGAGGTTTCTGCCATCTCTACGACGGTTAAGTAAA
TATCATATCATCAATTTTCTTATTATATAGCAAGTTTTTTACATTGACAAGATAACATAA
TGAGATCAATAGTATGACTTTTTAAATTTATAATAAAATATCTTTTAAAAATAATAGGAA
GCTGTTATCTCAGGTATTGAAGCTGCTTGCAATCTTGAGGATGCAATAATCACTGCCTAT
AGATGCCATTGTCACGCTTACACAAGAGGTGACACTCCCCATTAAATTATTGCTGAACTT
ATGGGAAGAAAGACTGGTTCTACAGGTGGTAAGGGTGGTTCTATGCACTTCTACAGAAAG
AAAACTCACTTCTATGGTGGTCACGGTATTGTCGGTGCTCAAGTAAAAATAATTTTCTAA
TTTATTATTTATTTTTCAGATATCATTTTTTCAGTTGTTAATTTAATTGAATAAAGGGAC
ATGGTTTTTTTTTTAAAAAAGTAAGTATCTTTATTCAAAAAATAAAAAATTAATTAAAAA
AAATAAAATTATATCAAAGACCTAGCTTTAATTAATATTCTTAATTTAACAATTTTTTTA
AAAAAAGGTTCCCATGGGTGCTGGATTAGCCTTTGCTTTGAAATATGAAAAGAAGCCCAA
CGTTTCTATCACTATGTACGGTGACGGTGCTGCCAATCAAGGTTAAATTGCTGAAGCTGC
CAACATGGCTGGTTTATGGAATTTACCATGCTTGTTTGTTTGTGAAAACAATCTTTACGG
TATGGGTACCTCTACTGCAAGAGCTTCTCACAATACTGATTTCTACACCAGAGGTGACAA
GATTCCTGGTATCAGAGTAATCAAAATCAAATAAAAATATAAAAGTTGTGTCTAAATAAT
TTTTTAAATCAATAAAAGATGGACGGTAATAACTATTTCCATGTTAAGGAAGGTTTCAAG
TTTGCTAAGCAATATGCCTTAGAACATGGTCCTCTCTTCATTGAATTGAGAACTTACAGA
TATCACGGTCACTCTATGTCTGACTCCGGTACTACTTATAGAACTCAAGAAGAAATCAAA
GAATTCAGATAAAAGAAGGATTGCATATAATTTATTGCTAATACCATTTTATAAAATAAC
TTTGCTACTCAAGAATAACTCGAAGTGATAATTTTAAATTACATTTTTAATAGAAATTAA
AACTTTATTTTTCTCAAAATTAGGCTATCCAAGATGAAACTAGAGAAATTGTTGATAAAG
CCGTTGAACAAGCTCTTAAAGACCCATTACCTGATGATCACGAATTGTGCACCGATGTTT
ACATTAACAACGATAAATGTAAATTGAAAAATTTCCAAAAAAAAATTTATTTAATTTAAT
TTTAACAAATAAAGACTACATCAGAGGTATTGAATACGAATAAGGTTACTTCCCTGAAGG
CAAGCCCTACTGA

>TTHERM_00193230(protein)
MRYQRVQLFLAQIKRKERKKEEKKEKKQKQNTNKQNNHQKAKLMISKFFNPVAGKTFNRL
NKYAFSSVTINLEGYQTKMLDGFKLPTQSTATKEELLKLYKDMNVMRKIELACDKLYKQR
EIRGFCHLYDGQEAVISGIEAACNLEDAIITAYRCHCHAYTRGDTPHQIIAELMGRKTGS
TGGKGGSMHFYRKKTHFYGGHGIVGAQVPMGAGLAFALKYEKKPNVSITMYGDGAANQGQ
IAEAANMAGLWNLPCLFVCENNLYGMGTSTARASHNTDFYTRGDKIPGIRMDGNNYFHVK
EGFKFAKQYALEHGPLFIELRTYRYHGHSMSDSGTTYRTQEEIKEFRQKKDCIQFIANTI
LQNNFATQEQLEAIQDETREIVDKAVEQALKDPLPDDHELCTDVYINNDKYYIRGIEYEQ
GYFPEGKPY